analog 18 [PMID: 28696697] [Ligand Id: 11567] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL4086345
  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
1 CHEMBL4086345_lig_chart_1 Plasmodium falciparum Plasmodium falciparum
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum NF54 [GtoPdb: 3088]
  • Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum Dd2 [GtoPdb: 3088]
  • This target only has 0 pki data point
  • 0
2 CHEMBL4086345_lig_chart_2 Plasmodium falciparum proteasome subunit beta type-5 Plasmodium falciparum NF54Plasmodium falciparum Dd2
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimalarial activity against stage V gametocytes of Plasmodium falciparum NF54 infected in human erythrocytes after 72 hrs by mitotracker red based bioluminescence assay F 6.89 pIC50 130 nM IC50 J Med Chem (2017) 60: 6721-6732 [PMID:28696697]
ChEMBL Potentiation of artemisinin-induced antimalarial activity against Plasmodium falciparum Dd2 assessed as artimisinin IC50 at 0.5 nM after 72 hrs by SYBR green dye based assay (Rvb = 19 +/- 0.6 nM) F 7.96 pIC50 11 nM IC50 J Med Chem (2017) 60: 6721-6732 [PMID:28696697]
ChEMBL Potentiation of artemisinin-induced antimalarial activity against Plasmodium falciparum Dd2 assessed as artimisinin IC50 at 1 nM after 72 hrs by SYBR green dye based assay (Rvb = 19 +/- 0.6 nM) F 8.12 pIC50 7.5 nM IC50 J Med Chem (2017) 60: 6721-6732 [PMID:28696697]
ChEMBL Antimalarial activity against asexual blood stage Plasmodium falciparum Dd2 infected in human erythrocytes after 72 hrs by SYBR green 1 dye based fluorescence assay F 8.49 pIC50 3.27 nM IC50 J Med Chem (2017) 60: 6721-6732 [PMID:28696697]
Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum NF54 [GtoPdb: 3088]
GtoPdb Parasite late stage (V) gametocyte assay - 6.89 pIC50 130 nM IC50 J Med Chem (2017) 60: 6721-6732 [PMID:28696697]
Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum Dd2 [GtoPdb: 3088]
GtoPdb Parasite growth inhibition assay - 8.49 pIC50 3.27 nM IC50 J Med Chem (2017) 60: 6721-6732 [PMID:28696697]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]