lumefantrine [Ligand Id: 9969] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL38827 (CPG-56695, Lumefantrine, GNF-PF-1971)
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  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibitory concentration against IKr potassium channel B 5.09 pIC50 8100 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 4771-4777 [PMID:15324906]
ChEMBL Inhibition of human ERG by fluorescence polarization assay B 6.42 pIC50 377 nM IC50 J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay F 5.77 pIC50 1689 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 and wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 6.76 pIC50 173 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 6.91 pIC50 124 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 and wild type pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 7 pIC50 99 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum 3D7 after 18 hrs by [3H]hypoxanthine incorporation assay F 7.02 pIC50 96 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring wild type and mutant pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 7.17 pIC50 67 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring wild type pfcrt-76 and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 7.2 pIC50 63 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring wild type and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 7.24 pIC50 57 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2mef infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by beta liquid scintillation counting method F 7.25 pIC50 56 nM IC50 Bioorg. Med. Chem. (2011) 19: 7519-7525 [PMID:22055713]
ChEMBL Antimalarial activity against Plasmodium falciparum F 7.25 pIC50 56 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3302-3307 [PMID:20516285]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 by [3H]hypoxanthine incorporation assay F 7.28 pIC50 53 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 3131-3134 [PMID:19364853]
ChEMBL Antiplasmodial activity against Plasmodium falciparum clinical isolate after 18 hrs by [3H]hypoxanthine incorporation assay F 7.3 pIC50 50 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 7.37 pIC50 43 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 7.37 pIC50 43 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring mutant pfcrt-76 and mutant pfmdr-1-86 gene after 18 hrs by [3H]hypoxanthine incorporation assay F 7.51 pIC50 31 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Inhibitory activity against Plasmodium falciparum Dd2 in erythrocytes by semiautomated micro dilution F 7.52 pIC50 30 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 361-363 [PMID:12565929]
ChEMBL Antimalarial activity against Plasmodium falciparum Dd2 in erythrocytes F 7.52 pIC50 30 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 543-545 [PMID:11844668]
ChEMBL Inhibition against Plasmodium falciparum Dd2 in erythrocytes in semiautomated micro dilution assay F 7.52 pIC50 30 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2159-2161 [PMID:12798326]
ChEMBL Anti-malarial activity against Plasmodium falciparum Dd2 F 7.52 pIC50 30 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 1539-1541 [PMID:12699750]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 in erythrocytes F 7.54 pIC50 29 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 543-545 [PMID:11844668]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum VS/1 after 18 hrs by [3H]hypoxanthine incorporation assay F 7.62 pIC50 24 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 5069-5073 [PMID:19770282]
ChEMBL Antiplasmodial activity against Plasmodium falciparum harboring K1 allele group of msp1, 3D7 allele group of msp2 gene and 94 bp of 7A11, 196bp of C4M79 and 336bp of C4M69 locus measured on day 23 by [3H]hypoxanthine incorporation assay F 7.82 pIC50 15.2 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 2283-2284 [PMID:18411319]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically F 7.92 pIC50 12 nM IC50 Bioorg. Med. Chem. (2014) 22: 5757-5765 [PMID:25311562]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 8.1 pIC50 8 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum D6 by ELISA F 8.74 pIC50 1.82 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimicrobial activity against chloroquine-resistant Plasmodium falciparum HB3 by ELISA F 8.85 pIC50 1.41 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimicrobial activity against Plasmodium falciparum by ELISA F 9.29 pIC50 0.51 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum W2 by ELISA F 9.35 pIC50 0.45 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antimicrobial activity against Plasmodium falciparum harboring mdr1 N86Y/D1246Y/Y184F mutant gene by ELISA F 9.72 pIC50 0.19 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum W2 infected in human erythrocytes F 9.35 pEC50 0.45 nM EC50 Bioorg. Med. Chem. Lett. (2013) 23: 2829-2843 [PMID:23587422]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically F 7.92 pIC50 12 nM IC50 Bioorg. Med. Chem. (2014) 22: 5757-5765 [PMID:25311562]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antimicrobial activity against chloroquine-resistant Plasmodium falciparum K1 by ELISA F 9.51 pIC50 0.31 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 1200-1206 [PMID:20065051]
Plasmodium vivax (target type: ORGANISM) [ChEMBL: CHEMBL613013]
ChEMBL Antimicrobial activity against Plasmodium vivax at the ring stage measured after 30 hrs by microscopy F 7.42 pIC50 37.6 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL Antimicrobial activity against Plasmodium vivax trophozoites measured after 30 hrs by microscopy F 7.48 pIC50 32.9 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL Antimicrobial activity against Plasmodium vivax at the ring stage measured within 30 hrs by microscopy F 7.61 pIC50 24.8 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium vivax by Giemsa staining F 7.8 pIC50 16 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 1094-1099 [PMID:19104023]
ChEMBL Antimicrobial activity against Plasmodium vivax trophozoites measured within 30 hrs by microscopy F 7.84 pIC50 14.6 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 1040-1045 [PMID:18180357]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]