mupirocin [Ligand Id: 10916] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL719 (Bactroban, Centany, Pseudomonic acid, Mupirocin, BRL-4910A, BRL 4910A)
  • Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690]
There should be some charts here, you may need to enable JavaScript!
  • Isoleucyl-tRNA synthetase in Human [ChEMBL: CHEMBL3235] [UniProtKB: P41252]
  • Isoleucyl-tRNA synthetase in Escherichia coli K-12 [ChEMBL: CHEMBL3657] [UniProtKB: P00956]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Isoleucine--tRNA ligase in Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879837] [UniProtKB: P56690]
ChEMBL Inhibition of recombinant Thermus thermophilus HB8 IleRS H581S/L583I double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation B 4.82 pKi 15000 nM Ki MedChemComm (2016) 7: 1535-1545
ChEMBL Inhibition of recombinant Thermus thermophilus HB8 IleRS H581N/L583F double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation B 5.56 pKi 2730 nM Ki MedChemComm (2016) 7: 1535-1545
ChEMBL Inhibition of recombinant Thermus thermophilus HB8 IleRS H581L/L583H double mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation B 5.64 pKi 2310 nM Ki MedChemComm (2016) 7: 1535-1545
ChEMBL Inhibition of recombinant Thermus thermophilus HB8 wild type IleRS assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation B 6.6 pKi 250 nM Ki MedChemComm (2016) 7: 1535-1545
ChEMBL Inhibition of recombinant Thermus thermophilus HB8 IleRS L583F mutant assessed as suppression of L-[14C]isoleucyl-tRNA(Ile) formation B 7.22 pKi 60 nM Ki MedChemComm (2016) 7: 1535-1545
Isoleucyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3235] [UniProtKB: P41252]
ChEMBL Compound was evaluated for inhibitory activity against Isoleucyl-tRNA synthetase B 9.1 pIC50 0.8 nM IC50 Bioorg. Med. Chem. Lett. (1997) 7: 2805-2808
Isoleucyl-tRNA synthetase in Escherichia coli K-12 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3657] [UniProtKB: P00956]
ChEMBL Competitive inhibition of Escherichia coli Isoleucyl-tRNA synthetase B 8.6 pKi 2.5 nM Ki Eur. J. Med. Chem. (2011) 46: 5227-5236 [PMID:21968372]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]