Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL144037 |
---|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake | F | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green assay | F | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 by [3H]hypoxanthine uptake | F | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina I by [3H]hypoxanthine uptake | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
ChEMBL | In vitro antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Indochina I | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (1998) 41: 4918-4926 [PMID:9836608] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 by [3H]hypoxanthine uptake | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
ChEMBL | In vitro antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (1998) 41: 4918-4926 [PMID:9836608] |
ChEMBL | Effective concentration for Plasmodium falciparum W2 | F | 7.64 | pEC50 | 23 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 1015-1018 [PMID:15686903] |
ChEMBL | Effective concentration for Plasmodium falciparum 3D7 | F | 8.7 | pEC50 | 2 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 1015-1018 [PMID:15686903] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]