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ChEMBL ligand: CHEMBL38827 (CPG-56695, Lumefantrine, GNF-PF-1971) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG | B | 5.09 | pIC50 | 8128.31 | nM | IC50 | Eur. J. Med. Chem. (2011) 46: 618-630 [PMID:21185626] |
ChEMBL | Inhibitory concentration against IKr potassium channel | B | 5.09 | pIC50 | 8100 | nM | IC50 | Bioorg. Med. Chem. Lett. (2004) 14: 4771-4777 [PMID:15324906] |
ChEMBL | Inhibition of human ERG by fluorescence polarization assay | B | 6.42 | pIC50 | 377 | nM | IC50 | J Med Chem (2017) 60: 6036-6044 [PMID:28653845] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay | F | 5.77 | pIC50 | 1689 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 3131-3134 [PMID:19364853] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 and wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay | F | 6.76 | pIC50 | 173 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay | F | 6.91 | pIC50 | 124 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 and wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7 | pIC50 | 99 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum 3D7 after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7.02 | pIC50 | 96 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring wild type and mutant pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7.17 | pIC50 | 67 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7.2 | pIC50 | 63 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring wild type and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7.24 | pIC50 | 57 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2mef infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by beta liquid scintillation counting method | F | 7.25 | pIC50 | 56 | nM | IC50 | Bioorg. Med. Chem. (2011) 19: 7519-7525 [PMID:22055713] |
ChEMBL | Antimalarial activity against Plasmodium falciparum | F | 7.25 | pIC50 | 56 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285] |
ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay | F | 7.28 | pIC50 | 53 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 3131-3134 [PMID:19364853] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum clinical isolate after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7.3 | pIC50 | 50 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7.37 | pIC50 | 43 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7.37 | pIC50 | 43 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7.51 | pIC50 | 31 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes by semiautomated micro dilution | F | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg. Med. Chem. Lett. (2003) 13: 361-363 [PMID:12565929] |
ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes | F | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg. Med. Chem. Lett. (2002) 12: 543-545 [PMID:11844668] |
ChEMBL | Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay | F | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg. Med. Chem. Lett. (2003) 13: 2159-2161 [PMID:12798326] |
ChEMBL | Anti-malarial activity against Plasmodium falciparum Dd2 | F | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg. Med. Chem. Lett. (2003) 13: 1539-1541 [PMID:12699750] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 in erythrocytes | F | 7.54 | pIC50 | 29 | nM | IC50 | Bioorg. Med. Chem. Lett. (2002) 12: 543-545 [PMID:11844668] |
ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 after 18 hrs by [3H]hypoxanthine incorporation assay | F | 7.62 | pIC50 | 24 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum harboring K1 allele group of msp1, 3D7 allele group of msp2 gene and 94 bp of 7A11, 196bp of C4M79 and 336bp of C4M69 locus measured on day 23 by [3H]hypoxanthine incorporation assay | F | 7.82 | pIC50 | 15.2 | nM | IC50 | Antimicrob. Agents Chemother. (2008) 52: 2283-2284 [PMID:18411319] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically | F | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg. Med. Chem. (2014) 22: 5757-5765 [PMID:25311562] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 8.1 | pIC50 | 8 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369] |
ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring V259L mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay | F | 8.19 | pIC50 | 6.5 | nM | IC50 | J Med Chem (2019) 62: 3475-3502 [PMID:30852885] |
ChEMBL | Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by SYBR green 1-based fluorescence assay | F | 8.24 | pIC50 | 5.7 | nM | IC50 | J Med Chem (2019) 62: 3475-3502 [PMID:30852885] |
ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum 3D7 harboring A82T/V259L double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay | F | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (2019) 62: 3475-3502 [PMID:30852885] |
ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I/A138T double mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay | F | 8.44 | pIC50 | 3.6 | nM | IC50 | J Med Chem (2019) 62: 3475-3502 [PMID:30852885] |
ChEMBL | Antimalarial activity against drug-resistant Plasmodium falciparum Dd2 harboring M133I mutant infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay | F | 8.44 | pIC50 | 3.6 | nM | IC50 | J Med Chem (2019) 62: 3475-3502 [PMID:30852885] |
ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorescence assay | F | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2019) 62: 3475-3502 [PMID:30852885] |
ChEMBL | Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D6 by ELISA | F | 8.74 | pIC50 | 1.82 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051] |
ChEMBL | Antimicrobial activity against chloroquine-resistant Plasmodium falciparum HB3 by ELISA | F | 8.85 | pIC50 | 1.41 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051] |
ChEMBL | Antimicrobial activity against Plasmodium falciparum by ELISA | F | 9.29 | pIC50 | 0.51 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051] |
ChEMBL | Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA | F | 9.35 | pIC50 | 0.45 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051] |
ChEMBL | Antimicrobial activity against Plasmodium falciparum harboring mdr1 N86Y/D1246Y/Y184F mutant gene by ELISA | F | 9.72 | pIC50 | 0.19 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051] |
ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | F | 6.11 | pEC50 | 777 | nM | EC50 | Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783] |
ChEMBL | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | F | 6.29 | pEC50 | 518 | nM | EC50 | Proc. Natl. Acad. Sci. U.S.A. (2008) 105: 9059-9064 [PMID:18579783] |
ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 infected in human erythrocytes | F | 9.35 | pEC50 | 0.45 | nM | EC50 | Bioorg. Med. Chem. Lett. (2013) 23: 2829-2843 [PMID:23587422] |
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically | F | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg. Med. Chem. (2014) 22: 5757-5765 [PMID:25311562] |
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
ChEMBL | Antimicrobial activity against chloroquine-resistant Plasmodium falciparum K1 by ELISA | F | 9.51 | pIC50 | 0.31 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051] |
Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013] | ||||||||
ChEMBL | Antimicrobial activity against Plasmodium vivax at the ring stage measured after 30 hrs by microscopy | F | 7.42 | pIC50 | 37.6 | nM | IC50 | Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357] |
ChEMBL | Antimicrobial activity against Plasmodium vivax trophozoites measured after 30 hrs by microscopy | F | 7.48 | pIC50 | 32.9 | nM | IC50 | Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357] |
ChEMBL | Antimicrobial activity against Plasmodium vivax at the ring stage measured within 30 hrs by microscopy | F | 7.61 | pIC50 | 24.8 | nM | IC50 | Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357] |
ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium vivax by Giemsa staining | F | 7.8 | pIC50 | 16 | nM | IC50 | Antimicrob. Agents Chemother. (2009) 53: 1094-1099 [PMID:19104023] |
ChEMBL | Antimicrobial activity against Plasmodium vivax trophozoites measured within 30 hrs by microscopy | F | 7.84 | pIC50 | 14.6 | nM | IC50 | Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]