borrelidin [Ligand Id: 11306] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL70590 (Borrelidin)
  • Cell division control protein 28 in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
Created with Highcharts 10.3.3ValuesChart context menuCell division control protein 28pKd Saccharomyces cerevisiae S288cpKi Saccharomyces cerevisiae S288cpIC50 Saccharomyces cerevisiae S288cpEC50 Saccharomyces cerevisiae S288c012345Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuPlasmodium falciparumpKd Plasmodium falciparumpKi Plasmodium falciparumpIC50 Plasmodium falciparumpEC50 Plasmodium falciparum0246810Highcharts.com
  • Plasmodium falciparum threonyl-tRNA synthetase/threonine--tRNA ligase in Plasmodium falciparum [ChEMBL: CHEMBL5465377] [GtoPdb: 3058] [UniProtKB: Q8IIA4]
  • Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum FCR3 [GtoPdb: 3058]
  • Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3058]
  • Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3058] [UniProtKB: Q8IIA4]
Created with Highcharts 10.3.3ValuesChart context menuthreonine--tRNA ligasepKd Plasmodium falciparumpKd Plasmodium falci…pKi Plasmodium falciparumpKi Plasmodium falci…pIC50 Plasmodium falciparumpIC50 Plasmodium fa…pEC50 Plasmodium falciparumpEC50 Plasmodium f…pKd Plasmodium falciparum FCR3pKd Plasmodium falci…pKi Plasmodium falciparum FCR3pKi Plasmodium falci…pIC50 Plasmodium falciparum FCR3pIC50 Plasmodium fa…pEC50 Plasmodium falciparum FCR3pEC50 Plasmodium f…pKd Plasmodium falciparum K1pKd Plasmodium falci…pKi Plasmodium falciparum K1pKi Plasmodium falci…pIC50 Plasmodium falciparum K1pIC50 Plasmodium fa…pEC50 Plasmodium falciparum K1pEC50 Plasmodium f…pKd Plasmodium falciparum 3D7pKd Plasmodium falci…pKi Plasmodium falciparum 3D7pKi Plasmodium falci…pIC50 Plasmodium falciparum 3D7pIC50 Plasmodium fa…pEC50 Plasmodium falciparum 3D7pEC50 Plasmodium f…0246810Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuThreonyl-tRNA synthasepKd Phytophthora sojaepKi Phytophthora sojaepIC50 Phytophthora sojaepEC50 Phytophthora sojae0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
ChEMBL Inhibition of cyclin-dependent kinase activity of Cdc28p/CDK2p in Saccharomyces cerevisiae B 4.62 pIC50 24000 nM IC50 Bioorg Med Chem Lett (2003) 13: 2235-2237 [PMID:12798341]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against drug-resistant asynchronous culture of Plasmodium falciparum K1 after 72 hrs by p-LDH assay F 8.72 pIC50 1.9 nM IC50 Medchemcomm (2016) 7: 1535-1545
Plasmodium falciparum threonyl-tRNA synthetase/threonine--tRNA ligase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5465377] [GtoPdb: 3058] [UniProtKB: Q8IIA4]
ChEMBL Inhibition of Plasmodium falciparum Threonyl tRNA synthetase expressed in Escherichia coli Rossetta 2 (DE3) assessed as apparent inhibition constant by measuring formation of Thr-tRNA Thr using [14C]threonine and unlabeled threonine by scintillation counting analysis B 6.8 pKi 160 nM Ki ACS Med Chem Lett (2024) 15: 76-80 [PMID:38229753]
ChEMBL Inhibition of Plasmodium falciparum Threonyl tRNA synthetase B 7.37 pIC50 43 nM IC50 ACS Med Chem Lett (2024) 15: 76-80 [PMID:38229753]
Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum FCR3 [GtoPdb: 3058]
GtoPdb Parasite growth inhibition assay - 8.74 pIC50 1.8 nM IC50 J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165]
Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3058]
GtoPdb Parasite growth inhibition assay - 8.72 pIC50 1.9 nM IC50 J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165]
Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3058] [UniProtKB: Q8IIA4]
GtoPdb Parasite growth inhibition assay - 8.91 pIC50 1.24 nM IC50 Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076]
GtoPdb Parasite growth inhibition assay - 9.01 pIC50 0.97 nM IC50 Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076]
Threonyl-tRNA synthase in Phytophthora sojae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366435] [UniProtKB: G3FIN0]
ChEMBL Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis B 5 pKi 10000 nM Ki J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236]
ChEMBL Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis B 5.1 pIC50 8000 nM IC50 J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]