borrelidin [Ligand Id: 11306] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL70590 (Borrelidin)
  • Cell division control protein 28 in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
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  • Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum FCR3 [GtoPdb: 3058]
  • Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3058]
  • Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3058] [UniProtKB: Q8IIA4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
ChEMBL Inhibition of cyclin-dependent kinase activity of Cdc28p/CDK2p in Saccharomyces cerevisiae B 4.62 pIC50 24000 nM IC50 Bioorg Med Chem Lett (2003) 13: 2235-2237 [PMID:12798341]
Threonyl-tRNA synthase in Phytophthora sojae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366435] [UniProtKB: G3FIN0]
ChEMBL Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis B 5 pKi 10000 nM Ki J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236]
ChEMBL Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis B 5.1 pIC50 8000 nM IC50 J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236]
Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum FCR3 [GtoPdb: 3058]
GtoPdb Parasite growth inhibition assay - 8.74 pIC50 1.8 nM IC50 J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165]
Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3058]
GtoPdb Parasite growth inhibition assay - 8.72 pIC50 1.9 nM IC50 J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165]
Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3058] [UniProtKB: Q8IIA4]
GtoPdb Parasite growth inhibition assay - 8.91 pIC50 1.24 nM IC50 Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076]
GtoPdb Parasite growth inhibition assay - 9.01 pIC50 0.97 nM IC50 Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]