analog 18 [PMID: 28696697] [Ligand Id: 11567] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4086345 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against stage V gametocytes of Plasmodium falciparum NF54 infected in human erythrocytes after 72 hrs by mitotracker red based bioluminescence assay | F | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| ChEMBL | Potentiation of artemisinin-induced antimalarial activity against Plasmodium falciparum Dd2 assessed as artimisinin IC50 at 0.5 nM after 72 hrs by SYBR green dye based assay (Rvb = 19 +/- 0.6 nM) | F | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| ChEMBL | Potentiation of artemisinin-induced antimalarial activity against Plasmodium falciparum Dd2 assessed as artimisinin IC50 at 1 nM after 72 hrs by SYBR green dye based assay (Rvb = 19 +/- 0.6 nM) | F | 8.12 | pIC50 | 7.5 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| ChEMBL | Antimalarial activity against asexual blood stage Plasmodium falciparum Dd2 infected in human erythrocytes after 72 hrs by SYBR green 1 dye based fluorescence assay | F | 8.49 | pIC50 | 3.27 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum NF54 [GtoPdb: 3088] | ||||||||
| GtoPdb | Parasite late stage (V) gametocyte assay | - | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
| Plasmodium falciparum proteasome subunit beta type-5 in Plasmodium falciparum Dd2 [GtoPdb: 3088] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 8.49 | pIC50 | 3.27 | nM | IC50 | J Med Chem (2017) 60: 6721-6732 [PMID:28696697] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
