arteflene [Ligand Id: 10397] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL380230 (Arteflene, RO 42-1611, RO-421611, RO-42-1611)
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 F 7.12 pIC50 76 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 2991-2995 [PMID:16527481]
ChEMBL In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF 54 F 7.15 pIC50 71 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 903-908 [PMID:9871509]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth F 7.82 pIC50 15 nM IC50 Bioorg. Med. Chem. (2015) 23: 5120-5130 [PMID:25913864]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]