pyrimethamine [Ligand Id: 4800] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL36
  • Multidrug and toxin extrusion in Human [GtoPdb: 1216] [UniProtKB: Q96FL8]
  • This target only has 1 pki data point
1 CHEMBL36_lig_chart_1 Multidrug and toxin extrusion Human
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  • MATE2 in Mouse [GtoPdb: 1217] [UniProtKB: Q3V050]
  • This target only has 1 pki data point
2 CHEMBL36_lig_chart_2 MATE2 Mouse
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  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum TM4 [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum K1 [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum 7G8 [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum D6 [GtoPdb: 2981]
  • This target only has 0 pki data point
3 CHEMBL36_lig_chart_3 Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Plasmodium falciparum TM4Plasmodium falciparum K1Plasmodium falciparum NF54Plasmodium falciparum 7G8Plasmodium falciparum D6
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Multidrug and toxin extrusion in Human [GtoPdb: 1216] [UniProtKB: Q96FL8]
GtoPdb - - 7.1 pKi 77 nM Ki J. Pharmacol. Exp. Ther. (2010) 333: 341-50 [PMID:20065018]
MATE2 in Mouse [GtoPdb: 1217] [UniProtKB: Q3V050]
GtoPdb - - 6.3 pKi 460 nM Ki J. Pharmacol. Exp. Ther. (2010) 333: 341-50 [PMID:20065018]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum TM4 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 7.24 pIC50 58 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 16823-8 [PMID:23035243]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum K1 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 5 pIC50 >10000 nM IC50 PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 7.77 pIC50 17 nM IC50 PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum 7G8 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 5.17 pIC50 6688.7 nM IC50 PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum D6 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 8.34 pIC50 4.6 nM IC50 PLoS Med. (2012) 9: e1001169 [PMID:22363211]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]