AQ-13 [Ligand Id: 10391] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL144037
  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
1 CHEMBL144037_lig_chart_1 Plasmodium falciparum Plasmodium falciparum
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
  • This target only has 0 pki data point
2 CHEMBL144037_lig_chart_2 Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake F 7.22 pIC50 60 nM IC50 J. Med. Chem. (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green assay F 7.54 pIC50 29 nM IC50 J. Med. Chem. (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay F 7.59 pIC50 26 nM IC50 J. Med. Chem. (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 by [3H]hypoxanthine uptake F 7.74 pIC50 18 nM IC50 J. Med. Chem. (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green assay F 8.15 pIC50 7 nM IC50 J. Med. Chem. (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina I by [3H]hypoxanthine uptake F 8.22 pIC50 6 nM IC50 J. Med. Chem. (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL In vitro antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Indochina I F 8.22 pIC50 6 nM IC50 J. Med. Chem. (1998) 41: 4918-4926 [PMID:9836608]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 8.22 pIC50 6 nM IC50 J. Med. Chem. (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 by [3H]hypoxanthine uptake F 8.3 pIC50 5 nM IC50 J. Med. Chem. (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL In vitro antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 F 8.3 pIC50 5 nM IC50 J. Med. Chem. (1998) 41: 4918-4926 [PMID:9836608]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Effective concentration for Plasmodium falciparum W2 F 7.64 pEC50 23 nM EC50 Bioorg. Med. Chem. Lett. (2005) 15: 1015-1018 [PMID:15686903]
ChEMBL Effective concentration for Plasmodium falciparum 3D7 F 8.7 pEC50 2 nM EC50 Bioorg. Med. Chem. Lett. (2005) 15: 1015-1018 [PMID:15686903]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]