AQ-13 [Ligand Id: 10391] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL144037 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake | F | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green assay | F | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 by [3H]hypoxanthine uptake | F | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green assay | F | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina I by [3H]hypoxanthine uptake | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
| ChEMBL | In vitro antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Indochina I | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (1998) 41: 4918-4926 [PMID:9836608] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 by [3H]hypoxanthine uptake | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2008) 51: 3466-3479 [PMID:18512900] |
| ChEMBL | In vitro antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 | F | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (1998) 41: 4918-4926 [PMID:9836608] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Effective concentration for Plasmodium falciparum W2 | F | 7.64 | pEC50 | 23 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 1015-1018 [PMID:15686903] |
| ChEMBL | Effective concentration for Plasmodium falciparum 3D7 | F | 8.7 | pEC50 | 2 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 1015-1018 [PMID:15686903] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
