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ChEMBL ligand: CHEMBL4570969 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831] | ||||||||
ChEMBL | Binding affinity to human PCAF bromodomain by isothermal titration calorimetry | B | 6.9 | pKd | 126 | nM | Kd | J Med Chem (2019) 62: 4526-4542 [PMID:30998845] |
ChEMBL | Inhibition of biotinylated peptide binding to human GST-tagged PCAF bromodomain expressed in Escherichia coli Rosetta (DE3) measured after 15 hrs by HTRF assay | B | 7.44 | pIC50 | 36 | nM | IC50 | J Med Chem (2019) 62: 4526-4542 [PMID:30998845] |
Plasmodium falciparum histone acetyltransferase GCN5 in Plasmodium falciparum [GtoPdb: 3191] | ||||||||
GtoPdb | Isothermal titration calorimetry. | - | 6.55 | pKd | 280 | nM | Kd | Angew Chem Int Ed Engl (2017) 56: 827-831 [PMID:27966810] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]