ChEMBL ligand: CHEMBL530228 (TCMDC-134293)
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity: Liver Stage Plasmodium berghei sporozoite Luciferase assay IC50 (uM)	F	5.66	pIC50	2170	nM	IC50	MMV Pathogen Box Bioactivity Data
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity: Asexual Blood Stage Plasmodium falciparum W2 IC50 (uM)	F	6.14	pIC50	730	nM	IC50	MMV Pathogen Box Bioactivity Data
ChEMBL	Antimalarial activity: Asexual Blood Stage Plasmodium falciparum Dd2 IC50 (uM)	F	6.2	pIC50	630	nM	IC50	MMV Pathogen Box Bioactivity Data
ChEMBL	Antimalarial activity: Asexual Blood Stage Plasmodium falciparum 3D7 IC50 (uM)	F	6.22	pIC50	600	nM	IC50	MMV Pathogen Box Bioactivity Data
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7A infected in RBC assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by microbeta counting method	F	6.22	pIC50	600	nM	IC50	J Med Chem (2018) 61: 5692-5703 [PMID:29889526]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay	F	6.27	pIC50	543	nM	IC50	J Med Chem (2018) 61: 5692-5703 [PMID:29889526]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972]
GtoPdb	Parasite growth inhibition assay	-	6.27	pIC50	543	nM	IC50	J Med Chem (2018) 61: 5692-5703 [PMID:29889526]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]