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ChEMBL ligand: CHEMBL719 (Bactoderm, Bactroban, BRL 4910A, BRL-4910A, Centany, Mupirocin, NSC-759182, Pseudomonic acid, Trans-pseudomonic acid, Turixin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690] | ||||||||
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 IleRS H581S/L583I double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 4.82 | pKi | 15000 | nM | Ki | Medchemcomm (2016) 7: 1535-1545 |
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 IleRS H581N/L583F double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 5.56 | pKi | 2730 | nM | Ki | Medchemcomm (2016) 7: 1535-1545 |
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 IleRS H581L/L583H double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 5.64 | pKi | 2310 | nM | Ki | Medchemcomm (2016) 7: 1535-1545 |
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 wild type IleRS assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 6.6 | pKi | 250 | nM | Ki | Medchemcomm (2016) 7: 1535-1545 |
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 IleRS L583F mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 7.22 | pKi | 60 | nM | Ki | Medchemcomm (2016) 7: 1535-1545 |
Isoleucyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3235] [UniProtKB: P41252] | ||||||||
ChEMBL | Compound was evaluated for inhibitory activity against Isoleucyl-tRNA synthetase | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2805-2808 |
Isoleucyl-tRNA synthetase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3657] [UniProtKB: P00956] | ||||||||
ChEMBL | Competitive inhibition of Escherichia coli Isoleucyl-tRNA synthetase | B | 8.6 | pKi | 2.5 | nM | Ki | Eur J Med Chem (2011) 46: 5227-5236 [PMID:21968372] |
Plasmodium falciparum isoleucyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3168] [UniProtKB: Q8I5G6] | ||||||||
GtoPdb | - | - | 7.24 | pIC50 | 57.4 | nM | IC50 | Proc Natl Acad Sci U S A (2011) 108: 1627-32 [PMID:21205898] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]