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ChEMBL ligand: CHEMBL719 (Bactoderm, Bactroban, BRL 4910A, BRL-4910A, Centany, Mupirocin, NSC-759182, Pseudomonic acid, Trans-pseudomonic acid, Turixin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690] | ||||||||
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 IleRS H581S/L583I double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 4.82 | pKi | 15000 | nM | Ki | MedChemComm (2016) 7: 1535-1545 |
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 IleRS H581N/L583F double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 5.56 | pKi | 2730 | nM | Ki | MedChemComm (2016) 7: 1535-1545 |
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 IleRS H581L/L583H double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 5.64 | pKi | 2310 | nM | Ki | MedChemComm (2016) 7: 1535-1545 |
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 wild type IleRS assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 6.6 | pKi | 250 | nM | Ki | MedChemComm (2016) 7: 1535-1545 |
ChEMBL | Inhibition of recombinant Thermus thermophilus HB8 IleRS L583F mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation | B | 7.22 | pKi | 60 | nM | Ki | MedChemComm (2016) 7: 1535-1545 |
Isoleucyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3235] [UniProtKB: P41252] | ||||||||
ChEMBL | Compound was evaluated for inhibitory activity against Isoleucyl-tRNA synthetase | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Bioorg. Med. Chem. Lett. (1997) 7: 2805-2808 |
Isoleucyl-tRNA synthetase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3657] [UniProtKB: P00956] | ||||||||
ChEMBL | Competitive inhibition of Escherichia coli Isoleucyl-tRNA synthetase | B | 8.6 | pKi | 2.5 | nM | Ki | Eur. J. Med. Chem. (2011) 46: 5227-5236 [PMID:21968372] |
Plasmodium falciparum isoleucyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3168] [UniProtKB: Q8I5G6] | ||||||||
GtoPdb | - | - | 7.24 | pIC50 | 57.4 | nM | IC50 | Proc Natl Acad Sci U S A (2011) 108: 1627-32 [PMID:21205898] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]