ChEMBL ligand: CHEMBL4091762 (Cabamiquine, DDD107498, DDD-107498, DDD498, M5717, M-5717, MMV121, MMV-121)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii [ChEMBL: CHEMBL612889] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum elongation factor 2 in Plasmodium berghei [GtoPdb: 2975] Plasmodium falciparum elongation factor 2 in Plasmodium falciparum NF54 [GtoPdb: 2975] Plasmodium falciparum elongation factor 2 in Plasmodium falciparum 3D7 [GtoPdb: 2975] [UniProtKB: Q8IKW5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG by IonWorks patch-clamp electrophysiology method	B	4.8	pIC50	16000	nM	IC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antiplasmodial activity against Plasmodium berghei ookinete form assessed as growth inhibition incubated for 22 hrs by GFP-based fluorescence microscopic analysis	F	8.3	pEC50	5	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antimalarial activity against Plasmodium berghei ookinete form	F	8.3	pEC50	5	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method	F	9.89	pIC50	0.13	nM	IC50	Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559]
ChEMBL	Antiplasmodial activity against late stage (IV/V) Plasmodium falciparum NF54 gametocytes transfected with GFP-LUC assessed as growth inhibition incubated for 72 hrs by mitotracker Red-CMXROS dye based fluorescence microscopic analysis	F	7.62	pEC50	24	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antimalarial activity against Plasmodium falciparum late stage (IV-V) gametocytes	F	7.62	pEC50	24	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	9	pEC50	1	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum D6	F	9	pEC50	<1	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum V1/S	F	9	pEC50	<1	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum 7G8	F	9	pEC50	<1	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum TM90C2A	F	9	pEC50	<1	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum K1	F	9	pEC50	<1	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum W2	F	9	pEC50	<1	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum NF5	F	9	pEC50	<1	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human red blood cells assessed as growth inhibition by SYBR Green fluorescence assay	F	9	pEC50	1	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum V1/S by [3H]hypoxanthine incorporation assay	F	9.15	pEC50	0.7	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	9.4	pEC50	0.4	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine incorporation assay	F	9.4	pEC50	0.4	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum D6 by [3H]hypoxanthine incorporation assay	F	9.4	pEC50	0.4	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum TM90C2A by [3H]hypoxanthine incorporation assay	F	9.4	pEC50	0.4	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum W2 by [3H]hypoxanthine incorporation assay	F	9.4	pEC50	0.4	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antiplasmodial activity against drug resistant Plasmodium falciparum NF5 by [3H]hypoxanthine incorporation assay	F	9.52	pEC50	0.3	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method	F	9.66	pIC50	0.22	nM	IC50	Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559]
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889]
ChEMBL	Antiplasmodial activity against Plasmodium yoelli liver stage forms	F	9	pEC50	1	nM	EC50	J Med Chem (2016) 59: 9672-9685 [PMID:27631715]
ChEMBL	Antimalarial activity against Plasmodium yoelii	F	9	pEC50	1	nM	EC50	J Med Chem (2016) 59: 9668-9671 [PMID:27775354]
Plasmodium falciparum elongation factor 2 in Plasmodium berghei [GtoPdb: 2975]
GtoPdb	Parasite liver stage assay	-	8.78	pEC50	1.65	nM	EC50	Nature (2015) 522: 315-20 [PMID:26085270]
Plasmodium falciparum elongation factor 2 in Plasmodium falciparum NF54 [GtoPdb: 2975]
GtoPdb	Standard membrane feeding assay (SMFA)	-	8	pEC50	10	nM	EC50	Nature (2015) 522: 315-20 [PMID:26085270]
GtoPdb	Standard membrane feeding assay (SMFA)	-	8.74	pEC50	1.8	nM	EC50	Nature (2015) 522: 315-20 [PMID:26085270]
GtoPdb	Parasite gamete formation assay	-	8.74	pEC50	1.8	nM	EC50	Nature (2015) 522: 315-20 [PMID:26085270]
GtoPdb	Parasite gamete formation assay	-	8.92	pEC50	1.2	nM	EC50	Nature (2015) 522: 315-20 [PMID:26085270]
Plasmodium falciparum elongation factor 2 in Plasmodium falciparum 3D7 [GtoPdb: 2975] [UniProtKB: Q8IKW5]
GtoPdb	Parasite growth inhibition assay	-	9	pEC50	1	nM	EC50	Nature (2015) 522: 315-20 [PMID:26085270]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]