MMV024101 [Ligand Id: 10017] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL530228 (TCMDC-134293)
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  • Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL Antimalarial activity: Liver Stage Plasmodium berghei sporozoite Luciferase assay IC50 (uM) F 5.66 pIC50 2170 nM IC50 MMV Pathogen Box Bioactivity Data
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity: Asexual Blood Stage Plasmodium falciparum W2 IC50 (uM) F 6.14 pIC50 730 nM IC50 MMV Pathogen Box Bioactivity Data
ChEMBL Antimalarial activity: Asexual Blood Stage Plasmodium falciparum Dd2 IC50 (uM) F 6.2 pIC50 630 nM IC50 MMV Pathogen Box Bioactivity Data
ChEMBL Antimalarial activity: Asexual Blood Stage Plasmodium falciparum 3D7 IC50 (uM) F 6.22 pIC50 600 nM IC50 MMV Pathogen Box Bioactivity Data
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7A infected in RBC assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by microbeta counting method F 6.22 pIC50 600 nM IC50 J Med Chem (2018) 61: 5692-5703 [PMID:29889526]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay F 6.27 pIC50 543 nM IC50 J Med Chem (2018) 61: 5692-5703 [PMID:29889526]
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972]
GtoPdb Parasite growth inhibition assay - 6.27 pIC50 543 nM IC50 J Med Chem (2018) 61: 5692-5703 [PMID:29889526]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]