M5717 [Ligand Id: 9737] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL4091762
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum elongation factor 2 in Plasmodium berghei [GtoPdb: 2975]
  • Plasmodium falciparum elongation factor 2 in Plasmodium falciparum NF54 [GtoPdb: 2975]
  • Plasmodium falciparum elongation factor 2 in Plasmodium falciparum 3D7 [GtoPdb: 2975] [UniProtKB: Q8IKW5]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum NF54 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method F 9.89 pIC50 0.13 nM IC50 Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antiplasmodial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 assessed as reduction in [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting method F 9.66 pIC50 0.22 nM IC50 Bioorg Med Chem (2017) 25: 2251-2259 [PMID:28279559]
Plasmodium falciparum elongation factor 2 in Plasmodium berghei [GtoPdb: 2975]
GtoPdb Parasite liver stage assay - 8.78 pEC50 1.65 nM EC50 Nature (2015) 522: 315-20 [PMID:26085270]
Plasmodium falciparum elongation factor 2 in Plasmodium falciparum NF54 [GtoPdb: 2975]
GtoPdb Standard membrane feeding assay (SMFA) - 8 pEC50 10 nM EC50 Nature (2015) 522: 315-20 [PMID:26085270]
GtoPdb Parasite gamete formation assay - 8.74 pEC50 1.8 nM EC50 Nature (2015) 522: 315-20 [PMID:26085270]
GtoPdb Standard membrane feeding assay (SMFA) - 8.74 pEC50 1.8 nM EC50 Nature (2015) 522: 315-20 [PMID:26085270]
GtoPdb Parasite gamete formation assay - 8.92 pEC50 1.2 nM EC50 Nature (2015) 522: 315-20 [PMID:26085270]
Plasmodium falciparum elongation factor 2 in Plasmodium falciparum 3D7 [GtoPdb: 2975] [UniProtKB: Q8IKW5]
GtoPdb Parasite growth inhibition assay - 9 pEC50 1 nM EC50 Nature (2015) 522: 315-20 [PMID:26085270]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]