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ChEMBL ligand: CHEMBL530228 (TCMDC-134293) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
ChEMBL | Antimalarial activity: Liver Stage Plasmodium berghei sporozoite Luciferase assay IC50 (uM) | F | 5.66 | pIC50 | 2170 | nM | IC50 | MMV Pathogen Box Bioactivity Data |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimalarial activity: Asexual Blood Stage Plasmodium falciparum W2 IC50 (uM) | F | 6.14 | pIC50 | 730 | nM | IC50 | MMV Pathogen Box Bioactivity Data |
ChEMBL | Antimalarial activity: Asexual Blood Stage Plasmodium falciparum Dd2 IC50 (uM) | F | 6.2 | pIC50 | 630 | nM | IC50 | MMV Pathogen Box Bioactivity Data |
ChEMBL | Antimalarial activity: Asexual Blood Stage Plasmodium falciparum 3D7 IC50 (uM) | F | 6.22 | pIC50 | 600 | nM | IC50 | MMV Pathogen Box Bioactivity Data |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7A infected in RBC assessed as reduction in [3H]-hypoxanthine incorporation preincubated for 24 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by microbeta counting method | F | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2018) 61: 5692-5703 [PMID:29889526] |
ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay | F | 6.27 | pIC50 | 543 | nM | IC50 | J Med Chem (2018) 61: 5692-5703 [PMID:29889526] |
Plasmodium falciparum phosphatidylinositol 4-kinase beta in Plasmodium falciparum NF54 [GtoPdb: 2972] | ||||||||
GtoPdb | Parasite growth inhibition assay | - | 6.27 | pIC50 | 543 | nM | IC50 | J Med Chem (2018) 61: 5692-5703 [PMID:29889526] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]