artemether [Ligand Id: 9955] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL566534 (SM 224, Artemetheri, NSC-665970, Dihydroartemisinin impurity g, Artemether)
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL Antiplasmodial activity against Plasmodium berghei ANKA early trophozoite stage by parasite LDH assay F 8.52 pIC50 3 nM IC50 J. Med. Chem. (2015) 58: 7895-7899 [PMID:26367273]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL In vitro anti-protozoal activity against Plasmodium falciparum Ghana F 7.6 pIC50 25 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2013-2015 [PMID:12781185]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O-positive erythrocytes assessed as decrease in parasitaemia after 72 hrs by NBT dye-based spectrophotometric method F 7.7 pIC50 20 nM IC50 Eur J Med Chem (2018) 143: 306-319 [PMID:29197735]
ChEMBL In vitro antimalarial activity against Plasmodium falciparum FCR3 F 7.85 pIC50 14 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 75-77 [PMID:12467620]
ChEMBL In vitro inhibitory concentration against chloroquine-sensitive Plasmodium falciparum HB3 F 8.04 pIC50 9.2 nM IC50 J. Med. Chem. (2002) 45: 1052-1063 [PMID:11855985]
ChEMBL In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1 F 8.1 pIC50 7.94 nM IC50 J. Med. Chem. (2002) 45: 1052-1063 [PMID:11855985]
ChEMBL In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1 F 8.19 pIC50 6.5 nM IC50 J. Med. Chem. (2002) 45: 1052-1063 [PMID:11855985]
ChEMBL In vitro antimalarial activity for Plasmodium falciparum W-2 F 8.27 pIC50 5.4 nM IC50 J. Med. Chem. (1998) 41: 4101-4108 [PMID:9767645]
ChEMBL In vitro inhibitory activity against the chloroquine-resistant Plasmodium falciparum W2 Indochina F 8.27 pIC50 5.4 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 1059-1062 [PMID:12643911]
ChEMBL In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 8.34 pIC50 4.55 nM IC50 J. Med. Chem. (2001) 44: 58-68 [PMID:11141088]
ChEMBL Antimalarial activity against multidrug resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay F 8.35 pIC50 4.5 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone) F 8.35 pIC50 4.49 nM IC50 J. Med. Chem. (1988) 31: 645-650 [PMID:3279208]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by [3H]hypoxanthine incorporation assay F 8.38 pIC50 4.2 nM IC50 J. Med. Chem. (2010) 53: 633-640 [PMID:19957999]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake F 8.45 pIC50 3.53 nM IC50 Bioorg. Med. Chem. (2009) 17: 1325-1338 [PMID:19136263]
ChEMBL Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake F 8.45 pIC50 3.53 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 2033-2037 [PMID:19249201]
ChEMBL In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum FcB1 F 8.46 pIC50 3.5 nM IC50 J. Med. Chem. (2004) 47: 1423-1433 [PMID:14998331]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake F 8.46 pIC50 3.45 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 2038-2043 [PMID:19251414]
ChEMBL In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 F 8.47 pIC50 3.42 nM IC50 J. Med. Chem. (2001) 44: 58-68 [PMID:11141088]
ChEMBL Inhibitory concentration against Plasmodium falciparum W2 Indochina F 8.48 pIC50 3.34 nM IC50 J. Med. Chem. (1988) 31: 645-650 [PMID:3279208]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 F 8.49 pIC50 3.2 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 1720-1724 [PMID:18243702]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 F 8.49 pIC50 3.2 nM IC50 J. Med. Chem. (2008) 51: 2170-2177 [PMID:18341274]
ChEMBL Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation F 8.55 pIC50 2.8 nM IC50 J. Med. Chem. (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS F 8.63 pIC50 2.34 nM IC50 J. Med. Chem. (1988) 31: 645-650 [PMID:3279208]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake F 8.68 pIC50 2.11 nM IC50 Bioorg. Med. Chem. (2009) 17: 1325-1338 [PMID:19136263]
ChEMBL Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS F 8.72 pIC50 1.92 nM IC50 J. Med. Chem. (1988) 31: 645-650 [PMID:3279208]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake F 8.9 pIC50 1.26 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 5804-5804 [PMID:18845438]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O positive erythrocyte assessed as reduction in parasitemia after 72 hrs F 4.19 pIC50 >64000 nM IC50 Bioorg. Med. Chem. (2014) 22: 5241-5248 [PMID:25199582]
ChEMBL Antimalarial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay F 8.14 pIC50 7.26 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 (Thailand) assessed as growth inhibition by [3H]hypoxanthine incorporation assay F 8.47 pIC50 3.4 nM IC50 J. Med. Chem. (2010) 53: 633-640 [PMID:19957999]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 8.6 pIC50 2.5 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1291-1296 [PMID:18268087]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake F 8.9 pIC50 1.26 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 2038-2043 [PMID:19251414]
Plasmodium falciparum NF54 (target type: ORGANISM) [ChEMBL: CHEMBL2367131]
ChEMBL Antimalarial activity against chloroquine-sensitive asexual Plasmodium falciparum NF54 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay F 8.24 pIC50 5.77 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3006-3009 [PMID:27210430]
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889]
ChEMBL Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin F 6 pIC50 <1000 nM IC50 J. Med. Chem. (2013) 56: 7761-7771 [PMID:23927658]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]