DSM421 [Ligand Id: 10020] activity data from GtoPdb

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  • dihydroorotate dehydrogenase (quinone) in Human [GtoPdb: 2604] [UniProtKB: Q02127]
  • dihydroorotate dehydrogenase (quinone) in Mouse [GtoPdb: 2604] [UniProtKB: O35435]
  • dihydroorotate dehydrogenase (quinone) in Rat [GtoPdb: 2604] [UniProtKB: Q63707]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 dihydroorotate dehydrogenase (quinone) HumanMouseRat
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  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949]
  • Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 Plasmodium falciparum dihydroorotate dehydrogenase Plasmodium falciparumPlasmodium vivaxPlasmodium falciparum 3D7
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dihydroorotate dehydrogenase (quinone) in Human [GtoPdb: 2604] [UniProtKB: Q02127]
GtoPdb Steady-state kinetic analysis performed to measure recombinant enzyme inhibition. - 4 pIC50 >100000 nM IC50 ACS Infect Dis (2016) 2: 945-957 [PMID:27641613]
dihydroorotate dehydrogenase (quinone) in Mouse [GtoPdb: 2604] [UniProtKB: O35435]
GtoPdb Steady-state kinetic analysis performed to measure recombinant enzyme inhibition. - 4 pIC50 >100000 nM IC50 ACS Infect Dis (2016) 2: 945-957 [PMID:27641613]
dihydroorotate dehydrogenase (quinone) in Rat [GtoPdb: 2604] [UniProtKB: Q63707]
GtoPdb Steady-state kinetic analysis performed to measure recombinant enzyme inhibition. - 4 pIC50 >100000 nM IC50 ACS Infect Dis (2016) 2: 945-957 [PMID:27641613]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949]
GtoPdb Steady-state kinetic analysis of recombinant enzyme inhibition. - 7.28 pIC50 53 nM IC50 ACS Infect Dis (2016) 2: 945-957 [PMID:27641613]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949]
GtoPdb Steady-state kinetic analysis of recombinant enzyme inhibition. - 7.03 pIC50 94 nM IC50 ACS Infect Dis (2016) 2: 945-957 [PMID:27641613]
GtoPdb Blood-stage: schizont maturation assay using P. vivax field isolates. - 6.74 pEC50 180 nM EC50 ACS Infect Dis (2016) 2: 945-957 [PMID:27641613]
Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210]
GtoPdb Parasite growth inhibition assay - 7.37 pEC50 43 nM EC50 ACS Infect Dis (2016) 2: 945-957 [PMID:27641613]
GtoPdb Parasite growth inhibition assay - 7.85 pEC50 14 nM EC50 ACS Infect Dis (2016) 2: 945-957 [PMID:27641613]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.