pyrimethamine [Ligand Id: 4800] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL36 (Malacide, TCMDC-123831, GNF-PF-5586, Chloridin, Daraprim, Pyrimethamine, TCMDC-125860, WR-2978, NSC-3061, RP-4753)
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  • Beta-hexosaminidase subunit beta in Human [ChEMBL: CHEMBL5877] [UniProtKB: P07686]
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  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum V1/S [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum K1 [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase/Bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL4296323] [GtoPdb: 2981] [UniProtKB: Q8I1R6]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum 7G8 [GtoPdb: 2981]
  • Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum D6 [GtoPdb: 2981]
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  • Dihydrofolate reductase in Escherichia coli [ChEMBL: CHEMBL5441] [UniProtKB: B0BL08]
  • Dihydrofolate reductase in Pneumocystis carinii [ChEMBL: CHEMBL1926] [UniProtKB: P16184]
  • Dihydrofolate reductase in Candida albicans [ChEMBL: CHEMBL2329] [UniProtKB: P22906]
  • Dihydrofolate reductase in Toxoplasma gondii [ChEMBL: CHEMBL2425] [UniProtKB: Q07422]
  • Dihydrofolate reductase in Plasmodium falciparum K1 [ChEMBL: CHEMBL1939] [UniProtKB: P13922]
  • dihydrofolate reductase/Dihydrofolate reductase in Human [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
  • Dihydrofolate reductase in Bovine [ChEMBL: CHEMBL1075051] [UniProtKB: P00376]
  • dihydrofolate reductase/Dihydrofolate reductase in Rat [ChEMBL: CHEMBL2363] [GtoPdb: 2603] [UniProtKB: Q920D2]
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  • Multidrug and toxin extrusion in Human [GtoPdb: 1216] [UniProtKB: Q96FL8]
  • Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Mouse [ChEMBL: CHEMBL3091264] [GtoPdb: 1216] [UniProtKB: Q8K0H1]
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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  • Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
  • Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966]
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  • MATE2 in Mouse [GtoPdb: 1217] [UniProtKB: Q3V050]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-hexosaminidase subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250415] [UniProtKB: P06865]
ChEMBL Inhibition of HexA alpha G269S mutant in ATSD patient fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometry B 5.07 pIC50 8500 nM IC50 J. Med. Chem. (2015) 58: 4483-4493 [PMID:25984755]
Beta-hexosaminidase subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5877] [UniProtKB: P07686]
ChEMBL Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometry B 5.04 pIC50 9100 nM IC50 J. Med. Chem. (2015) 58: 4483-4493 [PMID:25984755]
ChEMBL Inhibition of human placental HexB using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometry B 5.35 pIC50 4500 nM IC50 J. Med. Chem. (2015) 58: 4483-4493 [PMID:25984755]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum V1/S [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 4 pIC50 >100000 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 16823-8 [PMID:23035243]
GtoPdb Parasite growth inhibition assay - 5 pIC50 >10000 nM IC50 PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum K1 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 5 pIC50 >10000 nM IC50 PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum NF54 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 7.77 pIC50 17 nM IC50 PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase/Bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296323] [GtoPdb: 2981] [UniProtKB: Q8I1R6]
ChEMBL Inhibition of pyrimethamine-resistant form-2 Plasmodium falciparum N51I, C59R, S108N, I164L, K96N mutant expressed in Escherichia coli BL21(DE3) by Michaelis-Menten based competitive inhibition assay B 9.07 pKi 0.85 nM Ki Antimicrob. Agents Chemother. (2007) 51: 4356-4360 [PMID:17875995]
ChEMBL Inhibition of pyrimethamine-resistant form-2 Plasmodium falciparum N51I, C59R, S108N, I164L, K96N mutant expressed in Escherichia coli BL21(DE3) B 5.61 pIC50 2480 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 4356-4360 [PMID:17875995]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum 7G8 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 5.17 pIC50 6688.7 nM IC50 PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase in Plasmodium falciparum D6 [GtoPdb: 2981]
GtoPdb Parasite growth inhibition assay - 8.34 pIC50 4.6 nM IC50 PLoS Med. (2012) 9: e1001169 [PMID:22363211]
Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5441] [UniProtKB: B0BL08]
ChEMBL Thermodynamic dissociation constant of compound for mutant T46N Escherichia coli dihydrofolate reductase B 7.8 pKd 16 nM Kd J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL Thermodynamic dissociation constant of compound for wild type Escherichia coli dihydrofolate reductase B 7.89 pKd 13 nM Kd J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL Thermodynamic dissociation constant of compound for mutant T46S Escherichia coli dihydrofolate reductase B 8.82 pKd 1.5 nM Kd J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL Thermodynamic dissociation constant of compound for mutant T46A Escherichia coli dihydrofolate reductase B 8.85 pKd 1.4 nM Kd J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL Inhibitor constant of compound for mutant T46N Escherichia coli dihydrofolate reductase B 7.7 pKi 20 nM Ki J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL Inhibitor constant of compound for wild type Escherichia coli dihydrofolate reductase B 8 pKi 10 nM Ki J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL Inhibitor constant of compound for mutant T46S Escherichia coli dihydrofolate reductase B 8.28 pKi 5.2 nM Ki J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL Inhibitor constant of compound for mutant T46A Escherichia coli dihydrofolate reductase B 8.92 pKi 1.2 nM Ki J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL Inhibition of Escherichia coli DHFR B 5.18 pIC50 6600 nM IC50 Bioorg. Med. Chem. (2012) 20: 4217-4225 [PMID:22739090]
ChEMBL Inhibition of Escherichia coli dihydrofolate reductase B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (2008) 51: 4589-4600 [PMID:18605720]
Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184]
ChEMBL Binding affinity was reported with purified recombinant Pneumocystis carinii Dihydrofolate reductase B 8.01 pKi 9.7 nM Ki J. Med. Chem. (1995) 38: 4739-4759 [PMID:7490723]
ChEMBL Inhibition of Dihydrofolate reductase of Pneumocystis carinii B 5.43 pIC50 3700 nM IC50 J. Med. Chem. (1994) 37: 4522-4528 [PMID:7799402]
ChEMBL Inhibitory activity against Pneumocystis carinii Dihydrofolate reductase B 5.43 pIC50 3700 nM IC50 J. Med. Chem. (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibition of Pneumocystis carinii Dihydrofolate Reductase B 5.43 pIC50 3700 nM IC50 J. Med. Chem. (1997) 40: 3694-3699 [PMID:9357537]
ChEMBL In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductase B 5.44 pIC50 3650 nM IC50 J. Med. Chem. (1997) 40: 1886-1893 [PMID:9191966]
ChEMBL Inhibitory activity against Pneumocystis carinii dihydrofolate reductase B 5.44 pIC50 3650 nM IC50 J. Med. Chem. (1996) 39: 1271-1280 [PMID:8632434]
ChEMBL Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii at 37 centigrade. B 5.55 pIC50 2800 nM IC50 J. Med. Chem. (1995) 38: 4739-4759 [PMID:7490723]
ChEMBL Compound was tested for inhibition activity against pneumocystis carinii (Pneumocystis carinii) Dihydrofolate reductase B 5.62 pIC50 2400 nM IC50 J. Med. Chem. (1998) 41: 913-918 [PMID:9526565]
ChEMBL Inhibition of Pneumocystis carinii DHFR B 5.62 pIC50 2400 nM IC50 J. Med. Chem. (2013) 56: 4422-4441 [PMID:23627352]
Dihydrofolate reductase in Candida albicans (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2329] [UniProtKB: P22906]
ChEMBL Inhibition of dihydrofolate reductase in Candida albicans (in vitro). B 5.3 pIC50 5000 nM IC50 J. Med. Chem. (1995) 38: 3608-3616 [PMID:7658448]
Dihydrofolate reductase in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2425] [UniProtKB: Q07422]
ChEMBL Compound was tested for inhibition activity against Toxoplasma gondii (Toxoplasma gondii) Dihydrofolate reductase B 6.41 pIC50 390 nM IC50 J. Med. Chem. (1998) 41: 913-918 [PMID:9526565]
ChEMBL Inhibitory activity against Toxoplasma gondii dihydrofolate reductase B 6.41 pIC50 390 nM IC50 J. Med. Chem. (1996) 39: 1271-1280 [PMID:8632434]
ChEMBL Inhibitory activity against Toxoplasma gondii Dihydrofolate reductase B 6.41 pIC50 390 nM IC50 J. Med. Chem. (1995) 38: 745-752 [PMID:7877140]
ChEMBL The ability to inhibit Toxoplasma gondii Dihydrofolate reductase was tested B 6.41 pIC50 390 nM IC50 J. Med. Chem. (1999) 42: 1007-1017 [PMID:10090784]
ChEMBL Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii. B 6.41 pIC50 390 nM IC50 J. Med. Chem. (2001) 44: 2555-2564 [PMID:11472209]
ChEMBL Inhibition of Toxoplasma gondii Dihydrofolate Reductase B 6.41 pIC50 390 nM IC50 J. Med. Chem. (1997) 40: 3694-3699 [PMID:9357537]
ChEMBL Inhibitory concentration against Toxoplasma gondii dihydrofolate reductase B 6.41 pIC50 390 nM IC50 J. Med. Chem. (1997) 40: 1886-1893 [PMID:9191966]
ChEMBL Inhibition of Dihydrofolate reductase of Toxoplasma gondii B 6.41 pIC50 390 nM IC50 J. Med. Chem. (1994) 37: 4522-4528 [PMID:7799402]
ChEMBL Inhibition of Toxoplasma gondii TS-DHFR expressed in Escherichia coli BL21 preincubated for 15 mins followed by addition of DHF as substrate and NADPH measured after 60 mins by resazurin/diaphorase coupled assay B 6.64 pIC50 230 nM IC50 ACS Med Chem Lett (2016) 7: 1124-1129 [PMID:27994750]
ChEMBL Inhibition of Toxoplasma gondii DHFR B 6.7 pIC50 200 nM IC50 Bioorg. Med. Chem. (2012) 20: 4217-4225 [PMID:22739090]
ChEMBL Inhibition of Toxoplasma gondii dihydrofolate reductase B 7.1 pIC50 80 nM IC50 J. Med. Chem. (2008) 51: 4589-4600 [PMID:18605720]
Dihydrofolate reductase in Plasmodium falciparum K1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1939] [UniProtKB: P13922]
ChEMBL Inhibition constant against PfDHFR (Plasmodium falciparum dihydrofolate reductase) with quadruple (N51I + C59R + S108N + I164L) mutations B 6.07 pKi 860 nM Ki J. Med. Chem. (2003) 46: 2834-2845 [PMID:12825927]
ChEMBL Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N+I164L DHFR) of Plasmodium falciparum B 6.41 pKi 385 nM Ki J. Med. Chem. (2004) 47: 673-680 [PMID:14736247]
ChEMBL Inhibition constant against PfDHFR (Plasmodium falciparum dihydrofolate reductase) with triple (C59R + S108N + I164L) mutations B 6.42 pKi 380 nM Ki J. Med. Chem. (2003) 46: 2834-2845 [PMID:12825927]
ChEMBL Binding affinity towards mutant dihydrofolate reductase (C59R+S108N+I164L DHFR) of Plasmodium falciparum B 6.95 pKi 112 nM Ki J. Med. Chem. (2004) 47: 673-680 [PMID:14736247]
ChEMBL Binding affinity was evaluated as inhibition of mutant (C59R + S108N) Plasmodium falciparum DHFR-TS. B 7.14 pKi 71.7 nM Ki J. Med. Chem. (1998) 41: 1367-1370 [PMID:9554869]
ChEMBL Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N DHFR) of Plasmodium falciparum B 7.17 pKi 67.1 nM Ki J. Med. Chem. (2004) 47: 673-680 [PMID:14736247]
ChEMBL Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) B 7.27 pKi 53.9 nM Ki J. Med. Chem. (2002) 45: 1244-1252 [PMID:11881993]
ChEMBL Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) B 7.54 pKi 28.6 nM Ki J. Med. Chem. (2002) 45: 1244-1252 [PMID:11881993]
ChEMBL Inhibition constant against PfDHFR (Plasmodium falciparum dihydrofolate reductase) with single A16V mutation B 8.22 pKi 6 nM Ki J. Med. Chem. (2003) 46: 2834-2845 [PMID:12825927]
ChEMBL Inhibition constant against PfDHFR (Plasmodium falciparum dihydrofolate reductase) with double (A16V + S108T) mutations B 8.44 pKi 3.6 nM Ki J. Med. Chem. (2003) 46: 2834-2845 [PMID:12825927]
ChEMBL Inhibitor constant of compound for mutant S108 N Plasmodium falciparum in dihydrofolate reductase B 8.7 pKi 2 nM Ki J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL Binding affinity was evaluated as inhibition of recombinant wild type (WT) Plasmodium falciparum DHFR-TS. B 8.82 pKi 1.5 nM Ki J. Med. Chem. (1998) 41: 1367-1370 [PMID:9554869]
ChEMBL Inhibition constant against wild-type PfDHFR (Plasmodium falciparum dihydrofolate reductase) B 8.82 pKi 1.5 nM Ki J. Med. Chem. (2003) 46: 2834-2845 [PMID:12825927]
ChEMBL Inhibition constant against PfDHFR (Plasmodium falciparum dihydrofolate reductase) with single S108T mutation B 8.85 pKi 1.4 nM Ki J. Med. Chem. (2003) 46: 2834-2845 [PMID:12825927]
ChEMBL Inhibition constant against Plasmodium falciparum dihydrofolate reductase B 9.06 pKi 0.87 nM Ki J. Med. Chem. (2004) 47: 4258-4267 [PMID:15293997]
ChEMBL Binding affinity towards wild-type dihydrofolate reductase of Plasmodium falciparum. B 9.22 pKi 0.6 nM Ki J. Med. Chem. (2004) 47: 673-680 [PMID:14736247]
ChEMBL Inhibition of the wild-type dihydrofolate reductase (DHFR) B 9.22 pKi 0.6 nM Ki J. Med. Chem. (2002) 45: 1244-1252 [PMID:11881993]
ChEMBL Inhibitor constant of compound for Plasmodium falciparum dihydrofolate reductase B 9.72 pKi 0.19 nM Ki J. Med. Chem. (1992) 35: 2912-2915 [PMID:1495020]
ChEMBL In vitro anti-plasmodial activity against Plasmodium falciparum dihydrofolate reductase CN51I/C59R/S108N/I164L (V1/S) mutant F 4 pIC50 >100000 nM IC50 J. Med. Chem. (2004) 47: 673-680 [PMID:14736247]
ChEMBL In vitro anti-plasmodial activity against Plasmodium falciparum dihydrofolate reductase N51I/C59R/S108N (W2) F 4.13 pIC50 73500 nM IC50 J. Med. Chem. (2004) 47: 673-680 [PMID:14736247]
ChEMBL In vitro anti-plasmodial activity against Plasmodium falciparum dihydrofolate reductase C59R+S108N/I164L (Csl-2) mutant F 4.38 pIC50 41700 nM IC50 J. Med. Chem. (2004) 47: 673-680 [PMID:14736247]
ChEMBL Antiplasmodial activity IC50 against Plasmodium falciparum K1CB1 DHFR double-mutant (C59R/S10) F 4.51 pIC50 30900 nM IC50 J. Med. Chem. (2002) 45: 1244-1252 [PMID:11881993]
ChEMBL In vitro anti-plasmodial activity against Plasmodium falciparum dihydrofolate reductase wild type (TM4/8.2) F 7.1 pIC50 80 nM IC50 J. Med. Chem. (2004) 47: 673-680 [PMID:14736247]
ChEMBL Inhibition of Plasmodium falciparum DHFR B 7.1 pIC50 80 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 4366-4370 [PMID:16750361]
ChEMBL Inhibition of Plasmodium falciparum DHFR B 7.24 pIC50 58 nM IC50 Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368]
ChEMBL Inhibition of Plasmodium falciparum DHFR using DHF as substrate preincubated for 15 mins followed DHF addition measured after 15 mins by spectrophotometric method B 7.59 pIC50 25.5 nM IC50 Bioorg Med Chem (2017) 25: 6467-6478 [PMID:29111368]
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
ChEMBL Inhibition of human DHFR using dihydrofolate as substrate after 180 secs by spectrophotometric analysis B 6.33 pKi 470 nM Ki Eur J Med Chem (2017) 135: 467-478 [PMID:28477572]
ChEMBL Inhibition of recombinant Dihydrofolate reductase from Leishmania major. B 6.6 pKi 250 nM Ki J. Med. Chem. (1999) 42: 4300-4312 [PMID:10543874]
ChEMBL Inhibition of recombinant Dihydrofolate reductase from humans. B 6.92 pKi 120 nM Ki J. Med. Chem. (1999) 42: 4300-4312 [PMID:10543874]
ChEMBL Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi. B 7.01 pKi 98 nM Ki J. Med. Chem. (1999) 42: 4300-4312 [PMID:10543874]
ChEMBL Binding affinity to human recombinant DHFR expressed in Escherichia coli BL21(DE3) by competitive binding assay B 7.51 pKi 30.8 nM Ki Antimicrob. Agents Chemother. (2010) 54: 2603-2610 [PMID:20350951]
ChEMBL Inhibition of recombinant Dihydrofolate reductase from humans. B 7.96 pKi 11 nM Ki J. Med. Chem. (1999) 42: 4300-4312 [PMID:10543874]
ChEMBL Cytotoxicity by selective inhibition against human dihydrofolate reductase (DHFR). B 8.1 pKi 8 nM Ki J. Med. Chem. (2002) 45: 1244-1252 [PMID:11881993]
ChEMBL Inhibition of human dihydrofolate reductase B 5.22 pIC50 6000 nM IC50 J. Med. Chem. (2008) 51: 4589-4600 [PMID:18605720]
ChEMBL Inhibition of human DHFR B 5.22 pIC50 6000 nM IC50 Bioorg. Med. Chem. (2012) 20: 4217-4225 [PMID:22739090]
ChEMBL In vitro inhibition of human dihydrofolate reductase B 5.59 pIC50 2600 nM IC50 J. Med. Chem. (1995) 38: 3608-3616 [PMID:7658448]
ChEMBL Inhibition of human recombinant DHFR B 6.4 pIC50 400 nM IC50 J. Med. Chem. (2013) 56: 4422-4441 [PMID:23627352]
Dihydrofolate reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075051] [UniProtKB: P00376]
ChEMBL Inhibition of bovine liver DHFR B 7 pIC50 100.7 nM IC50 Bioorg Med Chem (2017) 25: 5396-5406 [PMID:28789907]
ChEMBL Inhibition of bovine liver DHFR pre-incubated 2 mins before dihydrofolic acid substrate addition and measured over 10 mins in presence of NADPH B 7 pIC50 100.7 nM IC50 Bioorg Med Chem (2017) 25: 4064-4075 [PMID:28634040]
dihydrofolate reductase/Dihydrofolate reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2363] [GtoPdb: 2603] [UniProtKB: Q920D2]
ChEMBL Inhibitory activity against dihydrofolate reductase in rat. B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (1995) 38: 4739-4759 [PMID:7490723]
ChEMBL Inhibition of rat liver Dihydrofolate Reductase B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (1997) 40: 3694-3699 [PMID:9357537]
ChEMBL In vitro inhibitory concentration against rat liver dihydrofolate reductase B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (1997) 40: 1886-1893 [PMID:9191966]
ChEMBL Inhibition of Dihydrofolate reductase (DHFR) of in rat liver B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (1994) 37: 4522-4528 [PMID:7799402]
ChEMBL Inhibitory activity against rat liver dihydrofolate reductase B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (1996) 39: 1271-1280 [PMID:8632434]
ChEMBL Inhibitory activity against rat liver Dihydrofolate reductase B 5.64 pIC50 2300 nM IC50 J. Med. Chem. (1995) 38: 745-752 [PMID:7877140]
ChEMBL Inhibitory activity against dihydrofolate reductase DHFR in rat liver B 5.64 pIC50