cladosporin [Ligand Id: 10247] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL448685 (Cladosporin)
  • Plasmodium falciparum lysine--tRNA ligase in Plasmodium falciparum K1 [GtoPdb: 3059]
  • Plasmodium falciparum lysine--tRNA ligase in Plasmodium falciparum NF54 [GtoPdb: 3059]
  • Plasmodium falciparum lysine--tRNA ligase in Plasmodium yoelii [GtoPdb: 3059]
  • Plasmodium falciparum lysine--tRNA ligase/Lysine--tRNA ligase in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL3301561] [GtoPdb: 3059] [UniProtKB: Q8IDJ8]
  • Plasmodium falciparum lysine--tRNA ligase in Plasmodium falciparum D6 [GtoPdb: 3059]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum lysine--tRNA ligase in Plasmodium falciparum K1 [GtoPdb: 3059]
GtoPdb Parasite growth inhibition assay - 7.1 pIC50 80.1 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Plasmodium falciparum lysine--tRNA ligase in Plasmodium falciparum NF54 [GtoPdb: 3059]
GtoPdb Parasite growth inhibition assay - 7.06 pIC50 87.9 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Plasmodium falciparum lysine--tRNA ligase in Plasmodium yoelii [GtoPdb: 3059]
GtoPdb Parasite liver stage assay - 7.41 pIC50 39.1 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Plasmodium falciparum lysine--tRNA ligase/Lysine--tRNA ligase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3301561] [GtoPdb: 3059] [UniProtKB: Q8IDJ8]
ChEMBL Inhibition of Plasmodium falciparum KRS expressed in Escherichia coli BL21 using tRNA(Lys) as substrate after 45 mins in presence of L-lysine by AMP-GLO assay B 6.92 pIC50 120 nM IC50 J Med Chem (2018) 61: 5664-5678 [PMID:29779382]
GtoPdb Parasite growth inhibition assay - 7.34 pIC50 45.4 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Plasmodium falciparum lysine--tRNA ligase in Plasmodium falciparum D6 [GtoPdb: 3059]
GtoPdb Parasite growth inhibition assay - 7.14 pIC50 72.1 nM IC50 Cell Host Microbe (2012) 11: 654-63 [PMID:22704625]
Lysyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5575] [UniProtKB: Q15046]
ChEMBL Inhibition of human recombinant cytoplasmic lysyl-tRNA synthetase B 4.7 pIC50 >20000 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 2829-2843 [PMID:23587422]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against liver stage of drug-sensitive Plasmodium falciparum D10 F 7.05 pEC50 90 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 2829-2843 [PMID:23587422]
ChEMBL Antiplasmodial activity against liver stage of drug-sensitive Plasmodium falciparum 3D7 F 7.35 pEC50 45 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 2829-2843 [PMID:23587422]
ChEMBL Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green-1 staining based assay F 7.4 pEC50 40 nM EC50 J Med Chem (2018) 61: 5664-5678 [PMID:29779382]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]