doxycycline [Ligand Id: 6464] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1433 (Anhydrous doxycycline, Doxycycline (anhydrous)) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum K1 infected in erythrocytes assessed as reduction in parasite DNA after 72 hrs by SYBR Green I fluorescence based assay | F | 5.3 | pEC50 | 5000 | nM | EC50 | Bioorg Med Chem (2024) 102: 117654-117654 [PMID:38452406] |
| ChEMBL | Antiplasmodial activity against erythrocytic stage of chloroquine, pyrimethamine and sulfadoxine resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green I fluorescence based spectrophotometric analysis | F | 5.3 | pEC50 | 5000 | nM | EC50 | Eur J Med Chem (2023) 261: 115873-115873 [PMID:37857143] |
| MMP7 in Human [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| GtoPdb | - | - | 4.14 | pKd | 73000 | nM | Kd | Mol Pharmacol (2005) 67: 1128-36 [PMID:15665254] |
| MMP8 in Human [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| GtoPdb | - | - | 4.6 | pIC50 | 26000 | nM | IC50 | Chest (1995) 107: 1641-7 [PMID:7781360] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
