ChEMBL ligand: CHEMBL566534 (Artemetero, Artemether, Artemetheri, Artemetherum, Artesaph, .beta.-artemether, Dihydroartemisinin impurity g, Falcidol, Gvither, Larither, Malartem, NSC-665970, NSC-759820, Paluther, SM 224, SM224)
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii [ChEMBL: CHEMBL612889] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	In vivo antimalarial activity against Plasmodium berghei infected mouse model assessed as parasitemia at 8 mg/kg, po in presence of Mefloquine hydrochloride	F	7.64	pIC50	23	nM	IC50	J Med Chem (2016) 59: 7360-7388 [PMID:27010926]
ChEMBL	Antiplasmodial activity against Plasmodium berghei ANKA early trophozoite stage by parasite LDH assay	F	8.52	pIC50	3	nM	IC50	J Med Chem (2015) 58: 7895-7899 [PMID:26367273]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O positive erythrocyte assessed as reduction in parasitemia after 72 hrs	F	4.19	pIC50	>64000	nM	IC50	Bioorg Med Chem (2014) 22: 5241-5248 [PMID:25199582]
ChEMBL	In vitro anti-protozoal activity against Plasmodium falciparum Ghana	F	7.6	pIC50	25	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2013-2015 [PMID:12781185]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human O-positive erythrocytes assessed as decrease in parasitaemia after 72 hrs by NBT dye-based spectrophotometric method	F	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2018) 143: 306-319 [PMID:29197735]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum FCR3	F	7.85	pIC50	14	nM	IC50	Bioorg Med Chem Lett (2003) 13: 75-77 [PMID:12467620]
ChEMBL	In vitro inhibitory concentration against chloroquine-sensitive Plasmodium falciparum HB3	F	8.04	pIC50	9.2	nM	IC50	J Med Chem (2002) 45: 1052-1063 [PMID:11855985]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1	F	8.05	pIC50	9	nM	IC50	Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	8.1	pIC50	7.94	nM	IC50	Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479]
ChEMBL	In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1	F	8.1	pIC50	7.94	nM	IC50	J Med Chem (2002) 45: 1052-1063 [PMID:11855985]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	8.14	pIC50	7.26	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2	F	8.15	pIC50	7	nM	IC50	Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479]
ChEMBL	In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum K1	F	8.19	pIC50	6.5	nM	IC50	J Med Chem (2002) 45: 1052-1063 [PMID:11855985]
ChEMBL	Antimalarial activity against chloroquine-sensitive asexual Plasmodium falciparum NF54 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	8.24	pIC50	5.77	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	In vitro inhibitory activity against the chloroquine-resistant Plasmodium falciparum W2 Indochina	F	8.27	pIC50	5.4	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1059-1062 [PMID:12643911]
ChEMBL	In vitro antimalarial activity for Plasmodium falciparum W-2	F	8.27	pIC50	5.4	nM	IC50	J Med Chem (1998) 41: 4101-4108 [PMID:9767645]
ChEMBL	In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	8.34	pIC50	4.55	nM	IC50	J Med Chem (2001) 44: 58-68 [PMID:11141088]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	8.35	pIC50	4.5	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone)	F	8.35	pIC50	4.49	nM	IC50	J Med Chem (1988) 31: 645-650 [PMID:3279208]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by [3H]hypoxanthine incorporation assay	F	8.38	pIC50	4.2	nM	IC50	J Med Chem (2010) 53: 633-640 [PMID:19957999]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual erythrocyte stage form Plasmodium falciparum NF54 measured after 48 hrs by pLDH assay	F	8.42	pIC50	3.8	nM	IC50	Eur J Med Chem (2016) 122: 635-646 [PMID:27448920]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay	F	8.42	pIC50	3.8	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127581-127581 [PMID:32987134]
ChEMBL	Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake	F	8.45	pIC50	3.53	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2033-2037 [PMID:19249201]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake	F	8.45	pIC50	3.53	nM	IC50	Bioorg Med Chem (2009) 17: 1325-1338 [PMID:19136263]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum FCB1 assessed as inhibition of parasite growth	F	8.46	pIC50	3.5	nM	IC50	J Med Chem (2021) 64: 9786-9874 [PMID:34213340]
ChEMBL	In vitro inhibitory concentration against chloroquine-resistant Plasmodium falciparum FcB1	F	8.46	pIC50	3.5	nM	IC50	J Med Chem (2004) 47: 1423-1433 [PMID:14998331]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake	F	8.46	pIC50	3.45	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2038-2043 [PMID:19251414]
ChEMBL	In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3	F	8.47	pIC50	3.42	nM	IC50	J Med Chem (2001) 44: 58-68 [PMID:11141088]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 (Thailand) assessed as growth inhibition by [3H]hypoxanthine incorporation assay	F	8.47	pIC50	3.4	nM	IC50	J Med Chem (2010) 53: 633-640 [PMID:19957999]
ChEMBL	Inhibitory concentration against Plasmodium falciparum W2 Indochina	F	8.48	pIC50	3.34	nM	IC50	J Med Chem (1988) 31: 645-650 [PMID:3279208]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	8.49	pIC50	3.2	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1720-1724 [PMID:18243702]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7	F	8.49	pIC50	3.2	nM	IC50	J Med Chem (2008) 51: 2170-2177 [PMID:18341274]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation	F	8.55	pIC50	2.8	nM	IC50	J Med Chem (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	8.6	pIC50	2.5	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1291-1296 [PMID:18268087]
ChEMBL	Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS	F	8.63	pIC50	2.34	nM	IC50	J Med Chem (1988) 31: 645-650 [PMID:3279208]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH assay	F	8.64	pIC50	2.3	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127581-127581 [PMID:32987134]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual erythrocyte stage form Plasmodium falciparum Dd2 measured after 48 hrs by pLDH assay	F	8.64	pIC50	2.3	nM	IC50	Eur J Med Chem (2016) 122: 635-646 [PMID:27448920]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake	F	8.68	pIC50	2.11	nM	IC50	Bioorg Med Chem (2009) 17: 1325-1338 [PMID:19136263]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54	F	8.7	pIC50	2	nM	IC50	Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479]
ChEMBL	Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS	F	8.72	pIC50	1.92	nM	IC50	J Med Chem (1988) 31: 645-650 [PMID:3279208]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake	F	8.9	pIC50	1.26	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5804-5804 [PMID:18845438]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake	F	8.9	pIC50	1.26	nM	IC50	Bioorg Med Chem Lett (2009) 19: 2038-2043 [PMID:19251414]
Plasmodium yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612889]
ChEMBL	Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin	F	6	pIC50	<1000	nM	IC50	J Med Chem (2013) 56: 7761-7771 [PMID:23927658]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]