clindamycin [Ligand Id: 10607] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1753 (7(s)-chloro-7-deoxylincomycin, Antirobe, Chlorodeoxylincomycin, Chlorolincomycin, Cleocin, Cleocin T, Clindamycin, Sobelin, U-21251, U-21,251)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity as 2nd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by flow cytometry F 4 pIC50 >100000 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity as 2nd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry F 4 pIC50 >100000 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs F 5 pIC50 >10000 nM IC50 J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 after 48 hrs F 5 pIC50 >10000 nM IC50 J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 96 hrs F 6.35 pIC50 450 nM IC50 J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL Antimalarial activity against Plasmodium falciparum clinical isolate after 6 days by HRP2 enzyme-linked immunosorbent assay F 7.94 pIC50 11.6 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 540-542 [PMID:19841147]
ChEMBL Antimalarial activity as 3rd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs dose then 48 hrs drug-free F 8.06 pIC50 8.81 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free F 8.51 pIC50 3.12 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 after 96 hrs F 8.51 pIC50 3.1 nM IC50 J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs F 8.89 pIC50 1.3 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 307-316 [PMID:17060533]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]