clindamycin [Ligand Id: 10607] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1753 (7(s)-chloro-7-deoxylincomycin, Antirobe, Chlorodeoxylincomycin, Chlorolincomycin, Cleocin, Cleocin T, Clindamycin, Sobelin, U-21251, U-21,251)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity as 2nd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by flow cytometry F 4 pIC50 >100000 nM IC50 Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity as 2nd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry F 4 pIC50 >100000 nM IC50 Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs F 5 pIC50 >10000 nM IC50 J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 after 48 hrs F 5 pIC50 >10000 nM IC50 J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 after 96 hrs F 6.35 pIC50 450 nM IC50 J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL Antimalarial activity against Plasmodium falciparum clinical isolate after 6 days by HRP2 enzyme-linked immunosorbent assay F 7.94 pIC50 11.6 nM IC50 Antimicrob Agents Chemother (2010) 54: 540-542 [PMID:19841147]
ChEMBL Antimalarial activity as 3rd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs dose then 48 hrs drug-free F 8.06 pIC50 8.81 nM IC50 Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free F 8.51 pIC50 3.12 nM IC50 Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 after 96 hrs F 8.51 pIC50 3.1 nM IC50 J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs F 8.89 pIC50 1.3 nM IC50 Antimicrob Agents Chemother (2007) 51: 307-316 [PMID:17060533]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]