- Guide to PHARMACOLOGY
Synonyms: ML-324 | MMV1580488
Compound class: Synthetic organic
Comment: ML324 is a cell-permeable, small molecule inhibitor of lysine demethylase 4 (KDM4) family of histone modifying enzymes . KDM4 demethylases are responsible for the removal of H3K9 trimethylation marks from histones. The family members exhibit substantial mechanistic redundancy . ML324 demonstrates antiviral activity and is one of the chemotypes included in the Medicines for Malaria Pandemic Response Box (MMV PRB).
The compound also has antimalarial activity. The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Ligand families/groups||Antimalarial ligands|
|ML-324 | MMV1580488|
|CAS Registry No.||1222800-79-4 (source: Scifinder)|
|GtoPdb PubChem SID||340590215|
|Search Google for chemical match using the InChIKey||QDBVSOZTVKXUES-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||QDBVSOZTVKXUES|
|Search UniChem for chemical match using the InChIKey||QDBVSOZTVKXUES-UHFFFAOYSA-N|
|Search UniChem for chemicals with the same backbone||QDBVSOZTVKXUES|