ChEMBL ligand: CHEMBL1535 (Hydroxychloroquine)
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] This target only has 1 pki data point 5.63 1 CHEMBL1535_lig_chart_1 Alpha-1d adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] This target only has 1 pki data point 5.19 2 CHEMBL1535_lig_chart_2 Alpha-2a adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] This target only has 1 pki data point 4.14 3 CHEMBL1535_lig_chart_3 Alpha-2b adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] This target only has 1 pki data point 4.8 4 CHEMBL1535_lig_chart_4 Alpha-2c adrenergic receptor Human There should be some charts here, you may need to enable JavaScript!
M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] This target only has 1 pki data point 4.81 5 CHEMBL1535_lig_chart_5 Muscarinic acetylcholine receptor M1 Human There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] 5.63 6 CHEMBL1535_lig_chart_6 Muscarinic acetylcholine receptor M2 Human There should be some charts here, you may need to enable JavaScript!
M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] This target only has 1 pki data point 5.32 7 CHEMBL1535_lig_chart_7 Muscarinic acetylcholine receptor M3 Human There should be some charts here, you may need to enable JavaScript!
M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] This target only has 1 pki data point 5.26 8 CHEMBL1535_lig_chart_8 Muscarinic acetylcholine receptor M4 Human There should be some charts here, you may need to enable JavaScript!
M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] This target only has 1 pki data point 4.7 9 CHEMBL1535_lig_chart_9 Muscarinic acetylcholine receptor M5 Human There should be some charts here, you may need to enable JavaScript!
σ2/Sigma intracellular receptor 2 in Human [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] This target only has 1 pki data point 6 10 CHEMBL1535_lig_chart_10 Sigma intracellular receptor 2 Human There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] This target only has 1 pki data point 6.9 11 CHEMBL1535_lig_chart_11 Sigma opioid receptor Human There should be some charts here, you may need to enable JavaScript!
TLR7/Toll-like receptor 7 in Human [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1] This target only has 0 pki data point 0 12 CHEMBL1535_lig_chart_12 Toll-like receptor 7 Human There should be some charts here, you may need to enable JavaScript!
TLR9/Toll-like receptor 9 in Human [ChEMBL: CHEMBL5804] [GtoPdb: 1759] [UniProtKB: Q9NR96] This target only has 0 pki data point 0 13 CHEMBL1535_lig_chart_13 Toll-like receptor 9 Human There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	5.63	pKi	2346	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	5.32	pIC50	4772	nM	IC50	DrugMatrix in vitro pharmacology data
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	Activity of compound against Alpha-2A (ADRA2A) adrenergic receptor by displacement of [3H]-rauwolscine	B	5.19	pKi	6456.54	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	Activity of compound against Alpha 2B (ADRA2B) adrenergic receptor by displacement of [3H]-rauwolscine	B	4.14	pKi	72443.6	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL	Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine	B	4.8	pKi	15848.93	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNB	B	4.81	pKi	15488.17	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB	B	5.29	pKi	5128.61	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
ChEMBL	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	5.98	pKi	1049	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	5.53	pIC50	2951	nM	IC50	DrugMatrix in vitro pharmacology data
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNB	B	5.32	pKi	4786.3	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNB	B	5.26	pKi	5495.41	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL	Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNB	B	4.7	pKi	19952.62	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2]
ChEMBL	Displacement of [3H]-DTG from the Sigma2 receptor	B	6	pKi	1000	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Displacement of [3H]-pentazocin from the Sigma1 receptor	B	6.9	pKi	125.89	nM	Ki	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
TLR7/Toll-like receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5936] [GtoPdb: 1757] [UniProtKB: Q9NYK1]
ChEMBL	Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as inhibition of CL264-induced NFkappaB activation by measuring reduction in SEAP level after overnight incubation using qunati-blue reagent by SEAP reporter gene-based spectrophotometric method	B	5.07	pIC50	8600	nM	IC50	J Med Chem (2020) 63: 4776-4789 [PMID:32302115]
GtoPdb	Inhibition of hTLR7 R848-induced luciferase reporter gene activation.	-	5.56	pIC50	2780	nM	IC50	Mol Pharmacol (2014) 85: 429-40 [PMID:24342772]
ChEMBL	Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as reduction in CL264-induced NF-kappaB levels after 24 hrs by spectrophotometric analysis	B	6.1	pIC50	800	nM	IC50	Eur J Med Chem (2018) 159: 187-205 [PMID:30292896]
TLR9/Toll-like receptor 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5804] [GtoPdb: 1759] [UniProtKB: Q9NR96]
ChEMBL	Antagonist activity at human TLR9 expressed in HEK-Blue cells assessed as reduction in CpGB-induced NF-kappaB levels after 24 hrs by spectrophotometric analysis	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2018) 159: 187-205 [PMID:30292896]
GtoPdb	Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.	-	7.1	pIC50	80	nM	IC50	Mol Pharmacol (2014) 85: 429-40 [PMID:24342772]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]