doxycycline [Ligand Id: 6464] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1433 (Doxycycline, GS-3065)
  • MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
There should be some charts here, you may need to enable JavaScript!
  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
There should be some charts here, you may need to enable JavaScript!
  • MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 [ChEMBL: CHEMBL612856]
There should be some charts here, you may need to enable JavaScript!
  • MMP7 in Human [GtoPdb: 1631] [UniProtKB: P09237]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL Inhibition of human MMP13 B 4.4 pIC50 40000 nM IC50 Bioorg. Med. Chem. (2007) 15: 2368-2374 [PMID:17267227]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibition of human MMP2 B 4.62 pIC50 24000 nM IC50 Bioorg. Med. Chem. (2007) 15: 2368-2374 [PMID:17267227]
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL Inhibition of human MMP3 B 4.6 pIC50 25000 nM IC50 Bioorg. Med. Chem. (2007) 15: 2368-2374 [PMID:17267227]
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL Inhibition of human MMP8 B 4.51 pIC50 31000 nM IC50 Bioorg. Med. Chem. (2007) 15: 2368-2374 [PMID:17267227]
GtoPdb - - 4.6 pIC50 26000 nM IC50 Chest (1995) 107: 1641-7 [PMID:7781360]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antimicrobial activity against Plasmodium falciparum F 4.74 pIC50 18000 nM IC50 Bioorg. Med. Chem. (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.83 pIC50 14900 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 4.83 pIC50 14900 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.86 pIC50 13700 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.87 pIC50 13400 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Bres assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.88 pIC50 13300 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 4.88 pIC50 13300 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.88 pIC50 13300 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.88 pIC50 13200 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum PA infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 4.89 pIC50 12900 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum PA assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.89 pIC50 12900 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum 106/1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.89 pIC50 12800 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum HB3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.92 pIC50 12100 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 4.92 pIC50 12000 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum FCM29 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.94 pIC50 11600 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K14 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.94 pIC50 11500 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCM29 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 4.96 pIC50 11060 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.96 pIC50 10900 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.97 pIC50 10800 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 4.97 pIC50 10700 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.97 pIC50 10600 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Guy assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.97 pIC50 10600 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 4.99 pIC50 10200 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR3 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 5.01 pIC50 9700 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 31 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 5.01 pIC50 9700 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT A4 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 5.04 pIC50 9200 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 5.04 pIC50 9100 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Vol assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 5.04 pIC50 9100 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antiplasmodial activity against chloroquinone-resistant Plasmodium falciparum W2 F 5.05 pIC50 9000 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 396-401 [PMID:17981462]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 5.06 pIC50 8700 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum FCM29 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum FCR3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum PA assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum HB3 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum 106/1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Bres assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Guy assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT A4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 31 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 8425 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 9881 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10336 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10500 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K14 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT K4 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT L1 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT Vol assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT L1 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 16332 assessed as incorporation of [3H]hypoxanthine after 48 hrs by scintillation counter F 5.08 pIC50 8400 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 2248-2252 [PMID:19307369]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTL1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay F 5.08 pIC50 8400 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocyte after 48 hrs by flow cytometry F 5.19 pIC50 6500 nM IC50 Eur. J. Med. Chem. (2010) 45: 616-622 [PMID:19926173]
ChEMBL Antimalarial activity as reduced parasitaemia after 48 hrs against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in type A+ human erythrocytes by flow cytometry F 5.19 pIC50 6500 nM IC50 Bioorg. Med. Chem. (2009) 17: 4313-4322 [PMID:19482476]
ChEMBL Antimalarial activity against chloroquine, pyrimethamine, proguanil-resistant Plasmodium falciparum infected in human erythrocytes after 48 hrs by flow cytometry F 5.19 pIC50 6500 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 5962-5964 [PMID:19748781]
ChEMBL Antiplasmodial activity after 48 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity F 5.27 pIC50 5420 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 774-777 [PMID:18056275]
ChEMBL Antimalarial activity as 2nd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by flow cytometry F 5.27 pIC50 5320 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum W2 infected in human A positive erythrocytes after 72 hrs by SYBR Green I assay F 5.32 pIC50 4800 nM IC50 Eur. J. Med. Chem. (2011) 46: 4184-4191 [PMID:21741131]
ChEMBL Antimalarial activity against Plasmodium falciparum IMT 10354 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter F 5.34 pIC50 4600 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3537-3544 [PMID:20547801]
ChEMBL Antimalarial activity against Plasmodium falciparum isolates assessed as parasite growth inhibition after 72 hrs by ELISA based histidine-rich protein 2 in vitro drug susceptibility assay F 5.37 pIC50 4276.01 nM IC50 Antimicrob. Agents Chemother. (2009) 53: 4040-4042 [PMID:19596882]
ChEMBL Antimalarial activity as 2nd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry F 5.48 pIC50 3300 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay F 5.77 pIC50 1700 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antiplasmodial activity after 72 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity F 5.83 pIC50 1490 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 774-777 [PMID:18056275]
ChEMBL Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake F 5.84 pIC50 1444.1 nM IC50 J. Biol. Chem. (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay F 5.92 pIC50 1200 nM IC50 J. Med. Chem. (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL Antimalarial activity against Plasmodium falciparum clinical isolate after 6 days by HRP2 enzyme-linked immunosorbent assay F 6.14 pIC50 720 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 540-542 [PMID:19841147]
ChEMBL Antiplasmodial activity after 96 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity F 6.14 pIC50 720 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 774-777 [PMID:18056275]
ChEMBL Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake F 6.22 pIC50 603.1 nM IC50 J. Biol. Chem. (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity as 3rd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs dose then 48 hrs drug-free F 6.34 pIC50 453 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake F 6.36 pIC50 432.2 nM IC50 J. Biol. Chem. (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake F 6.52 pIC50 302.5 nM IC50 J. Biol. Chem. (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free F 6.68 pIC50 211 nM IC50 Antimicrob. Agents Chemother. (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL Antiplasmodial activity after 120 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity F 6.92 pIC50 120 nM IC50 Antimicrob. Agents Chemother. (2008) 52: 774-777 [PMID:18056275]
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856]
ChEMBL Antiplasmodial activity against chloroquine-, pyrimethamine- and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by SYBR Green I fluorescence-based method F 5.22 pIC50 6000 nM IC50 Eur. J. Med. Chem. (2014) 83: 26-35 [PMID:24946216]
ChEMBL Antiplasmodial activity against chloroquine/purimethamine/proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as reduction in parasitaemia measured after 72 hrs by SYBR Green I fluorescence-based assay F 5.22 pIC50 6000 nM IC50 Eur. J. Med. Chem. (2016) 119: 34-44 [PMID:27155463]
ChEMBL Antiplasmodial activity against chloroquine, pyrimethamine, and proguanil-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes after 72 hrs by SYBR Green-I fluorescence-based method F 5.3 pIC50 5000 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6003-6006 [PMID:21852132]
ChEMBL Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 ring stage after 72 hrs by SYBP Green fluorescence-based assay F 5.3 pIC50 5000 nM IC50 Eur. J. Med. Chem. (2012) 55: 315-324 [PMID:22889559]
ChEMBL Antiplasmodial activity against chloroquine, pyrimethamine and proguanil-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in Parasitemia incubated for 72 hrs by SYBR Green I fluorescence-based method F 5.3 pIC50 5000 nM IC50 Eur. J. Med. Chem. (2014) 87: 440-453 [PMID:25282267]
ChEMBL Antiplasmodial activity against multi-drug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay F 5.3 pIC50 5000 nM IC50 Eur. J. Med. Chem. (2015) 95: 16-28 [PMID:25791675]
MMP7 in Human [GtoPdb: 1631] [UniProtKB: P09237]
GtoPdb - - 4.14 pKd 73000 nM Kd Mol. Pharmacol. (2005) 67: 1128-36 [PMID:15665254]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]