ChEMBL ligand: CHEMBL719 (Bactoderm, Bactroban, BRL 4910A, BRL-4910A, Centany, Mupirocin, NSC-759182, Pseudomonic acid, Trans-pseudomonic acid, Turixin)
Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690] There should be some charts here, you may need to enable JavaScript!
Isoleucyl-tRNA synthetase in Human [ChEMBL: CHEMBL3235] [UniProtKB: P41252] Isoleucyl-tRNA synthetase in Escherichia coli K-12 [ChEMBL: CHEMBL3657] [UniProtKB: P00956] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum isoleucyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3168] [UniProtKB: Q8I5G6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690]
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 IleRS H581S/L583I double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	4.82	pKi	15000	nM	Ki	MedChemComm (2016) 7: 1535-1545
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 IleRS H581N/L583F double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	5.56	pKi	2730	nM	Ki	MedChemComm (2016) 7: 1535-1545
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 IleRS H581L/L583H double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	5.64	pKi	2310	nM	Ki	MedChemComm (2016) 7: 1535-1545
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 wild type IleRS assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	6.6	pKi	250	nM	Ki	MedChemComm (2016) 7: 1535-1545
ChEMBL	Inhibition of recombinant Thermus thermophilus HB8 IleRS L583F mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation	B	7.22	pKi	60	nM	Ki	MedChemComm (2016) 7: 1535-1545
Isoleucyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3235] [UniProtKB: P41252]
ChEMBL	Compound was evaluated for inhibitory activity against Isoleucyl-tRNA synthetase	B	9.1	pIC50	0.8	nM	IC50	Bioorg. Med. Chem. Lett. (1997) 7: 2805-2808
Isoleucyl-tRNA synthetase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3657] [UniProtKB: P00956]
ChEMBL	Competitive inhibition of Escherichia coli Isoleucyl-tRNA synthetase	B	8.6	pKi	2.5	nM	Ki	Eur. J. Med. Chem. (2011) 46: 5227-5236 [PMID:21968372]
Plasmodium falciparum isoleucyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3168] [UniProtKB: Q8I5G6]
GtoPdb	-	-	7.24	pIC50	57.4	nM	IC50	Proc Natl Acad Sci U S A (2011) 108: 1627-32 [PMID:21205898]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]