- Guide to PHARMACOLOGY
Molecular properties generated using the CDK
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Ligand families/groups||Antimalarial ligands|
|BRD3444 is from a series of bicyclic azetidines with promising antimalarial activity .
Note this paper specifies more soluble but slightly less potent analogues likely to have the same mechanism of action including BRD7539 = PubChem CID 54650356 and BRD1095 = PubChem CID 91758335. Note also that BRD3444 has complex stereoisomers as PubChem same connectivity and via the UniChem InChIKey backbone search (see link below).
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
|GtoPdb PubChem SID||340590278|
|Search Google for chemical match using the InChIKey||OJOYTIQMDFICSJ-FRXPANAUSA-N|
|Search Google for chemicals with the same backbone||OJOYTIQMDFICSJ|
|Search UniChem for chemical match using the InChIKey||OJOYTIQMDFICSJ-FRXPANAUSA-N|
|Search UniChem for chemicals with the same backbone||OJOYTIQMDFICSJ|