cladosporin [Ligand Id: 10247] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL448685 (Cladosporin)
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059]
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059]
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium yoelii [GtoPdb: 3059]
  • Plasmodium falciparum lysyl-tRNA synthetase/Lysine--tRNA ligase in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL3301561] [GtoPdb: 3059] [UniProtKB: Q8IDJ8]
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum D6 [GtoPdb: 3059]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059]
GtoPdb Parasite growth inhibition assay - 7.1 pIC50 80.1 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059]
GtoPdb Parasite growth inhibition assay - 7.06 pIC50 87.9 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium yoelii [GtoPdb: 3059]
GtoPdb Parasite liver stage assay - 7.41 pIC50 39.1 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Plasmodium falciparum lysyl-tRNA synthetase/Lysine--tRNA ligase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3301561] [GtoPdb: 3059] [UniProtKB: Q8IDJ8]
ChEMBL Inhibition of Plasmodium falciparum KRS expressed in Escherichia coli BL21 using tRNA(Lys) as substrate after 45 mins in presence of L-lysine by AMP-GLO assay B 6.92 pIC50 120 nM IC50 J Med Chem (2018) 61: 5664-5678 [PMID:29779382]
GtoPdb Parasite growth inhibition assay - 7.34 pIC50 45.4 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum D6 [GtoPdb: 3059]
GtoPdb Parasite growth inhibition assay - 7.14 pIC50 72.1 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Lysyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5575] [UniProtKB: Q15046]
ChEMBL Inhibition of human recombinant cytoplasmic lysyl-tRNA synthetase B 4.7 pIC50 >20000 nM IC50 Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against liver stage of drug-sensitive Plasmodium falciparum D10 F 7.05 pEC50 90 nM EC50 Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422]
ChEMBL Antiplasmodial activity against liver stage of drug-sensitive Plasmodium falciparum 3D7 F 7.35 pEC50 45 nM EC50 Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422]
ChEMBL Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green-1 staining based assay F 7.4 pEC50 40 nM EC50 J Med Chem (2018) 61: 5664-5678 [PMID:29779382]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]