sulfadoxine

Ligand id: 10173

Name: sulfadoxine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 124.81
Molecular weight 310.07
XLogP 0.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Ligand families/groups Antimalarial ligands
Approved drug? Yes (FDA (1981) in combination with pyrimethamine)
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
International Nonproprietary Names
INN number INN
2061 sulfadoxine
Synonyms
sulphadoxine
Comments
Sulfadoxine is a sulfonamide containing compound with antimalarial activity. It is used in the treatment of malaria as a combination therapy.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Database Links
CAS Registry No. 2447-57-6 (source: Scifinder)
ChEBI CHEBI:9329
ChEMBL Ligand CHEMBL1539
DrugBank Ligand DB01299
GtoPdb PubChem SID 381118883
PubChem CID 17134
Search Google for chemical match using the InChIKey PJSFRIWCGOHTNF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone PJSFRIWCGOHTNF
Search PubMed clinical trials sulfadoxine
Search PubMed titles sulfadoxine
Search PubMed titles/abstracts sulfadoxine
Search UniChem for chemical match using the InChIKey PJSFRIWCGOHTNF-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone PJSFRIWCGOHTNF