BRD9185 [Ligand Id: 11469] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4064731 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| dihydroorotate dehydrogenase (quinone)/Dihydroorotate dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1966] [GtoPdb: 2604] [UniProtKB: Q02127] | ||||||||
| GtoPdb | - | - | 4.3 | pIC50 | >50000 | nM | IC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
| ChEMBL | Inhibition of recombinant human DHODH | B | 4.3 | pIC50 | >50000 | nM | IC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 infected in human blood after 72 hrs by SYBR Green dye based assay | F | 7.8 | pEC50 | 16 | nM | EC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949] | ||||||||
| GtoPdb | - | - | 7.92 | pIC50 | 12 | nM | IC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum Dd2 [GtoPdb: 2949] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.8 | pEC50 | 16 | nM | EC50 | ACS Med Chem Lett (2017) 8: 438-442 [PMID:28435533] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
