ChEMBL ligand: CHEMBL2105763 (JNJ 26481585, JNJ-26481585, Quisinostat)
histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 11/Histone deacetylase 11 in Human [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 4/Histone deacetylase 4 in Human [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 5/Histone deacetylase 5 in Human [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 7/Histone deacetylase 7 in Human [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] There should be some charts here, you may need to enable JavaScript!
Histone deacetylase 8 in Schistosoma mansoni [ChEMBL: CHEMBL3797017] [UniProtKB: A5H660] histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 9/Histone deacetylase 9 in Human [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] There should be some charts here, you may need to enable JavaScript!
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] There should be some charts here, you may need to enable JavaScript!
sirtuin 1/NAD-dependent deacetylase sirtuin 1 in Human [ChEMBL: CHEMBL4506] [GtoPdb: 2707] [UniProtKB: Q96EB6] There should be some charts here, you may need to enable JavaScript!
sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6] There should be some charts here, you may need to enable JavaScript!
sirtuin 3/NAD-dependent deacetylase sirtuin 3 in Human [ChEMBL: CHEMBL4461] [GtoPdb: 2709] [UniProtKB: Q9NTG7] There should be some charts here, you may need to enable JavaScript!
sirtuin 7/NAD-dependent protein deacetylase sirtuin-7 in Human [ChEMBL: CHEMBL2163184] [GtoPdb: 2713] [UniProtKB: Q9NRC8] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum 3D7 [GtoPdb: 3072] [UniProtKB: Q7K6A1] Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum Dd2 [GtoPdb: 3072] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL	Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate after 15 mins by fluorimetrc method	B	8.14	pKi	7.3	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method	B	9.32	pKi	0.48	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC1	B	10.52	pKi	0.03	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of HDAC1 (unknown origin)	B	8.37	pIC50	4.26	nM	IC50	Eur J Med Chem (2019) 164: 214-240 [PMID:30594678]
ChEMBL	Inhibition of recombinant full length human HDAC1 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electrophoretic mobility shift assay	B	9.21	pIC50	0.62	nM	IC50	Eur J Med Chem (2020) 201: 112411-112411 [PMID:32615502]
ChEMBL	Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay	B	9.21	pIC50	0.62	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL	Inhibition of recombinant human full length C-terminal His/FLAG tagged HDAC1 (1 to 482 residues) expressed in baculovirus-infected Sf9 cells using Ac-peptide as substrate incubated for 4 hrs	B	9.34	pIC50	0.46	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
ChEMBL	Inhibition of recombinant full length C-terminal FLAG His-tagged human HDAC1 expressed in baculovirus infected Sf21 insect cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetry analysis	B	9.96	pIC50	0.11	nM	IC50	J Med Chem (2021) 64: 3392-3426 [PMID:33661013]
GtoPdb	-	-	9.96	pIC50	0.11	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
ChEMBL	Inhibition of human HDAC1 expressed in baculovirus infected sf9 cells using p53 residues 379-382 (RHKKAc) as substrate by fluorescence-based assay	B	10	pIC50	0.1	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
ChEMBL	Inhibition of human recombinant HDAC10 using fluorogenic HDAC substrate after 45 mins by fluorimetrc method	B	8.36	pKi	4.4	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC10	B	10.3	pKi	0.05	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter gene-based BRET assay	B	7.4	pIC50	39.81	nM	IC50	J Med Chem (2019) 62: 4426-4443 [PMID:30964290]
ChEMBL	Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assay	B	8	pIC50	10	nM	IC50	J Med Chem (2019) 62: 4426-4443 [PMID:30964290]
ChEMBL	Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay	B	8.71	pIC50	1.96	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL	Inhibition of recombinant full length human HDAC10 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electrophoretic mobility shift assay	B	8.71	pIC50	1.96	nM	IC50	Eur J Med Chem (2020) 201: 112411-112411 [PMID:32615502]
ChEMBL	Inhibition of HDAC10 (unknown origin)	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
GtoPdb	-	-	9.34	pIC50	0.46	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2]
ChEMBL	Inhibition of human recombinant HDAC11 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc method	B	5.89	pKi	1300	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC11	B	10.15	pKi	0.07	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of human HDAC11 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
GtoPdb	-	-	9.43	pIC50	0.37	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
ChEMBL	Inhibition of human recombinant HDAC2 using fluorogenic HDAC substrate after 15 mins by fluorimetrc method	B	7.51	pKi	31	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC2	B	10.22	pKi	0.06	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of HDAC2 (unknown origin)	B	8.37	pIC50	4.26	nM	IC50	Eur J Med Chem (2019) 164: 214-240 [PMID:30594678]
ChEMBL	Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay	B	8.67	pIC50	2.16	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL	Inhibition of recombinant full length human HDAC2 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electrophoretic mobility shift assay	B	8.67	pIC50	2.16	nM	IC50	Eur J Med Chem (2020) 201: 112411-112411 [PMID:32615502]
ChEMBL	Inhibition of recombinant human full length C-terminal His tagged HDAC2 (1 to 488 residues) expressed in baculovirus-infected Sf9 insect cells using Ac-peptide as substrate incubated for 4 hrs	B	8.96	pIC50	1.1	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
GtoPdb	-	-	9.48	pIC50	0.33	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
ChEMBL	Inhibition of recombinant full length C-terminal GST fusion-tagged human HDAC2 expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetry analysis	B	9.48	pIC50	0.33	nM	IC50	J Med Chem (2021) 64: 3392-3426 [PMID:33661013]
ChEMBL	Inhibition of human HDAC2 expressed in baculovirus infected sf9 cells using p53 residues 379-382 (RHKKAc) as substrate by fluorescence-based assay	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL	Inhibition of human recombinant HDAC3 using fluorogenic HDAC substrate after 10 mins by spectrophotometric method	B	8.37	pKi	4.3	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC3	B	8.68	pKi	2.1	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
GtoPdb	-	-	8.31	pIC50	4.86	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
ChEMBL	Inhibition of human C-terminal His tagged HDAC3 (1 to 428 residues) expressed in baculovirus-infected Sf9 cells using Ac-peptide as substrate incubated for 4 hrs	B	8.68	pIC50	2.1	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618]
ChEMBL	Inhibition of human HDAC3/NcoR2 expressed in sf9 cells using p53 residues 379-382 (RHKKAc) as substrate by fluorescence-based assay	B	8.3	pIC50	5	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
GtoPdb	-	-	8.31	pIC50	4.86	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
ChEMBL	Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) co-expressed in baculovirus infected Sf9 cells using RHK-K(Ac)-AMCas substrate measured after 60 mins by fluorimetry analysis	B	8.31	pIC50	4.86	nM	IC50	J Med Chem (2021) 64: 3392-3426 [PMID:33661013]
histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
ChEMBL	Inhibition of human recombinant HDAC4 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc method	B	8.17	pKi	6.7	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC4	B	9.52	pKi	0.3	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs by electrophoretic mobility shift assay	B	8.34	pIC50	4.61	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL	Inhibition of recombinant full length human HDAC4 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electrophoretic mobility shift assay	B	8.34	pIC50	4.61	nM	IC50	Eur J Med Chem (2020) 201: 112411-112411 [PMID:32615502]
GtoPdb	-	-	9.19	pIC50	0.64	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
ChEMBL	Inhibition of human HDAC4 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6]
ChEMBL	Inhibition of human recombinant HDAC5 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc method	B	8.37	pKi	4.3	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC5	B	8.68	pKi	2.1	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of recombinant full length human HDAC5 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay	B	8.23	pIC50	5.95	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL	Inhibition of recombinant full length human HDAC5 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electrophoretic mobility shift assay	B	8.23	pIC50	5.95	nM	IC50	Eur J Med Chem (2020) 201: 112411-112411 [PMID:32615502]
ChEMBL	Inhibition of human HDAC5 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	8.4	pIC50	4	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
GtoPdb	-	-	8.43	pIC50	3.69	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Inhibition of human recombinant HDAC6 using fluorogenic HDAC substrate after 30 mins by fluorimetrc method	B	6.46	pKi	350	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC6	B	7.77	pKi	16.9	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
GtoPdb	-	-	7.11	pIC50	76.8	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
ChEMBL	Inhibition of human HDAC6 expressed in baculovirus infected sf9 cells using p53 residues 379-382 (RHKKAc) as substrate by fluorescence-based assay	B	7.11	pIC50	77	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
ChEMBL	Inhibition of full length recombinant human HDAC6 expressed in baculovirus infected Sf9 cells using RHKK-Ac as substrate by fluorescence analysis	B	7.11	pIC50	76.8	nM	IC50	J Med Chem (2016) 59: 8967-9004 [PMID:27606546]
ChEMBL	Inhibition of recombinant full length N-terminal GST fusion-tagged human HDAC6 expressed in baculovirus infected Sf9 insect cells using RHK-K(Ac)-AMC as substrate measured after 90 mins by fluorimetry analysis	B	7.11	pIC50	76.8	nM	IC50	J Med Chem (2021) 64: 3392-3426 [PMID:33661013]
ChEMBL	Inhibition of recombinant human full length N-terminal GST tagged HDAC6 (1 to 1215 residues) expressed in baculovirus-infected Sf9 cells using Ac-peptide as substrate incubated for 4 hrs	B	7.46	pIC50	34.9	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4]
ChEMBL	Inhibition of human HDAC7	B	7.18	pKi	66.6	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of human recombinant HDAC7 using fluorogenic HDAC substrate class 2a after 45 mins by fluorimetrc method	B	8.77	pKi	1.7	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
GtoPdb	-	-	6.92	pIC50	119	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
ChEMBL	Inhibition of human HDAC7 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	6.92	pIC50	119	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
ChEMBL	Inhibition of recombinant full length human HDAC7 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay	B	8.39	pIC50	4.04	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL	Inhibition of recombinant full length human HDAC7 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electrophoretic mobility shift assay	B	8.39	pIC50	4.04	nM	IC50	Eur J Med Chem (2020) 201: 112411-112411 [PMID:32615502]
Histone deacetylase 8 in Schistosoma mansoni (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3797017] [UniProtKB: A5H660]
ChEMBL	Binding affinity to Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC method	B	7.55	pKd	28.4	nM	Kd	J Med Chem (2018) 61: 10000-10016 [PMID:30347148]
ChEMBL	Inhibition of Schistosoma mansoni His-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorometric method	B	6.52	pIC50	303.4	nM	IC50	J Med Chem (2018) 61: 10000-10016 [PMID:30347148]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
ChEMBL	Binding affinity to human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells by ITC method	B	7.64	pKd	22.7	nM	Kd	J Med Chem (2018) 61: 10000-10016 [PMID:30347148]
ChEMBL	Inhibition of human recombinant HDAC8 using fluorogenic HDAC substrate after 15 mins by fluorimetrc method	B	7.62	pKi	24	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC8	B	9.3	pKi	0.5	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of human His-thioredoxin-tagged HDAC8 mL1/mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorometric method	B	6.66	pIC50	217	nM	IC50	J Med Chem (2018) 61: 10000-10016 [PMID:30347148]
ChEMBL	Inhibition of human His-thioredoxin-tagged HDAC8 mL6/L179I mutant expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorometric method	B	6.77	pIC50	169	nM	IC50	J Med Chem (2018) 61: 10000-10016 [PMID:30347148]
ChEMBL	Inhibition of human His-thioredoxin-tagged HDAC8 expressed in Escherichia coli BL21 (DE3) cells using Fluor de Lys (R)-HDAC8 as substrate by fluorometric method	B	7.19	pIC50	64.4	nM	IC50	J Med Chem (2018) 61: 10000-10016 [PMID:30347148]
ChEMBL	Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus-infected Sf9 insect cells using Ac-peptide as substrate incubated for 4 hrs followed by trypsin addition and further incubated for 2 hrs	B	8.04	pIC50	9.2	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
GtoPdb	-	-	8.37	pIC50	4.26	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
ChEMBL	Inhibition of human HDAC8 expressed in baculovirus infected sf9 cells using p53 residues 379-382 (RHKAcKAc) as substrate by fluorescence-based assay	B	8.4	pIC50	4	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0]
ChEMBL	Inhibition of human recombinant HDAC9 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc method	B	8.28	pKi	5.3	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human HDAC9	B	8.42	pKi	3.8	nM	Ki	Bioorg Med Chem (2015) 23: 5151-5155 [PMID:25637120]
GtoPdb	-	-	7.49	pIC50	32.1	nM	IC50	Clin Cancer Res (2009) 15: 6841-51 [PMID:19861438]
ChEMBL	Inhibition of human HDAC9 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	7.49	pIC50	32	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
ChEMBL	Inhibition of recombinant human HDAC9 (604-1066 residues) expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay	B	8.17	pIC50	6.7	nM	IC50	ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL	Inhibition of recombinant full length human HDAC9 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electrophoretic mobility shift assay	B	8.17	pIC50	6.7	nM	IC50	Eur J Med Chem (2020) 201: 112411-112411 [PMID:32615502]
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
ChEMBL	Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by addition of LTA4 as substrate measured after 15 mins by reverse-phase HPLC analysis	B	5	pIC50	>10000	nM	IC50	J Med Chem (2017) 60: 1817-1828 [PMID:28218840]
sirtuin 1/NAD-dependent deacetylase sirtuin 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4506] [GtoPdb: 2707] [UniProtKB: Q96EB6]
ChEMBL	Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc method	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
sirtuin 2/NAD-dependent deacetylase sirtuin 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4462] [GtoPdb: 2708] [UniProtKB: Q8IXJ6]
ChEMBL	Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc method	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
ChEMBL	Inhibition of human C-terminal His-tagged SIRT2 (50 to 356 residues) expressed in Escherichia coli using Ac-peptide as substrate incubated for 4 hrs followed by trypsin addition and further incubated for 2 hrs	B	5	pIC50	>10000	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
sirtuin 3/NAD-dependent deacetylase sirtuin 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4461] [GtoPdb: 2709] [UniProtKB: Q9NTG7]
ChEMBL	Inhibition of human recombinant SIRT3 using fluoro-lysine sirtuin 2 deacetylase substrate after 45 mins by fluorimetrc method	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
sirtuin 7/NAD-dependent protein deacetylase sirtuin-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163184] [GtoPdb: 2713] [UniProtKB: Q9NRC8]
ChEMBL	Inhibition of SIRT7 (unknown origin)	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2018) 28: 2985-2992 [PMID:30122227]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against asexual blood stage chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition incubated for 72 hrs by SYBR Green I staining based fluorescence analysis	F	8.15	pIC50	7.09	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
ChEMBL	Antimalarial activity against asexual blood stage wild-type Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 72 hrs by SYBR Green I staining based fluorescence analysis	F	8.4	pIC50	4.01	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
ChEMBL	Antimalarial activity against asexual blood stage quinine-resistant Plasmodium falcipuram C2A assessed as parasite growth inhibition incubated for 72 hrs by SYBR Green I staining based fluorescence analysis	F	8.6	pIC50	2.52	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
ChEMBL	Antimalarial activity against asexual blood stage sulfadoxine-pyrimethamine/mefloquine-resistant Plasmodium falcipuram CP286 assessed as parasite growth inhibition incubated for 72 hrs by SYBR Green I staining based fluorescence analysis	F	8.69	pIC50	2.04	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
ChEMBL	Antimalarial activity against asexual blood stage chloroquine-resistant Plasmodium falcipuram GB4 assessed as parasite growth inhibition incubated for 72 hrs by SYBR Green I staining based fluorescence analysis	F	8.76	pIC50	1.75	nM	IC50	J Med Chem (2022) 65: 4156-4181 [PMID:35175762]
Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum 3D7 [GtoPdb: 3072] [UniProtKB: Q7K6A1]
GtoPdb	Parasite growth inhibition assay	-	8.28	pEC50	5.2	nM	EC50	Cell Discov (2020) 6: 93 [PMID:33311461]
Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum Dd2 [GtoPdb: 3072]
GtoPdb	Parasite growth inhibition assay	-	8.15	pEC50	7.1	nM	EC50	Cell Discov (2020) 6: 93 [PMID:33311461]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]