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Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)

Stage ID:3
Name:Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Associated with:9 targets
39 ligands
Description
The collective lifecycle stage that occurs as a result of asexual replication in erythrocytes of the host organism and can include:
  • erythrocytic merozoite, non-motile but recognises specific proteins on the surface of the erythrocyte and has an apical complex that facilitates entry into the host cell. This form of the parasite is also found in host hepatocytes (see hepatic merozoites).
  • trophozoite, the intracellular trophic form that develops from the merozoite. The young trophozoite has a distinctive 'ring' morphology in Geimsa-stained blood smears but this disappears as the parasite grows in size. During the trophic period the parasite ingests the host cell cytoplasm and breaks down the haemoglobin, producing non-toxic hemozoin as a by-product. After feeding and growth is complete the trophozoite undergoes asexual reproduction (schizony) and develops into a schizont.
  • erythrocytic schizont, a multinucleate form of the parasite that develops in erythrocytes from the trophozoite by schizogony with incomplete cytokineses. This developmental form is also found in host hepatocytes (see hepatic schizont).
Completion of cytokinesis produces several thousand merozoites from a single schizont, leading to rupture of the infected erythrocyte and release of merozoites into the bloodstream. These merozoites invade new erythrocytes and initiate either another cycle of schizogony or, under certain conditions, a small percentage of merozoites commit to sexual reproduction instead (see Plasmodium sexual blood stage).
It is the repeated cycles of schizogony in erythrocytes that leads to clinical symptoms: the simultaneous rupture of infected erythrocytes and the associated release of antigens and waste products accounts for the intermittent bouts of fever associated with malaria. As a result, almost all available antimalarial therapies target the asexual blood stage.

Interactions

Interactions
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Target Ligand Sp. Action Affinity Parameter Reference
Plasmodium falciparum dihydroorotate dehydrogenase DSM421 Pf3D7 - 7.4 – 7.8 pEC50 19
pEC50 7.8 (EC50 1.4x10-8 M) SYBR Green incorporation (72h assay) [19]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
pEC50 7.4 (EC50 4.3x10-8 M) SYBR Green incorporation (48h assay) [19]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum dihydroorotate dehydrogenase DSM265 PfNF54 - 7.5 pIC50 18
pIC50 7.5 (IC50 3x10-8 M) [3H]-hypoxanthine incorporation [18]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum dihydroorotate dehydrogenase DSM421 Pv - 6.7 pEC50 19
pEC50 6.7 (EC50 1.8x10-7 M) [19]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Blood-stage: schizont maturation assay using P. vivax field isolates.
Plasmodium falciparum N-Myristoyltransferase Compound 34c [PMID 24641010] Pf3D7 - 6.5 pEC50 20
pEC50 6.5 (EC50 3.02x10-7 M) [3H]-hypoxanthine incorporation [20]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-Myristoyltransferase Compound 34c [PMID 24641010] PfNF54 - 6.6 pEC50 20
pEC50 6.6 (EC50 2.32x10-7 M) [3H]-hypoxanthine incorporation [20]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-Myristoyltransferase Compound 34c [PMID 24641010] PfK1 - 6.5 pEC50 20
pEC50 6.5 (EC50 3.39x10-7 M) [3H]-hypoxanthine incorporation [20]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum N-Myristoyltransferase Compound 34c [PMID 24641010] PfDd2 - 6.0 pEC50 20
pEC50 6.0 (EC50 9.16x10-7 M) [3H]-hypoxanthine incorporation [20]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 (+)-SJ733 Pf3D7 - 7.5 pEC50 10
pEC50 7.5 (EC50 3x10-8 M) SYBR Green I assay [10]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 cipargamin Pf3D7 - 9.1 pIC50 21
pIC50 9.1 (IC50 7x10-10 M) [3H]-hypoxanthine incorporation assay [21]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 cipargamin PfNF54 - 9.3 pIC50 21
pIC50 9.3 (IC50 5x10-10 M) [3H]-hypoxanthine incorporation assay [21]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 (+)-SJ733 PfV1/S - 7.2 pEC50 10
pEC50 7.2 (EC50 6x10-8 M) SYBR Green I assay [10]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 cipargamin PfV1/S - 8.9 pIC50 21
pIC50 8.9 (IC50 1.4x10-9 M) [3H]-hypoxanthine incorporation assay [21]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 MMV253 Pf - 8.1 pIC50 8
pIC50 8.1 (IC50 9x10-9 M) SYBR Green assay [8]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 (+)-SJ733 PfK1 - 7.4 pEC50 10
pEC50 7.4 (EC50 4x10-8 M) SYBR Green I assay [10]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 cipargamin PfK1 - 9.2 pIC50 21
pIC50 9.2 (IC50 6x10-10 M) [3H]-hypoxanthine incorporation assay [21]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 cipargamin PfD6 - 9.0 pIC50 21
pIC50 9.0 (IC50 1x10-9 M) [3H]-hypoxanthine incorporation assay [21]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 cipargamin Pf7G8 - 8.9 pIC50 21
pIC50 8.9 (IC50 1.2x10-9 M) [3H]-hypoxanthine incorporation assay [21]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 cipargamin PfTM90C2A - 9.3 pIC50 21
pIC50 9.3 (IC50 5x10-10 M) [3H]-hypoxanthine incorporation assay [21]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum ATPase4 (+)-SJ733 PfDd2 - 7.7 pEC50 10
pEC50 7.7 (EC50 2x10-8 M) SYBR Green I assay [10]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase MMV024101 Pf3D7 - 6.2 pIC50 12
pIC50 6.2 (IC50 6x10-7 M) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum phosphatidylinositol 4-kinase MMV024101 PfNF54 - 6.3 pIC50 12
pIC50 6.3 (IC50 5.43x10-7 M) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum phosphatidylinositol 4-kinase MMV048 PfNF54 - 7.6 pIC50 16
pIC50 7.6 (IC50 2.8x10-8 M) [3H]-hypoxanthine incorporation assay [16]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase UCT943 PfNF54 - 8.3 pIC50 3
pIC50 8.3 (IC50 5.4x10-9 M) [3H]-hypoxanthine incorporation [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase compound 55 [PMID: 29889526] PfNF54 - 7.2 pIC50 12
pIC50 7.2 (IC50 6.3x10-8 M) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum phosphatidylinositol 4-kinase UCT943 PfV1/S - 8.4 pIC50 3
pIC50 8.4 (IC50 4.2x10-9 M) [3H]-hypoxanthine incorporation [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase compound 55 [PMID: 29889526] PfK1 - 7.0 pIC50 12
pIC50 7.0 (IC50 1.02x10-7 M) [12]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Plasmodium falciparum phosphatidylinositol 4-kinase UCT943 PfK1 - 8.3 pIC50 3
pIC50 8.3 (IC50 4.7x10-9 M) [3H]-hypoxanthine incorporation [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase UCT943 PfD6 - 8.3 pIC50 3
pIC50 8.3 (IC50 5.2x10-9 M) [3H]-hypoxanthine incorporation [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase UCT943 Pf7G8 - 8.4 pIC50 3
pIC50 8.4 (IC50 4.1x10-9 M) [3H]-hypoxanthine incorporation [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase UCT943 PfDd2 - 8.2 pIC50 3
pIC50 8.2 (IC50 5.7x10-9 M) [3H]-hypoxanthine incorporation [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum phosphatidylinositol 4-kinase UCT943 PfHB3 - 8.4 pIC50 3
pIC50 8.4 (IC50 3.7x10-9 M) [3H]-hypoxanthine incorporation [3]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum elongation factor 2 M5717 Pf3D7 - 9.0 pEC50 1
pEC50 9.0 (EC50 1x10-9 M) [3H]-hypoxanthine incorporation assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase fosmidomycin PfDd2 - 6.5 pIC50 11
pIC50 6.5 (IC50 2.9x10-7 M) [3H]-hypoxanthine incorporation assay [11]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase fosmidomycin PfHB3 - 6.5 pIC50 11
pIC50 6.5 (IC50 3.5x10-7 M) [3H]-hypoxanthine incorporation assay [11]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase fosmidomycin PfA2 - 6.4 pIC50 11
pIC50 6.4 (IC50 3.7x10-7 M) [3H]-hypoxanthine incorporation assay [11]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfNF54 - 8.4 pIC50 6
pIC50 8.4 (IC50 4.5x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase P218 PfV1/S - 7.3 pIC50 26
pIC50 7.3 (IC50 5.6x10-8 M) [3H]-hypoxanthine incorporation [26]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfV1/S - <5.0 pIC50 6
pIC50 <5.0 (IC50 >1x10-5 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfK1 - 6.3 pIC50 6
pIC50 6.3 (IC50 4.45x10-7 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfD6 - 8.8 pIC50 6
pIC50 8.8 (IC50 1.7x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil Pf7G8 - 6.4 pIC50 6
pIC50 6.4 (IC50 3.657x10-7 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfW2 - 6.0 pIC50 6
pIC50 6.0 (IC50 1.002x10-6 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase cycloguanil PfTM90C2A - 5.4 pIC50 6
pIC50 5.4 (IC50 4.262x10-6 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase pyrimethamine PfTM4 - 7.2 pIC50 26
pIC50 7.2 (IC50 5.8x10-8 M) [3H]-hypoxanthine incorporation assay wild-type P. falciparum (TM4) [26]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase P218 PfTM4 - 8.3 pIC50 26
pIC50 8.3 (IC50 4.6x10-9 M) [3H]-hypoxanthine incorporation [26]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum proline--tRNA ligase halofuginone Pf3D7 - 9.1 pEC50 9
pEC50 9.1 (EC50 8.6x10-10 M) SYBR Green assay [9]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum proline--tRNA ligase halofuginone PfDd2 - 9.1 pEC50 9
pEC50 9.1 (EC50 8.1x10-10 M) SYBR Green assay [9]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase sulfadoxine Pf3D7 - 7.1 pIC50 24
pIC50 7.1 (IC50 7.3x10-8 M) [3H]-hypoxanthine incorporation [24]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase sulfadoxine PfK1 - 6.7 pIC50 24
pIC50 6.7 (IC50 2.23x10-7 M) [3H]-hypoxanthine incorporation [24]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase sulfadoxine PfDd2 - 5.4 pIC50 24
pIC50 5.4 (IC50 3.97x10-6 M) [3H]-hypoxanthine incorporation [24]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase sulfadoxine PfHB3 - 8.4 pIC50 24
pIC50 8.4 (IC50 4x10-9 M) [3H]-hypoxanthine incorporation [24]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA azithromycin Pf3D7 - 7.3 pIC50 5
pIC50 7.3 (IC50 5.27x10-8 M) FACS analysis following 96 hours in culture (third-generation rings) [5]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (96 hours)
Unknown MOA doxycycline Pf3D7 - 7.3 pIC50 5
pIC50 7.3 (IC50 4.53x10-8 M) FACS analysis following 96 hours in culture (third-generation rings) [5]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (96 hours)
Unknown MOA KAF156 Pf3D7 - 8.1 pIC50 13
pIC50 8.1 (IC50 9x10-9 M) SYBR Green assay [13]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA OSM-S-38 Pf3D7 - 7.1 pIC50 25
pIC50 7.1 (IC50 7.9x10-8 M) [25]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA doxycycline Pf3D7 - 6.3 pIC50 5
pIC50 6.3 (IC50 5.32x10-7 M) FACS analysis following 48 hours in culture (second-generation rings) [5]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (48 hours)
Unknown MOA SC83288 Pf3D7 - 8.1 pIC50 17
pIC50 8.1 (IC50 8x10-9 M) [17]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA azithromycin Pf3D7 - 5.1 pIC50 5
pIC50 5.1 (IC50 8.67x10-6 M) FACS analysis following 48 hours in culture (second-generation rings) [5]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Ring formation assay (48 hours)
Unknown MOA artefenomel PfNF54 - 8.7 pIC50 4
pIC50 8.7 (IC50 1.9x10-9 M) [3H]-hypoxanthine incorporation [4]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether PfNF54 - 8.5 pIC50 6
pIC50 8.5 (IC50 3.5x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfNF54 - 8.4 pIC50 6
pIC50 8.4 (IC50 3.9x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin PfNF54 - 8.2 pIC50 6
pIC50 8.2 (IC50 5.8x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mepacrine PfNF54 - 8.1 pIC50 7
pIC50 8.1 (IC50 8.3x10-9 M) [3H]-hypoxanthine incorporation [7]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine PfNF54 - 8.0 pIC50 6
pIC50 8.0 (IC50 1.07x10-8 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine PfNF54 - 8.1 pIC50 6
pIC50 8.1 (IC50 8.3x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA SC83288 PfNF54 - 8.7 pIC50 17
pIC50 8.7 (IC50 2x10-9 M) [17]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine PfNF54 - 8.6 pIC50 6
pIC50 8.6 (IC50 2.8x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine PfNF54 - 9.1 pIC50 6
pIC50 9.1 (IC50 9x10-10 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ACT-451840 PfNF54 - 9.4 pIC50 14
pIC50 9.4 (IC50 4x10-10 M) [3H]-hypoxanthine incorporation [14]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol PfNF54 - 9.0 pIC50 6
pIC50 9.0 (IC50 1.1x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA KAF156 PfNF54 - 7.8 pIC50 13
pIC50 7.8 (IC50 1.64x10-8 M) SYBR Green assay [13]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate PfNF54 - 8.5 pIC50 6
pIC50 8.5 (IC50 3.5x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine PfNF54 - 5.9 pIC50 6
pIC50 5.9 (IC50 1.191x10-6 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine PfV1/S - 8.9 pIC50 6
pIC50 8.9 (IC50 1.3x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine PfV1/S - 8.0 pIC50 6
pIC50 8.0 (IC50 1.05x10-8 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine PfV1/S - 8.2 pIC50 6
pIC50 8.2 (IC50 5.7x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfV1/S - 8.0 pIC50 6
pIC50 8.0 (IC50 9.4x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin PfV1/S - 9.2 pIC50 6
pIC50 9.2 (IC50 6x10-10 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine PfV1/S - 6.3 pIC50 6
pIC50 6.3 (IC50 5.427x10-7 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate PfV1/S - 8.5 pIC50 6
pIC50 8.5 (IC50 3.1x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ACT-451840 PfV1/S - 9.5 pIC50 14
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [14]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether PfV1/S - 8.5 pIC50 6
pIC50 8.5 (IC50 2.9x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine PfV1/S - 9.5 pIC50 6
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol PfV1/S - 9.0 pIC50 6
pIC50 9.0 (IC50 1x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ferroquine Pf - 9.4 pIC50 2
pIC50 9.4 (IC50 3.7x10-10 M) [3H]-hypoxanthine incorporation. Strain SGE2 (Zaire) designated as chloroquine sensitive. [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mepacrine PfK1 - 7.4 pIC50 7
pIC50 7.4 (IC50 3.99x10-8 M) [3H]-hypoxanthine incorporation [7]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artesunate PfK1 - 8.6 pIC50 6
pIC50 8.6 (IC50 2.6x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemether PfK1 - 8.7 pIC50 6
pIC50 8.7 (IC50 2.2x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artefenomel PfK1 - 8.8 pIC50 4
pIC50 8.8 (IC50 1.6x10-9 M) [3H]-hypoxanthine incorporation [4]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artemisinin PfK1 - 8.3 pIC50 6
pIC50 8.3 (IC50 5.4x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA primaquine PfK1 - 6.3 pIC50 6
pIC50 6.3 (IC50 5.57x10-7 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA SC83288 PfK1 - 8.3 pIC50 17
pIC50 8.3 (IC50 5x10-9 M) [17]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA KAF156 PfK1 - 8.1 pIC50 13
pIC50 8.1 (IC50 7.3x10-9 M) SYBR Green assay [13]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfK1 - 8.1 pIC50 6
pIC50 8.1 (IC50 7.7x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine PfK1 - 8.4 pIC50 6
pIC50 8.4 (IC50 3.8x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ACT-451840 PfK1 - 9.5 pIC50 14
pIC50 9.5 (IC50 3x10-10 M) [3H]-hypoxanthine incorporation [14]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA artenimol PfK1 - 9.1 pIC50 6
pIC50 9.1 (IC50 8x10-10 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA piperaquine PfK1 - 8.1 pIC50 6
pIC50 8.1 (IC50 9x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA halofantrine PfK1 - 9.7 pIC50 6
pIC50 9.7 (IC50 2x10-10 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA lumefantrine PfK1 - 9.0 pIC50 6
pIC50 9.0 (IC50 1.1x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA ELQ-300 PfD6 Inhibition 8.5 – 8.7 pIC50 15
pIC50 8.7 (IC50 2.2x10-9 M) [15]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Plasmodium growth inhibition assay using the SYBR green method, measured at 72h.
pIC50 8.5 (IC50 3.06x10-9 M) [15]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Plasmodium growth inhibition assay using the [3H]hypoxanthine incorporation (into parasite nucleic acids) method.
Unknown MOA ACT-451840 PfD6 - 9.3 pIC50 14
pIC50 9.3 (IC50 5x10-10 M) [3H]-hypoxanthine incorporation [14]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA amodiaquine PfD6 - 8.3 pIC50 6
pIC50 8.3 (IC50 4.6x10-9 M) [3H]-hypoxanthine incorporation [6]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Description: Parasite growth inhibition assay
Unknown MOA mefloquine