mupirocin [Ligand Id: 10916] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL719 (Bactroban, Pseudomonic Acid, Centany, Mupirocin, BRL-4910A)
  • Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690]
  • This target only has 1 pki data point
1 CHEMBL719_lig_chart_1 Isoleucine--tRNA ligase Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
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  • Isoleucyl-tRNA synthetase in Human [ChEMBL: CHEMBL3235] [UniProtKB: P41252]
  • Isoleucyl-tRNA synthetase in Escherichia coli K-12 [ChEMBL: CHEMBL3657] [UniProtKB: P00956]
  • This target only has 1 pki data point
2 CHEMBL719_lig_chart_2 Isoleucyl-tRNA synthetase HumanEscherichia coli K-12
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690]
ChEMBL Inhibition of recombinant Thermus thermophilus HB8 wild type IleRS assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation B 6.6 pKi 250 nM Ki MedChemComm (2016) 7: 1535-1545
Isoleucyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3235] [UniProtKB: P41252]
ChEMBL Compound was evaluated for inhibitory activity against Isoleucyl-tRNA synthetase B 9.1 pIC50 0.8 nM IC50 Bioorg. Med. Chem. Lett. (1997) 7: 2805-2808
Isoleucyl-tRNA synthetase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3657] [UniProtKB: P00956]
ChEMBL Competitive inhibition of Escherichia coli Isoleucyl-tRNA synthetase B 8.6 pKi 2.5 nM Ki Eur. J. Med. Chem. (2011) 46: 5227-5236 [PMID:21968372]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]