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ChEMBL ligand: CHEMBL4091762 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method | F | 9.89 | pIC50 | 0.13 | nM | IC50 | Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559] |
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
ChEMBL | Antiplasmodial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method | F | 9.66 | pIC50 | 0.22 | nM | IC50 | Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559] |
Plasmodium falciparum elongation factor 2 in Plasmodium berghei [GtoPdb: 2975] | ||||||||
GtoPdb | Parasite liver stage assay | - | 8.78 | pEC50 | 1.65 | nM | EC50 | Nature (2015) 522: 315-20 [PMID:26085270] |
Plasmodium falciparum elongation factor 2 in Plasmodium falciparum NF54 [GtoPdb: 2975] | ||||||||
GtoPdb | Standard membrane feeding assay (SMFA) | - | 8 | pEC50 | 10 | nM | EC50 | Nature (2015) 522: 315-20 [PMID:26085270] |
GtoPdb | Parasite gamete formation assay | - | 8.74 | pEC50 | 1.8 | nM | EC50 | Nature (2015) 522: 315-20 [PMID:26085270] |
GtoPdb | Standard membrane feeding assay (SMFA) | - | 8.74 | pEC50 | 1.8 | nM | EC50 | Nature (2015) 522: 315-20 [PMID:26085270] |
GtoPdb | Parasite gamete formation assay | - | 8.92 | pEC50 | 1.2 | nM | EC50 | Nature (2015) 522: 315-20 [PMID:26085270] |
Plasmodium falciparum elongation factor 2 in Plasmodium falciparum 3D7 [GtoPdb: 2975] [UniProtKB: Q8IKW5] | ||||||||
GtoPdb | Parasite growth inhibition assay | - | 9 | pEC50 | 1 | nM | EC50 | Nature (2015) 522: 315-20 [PMID:26085270] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]