ChEMBL ligand: CHEMBL38827 (CPG-56695, Lumefantrine, GNF-PF-1971)
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856] There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG	B	5.09	pIC50	8128.31	nM	IC50	Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626]
ChEMBL	Inhibitory concentration against IKr potassium channel	B	5.09	pIC50	8100	nM	IC50	Bioorg. Med. Chem. Lett. (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL	Inhibition of human ERG by fluorescence polarization assay	B	6.42	pIC50	377	nM	IC50	J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay	F	5.77	pIC50	1689	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 and wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	6.76	pIC50	173	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	6.91	pIC50	124	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 and wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7	pIC50	99	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum 3D7 after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.02	pIC50	96	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring wild type and mutant pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.17	pIC50	67	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.2	pIC50	63	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring wild type and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.24	pIC50	57	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2mef infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by beta liquid scintillation counting method	F	7.25	pIC50	56	nM	IC50	Bioorg. Med. Chem. (2011) 19: 7519-7525 [PMID:22055713]
ChEMBL	Antimalarial activity against Plasmodium falciparum	F	7.25	pIC50	56	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay	F	7.28	pIC50	53	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum clinical isolate after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.3	pIC50	50	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.37	pIC50	43	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.37	pIC50	43	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.51	pIC50	31	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes by semiautomated micro dilution	F	7.52	pIC50	30	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 361-363 [PMID:12565929]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes	F	7.52	pIC50	30	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 543-545 [PMID:11844668]
ChEMBL	Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay	F	7.52	pIC50	30	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 2159-2161 [PMID:12798326]
ChEMBL	Anti-malarial activity against Plasmodium falciparum Dd2	F	7.52	pIC50	30	nM	IC50	Bioorg. Med. Chem. Lett. (2003) 13: 1539-1541 [PMID:12699750]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 in erythrocytes	F	7.54	pIC50	29	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 543-545 [PMID:11844668]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 after 18 hrs by [3H]hypoxanthine incorporation assay	F	7.62	pIC50	24	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum harboring K1 allele group of msp1, 3D7 allele group of msp2 gene and 94 bp of 7A11, 196bp of C4M79 and 336bp of C4M69 locus measured on day 23 by [3H]hypoxanthine incorporation assay	F	7.82	pIC50	15.2	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 2283-2284 [PMID:18411319]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically	F	7.92	pIC50	12	nM	IC50	Bioorg. Med. Chem. (2014) 22: 5757-5765 [PMID:25311562]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter	F	8.1	pIC50	8	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring V259L mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	8.19	pIC50	6.5	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by SYBR green 1-based fluorescence assay	F	8.24	pIC50	5.7	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum 3D7 harboring A82T/V259L double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	8.35	pIC50	4.5	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I/A138T double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	8.44	pIC50	3.6	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	8.44	pIC50	3.6	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay	F	8.52	pIC50	3	nM	IC50	J Med Chem (2019) 62: 3475-3502 [PMID:30852885]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D6 by ELISA	F	8.74	pIC50	1.82	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum HB3 by ELISA	F	8.85	pIC50	1.41	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimicrobial activity against Plasmodium falciparum by ELISA	F	9.29	pIC50	0.51	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA	F	9.35	pIC50	0.45	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	Antimicrobial activity against Plasmodium falciparum harboring mdr1 N86Y/D1246Y/Y184F mutant gene by ELISA	F	9.72	pIC50	0.19	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL	NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay	F	6.11	pEC50	777	nM	EC50	Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL	NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay	F	6.29	pEC50	518	nM	EC50	Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 infected in human erythrocytes	F	9.35	pEC50	0.45	nM	EC50	Bioorg. Med. Chem. Lett. (2013) 23: 2829-2843 [PMID:23587422]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically	F	7.92	pIC50	12	nM	IC50	Bioorg. Med. Chem. (2014) 22: 5757-5765 [PMID:25311562]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL	Antimicrobial activity against chloroquine-resistant Plasmodium falciparum K1 by ELISA	F	9.51	pIC50	0.31	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013]
ChEMBL	Antimicrobial activity against Plasmodium vivax at the ring stage measured after 30 hrs by microscopy	F	7.42	pIC50	37.6	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimicrobial activity against Plasmodium vivax trophozoites measured after 30 hrs by microscopy	F	7.48	pIC50	32.9	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimicrobial activity against Plasmodium vivax at the ring stage measured within 30 hrs by microscopy	F	7.61	pIC50	24.8	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium vivax by Giemsa staining	F	7.8	pIC50	16	nM	IC50	Antimicrob. Agents Chemother. (2009) 53: 1094-1099 [PMID:19104023]
ChEMBL	Antimicrobial activity against Plasmodium vivax trophozoites measured within 30 hrs by microscopy	F	7.84	pIC50	14.6	nM	IC50	Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]