doxycycline [Ligand Id: 6464] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1433 (Anhydrous doxycycline, Doxycycline (anhydrous)) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of human MMP13 | B | 4.4 | pIC50 | 40000 | nM | IC50 | Bioorg Med Chem (2007) 15: 2368-2374 [PMID:17267227] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of human MMP2 | B | 4.62 | pIC50 | 24000 | nM | IC50 | Bioorg Med Chem (2007) 15: 2368-2374 [PMID:17267227] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of human MMP3 | B | 4.6 | pIC50 | 25000 | nM | IC50 | Bioorg Med Chem (2007) 15: 2368-2374 [PMID:17267227] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Inhibition of human MMP8 | B | 4.51 | pIC50 | 31000 | nM | IC50 | Bioorg Med Chem (2007) 15: 2368-2374 [PMID:17267227] |
| GtoPdb | - | - | 4.6 | pIC50 | 26000 | nM | IC50 | Chest (1995) 107: 1641-7 [PMID:7781360] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium falciparum | F | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.83 | pIC50 | 14900 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.83 | pIC50 | 14900 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.86 | pIC50 | 13700 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.87 | pIC50 | 13400 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.88 | pIC50 | 13300 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.88 | pIC50 | 13300 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.88 | pIC50 | 13300 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.88 | pIC50 | 13200 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.89 | pIC50 | 12900 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.89 | pIC50 | 12900 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 106/1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.89 | pIC50 | 12800 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.92 | pIC50 | 12100 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.94 | pIC50 | 11600 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.94 | pIC50 | 11500 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.96 | pIC50 | 11060 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.96 | pIC50 | 10900 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.97 | pIC50 | 10800 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 4.97 | pIC50 | 10700 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.97 | pIC50 | 10600 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.97 | pIC50 | 10600 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 4.99 | pIC50 | 10200 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.01 | pIC50 | 9700 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 31 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.01 | pIC50 | 9700 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.04 | pIC50 | 9200 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.04 | pIC50 | 9100 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 5.04 | pIC50 | 9100 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antiplasmodial activity against chloroquinone-resistant Plasmodium falciparum W2 | F | 5.05 | pIC50 | 9000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 396-401 [PMID:17981462] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.06 | pIC50 | 8700 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | F | 5.08 | pIC50 | 8400 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 2248-2252 [PMID:19307369] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.08 | pIC50 | 8400 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against chloroquine, pyrimethamine, proguanil-resistant Plasmodium falciparum infected in human erythrocytes after 48 hrs by flow cytometry | F | 5.19 | pIC50 | 6500 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5962-5964 [PMID:19748781] |
| ChEMBL | Antimalarial activity as reduced parasitaemia after 48 hrs against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in type A+ human erythrocytes by flow cytometry | F | 5.19 | pIC50 | 6500 | nM | IC50 | Bioorg Med Chem (2009) 17: 4313-4322 [PMID:19482476] |
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocyte after 48 hrs by flow cytometry | F | 5.19 | pIC50 | 6500 | nM | IC50 | Eur J Med Chem (2010) 45: 616-622 [PMID:19926173] |
| ChEMBL | Antiplasmodial activity after 48 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | F | 5.27 | pIC50 | 5420 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275] |
| ChEMBL | Antimalarial activity as 2nd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by flow cytometry | F | 5.27 | pIC50 | 5320 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity against multi-resistant Plasmodium falciparum infected in human erythrocytes assessed as inhibition of [G-3H]hypoxanthine uptake incubated for 42 hrs by liquid scintillation counting method | F | 5.29 | pIC50 | 5100 | nM | IC50 | Eur J Med Chem (2020) 188: 111983-111983 [PMID:31911292] |
| ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in human A positive erythrocytes after 72 hrs by SYBR Green I assay | F | 5.32 | pIC50 | 4800 | nM | IC50 | Eur J Med Chem (2011) 46: 4184-4191 [PMID:21741131] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum IMT 10354 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter | F | 5.34 | pIC50 | 4600 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3537-3544 [PMID:20547801] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum isolates assessed as parasite growth inhibition after 72 hrs by ELISA based histidine-rich protein 2 in vitro drug susceptibility assay | F | 5.37 | pIC50 | 4276.01 | nM | IC50 | Antimicrob Agents Chemother (2009) 53: 4040-4042 [PMID:19596882] |
| ChEMBL | Antimalarial activity as 2nd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry | F | 5.48 | pIC50 | 3300 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay | F | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antiplasmodial activity after 72 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | F | 5.83 | pIC50 | 1490 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275] |
| ChEMBL | Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake | F | 5.84 | pIC50 | 1444.1 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay | F | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2009) 52: 7954-7957 [PMID:19908867] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum clinical isolate after 6 days by HRP2 enzyme-linked immunosorbent assay | F | 6.14 | pIC50 | 720 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 540-542 [PMID:19841147] |
| ChEMBL | Antiplasmodial activity after 96 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | F | 6.14 | pIC50 | 720 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275] |
| ChEMBL | Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake | F | 6.22 | pIC50 | 603.1 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
| ChEMBL | Antimalarial activity as 3rd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs dose then 48 hrs drug-free | F | 6.34 | pIC50 | 453 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake | F | 6.36 | pIC50 | 432.2 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
| ChEMBL | Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake | F | 6.52 | pIC50 | 302.5 | nM | IC50 | J Biol Chem (2007) 282: 2494-2504 [PMID:17110371] |
| ChEMBL | Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free | F | 6.68 | pIC50 | 211 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630] |
| ChEMBL | Antiplasmodial activity after 120 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity | F | 6.92 | pIC50 | 120 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275] |
| ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green I fluorescence based assay | F | 5.22 | pEC50 | 6000 | nM | EC50 | Eur J Med Chem (2021) 224: 113722-113722 [PMID:34364164] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-, pyrimethamine- and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by SYBR Green I fluorescence-based method | F | 5.22 | pIC50 | 6000 | nM | IC50 | Eur J Med Chem (2014) 83: 26-35 [PMID:24946216] |
| ChEMBL | Antiplasmodial activity against chloroquine/purimethamine/proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as reduction in parasitaemia measured after 72 hrs by SYBR Green I fluorescence-based assay | F | 5.22 | pIC50 | 6000 | nM | IC50 | Eur J Med Chem (2016) 119: 34-44 [PMID:27155463] |
| ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine, and proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes after 72 hrs by SYBR Green-I fluorescence-based method | F | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6003-6006 [PMID:21852132] |
| ChEMBL | Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 ring stage after 72 hrs by SYBP Green fluorescence-based assay | F | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2012) 55: 315-324 [PMID:22889559] |
| ChEMBL | Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in Parasitemia incubated for 72 hrs by SYBR Green I fluorescence-based method | F | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2014) 87: 440-453 [PMID:25282267] |
| ChEMBL | Antiplasmodial activity against multi-drug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay | F | 5.3 | pIC50 | 5000 | nM | IC50 | Eur J Med Chem (2015) 95: 16-28 [PMID:25791675] |
| MMP7 in Human [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| GtoPdb | - | - | 4.14 | pKd | 73000 | nM | Kd | Mol Pharmacol (2005) 67: 1128-36 [PMID:15665254] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
