- Guide to PHARMACOLOGY
Compound class: Natural product or derivative
Comment: Artemisinin is a sesquiterpene lactone with an unusual endoperoxide bridge, believed to be responsible for the antimalarial activity of the compound. It is a natural product, isolated from the qinghao or sweet wormwood plant (Artemisia annua) and used in Chinese traditional medicine to treat fever.
Artemisinin is a prodrug that is converted to the active metabolite artenimol (dihydroartemisinin).
We show one representation of artemisinin here. As with other natural products, there are alternative chemical structures due to the complex stereochemistry.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Natural product or derivative|
|Ligand families/groups||Antimalarial ligands|
|International Nonproprietary Names|
|CAS Registry No.||63968-64-9 (source: Scifinder)|
|GtoPdb PubChem SID||374883841|
|Search Google for chemical match using the InChIKey||BLUAFEHZUWYNDE-NNWCWBAJSA-N|
|Search Google for chemicals with the same backbone||BLUAFEHZUWYNDE|
|Search PubMed clinical trials||artemisinin|
|Search PubMed titles||artemisinin|
|Search PubMed titles/abstracts||artemisinin|
|Search UniChem for chemical match using the InChIKey||BLUAFEHZUWYNDE-NNWCWBAJSA-N|
|Search UniChem for chemicals with the same backbone||BLUAFEHZUWYNDE|
Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.
Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.✖
Cat. No. 2668