clindamycin [Ligand Id: 10607] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1753 (7(s)-chloro-7-deoxylincomycin, Antirobe, Chlorodeoxylincomycin, Chlorolincomycin, Cleocin, Cleocin T, Clindamicina, Clindamycin, Clindamycine, Sobelin, U-21,251, U-21251) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity as 2nd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by flow cytometry | F | 4 | pIC50 | >100000 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity as 2nd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry | F | 4 | pIC50 | >100000 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 5587-5603 [PMID:26791529] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 48 hrs | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2016) 59: 5587-5603 [PMID:26791529] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 96 hrs | F | 6.35 | pIC50 | 450 | nM | IC50 | J Med Chem (2016) 59: 5587-5603 [PMID:26791529] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum clinical isolate after 6 days by HRP2 enzyme-linked immunosorbent assay | F | 7.94 | pIC50 | 11.6 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 540-542 [PMID:19841147] |
| ChEMBL | Antiplasmodial activity against sorbitol-synchronized post ring stage plasmodium falciparum 3D7 assessed as inhibition of parasite growth incubated for 72 to 96 hrs by parasite susceptibility based microplate reader assay | F | 8.06 | pIC50 | 8.81 | nM | IC50 | ACS Med Chem Lett (2023) 14: 217-222 [PMID:36793432] |
| ChEMBL | Antimalarial activity as 3rd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs dose then 48 hrs drug-free | F | 8.06 | pIC50 | 8.81 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free | F | 8.51 | pIC50 | 3.12 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 96 hrs | F | 8.51 | pIC50 | 3.1 | nM | IC50 | J Med Chem (2016) 59: 5587-5603 [PMID:26791529] |
| ChEMBL | Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs | F | 8.89 | pIC50 | 1.3 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 307-316 [PMID:17060533] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
