ChEMBL ligand: CHEMBL36
Multidrug and toxin extrusion in Human [GtoPdb: 1216] [UniProtKB: Q96FL8] This target only has 1 pki data point 1 CHEMBL36_lig_chart_1 Multidrug and toxin extrusion Human There should be some charts here, you may need to enable JavaScript!
MATE2 in Mouse [GtoPdb: 1217] [UniProtKB: Q3V050] This target only has 1 pki data point 2 CHEMBL36_lig_chart_2 MATE2 Mouse There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum TM4 [GtoPdb: 2981] Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum K1 [GtoPdb: 2981] Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981] Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum 7G8 [GtoPdb: 2981] Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum D6 [GtoPdb: 2981] This target only has 0 pki data point 3 CHEMBL36_lig_chart_3 Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Plasmodium falciparum TM4Plasmodium falciparum K1Plasmodium falciparum NF54Plasmodium falciparum 7G8Plasmodium falciparum D6 There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Multidrug and toxin extrusion in Human [GtoPdb: 1216] [UniProtKB: Q96FL8]
GtoPdb	-	-	7.1	pKi	77	nM	Ki	J. Pharmacol. Exp. Ther. (2010) 333: 341-50 [PMID:20065018]
MATE2 in Mouse [GtoPdb: 1217] [UniProtKB: Q3V050]
GtoPdb	-	-	6.3	pKi	460	nM	Ki	J. Pharmacol. Exp. Ther. (2010) 333: 341-50 [PMID:20065018]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum TM4 [GtoPdb: 2981]
GtoPdb	Parasite growth inhibition assay	-	7.24	pIC50	58	nM	IC50	Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 16823-8 [PMID:23035243]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum K1 [GtoPdb: 2981]
GtoPdb	Parasite growth inhibition assay	-	5	pIC50	>10000	nM	IC50	PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981]
GtoPdb	Parasite growth inhibition assay	-	7.77	pIC50	17	nM	IC50	PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum 7G8 [GtoPdb: 2981]
GtoPdb	Parasite growth inhibition assay	-	5.17	pIC50	6688.7	nM	IC50	PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum D6 [GtoPdb: 2981]
GtoPdb	Parasite growth inhibition assay	-	8.34	pIC50	4.6	nM	IC50	PLoS Med. (2012) 9: e1001169 [PMID:22363211]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]