borrelidin [Ligand Id: 11306] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL70590 (Borrelidin)
  • Cell division control protein 28 in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
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  • Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum FCR3 [GtoPdb: 3058]
  • Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3058]
  • Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3058] [UniProtKB: Q8IIA4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
ChEMBL Inhibition of cyclin-dependent kinase activity of Cdc28p/CDK2p in Saccharomyces cerevisiae B 4.62 pIC50 24000 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2235-2237 [PMID:12798341]
Threonyl-tRNA synthase in Phytophthora sojae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366435] [UniProtKB: G3FIN0]
ChEMBL Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis B 5 pKi 10000 nM Ki J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236]
ChEMBL Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduction in initial velocity at the step of threonine activation preincubated for 10 min with 4 uM enzyme before threonine addition measured after 30 min by HPLC analysis B 5.1 pIC50 8000 nM IC50 J Agric Food Chem (2012) 60: 9874-9881 [PMID:22967236]
Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum FCR3 [GtoPdb: 3058]
GtoPdb Parasite growth inhibition assay - 8.74 pIC50 1.8 nM IC50 J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165]
Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3058]
GtoPdb Parasite growth inhibition assay - 8.72 pIC50 1.9 nM IC50 J Antibiot (Tokyo) (2003) 56: 727-9 [PMID:14563165]
Plasmodium falciparum threonyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3058] [UniProtKB: Q8IIA4]
GtoPdb Parasite growth inhibition assay - 8.91 pIC50 1.24 nM IC50 Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076]
GtoPdb Parasite growth inhibition assay - 9.01 pIC50 0.97 nM IC50 Proc Natl Acad Sci U S A (2014) 111: E5508-17 [PMID:25489076]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]