AQ-13 [Ligand Id: 10391] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL144037
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake F 7.22 pIC50 60 nM IC50 J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green assay F 7.54 pIC50 29 nM IC50 J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay F 7.59 pIC50 26 nM IC50 J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 by [3H]hypoxanthine uptake F 7.74 pIC50 18 nM IC50 J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green assay F 8.15 pIC50 7 nM IC50 J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina I by [3H]hypoxanthine uptake F 8.22 pIC50 6 nM IC50 J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL In vitro antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Indochina I F 8.22 pIC50 6 nM IC50 J Med Chem (1998) 41: 4918-4926 [PMID:9836608]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green assay F 8.22 pIC50 6 nM IC50 J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 by [3H]hypoxanthine uptake F 8.3 pIC50 5 nM IC50 J Med Chem (2008) 51: 3466-3479 [PMID:18512900]
ChEMBL In vitro antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum Haiti 135 F 8.3 pIC50 5 nM IC50 J Med Chem (1998) 41: 4918-4926 [PMID:9836608]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Effective concentration for Plasmodium falciparum W2 F 7.64 pEC50 23 nM EC50 Bioorg Med Chem Lett (2005) 15: 1015-1018 [PMID:15686903]
ChEMBL Effective concentration for Plasmodium falciparum 3D7 F 8.7 pEC50 2 nM EC50 Bioorg Med Chem Lett (2005) 15: 1015-1018 [PMID:15686903]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]