tofacitinib [Ligand Id: 5677] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL221959 (550, CP-690, CP 690550, CP- 690 550, CP-690,550, CP-690-550, CP-690550, CP690,550, CP690550, CP-690,550 FREE BASE, CP-690550 FREE BASE, Cp-690 free base, Tofacitinib)
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  • 3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530]
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  • activin A receptor type 1/Activin receptor type-1 in Human [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
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  • activin A receptor type 1B/Activin receptor type-1B in Human [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896]
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  • activin A receptor type 2A/Activin receptor type-2A in Human [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037]
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  • activin A receptor type 2B/Activin receptor type-2B in Human [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705]
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  • AP2 associated kinase 1/Adaptor-associated kinase in Human [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8]
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  • Mitochondrial adenine nucleotide translocator 2/ADP/ATP translocase 2 in Human [ChEMBL: CHEMBL3709670] [GtoPdb: 1063] [UniProtKB: P05141]
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  • Mitochondrial adenine nucleotide translocator 3/ADP/ATP translocase 3 in Human [ChEMBL: CHEMBL4105854] [GtoPdb: 1064] [UniProtKB: P12236]
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  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
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  • protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Human [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131]
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  • protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646]
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  • protein kinase AMP-activated non-catalytic subunit gamma 1/AMP-activated protein kinase, gamma-1 subunit in Human [ChEMBL: CHEMBL2393] [GtoPdb: 1545] [UniProtKB: P54619]
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  • protein kinase AMP-activated non-catalytic subunit gamma 2/AMP-activated protein kinase, gamma-2 subunit in Human [ChEMBL: CHEMBL2453] [GtoPdb: 1546] [UniProtKB: Q9UGJ0]
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  • ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2]
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  • ATP-dependent RNA helicase DDX3X in Human [ChEMBL: CHEMBL5553] [UniProtKB: O00571]
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  • BMP2 inducible kinase/BMP-2-inducible protein kinase in Human [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1]
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  • bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
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  • bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238]
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  • bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873]
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  • Brain glycogen phosphorylase in Human [ChEMBL: CHEMBL3856] [UniProtKB: P11216]
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  • BCR activator of RhoGEF and GTPase/Breakpoint cluster region protein in Human [ChEMBL: CHEMBL5146] [GtoPdb: 2755] [UniProtKB: P11274]
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  • BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
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  • BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
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  • Calcium-dependent protein kinase 1 in Plasmodium falciparum [ChEMBL: CHEMBL1908387] [UniProtKB: P62344]
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  • calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
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  • calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
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  • calcium/calmodulin dependent protein kinase IG/CaM kinase I gamma in Human [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5]
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  • calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7]
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  • calcium/calmodulin-dependent protein kinase II beta subunit/CaM kinase II beta in Human [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554]
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  • calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557]
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  • calcium/calmodulin-dependent protein kinase II gamma subunit/CaM kinase II gamma in Human [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555]
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  • calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
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  • calcium/calmodulin dependent protein kinase kinase 1/CaM-kinase kinase alpha in Human [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9]
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  • calcium/calmodulin dependent protein kinase kinase 2/CaM-kinase kinase beta in Human [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4]
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  • protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
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  • protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694]
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  • protein kinase, cAMP-dependent, catalytic, gamma subunit/cAMP-dependent protein kinase, gamma catalytic subunit in Human [ChEMBL: CHEMBL2743] [GtoPdb: 1478] [UniProtKB: P22612]
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  • casein kinase 1 alpha 1/Casein kinase I alpha in Human [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
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  • casein kinase 1 delta/Casein kinase I delta in Human [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
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  • casein kinase 1 epsilon/Casein kinase I epsilon in Human [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674]
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  • casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
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  • casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368]
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  • casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
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  • casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784]
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  • casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752]
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  • casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4]
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  • Cell division control protein 2 homolog in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL1908388] [UniProtKB: P61075]
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  • cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1]
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  • cyclin dependent kinase 8/Cell division protein kinase 8 in Human [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336]
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  • Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
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  • Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
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  • coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60]
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  • Chromodomain-helicase-DNA-binding protein 4 in Human [ChEMBL: CHEMBL4105742] [UniProtKB: Q14839]
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  • citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578]
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  • mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
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  • mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
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  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
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  • cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
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  • cyclin dependent kinase 12/Cyclin-dependent kinase 12 in Human [ChEMBL: CHEMBL3559692] [GtoPdb: 1965] [UniProtKB: Q9NYV4]
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  • cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004]
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526]
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  • cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
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  • cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534]
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  • cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613]
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  • cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
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  • cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532]
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  • cyclin dependent kinase like 2/Cyclin-dependent kinase-like 2 in Human [ChEMBL: CHEMBL5728] [GtoPdb: 1983] [UniProtKB: Q92772]
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  • cyclin-dependent kinase like 3/Cyclin-dependent kinase-like 3 in Human [ChEMBL: CHEMBL1163117] [GtoPdb: 1984] [UniProtKB: Q8IVW4]
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  • cyclin-dependent kinase like 5/Cyclin-dependent kinase-like 5 in Human [ChEMBL: CHEMBL1163112] [GtoPdb: 1986] [UniProtKB: O76039]
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  • Cytochrome c1, heme protein, mitochondrial in Human [ChEMBL: CHEMBL4105975] [UniProtKB: P08574]
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  • death associated protein kinase 1/Death-associated protein kinase 1 in Human [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355]
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  • death associated protein kinase 2/Death-associated protein kinase 2 in Human [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
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  • death associated protein kinase 3/Death-associated protein kinase 3 in Human [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
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  • discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
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  • dual serine/threonine and tyrosine protein kinase/Dual serine/threonine and tyrosine protein kinase in Human [ChEMBL: CHEMBL1908386] [GtoPdb: 2008] [UniProtKB: Q6XUX3]
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  • mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
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  • mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
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  • mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734]
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  • mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
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  • mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163]
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  • mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
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  • mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
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  • CDC like kinase 1/Dual specificity protein kinase CLK1 in Human [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
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  • CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
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  • CDC like kinase 3/Dual specificity protein kinase CLK3 in Human [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
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  • CDC like kinase 4/Dual specificity protein kinase CLK4 in Human [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
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  • TTK protein kinase/Dual specificity protein kinase TTK in Human [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
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  • testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
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  • testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
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  • dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
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  • dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
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  • Dynamin-like 120 kDa protein, mitochondrial in Human [ChEMBL: CHEMBL4105705] [UniProtKB: O60313]
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  • EPH receptor A1/Ephrin type-A receptor 1 in Human [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709]
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  • EPH receptor A2/Ephrin type-A receptor 2 in Human [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
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  • EPH receptor A3/Ephrin type-A receptor 3 in Human [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320]
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  • EPH receptor A4/Ephrin type-A receptor 4 in Human [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764]
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  • EPH receptor A5/Ephrin type-A receptor 5 in Human [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756]
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  • EPH receptor A6/Ephrin type-A receptor 6 in Human [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33]
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  • EPH receptor A7/Ephrin type-A receptor 7 in Human [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375]
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  • EPH receptor A8/Ephrin type-A receptor 8 in Human [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322]
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  • EPH receptor B1/Ephrin type-B receptor 1 in Human [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
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  • EPH receptor B2/Ephrin type-B receptor 2 in Human [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
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  • EPH receptor B3/Ephrin type-B receptor 3 in Human [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753]
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  • EPH receptor B4/Ephrin type-B receptor 4 in Human [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760]
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  • EPH receptor B6/Ephrin type-B receptor 6 in Human [ChEMBL: CHEMBL5836] [GtoPdb: 1834] [UniProtKB: O15197]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
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  • eukaryotic translation initiation factor 2 alpha kinase 1/Eukaryotic translation initiation factor 2-alpha kinase 1 in Human [ChEMBL: CHEMBL6029] [GtoPdb: 2015] [UniProtKB: Q9BQI3]
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  • eukaryotic translation initiation factor 2 alpha kinase 4/Eukaryotic translation initiation factor 2-alpha kinase 4 in Human [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8]
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  • fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
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  • fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
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  • fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
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  • fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
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  • protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
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  • General transcription and DNA repair factor IIH helicase subunit XPD in Human [ChEMBL: CHEMBL4105743] [UniProtKB: P18074]
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  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098]
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  • G protein-coupled receptor kinase 4 in Human [ChEMBL: CHEMBL5861] [GtoPdb: 1468] [UniProtKB: P32298]
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  • Haem oxygenase 2/Heme oxygenase 2 in Human [ChEMBL: CHEMBL2546] [GtoPdb: 1442] [UniProtKB: P30519]
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  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
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  • homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02]
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  • homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
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  • homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422]
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  • homeodomain interacting protein kinase 4/Homeodomain-interacting protein kinase 4 in Human [ChEMBL: CHEMBL1075167] [GtoPdb: 2036] [UniProtKB: Q8NE63]
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  • hormonally up-regulated Neu-associated kinase/Hormonally up-regulated neu tumor-associated kinase in Human [ChEMBL: CHEMBL1795165] [GtoPdb: 2037] [UniProtKB: P57058]
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  • component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
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  • inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
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  • inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
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  • Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
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  • Insulin receptor-related receptor/Insulin receptor-related protein in Human [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616]
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  • eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
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  • interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
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  • interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616]
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  • interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
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  • leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
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  • leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376]
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  • Liver glycogen phosphorylase in Human [ChEMBL: CHEMBL2568] [UniProtKB: P06737]
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  • colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333]
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  • macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912]
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  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
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  • mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
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  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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  • MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • mitogen-activated protein kinase 11/MAP kinase p38 beta in Human [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
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  • mitogen-activated protein kinase 13/MAP kinase p38 delta in Human [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264]
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  • mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778]
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  • MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
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  • microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7]
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  • microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34]
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  • maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
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  • Membrane-associated progesterone receptor component 1 in Human [ChEMBL: CHEMBL4105706] [UniProtKB: O00264]
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  • Microtubule associated serine/threonine kinase 1/Microtubule-associated serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL1163128] [GtoPdb: 1510] [UniProtKB: Q9Y2H9]
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  • misshapen like kinase 1/Misshapen-like kinase 1 in Human [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
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  • mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08]
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  • mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152]
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  • mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659]
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  • mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164]
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  • mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233]
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  • mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779]
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  • mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
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  • mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852]
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  • mitogen-activated protein kinase kinase kinase 13/Mitogen-activated protein kinase kinase kinase 13 in Human [ChEMBL: CHEMBL1163124] [GtoPdb: 2073] [UniProtKB: O43283]
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  • mitogen-activated protein kinase kinase kinase 15/Mitogen-activated protein kinase kinase kinase 15 in Human [ChEMBL: CHEMBL1163127] [GtoPdb: 2075] [UniProtKB: Q6ZN16]
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  • mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5]
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  • mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759]
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  • mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4]
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  • mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
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  • mitogen-activated protein kinase kinase kinase 6/Mitogen-activated protein kinase kinase kinase 6 in Human [ChEMBL: CHEMBL1163123] [GtoPdb: 2081] [UniProtKB: O95382]
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  • mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318]
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  • mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
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  • mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918]
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  • mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
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  • mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8]
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  • mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819]
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  • mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4]
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  • BUB1 mitotic checkpoint serine/threonine kinase/Mitotic checkpoint serine/threonine-protein kinase BUB1 in Human [ChEMBL: CHEMBL1772932] [GtoPdb: 1949] [UniProtKB: O43683]
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  • ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
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  • Multifunctional protein ADE2 in Human [ChEMBL: CHEMBL5922] [UniProtKB: P22234]
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  • muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
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There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • myosin light chain kinase 3/Myosin light chain kinase in Human [ChEMBL: CHEMBL4627] [GtoPdb: 2110] [UniProtKB: Q32MK0]
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There should be some charts here, you may need to enable JavaScript!
  • myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6]
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  • Myosin light chain kinase, smooth muscle in Chicken [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
  • myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
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  • DM1 protein kinase/Myotonin-protein kinase in Human [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013]
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  • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 in Human [ChEMBL: CHEMBL4105781] [UniProtKB: Q9P0J0]
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  • neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
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  • neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
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  • tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470]
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  • neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288]
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  • NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285]
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  • NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093]
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There should be some charts here, you may need to enable JavaScript!
  • PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2]
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  • calcium/calmodulin dependent serine protein kinase/Peripheral plasma membrane protein CASK in Human [ChEMBL: CHEMBL1908381] [GtoPdb: 1959] [UniProtKB: O14936]
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There should be some charts here, you may need to enable JavaScript!
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  • phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide in Human [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750]
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  • phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma in Human [ChEMBL: CHEMBL1163120] [GtoPdb: 2288] [UniProtKB: O75747]
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  • phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha in Human [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755]
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  • phosphatidylinositol-4-phosphate 5-kinase type 1 gamma/Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma in Human [ChEMBL: CHEMBL1908383] [GtoPdb: 2165] [UniProtKB: O60331]
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  • phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol-5-phosphate 4-kinase type-2 beta in Human [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356]
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  • phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma in Human [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8]
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  • Phosphofructokinase platelet type in Human [ChEMBL: CHEMBL2972] [UniProtKB: Q01813]
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  • phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase gamma subunit 1 in Human [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816]
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  • phosphorylase kinase catalytic subunit gamma 2/Phosphorylase kinase gamma subunit 2 in Human [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
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  • phosphatidylinositol 4-kinase beta/PI4-kinase beta subunit in Human [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8]
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  • cyclin dependent kinase 11B/PITSLRE serine/threonine-protein kinase CDC2L1 in Human [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127]
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  • cyclin dependent kinase 11A/PITSLRE serine/threonine-protein kinase CDC2L2 in Human [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88]
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  • platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
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  • platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
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  • Probable ATP-dependent RNA helicase DDX6 in Human [ChEMBL: CHEMBL4105783] [UniProtKB: P26196]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
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  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
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  • protein kinase C eta/Protein kinase C eta in Human [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
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  • protein kinase C iota/Protein kinase C iota in Human [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
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  • protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
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  • protein kinase D3/Protein kinase C nu in Human [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806]
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  • protein kinase C theta/Protein kinase C theta in Human [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
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  • protein kinase N1/Protein kinase N1 in Human [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512]
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  • protein kinase N2/Protein kinase N2 in Human [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
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  • protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
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  • MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
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  • c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
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  • Putative heat shock protein HSP 90-beta 2 in Human [ChEMBL: CHEMBL4105858] [UniProtKB: Q58FF8]
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  • sugen kinase 110/Putative uncharacterized serine/threonine-protein kinase SgK110 in Human [ChEMBL: CHEMBL5116] [GtoPdb: 2290] [UniProtKB: P0C264]
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  • pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118]
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  • receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546]
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  • receptor interacting serine/threonine kinase 3/Receptor-interacting serine/threonine-protein kinase 3 in Human [ChEMBL: CHEMBL1795199] [GtoPdb: 2191] [UniProtKB: Q9Y572]
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  • receptor interacting serine/threonine kinase 4/Receptor-interacting serine/threonine-protein kinase 4 in Human [ChEMBL: CHEMBL6083] [GtoPdb: 2192] [UniProtKB: P57078]
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  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
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  • erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303]
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  • erb-b2 receptor tyrosine kinase 3/Receptor tyrosine-protein kinase erbB-3 in Human [ChEMBL: CHEMBL5838] [GtoPdb: 1798] [UniProtKB: P21860]
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  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
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  • G protein-coupled receptor kinase 1/Rhodopsin kinase in Human [ChEMBL: CHEMBL5607] [GtoPdb: 1465] [UniProtKB: Q15835]
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  • ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
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  • ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
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  • ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
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  • ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
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  • ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676]
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  • ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
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  • ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
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  • S-adenosylmethionine synthase isoform type-2 in Human [ChEMBL: CHEMBL3313835] [UniProtKB: P31153]
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  • ATR checkpoint kinase/Serine-protein kinase ATR in Human [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535]
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  • serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
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  • serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
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  • serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716]
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  • serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5]
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  • serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768]
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  • STE20 like kinase/Serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2]
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  • serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0]
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  • serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506]
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  • serine/threonine kinase 32A/Serine/threonine-protein kinase 32A in Human [ChEMBL: CHEMBL6150] [GtoPdb: 1537] [UniProtKB: Q8WU08]
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  • serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57]
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  • serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6]
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  • serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
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  • serine/threonine kinase 35/Serine/threonine-protein kinase 35 in Human [ChEMBL: CHEMBL5651] [GtoPdb: 2222] [UniProtKB: Q8TDR2]
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  • serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7]
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  • Serine/threonine kinase 38/Serine/threonine-protein kinase 38 in Human [ChEMBL: CHEMBL1075155] [GtoPdb: 1517] [UniProtKB: Q15208]
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  • Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1]
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  • AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
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  • AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
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  • AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
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  • A-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase A-Raf in Human [ChEMBL: CHEMBL1169596] [GtoPdb: 1933] [UniProtKB: P10398]
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  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
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  • aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
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  • aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9]
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  • B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
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  • checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
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  • checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
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  • microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
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  • protein kinase D2/Serine/threonine-protein kinase D2 in Human [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
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  • doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075]
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  • doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568]
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  • doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098]
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  • endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460]
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  • endoplasmic reticulum to nucleus signaling 2/Serine/threonine-protein kinase/endoribonuclease IRE2 in Human [ChEMBL: CHEMBL4105932] [GtoPdb: 2021] [UniProtKB: Q76MJ5]
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  • cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976]
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  • ciliogenesis associated kinase 1/Serine/threonine-protein kinase ICK in Human [ChEMBL: CHEMBL1163126] [GtoPdb: 2038] [UniProtKB: Q9UPZ9]
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  • integrin linked kinase/Serine/threonine-protein kinase ILK-1 in Human [ChEMBL: CHEMBL5247] [GtoPdb: 2041] [UniProtKB: Q13418]
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  • large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835]
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  • large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7]
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  • male germ cell associated kinase/Serine/threonine-protein kinase MAK in Human [ChEMBL: CHEMBL1163106] [GtoPdb: 2061] [UniProtKB: P20794]
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  • microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
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  • CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
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  • CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2]
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  • CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37]
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  • serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
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  • serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
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  • serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289]
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  • mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
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  • NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
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  • NIMA related kinase 11/Serine/threonine-protein kinase Nek11 in Human [ChEMBL: CHEMBL5638] [GtoPdb: 2116] [UniProtKB: Q8NG66]
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  • NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
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  • NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956]
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  • NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957]
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  • NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8]
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  • NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
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  • NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
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  • NIMA related kinase 9/Serine/threonine-protein kinase NEK9 in Human [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19]
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  • serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84]
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  • nemo like kinase/Serine/threonine protein kinase NLK in Human [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
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  • oxidative stress responsive kinase 1/Serine/threonine-protein kinase OSR1 in Human [ChEMBL: CHEMBL1163104] [GtoPdb: 2132] [UniProtKB: O95747]
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  • p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
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  • p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177]
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  • p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
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  • p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013]
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  • p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
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  • p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK7 in Human [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286]
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  • cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536]
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  • cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537]
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  • cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002]
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  • cyclin dependent kinase 14/Serine/threonine-protein kinase PFTAIRE-1 in Human [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921]
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  • cyclin dependent kinase 15/Serine/threonine-protein kinase PFTAIRE-2 in Human [ChEMBL: CHEMBL5856] [GtoPdb: 1968] [UniProtKB: Q96Q40]
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
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  • Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
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  • Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86]
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  • Serine/threonine-protein kinase pknB in Mycobacterium tuberculosis [ChEMBL: CHEMBL1908385] [UniProtKB: P9WI81]
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  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
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  • polo like kinase 2/Serine/threonine-protein kinase PLK2 in Human [ChEMBL: CHEMBL5938] [GtoPdb: 2169] [UniProtKB: Q9NYY3]
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  • polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
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  • polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
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  • protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817]
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  • pre-mRNA processing factor kinase PRP4K/Serine/threonine-protein kinase PRP4 homolog in Human [ChEMBL: CHEMBL1908382] [GtoPdb: 2177] [UniProtKB: Q13523]
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  • Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
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  • activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
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  • RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2]
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  • RIO kinase 2/Serine/threonine-protein kinase RIO2 in Human [ChEMBL: CHEMBL6000] [GtoPdb: 2187] [UniProtKB: Q9BVS4]
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  • RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730]
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  • receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
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  • SH3 domain binding kinase 1/Serine/threonine-protein kinase SBK1 in Human [ChEMBL: CHEMBL1163129] [GtoPdb: 2193] [UniProtKB: Q52WX2]
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  • serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141]
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  • serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
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  • salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059]
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  • salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1]
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  • SIK family kinase 3/Serine/threonine-protein kinase SIK3 in Human [ChEMBL: CHEMBL6149] [GtoPdb: 2199] [UniProtKB: Q9Y2K2]
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  • SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4]
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  • SRSF protein kinase 2/Serine/threonine-protein kinase SRPK2 in Human [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362]
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  • SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1]
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  • TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
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  • TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54]
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  • TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8]
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  • TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
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  • TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18]
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  • tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8]
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  • tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8]
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  • unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385]
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  • unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
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  • unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2]
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  • VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07]
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  • WEE1 G2 checkpoint kinase/Serine/threonine-protein kinase WEE1 in Human [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291]
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  • Signal recognition particle receptor subunit alpha in Human [ChEMBL: CHEMBL4105934] [UniProtKB: P08240]
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  • SNF related kinase/SNF-related serine/threonine-protein kinase in Human [ChEMBL: CHEMBL1908384] [GtoPdb: 2202] [UniProtKB: Q9NRH2]
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  • mitogen-activated protein kinase kinase kinase 19/SPS1/STE20-related protein kinase YSK4 in Human [ChEMBL: CHEMBL6191] [GtoPdb: 2076] [UniProtKB: Q56UN5]
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  • STE20 related adaptor alpha/STE20-related kinase adapter protein alpha in Human [ChEMBL: CHEMBL1795198] [GtoPdb: 2227] [UniProtKB: Q7RTN6]
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  • serine/threonine kinase 39/STE20/SPS1-related proline-alanine-rich protein kinase in Human [ChEMBL: CHEMBL1163108] [GtoPdb: 2224] [UniProtKB: Q9UEW8]
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  • KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
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  • Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial in Human [ChEMBL: CHEMBL4105973] [UniProtKB: Q9P2R7]
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  • testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
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  • transforming growth factor beta receptor 1/TGF-beta receptor type I in Human [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
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  • transforming growth factor beta receptor 2/TGF-beta receptor type II in Human [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
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  • Thyroid hormone receptor-associated protein 3 in Human [ChEMBL: CHEMBL4105820] [UniProtKB: Q9Y2W1]
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  • TP53 regulating kinase/TP53-regulating kinase in Human [ChEMBL: CHEMBL1938223] [GtoPdb: 2248] [UniProtKB: Q96S44]
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  • TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5]
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  • TRPM6/Transient receptor potential cation channel subfamily M member 6 in Human [ChEMBL: CHEMBL1628470] [GtoPdb: 498] [UniProtKB: Q9BX84]
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  • tubulin alpha 1a/Tubulin alpha-1 chain in Rat [ChEMBL: CHEMBL4139] [GtoPdb: 2638] [UniProtKB: P68370]
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  • protein kinase, membrane associated tyrosine/threonine 1/Tyrosine- and threonine-specific cdc2-inhibitory kinase in Human [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640]
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  • tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
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  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
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  • ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
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  • BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
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  • BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813]
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  • protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
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  • Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
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  • C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
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  • megakaryocyte-associated tyrosine kinase/Tyrosine-protein kinase CTK in Human [ChEMBL: CHEMBL4175] [GtoPdb: 2101] [UniProtKB: P42679]
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  • FER tyrosine kinase/Tyrosine-protein kinase FER in Human [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591]
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  • FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
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  • FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769]
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  • fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685]
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  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
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  • HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
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  • IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
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  • Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Mouse [ChEMBL: CHEMBL1649049] [GtoPdb: 2048] [UniProtKB: Q62120]
  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Rat [ChEMBL: CHEMBL1075225] [GtoPdb: 2048] [UniProtKB: Q62689]
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  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Mouse [ChEMBL: CHEMBL5250] [GtoPdb: 2049] [UniProtKB: Q62137]
  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Rat [ChEMBL: CHEMBL4295857] [GtoPdb: 2049] [UniProtKB: Q63272]
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  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
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  • fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
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  • ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
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  • tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590]
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  • TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
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  • AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
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  • src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6]
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
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  • tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680]
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  • TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
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  • TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
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  • tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
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  • YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
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  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
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  • U5 small nuclear ribonucleoprotein 200 kDa helicase in Human [ChEMBL: CHEMBL4105972] [UniProtKB: O75643]
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  • aarF domain containing kinase 1/Uncharacterized aarF domain-containing protein kinase 1 in Human [ChEMBL: CHEMBL4105885] [GtoPdb: 1925] [UniProtKB: Q86TW2]
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  • coenzyme Q8B/Uncharacterized aarF domain-containing protein kinase 4 in Human [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53]
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  • aarF domain containing kinase 5/Uncharacterized aarF domain-containing protein kinase 5 in Human [ChEMBL: CHEMBL4105886] [GtoPdb: 1929] [UniProtKB: Q3MIX3]
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  • fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
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  • fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
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  • Very long-chain specific acyl-CoA dehydrogenase, mitochondrial in Human [ChEMBL: CHEMBL4105892] [UniProtKB: P49748]
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  • WEE2 oocyte meiosis inhibiting kinase/Wee1-like protein kinase 2 in Human [ChEMBL: CHEMBL5095] [GtoPdb: 2279] [UniProtKB: P0C1S8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
26S protease regulatory subunit 6B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831205] [UniProtKB: P43686]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530]
ChEMBL Binding constant for full-length PDPK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PDPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Actin-related protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105857] [UniProtKB: P61158]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ACVR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ACVR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ACVR1B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ACVR1B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
activin A receptor type 2A/Activin receptor type-2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037]
ChEMBL Binding constant for ACVR2A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ACVR2A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
activin A receptor type 2B/Activin receptor type-2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ACVR2B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ACVR2B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Acyl-CoA dehydrogenase family member 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105816] [UniProtKB: Q6JQN1]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
AP2 associated kinase 1/Adaptor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for AAK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AAK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Adenylate kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4938] [UniProtKB: P54819]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Mitochondrial adenine nucleotide translocator 2/ADP/ATP translocase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3709670] [GtoPdb: 1063] [UniProtKB: P05141]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Mitochondrial adenine nucleotide translocator 3/ADP/ATP translocase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105854] [GtoPdb: 1064] [UniProtKB: P12236]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Binding constant for ALK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ALK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for AMPK-alpha1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AMPK-alpha1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646]
ChEMBL Binding constant for AMPK-alpha2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AMPK-alpha2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase AMP-activated non-catalytic subunit gamma 1/AMP-activated protein kinase, gamma-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2393] [GtoPdb: 1545] [UniProtKB: P54619]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
protein kinase AMP-activated non-catalytic subunit gamma 2/AMP-activated protein kinase, gamma-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2453] [GtoPdb: 1546] [UniProtKB: Q9UGJ0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2]
ChEMBL Binding constant for ANKK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ANKK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ATP-dependent RNA helicase DDX1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010634] [UniProtKB: Q92499]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ATP-dependent RNA helicase DDX3X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5553] [UniProtKB: O00571]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ATP-dependent RNA helicase DHX30 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105814] [UniProtKB: Q7L2E3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
BMP2 inducible kinase/BMP-2-inducible protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for BIKE kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BIKE kinase domain B 5.15 pKd 7100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for BMPR1A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BMPR1A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for BMPR1B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for BMPR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BMPR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Brain glycogen phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3856] [UniProtKB: P11216]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
BCR activator of RhoGEF and GTPase/Breakpoint cluster region protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5146] [GtoPdb: 2755] [UniProtKB: P11274]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
ChEMBL Binding constant for BRSK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BRSK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
ChEMBL Binding constant for full-length BRSK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BRSK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Calcium-dependent protein kinase 1 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908387] [UniProtKB: P62344]
ChEMBL Binding constant for PFCDPK1(P.falciparum) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
ChEMBL Binding affinity to Camk1 B 5.3 pKd 5000 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for full-length CAMK1 B 5.3 pKd 5000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMK1 kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
ChEMBL Binding constant for CAMK1D kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMK1D kinase domain B 5.8 pKd 1600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase IG/CaM kinase I gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CAMK1G kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMK1G kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7]
ChEMBL Binding constant for CAMK2A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMK2A kinase domain B 5.46 pKd 3500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin-dependent protein kinase II beta subunit/CaM kinase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554]
ChEMBL Binding constant for CAMK2B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMK2B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CAMK2D kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMK2D kinase domain B 5.57 pKd 2700 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin-dependent protein kinase II gamma subunit/CaM kinase II gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CAMK2G kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMK2G kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CAMK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase kinase 1/CaM-kinase kinase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9]
ChEMBL Binding constant for CAMKK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMKK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
calcium/calmodulin dependent protein kinase kinase 2/CaM-kinase kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CAMKK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CAMKK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PKAC-alpha kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PKAC-alpha kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length PKAC-beta B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PKAC-beta kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase, cAMP-dependent, catalytic, gamma subunit/cAMP-dependent protein kinase, gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2743] [GtoPdb: 1478] [UniProtKB: P22612]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CSNK1A1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CSNK1D B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSNK1D kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CSNK1E B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSNK1E kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CSNK1G1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSNK1G1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CSNK1G2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSNK1G2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL Binding constant for full-length CSNK2A1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSNK2A1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CSNK2A2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSNK2A2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752]
ChEMBL Binding constant for full-length CSNK1A1L B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSNK1A1L kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CSNK1G3 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSNK1G3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Cell division control protein 2 homolog in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908388] [UniProtKB: P61075]
ChEMBL Binding constant for PFPK5(P.falciparum) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1]
ChEMBL Binding constant for CDK11 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CDK11 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 8/Cell division protein kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336]
ChEMBL Binding constant for CDK8 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CDK8 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PRKG1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKG1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
ChEMBL Binding constant for PRKG2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKG2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ADCK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ADCK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Chromodomain-helicase-DNA-binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105742] [UniProtKB: Q14839]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CIT kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CIT kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length JNK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for JNK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of JNK1/SAPK1c B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length JNK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for JNK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for JNK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for JNK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin dependent kinase 12/Cyclin-dependent kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559692] [GtoPdb: 1965] [UniProtKB: Q9NYV4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CDC2L5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CDK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CDK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of Cdk2 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
ChEMBL Inhibition of CDK2/cyclin A B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CDK3 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CDK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CDK4-cyclinD1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for CDK4-cyclinD3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CDK5 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CDK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of Cdk5 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CDK7 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CDK7 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CDK9 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CDK9 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532]
ChEMBL Binding constant for CDKL1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase like 2/Cyclin-dependent kinase-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5728] [GtoPdb: 1983] [UniProtKB: Q92772]
ChEMBL Binding constant for CDKL2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin-dependent kinase like 3/Cyclin-dependent kinase-like 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163117] [GtoPdb: 1984] [UniProtKB: Q8IVW4]
ChEMBL Binding constant for CDKL3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin-dependent kinase like 5/Cyclin-dependent kinase-like 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163112] [GtoPdb: 1986] [UniProtKB: O76039]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CDKL5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Cysteine--tRNA ligase, cytoplasmic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105937] [UniProtKB: P49589]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Cytochrome c1, heme protein, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105975] [UniProtKB: P08574]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
dCTP pyrophosphatase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769292] [UniProtKB: Q9H773]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
death associated protein kinase 1/Death-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355]
ChEMBL Binding constant for DAPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DAPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
death associated protein kinase 2/Death-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
ChEMBL Binding constant for full-length DAPK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DAPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
ChEMBL Binding constant for full-length DLK B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DAPK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DAPK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Deoxycytidine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2447] [UniProtKB: P27707]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for DDR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DDR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
DnaJ homolog subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189122] [UniProtKB: P31689]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
DNA topoisomerase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1806] [GtoPdb: 2637] [UniProtKB: P11388]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
DNA topoisomerase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3396] [UniProtKB: Q02880]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
dual serine/threonine and tyrosine protein kinase/Dual serine/threonine and tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908386] [GtoPdb: 2008] [UniProtKB: Q6XUX3]
ChEMBL Binding constant for RIPK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL Binding constant for full-length MEK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MEK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.37 pKd 429 nM Kd Science (2017) 358: null-null [PMID:29191878]
mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length MEK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MEK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length MEK3 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MEK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
ChEMBL Binding constant for MEK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MEK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MEK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MEK6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MEK6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
ChEMBL Binding constant for MKK7 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC like kinase 1/Dual specificity protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CLK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CLK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CLK3 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CLK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
ChEMBL Binding constant for CLK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CLK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
ChEMBL Binding constant for TTK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TTK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TESK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TESK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for DYRK1A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
ChEMBL Binding constant for full-length DYRK1B B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DYRK1B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
ChEMBL Binding constant for DYRK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Dynamin-like 120 kDa protein, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105705] [UniProtKB: O60313]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Elongation factor Tu, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105970] [UniProtKB: P49411]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709]
ChEMBL Binding constant for EPHA1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHA1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EPHA2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHA2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320]
ChEMBL Binding constant for EPHA3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHA3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EPHA4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHA4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EPHA5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHA5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A6/Ephrin type-A receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33]
ChEMBL Binding constant for EPHA6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHA6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EPHA7 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHA7 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322]
ChEMBL Binding constant for EPHA8 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHA8 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
ChEMBL Binding constant for EPHB1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHB1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EPHB2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHB2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EPHB3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHB3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EPHB4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EPHB4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
EPH receptor B6/Ephrin type-B receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5836] [GtoPdb: 1834] [UniProtKB: O15197]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EPHB6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EGFR(E746-A750del) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(G719C) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(G719S) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L747-E749del, A750P) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L747-S752del, P753S) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L747-T751del,Sins) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L858R) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L861Q) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(S752-I759del) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(G719C) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(G719S) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(L747-E749del, A750P) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(L747-S752del, P753S) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(L747-T751del,Sins) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(L858R) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(L858R,T790M) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(L861Q) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(S752-I759del) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(T790M) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for EGFR(E746-A750del) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of EGFR B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for DDR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DDR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
eukaryotic translation initiation factor 2 alpha kinase 1/Eukaryotic translation initiation factor 2-alpha kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6029] [GtoPdb: 2015] [UniProtKB: Q9BQI3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for EIF2AK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
eukaryotic translation initiation factor 2 alpha kinase 4/Eukaryotic translation initiation factor 2-alpha kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8]
ChEMBL Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Exosome RNA helicase MTR4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105889] [UniProtKB: P42285]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Ferrochelatase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879831] [UniProtKB: P22830]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for FGFR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FGFR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
ChEMBL Binding constant for FGFR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FGFR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
ChEMBL Binding constant for FGFR3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FGFR3(G697C) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FGFR3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for FGFR3(G697C) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
ChEMBL Binding constant for FGFR4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FGFR4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PTK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FAK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
General transcription and DNA repair factor IIH helicase subunit XPD in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105743] [UniProtKB: P18074]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Glycine--tRNA ligase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105815] [UniProtKB: P41250]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length GSK3A B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for GSK3A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length GSK3B B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for GSK3B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of GSK3-beta B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
G protein-coupled receptor kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5861] [GtoPdb: 1468] [UniProtKB: P32298]
ChEMBL Binding constant for GRK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
G protein-coupled receptor kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075133] [GtoPdb: 1471] [UniProtKB: Q8WTQ7]
ChEMBL Binding constant for GRK7 kinase domain B 5.37 pKd 4300 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
GTP-binding nuclear protein Ran in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741190] [UniProtKB: P62826]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Haem oxygenase 2/Heme oxygenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2546] [GtoPdb: 1442] [UniProtKB: P30519]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MET kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MET kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for MET(M1250T) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for MET(Y1235D) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02]
ChEMBL Binding constant for HIPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
ChEMBL Binding constant for HIPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422]
ChEMBL Binding constant for HIPK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
homeodomain interacting protein kinase 4/Homeodomain-interacting protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075167] [GtoPdb: 2036] [UniProtKB: Q8NE63]
ChEMBL Binding constant for HIPK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
hormonally up-regulated Neu-associated kinase/Hormonally up-regulated neu tumor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795165] [GtoPdb: 2037] [UniProtKB: P57058]
ChEMBL Binding constant for HUNK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL Binding constant for IKK-alpha kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
ChEMBL Binding constant for IKK-beta kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length IKK-epsilon B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for IKK-epsilon kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for IGF1R kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for IGF1R kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for INSR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for INSR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of IRK B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
Insulin receptor-related receptor/Insulin receptor-related protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616]
ChEMBL Binding constant for INSRR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for INSRR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
ChEMBL Binding constant for PRKR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for IRAK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for IRAK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for IRAK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for IRAK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Janus kinase 2/Janus kinase 1/tyrosine kinase 2/JAK1/JAK2/TYK2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3301390] [GtoPdb: 204820472269] [UniProtKB: O60674P23458P29597]
GtoPdb In a biochemical enzyme assay. - 6.31 pIC50 489 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK1/JAK2/TYK2 in human PBMC expressing CD3 assessed as inhibition of IL-6-stimulated STAT3 phosphorylation after 30 mins by flow cytometric analysis B 6.42 pIC50 380 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
ChEMBL Inhibition of JAK1/JAK2/TYK2 in human PBMC expressing CD14 assessed as inhibition of IL-6-stimulated STAT3 phosphorylation after 30 mins by flow cytometric analysis B 6.62 pIC50 238 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
GtoPdb In a biochemical enzyme assay. - 7.11 pIC50 77 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK1/JAK2/TYK2 in human whole blood assessed as inhibition of IL-6-induced STAT-1 phosphorylation preincubated for 45 mins followed by IL-6 addition measured after 15 mins by FACS analysis B 7.12 pIC50 75.4 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
GtoPdb In a biochemical enzyme assay. - 7.82 pIC50 15 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
Janus kinase 1/tyrosine kinase 2/JAK1/TYK2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3301391] [GtoPdb: 20472269] [UniProtKB: P23458P29597]
GtoPdb In a biochemical enzyme assay. - 6.31 pIC50 489 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IL12 -induced STAT4 phosphorylation pre-incubated for 30 mins before IL12 stimulation for 30 mins AlphaLISAassay B 6.36 pIC50 440 nM IC50 J Med Chem (2020) 63: 2915-2929 [PMID:32134643]
ChEMBL Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation preincubated for 45 mins followed by IL-12 addition and measured measured after 15 mins by FACS assay B 6.5 pIC50 315 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-10 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-10 addition and measured measured after 15 mins by FACS assay B 6.54 pIC50 291 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK1/TYK2 in human M07E cells assessed as reduction of IFN alpha stimulated STAT phosphorylation preincubated for 30 mins followed by IFN alpha stimulation and measured after 15 mins by flow cytometry method B 7.17 pIC50 68 nM IC50 J Med Chem (2023) 66: 2161-2168 [PMID:36657024]
ChEMBL Inhibition of JAK1/TYK2 in human M07E cells assessed as reduction of IFN alpha stimulated STAT phosphorylation preincubated for 30 mins followed by IFN alpha stimulation for 15 mins by flow cytometry method B 7.17 pIC50 68 nM IC50 ACS Med Chem Lett (2023) 14: 841-845 [PMID:37312861]
ChEMBL Inhibition of JAK1/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IFN-alpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN-alpha addition and measured measured after 15 mins by FACS assay B 7.42 pIC50 38 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK1/TYK2 in human whole blood assessed as inhibition of IFN-alpha-induced STAT-3 phosphorylation preincubated for 45 mins followed by IFN-alpha addition measured after 15 mins by FACS analysis B 7.46 pIC50 35 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFNalpha addition measured after 15 mins by flow cytometric analysis B 7.46 pIC50 35 nM IC50 J Med Chem (2018) 61: 1130-1152 [PMID:29298069]
ChEMBL Inhibition of JAK1/Tyk2 in human PBMC assessed as reduction in IFNalpha-induced STAT4 phosphorylation pre-incubated for 30 mins before IFNalpha stimulation for 30 mins AlphaLISAassay B 7.59 pIC50 26 nM IC50 J Med Chem (2020) 63: 2915-2929 [PMID:32134643]
GtoPdb In a biochemical enzyme assay. - 7.82 pIC50 15 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
Janus kinase 1/tyrosine kinase 2/JAK1/TYK2 in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4523618] [GtoPdb: 20472269] [UniProtKB: P52332Q9R117]
ChEMBL Inhibition of JAK1/Tyk2-mediated STAT4 phosphorylation in IFNalpha-stimulated mouse whole blood B 6.95 pIC50 112 nM IC50 J Med Chem (2020) 63: 2915-2929 [PMID:32134643]
Janus kinase 2/Janus kinase 1/JAK2/JAK1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038492] [GtoPdb: 20482047] [UniProtKB: O60674P23458]
ChEMBL Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-6 addition and measured measured after 15 mins by FACS assay B 6.44 pIC50 367 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK2/1 in human T cells expressing CD3 assessed as inhibition of IFNgamma-stimulated STAT1 phosphorylation B 6.77 pIC50 170 nM IC50 Bioorg Med Chem Lett (2013) 23: 2793-2800 [PMID:23540648]
ChEMBL Inhibition of JAK1/2 in human PBMC expressing CD14 assessed as inhibition of IFNgamma-induced STAT1 phosphorylation B 6.77 pIC50 170 nM IC50 Bioorg Med Chem Lett (2013) 23: 2522-2526 [PMID:23541670]
ChEMBL Inhibition of JAK2/JAK1 in human PBMC expressing CD14 assessed as inhibition of IFN-gamma-stimulated STAT1 phosphorylation after 30 mins by flow cytometric analysis B 6.77 pIC50 170 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
GtoPdb In a biochemical enzyme assay. - 7.11 pIC50 77 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK1/JAK2 signaling pathway in human CD3 +ve cells of whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincubated for 45 mins followed by IL-6 addition and measured measured after 15 mins by FACS assay B 7.27 pIC50 54 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK1/JAK2 signaling pathway in human CD14 +ve cells of whole blood assessed as reduction in IFN-gamma induced STAT1 phosphorylation preincubated for 45 mins followed by IFN-gamma addition and measured measured after 15 mins by FACS assay B 7.28 pIC50 52 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK1/JAK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-27 addition and measured measured after 15 mins by FACS assay B 7.29 pIC50 51 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
GtoPdb In a biochemical enzyme assay. - 7.82 pIC50 15 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK2/JAK1 in human PBMC expressing CD14 assessed as inhibition of IFN-gamma-stimulated STAT1 phosphorylation after 30 mins by flow cytometric analysis B 6.77 pEC50 170 nM EC50 Bioorg Med Chem Lett (2014) 24: 4969-4975 [PMID:25262541]
Janus kinase 2/tyrosine kinase 2/JAK2/TYK2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3301392] [GtoPdb: 20482269] [UniProtKB: O60674P29597]
GtoPdb In a biochemical enzyme assay. - 6.31 pIC50 489 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-12-induced STAT-4 phosphorylation preincubated for 45 mins followed by IL-12 addition measured after 15 mins by FACS analysis B 6.39 pIC50 409 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of JAK2/TYK2 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-23 addition and measured measured after 15 mins by FACS assay B 6.6 pIC50 249 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK2/TYK2 in human whole blood assessed as inhibition of IL-23-induced STAT-3 phosphorylation preincubated for 45 mins followed by IL-23 addition measured after 15 mins by FACS analysis B 6.64 pIC50 229 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
GtoPdb In a biochemical enzyme assay. - 7.11 pIC50 77 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
Janus kinase 1/Janus kinase 3/JAK3/JAK1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038491] [GtoPdb: 20472049] [UniProtKB: P23458P52333]
ChEMBL Inhibition of JAK1/JAK3 in human whole blood assessed as inhibition of IL2-stimulated STATs phosphorylation preincubated for 30 mins prior to IL2 challenge measured after 15 mins by intracellular phosflow staining B 6.84 pIC50 143 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of JAK1/JAK3 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-15 induced STAT5 phosphorylation preincubated for 45 mins followed by IL-15 addition and measured measured after 15 mins by FACS assay B 7.24 pIC50 58 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK1/JAK3 in human whole blood assessed as inhibition of IL-15-induced STAT-5 phosphorylation preincubated for 45 mins followed by IL-15 addition measured after 15 mins by FACS analysis B 7.25 pIC50 55.8 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
GtoPdb In a biochemical enzyme assay. - 7.26 pIC50 55 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK3/JAK1 in human whole blood expressing CD13 assessed as inhibition of IL-2-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis B 7.27 pIC50 54 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
ChEMBL Inhibition of JAK1/JAK3 signaling pathway in human lymphocytes of whole blood assessed as reduction in IL-21 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-21 addition and measured measured after 15 mins by FACS assay B 7.29 pIC50 51 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK1/JAK3 in human PBMC assessed as inhibition of IL2-stimulated STATs phosphorylation preincubated for 30 mins prior to IL2 challenge measured after 15 mins by intracellular phosflow staining B 7.48 pIC50 33 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of JAK1/3 in human PBMC expressing CD3 assessed as inhibition of IL2-induced STAT5a phosphorylation B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (2013) 23: 2522-2526 [PMID:23541670]
ChEMBL Inhibition of JAK1/JAK3 in human blood assessed as reduction of IL-2 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-2 stimulation for 15 mins by flow cytometry method B 7.52 pIC50 30 nM IC50 ACS Med Chem Lett (2023) 14: 841-845 [PMID:37312861]
ChEMBL Inhibition of JAK1/JAK3 in human blood assessed as reduction of IL-2 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-2 stimulation and measured after 15 mins by flow cytometry method B 7.52 pIC50 30 nM IC50 J Med Chem (2023) 66: 2161-2168 [PMID:36657024]
ChEMBL Inhibition of JAK3/JAK1 in human PBMC expressing CD3 assessed as inhibition of IL-2-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis B 7.55 pIC50 28 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
ChEMBL Inhibition of JAK3/1 in human T cells expressing CD3 assessed as inhibition of IL2-stimulated STAT5a phosphorylation B 7.55 pIC50 28 nM IC50 Bioorg Med Chem Lett (2013) 23: 2793-2800 [PMID:23540648]
ChEMBL Inhibition of JAK1/JAK3 in human M07E cells assessed as reduction of IL-15 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-15 stimulation and measured after 15 mins by flow cytometry analysis B 7.66 pIC50 22 nM IC50 J Med Chem (2023) 66: 2161-2168 [PMID:36657024]
GtoPdb In a biochemical enzyme assay. - 7.82 pIC50 15 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK1/JAK3 in human PBMC assessed as reduction in IL2-induced STAT5 phosphorylation pre-incubated for 30 mins before IL2 stimulation for 30 mins AlphaLISAassay B 8.17 pIC50 6.7 nM IC50 J Med Chem (2020) 63: 2915-2929 [PMID:32134643]
GtoPdb - - 8.22 pIC50 6 nM IC50 Future Med Chem (2016) 8: 1537-51 [PMID:27572962]
GtoPdb - - 9 pIC50 1 nM IC50 J Med Chem (2010) 53: 8468-84 [PMID:21105711];
Science (2003) 302: 875-8 [PMID:14593182]
ChEMBL Inhibition of JAK3/JAK1 in human PBMC expressing CD3 assessed as inhibition of IL-2-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis B 7.55 pEC50 28 nM EC50 Bioorg Med Chem Lett (2014) 24: 4969-4975 [PMID:25262541]
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
ChEMBL Binding constant for LRRK2 kinase domain B 5.89 pKd 1300 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for LRRK2(G2019S) kinase domain B 6.26 pKd 550 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376]
ChEMBL Binding constant for LTK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for LTK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length LIMK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for LIMK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length LIMK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for LIMK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Liver glycogen phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2568] [UniProtKB: P06737]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Long-chain-fatty-acid--CoA ligase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105818] [UniProtKB: Q9ULC5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333]
ChEMBL Binding constant for CSF1R kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSF1R kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MST1R kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAPKAPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MAPKAPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of MAPK2/ERK2 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
ChEMBL Inhibition of MAPKAPK2 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAPKAPK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MAPKAPK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of PRAK B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length ERK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ERK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length ERK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ERK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
ChEMBL Binding constant for full-length MKNK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MKNK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length p38-alpha B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for p38-alpha kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of SAPK2a/p38 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length p38-beta B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for p38-beta kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of SAPK2b/p38b2 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
mitogen-activated protein kinase 13/MAP kinase p38 delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264]
ChEMBL Binding constant for p38-delta kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of SAPK4/p38d B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778]
ChEMBL Binding constant for full-length p38-gamma B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for p38-gamma kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of SAPK3/p38g B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
ChEMBL Binding constant for MKNK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MKNK2 kinase domain B 5.8 pKd 1600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7]
ChEMBL Binding constant for MARK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MARK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.18 pKd 6626 nM Kd Science (2017) 358: null-null [PMID:29191878]
microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MARK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MARK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length MELK B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MELK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Membrane-associated progesterone receptor component 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105706] [UniProtKB: O00264]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Microtubule associated serine/threonine kinase 1/Microtubule-associated serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163128] [GtoPdb: 1510] [UniProtKB: Q9Y2H9]
ChEMBL Binding constant for MAST1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Midasin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105779] [UniProtKB: Q9NU22]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MINK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ERK8 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ERK8 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152]
ChEMBL Binding constant for ERK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ERK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659]
ChEMBL Binding constant for ERK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ERK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ERK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ERK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP3K1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779]
ChEMBL Binding constant for MLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MLK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MLK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852]
ChEMBL Binding constant for DLK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 13/Mitogen-activated protein kinase kinase kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163124] [GtoPdb: 2073] [UniProtKB: O43283]
ChEMBL Binding constant for LZK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 15/Mitogen-activated protein kinase kinase kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163127] [GtoPdb: 2075] [UniProtKB: Q6ZN16]
ChEMBL Binding constant for MAP3K15 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP3K2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP3K3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP3K4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MAP3K4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP3K5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ASK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 6/Mitogen-activated protein kinase kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163123] [GtoPdb: 2081] [UniProtKB: O95382]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ASK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318]
ChEMBL Binding constant for TAK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
ChEMBL Binding constant for MLK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MLK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP4K1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for HPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP4K2 kinase domain B 5.32 pKd 4800 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP4K3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MAP4K3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP4K4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MAP4K4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MAP4K5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MAP4K5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
BUB1 mitotic checkpoint serine/threonine kinase/Mitotic checkpoint serine/threonine-protein kinase BUB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1772932] [GtoPdb: 1949] [UniProtKB: O43683]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ZAK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ZAK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Multifunctional protein ADE2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5922] [UniProtKB: P22234]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
ChEMBL Binding constant for MUSK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MUSK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Myosin-14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105888] [UniProtKB: Q7Z406]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
myosin IIIA/Myosin IIIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5546] [GtoPdb: 2112] [UniProtKB: Q8NEV4]
ChEMBL Binding constant for MYO3A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MYO3A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
myosin IIIB/Myosin-IIIB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5654] [GtoPdb: 2113] [UniProtKB: Q8WXR4]
ChEMBL Binding constant for MYO3B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MYO3B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
myosin light chain kinase 3/Myosin light chain kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4627] [GtoPdb: 2110] [UniProtKB: Q32MK0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MLCK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
myosin light chain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2777] [GtoPdb: 1553] [UniProtKB: Q9H1R3]
ChEMBL Binding constant for MYLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MYLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6]
ChEMBL Binding constant for SgK085 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MYLK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
ChEMBL Binding constant for MLCK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MYLK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MYLK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
DM1 protein kinase/Myotonin-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013]
ChEMBL Binding constant for DMPK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DMPK kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105781] [UniProtKB: Q9P0J0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TRKA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TRKA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
ChEMBL Binding constant for TRKB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TRKB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.77 pKd 1683 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to Tnk1 B 6.19 pKd 640 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for full-length TNK1 B 6.19 pKd 640 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TNK1 kinase domain B 6.92 pKd 120 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288]
ChEMBL Binding constant for TRKC kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TRKC kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285]
ChEMBL Binding constant for ARK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ARK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding affinity to SNARK B 6.38 pKd 420 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for SNARK kinase domain B 6.38 pKd 420 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for SNARK kinase domain B 6.62 pKd 240 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Nucleolar GTP-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105780] [UniProtKB: Q9BZE4]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
calcium/calmodulin dependent serine protein kinase/Peripheral plasma membrane protein CASK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908381] [GtoPdb: 1959] [UniProtKB: O14936]
ChEMBL Binding constant for CASK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Peroxisomal acyl-coenzyme A oxidase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105817] [UniProtKB: O15254]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Phenylalanine--tRNA ligase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105969] [UniProtKB: Q9NSD9]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750]
ChEMBL Binding constant for PIK3C2B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163120] [GtoPdb: 2288] [UniProtKB: O75747]
ChEMBL Binding constant for PIK3C2G kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755]
ChEMBL Binding constant for full-length PIP5K1A B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PIP5K1A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma/Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908383] [GtoPdb: 2165] [UniProtKB: O60331]
ChEMBL Binding constant for PIP5K1C kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol-5-phosphate 4-kinase type-2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356]
ChEMBL Binding constant for full-length PIP5K2B B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PIP5K2B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PIP5K2C kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Phosphofructokinase platelet type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2972] [UniProtKB: Q01813]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase gamma subunit 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816]
ChEMBL Binding constant for full-length PHKG1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PHKG1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphorylase kinase catalytic subunit gamma 2/Phosphorylase kinase gamma subunit 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PHKG2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PHKG2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL Binding constant for PIK3CA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PIK3CA(E545K) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PIK3CA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(C420R) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(E542K) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(E545A) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(E545K) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(H1047L) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(H1047Y) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(I800L) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(M1043I) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for PIK3CA(Q546K) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of PI3K B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
ChEMBL Binding constant for PIK3CB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL Binding constant for PIK3CD kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
ChEMBL Binding constant for PIK3CG kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
phosphatidylinositol 4-kinase beta/PI4-kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8]
ChEMBL Binding constant for PIK4CB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 11B/PITSLRE serine/threonine-protein kinase CDC2L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127]
ChEMBL Binding constant for CDC2L1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CDC2L1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 11A/PITSLRE serine/threonine-protein kinase CDC2L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88]
ChEMBL Binding constant for CDC2L2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CDC2L2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL Binding constant for PDGFRA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PDGFRA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PDGFRB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PDGFRB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Probable ATP-dependent RNA helicase DDX6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105783] [UniProtKB: P26196]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.55 pKd 28098 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Inhibition of PKCalpha B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Binding constant for PRKCD kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.04 pKd 9206 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PRKCD kinase domain B 5.7 pKd 2000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Binding constant for PRKCE kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKCE kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
ChEMBL Binding constant for PRKCH kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKCH kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase C iota/Protein kinase C iota in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PRKCI kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL Binding constant for PRKD1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKD1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase D3/Protein kinase C nu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PRKD3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKD3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PRKCQ kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKCQ kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase N1/Protein kinase N1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512]
ChEMBL Binding affinity to PKN1 B 6.7 pKd 200 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for PKN1 kinase domain B 6.7 pKd 200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PKN1 kinase domain B 6.77 pKd 170 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 7.24 pKd 58 nM Kd Science (2017) 358: null-null [PMID:29191878]
GtoPdb - - 6.91 pIC50 122 nM IC50 Future Med Chem (2016) 8: 1537-51 [PMID:27572962]
protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PKN2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PKN2 kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length PTK2B B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PYK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
ChEMBL Binding constant for MERTK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MERTK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
ChEMBL Binding constant for ROS1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ROS1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Putative heat shock protein HSP 90-beta 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105858] [UniProtKB: Q58FF8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
sugen kinase 110/Putative uncharacterized serine/threonine-protein kinase SgK110 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5116] [GtoPdb: 2290] [UniProtKB: P0C264]
ChEMBL Binding constant for SgK110 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Pyridoxal kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075181] [UniProtKB: O00764]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118]
ChEMBL Inhibition of PDK1 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
Quinone reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3959] [UniProtKB: P16083]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Rab-like protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105853] [UniProtKB: Q5HYI8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Ras-related protein Rab-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105971] [UniProtKB: P61026]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Ras-related protein Rab-6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105703] [UniProtKB: P20340]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546]
ChEMBL Binding constant for RIPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RIPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
receptor interacting serine/threonine kinase 3/Receptor-interacting serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795199] [GtoPdb: 2191] [UniProtKB: Q9Y572]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
receptor interacting serine/threonine kinase 4/Receptor-interacting serine/threonine-protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6083] [GtoPdb: 2192] [UniProtKB: P57078]
ChEMBL Binding constant for RIPK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL Binding constant for ERBB2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ERBB2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303]
ChEMBL Binding constant for ERBB4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
erb-b2 receptor tyrosine kinase 3/Receptor tyrosine-protein kinase erbB-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5838] [GtoPdb: 1798] [UniProtKB: P21860]
ChEMBL Binding constant for ERBB3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.56 pKd 2730 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ROCK1 kinase domain B 6.33 pKd 470 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.53 pKd 2977 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ROCK2 kinase domain B 6.38 pKd 420 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of ROCK2 B 5.47 pIC50 3400 nM IC50 J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Inhibition of ROCK2 B 5.47 pIC50 3400 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
G protein-coupled receptor kinase 1/Rhodopsin kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5607] [GtoPdb: 1465] [UniProtKB: Q15835]
ChEMBL Binding constant for GRK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for S6K1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of p70S6K B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RPS6KA1(Kin.Dom.1 - N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA1(Kin.Dom.2 - C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domain B 5.85 pKd 1400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
ChEMBL Binding constant for RPS6KA2(Kin.Dom.1 - N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to RPS6KA2 kinase domain.2- C-terminal B 5.85 pKd 1400 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for RPS6KA2(Kin.Dom.2 - C-terminal) kinase domain B 5.85 pKd 1400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain B 6.22 pKd 600 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RPS6KA3(Kin.Dom.1 - N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of MAPKAPK1b B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RPS6KA4(Kin.Dom.1 - C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA4(Kin.Dom.2 - N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA4(Kin.Dom.1-N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RPS6KA5(Kin.Dom.1 - C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA5(Kin.Dom.2 - N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for RPS6KA5(Kin.Dom.1-N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of MSK1 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RPS6KA6(Kin.Dom.1 - C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to RPS6KA6 kinase domain.2- C-terminal B 5.92 pKd 1200 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain B 6.27 pKd 540 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
RNA cytidine acetyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105935] [UniProtKB: Q9H0A0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
S-adenosylmethionine synthase isoform type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313835] [UniProtKB: P31153]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Septin-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105891] [UniProtKB: Q9UHD8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ATR checkpoint kinase/Serine-protein kinase ATR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for LOK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for LOK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length LKB1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for LKB1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for STK16 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for STK16 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5]
ChEMBL Binding constant for DRAK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DRAK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768]
ChEMBL Binding constant for full-length DRAK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DRAK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
STE20 like kinase/Serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for SLK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for SLK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MST3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MST3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506]
ChEMBL Binding constant for YSK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for YSK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 32A/Serine/threonine-protein kinase 32A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6150] [GtoPdb: 1537] [UniProtKB: Q8WU08]
ChEMBL Binding constant for YANK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57]
ChEMBL Binding constant for full-length YANK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for YANK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6]
ChEMBL Binding constant for YANK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for YANK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
ChEMBL Binding constant for full-length STK33 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for STK33 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 35/Serine/threonine-protein kinase 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5651] [GtoPdb: 2222] [UniProtKB: Q8TDR2]
ChEMBL Binding constant for STK35 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7]
ChEMBL Binding constant for STK36 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for STK36 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Serine/threonine kinase 38/Serine/threonine-protein kinase 38 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075155] [GtoPdb: 1517] [UniProtKB: Q15208]
ChEMBL Binding constant for NDR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1]
ChEMBL Binding constant for NDR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for NDR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for AKT1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AKT1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of PKBa B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for AKT2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AKT2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for AKT3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AKT3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
A-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase A-Raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169596] [GtoPdb: 1933] [UniProtKB: P10398]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for AURKA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AURKA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL Binding constant for AURKB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AURKB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 6.28 pKd 525 nM Kd Science (2017) 358: null-null [PMID:29191878]
aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9]
ChEMBL Binding constant for full-length AURKC B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AURKC kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for BRAF kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BRAF(V600E) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BRAF kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for BRAF(V600E) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for CHEK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CHEK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of CHK1 B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
ChEMBL Binding constant for CHEK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.97 pKd 10782 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length MARK3 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MARK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PRKD2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKD2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075]
ChEMBL Binding constant for DCAMKL1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DCAMKL1 kinase domain B 5.17 pKd 6700 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568]
ChEMBL Binding constant for DCAMKL2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DCAMKL2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098]
ChEMBL Binding constant for DCAMKL3 kinase domain B 7.92 pKd 12 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to DCamkL3 B 8.35 pKd 4.5 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for DCAMKL3 kinase domain B 8.35 pKd 4.5 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ERN1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
endoplasmic reticulum to nucleus signaling 2/Serine/threonine-protein kinase/endoribonuclease IRE2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105932] [GtoPdb: 2021] [UniProtKB: Q76MJ5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for GAK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for GAK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ciliogenesis associated kinase 1/Serine/threonine-protein kinase ICK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163126] [GtoPdb: 2038] [UniProtKB: Q9UPZ9]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ICK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
integrin linked kinase/Serine/threonine-protein kinase ILK-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5247] [GtoPdb: 2041] [UniProtKB: Q13418]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for LATS1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for LATS1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7]
ChEMBL Binding constant for LATS2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for LATS2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
male germ cell associated kinase/Serine/threonine-protein kinase MAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163106] [GtoPdb: 2061] [UniProtKB: P20794]
ChEMBL Binding constant for MAK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
ChEMBL Binding constant for MARK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MARK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MRCKA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MRCKA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MRCKB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MRCKB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for DMPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for DMPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length MST1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MST1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for MST2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding affinity to MST2 B 5.37 pKd 4300 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for MST2 kinase domain B 5.37 pKd 4300 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length MST4 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for MST4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
ChEMBL Binding constant for MTOR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for NEK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for NEK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 11/Serine/threonine-protein kinase Nek11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5638] [GtoPdb: 2116] [UniProtKB: Q8NG66]
ChEMBL Binding constant for NEK11 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for NEK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for NEK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for NEK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957]
ChEMBL Binding constant for NEK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8]
ChEMBL Binding constant for NEK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for NEK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
ChEMBL Binding constant for NEK6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for NEK6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length NEK7 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for NEK7 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
NIMA related kinase 9/Serine/threonine-protein kinase NEK9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for NEK9 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for NEK9 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84]
ChEMBL Binding constant for NIM1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length NLK B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for NLK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
oxidative stress responsive kinase 1/Serine/threonine-protein kinase OSR1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163104] [GtoPdb: 2132] [UniProtKB: O95747]
ChEMBL Binding constant for OSR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
ChEMBL Binding constant for PAK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PAK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PAK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PAK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
ChEMBL Binding constant for full-length PAK3 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PAK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PAK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PAK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PAK6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PAK6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286]
ChEMBL Binding constant for PAK7/PAK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PAK7 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PCTK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PCTK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length PCTK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PCTK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002]
ChEMBL Binding constant for full-length PCTK3 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PCTK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 14/Serine/threonine-protein kinase PFTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921]
ChEMBL Binding constant for full-length PFTK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PFTK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
cyclin dependent kinase 15/Serine/threonine-protein kinase PFTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5856] [GtoPdb: 1968] [UniProtKB: Q96Q40]
ChEMBL Binding constant for PFTAIRE2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PIM1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PIM1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
ChEMBL Binding constant for PIM2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PIM2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86]
ChEMBL Binding constant for PIM3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PIM3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Serine/threonine-protein kinase pknB in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908385] [UniProtKB: P9WI81]
ChEMBL Binding constant for PKNB(M.tuberculosis) kinase domain B 5.7 pKd 2000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL Binding constant for PLK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PLK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
polo like kinase 2/Serine/threonine-protein kinase PLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5938] [GtoPdb: 2169] [UniProtKB: Q9NYY3]
ChEMBL Binding constant for PLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
ChEMBL Binding constant for PLK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PLK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PLK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PLK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817]
ChEMBL Binding constant for full-length PRKX B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PRKX kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
pre-mRNA processing factor kinase PRP4K/Serine/threonine-protein kinase PRP4 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908382] [GtoPdb: 2177] [UniProtKB: Q13523]
ChEMBL Binding constant for PRP4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
ChEMBL Binding constant for RAF1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RAF1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
ChEMBL Binding constant for ACVRL1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ACVRL1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2]
ChEMBL Binding constant for full-length RIOK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RIOK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
RIO kinase 2/Serine/threonine-protein kinase RIO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6000] [GtoPdb: 2187] [UniProtKB: Q9BVS4]
ChEMBL Binding constant for RIOK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730]
ChEMBL Binding constant for full-length RIOK3 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RIOK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RIPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RIPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SH3 domain binding kinase 1/Serine/threonine-protein kinase SBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163129] [GtoPdb: 2193] [UniProtKB: Q52WX2]
ChEMBL Binding constant for SBK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141]
ChEMBL Inhibition of SGK B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
ChEMBL Binding constant for SGK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059]
ChEMBL Binding constant for SNF1LK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for SIK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length SNF1LK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for SIK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SIK family kinase 3/Serine/threonine-protein kinase SIK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6149] [GtoPdb: 2199] [UniProtKB: Q9Y2K2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for QSK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4]
ChEMBL Binding constant for full-length SRPK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for SRPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SRSF protein kinase 2/Serine/threonine-protein kinase SRPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362]
ChEMBL Binding constant for full-length SRPK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for SRPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1]
ChEMBL Binding constant for SRPK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TAOK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TAOK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TAOK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TBK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18]
ChEMBL Binding constant for full-length TNNI3K B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TNNI3K kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8]
ChEMBL Binding constant for TLK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TLK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8]
ChEMBL Binding constant for TLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ULK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
ChEMBL Binding constant for ULK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ULK3 kinase domain B 5.19 pKd 6400 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07]
ChEMBL Binding constant for VRK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
WEE1 G2 checkpoint kinase/Serine/threonine-protein kinase WEE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for WEE1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for WEE1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Signal recognition particle receptor subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105934] [UniProtKB: P08240]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
SNF related kinase/SNF-related serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908384] [GtoPdb: 2202] [UniProtKB: Q9NRH2]
ChEMBL Binding constant for SNRK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
mitogen-activated protein kinase kinase kinase 19/SPS1/STE20-related protein kinase YSK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6191] [GtoPdb: 2076] [UniProtKB: Q56UN5]
ChEMBL Binding constant for YSK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
STE20 related adaptor alpha/STE20-related kinase adapter protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795198] [GtoPdb: 2227] [UniProtKB: Q7RTN6]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
serine/threonine kinase 39/STE20/SPS1-related proline-alanine-rich protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163108] [GtoPdb: 2224] [UniProtKB: Q9UEW8]
ChEMBL Binding constant for STK39 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
ChEMBL Binding constant for KIT kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for KIT(D816V) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for KIT(V559D,T670I) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for KIT(V559D,V654A) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for KIT(V559D) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to human KIT incubated for 1 hr by kinase binding assay B 5 pKd >10000 nM Kd Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632]
ChEMBL Binding affinity to human KIT D816V mutant incubated for 1 hr by kinase binding assay B 5 pKd >10000 nM Kd Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632]
ChEMBL Binding constant for KIT kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(A829P) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(D816H) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(D816V) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(L576P) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(V559D) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(V559D,T670I) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for KIT(V559D,V654A) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105973] [UniProtKB: Q9P2R7]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
ChEMBL Binding constant for full-length TSSK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TSSK1B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TGFBR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TGFBR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TGFBR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TGFBR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Thyroid hormone receptor-associated protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105820] [UniProtKB: Q9Y2W1]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
TP53 regulating kinase/TP53-regulating kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938223] [GtoPdb: 2248] [UniProtKB: Q96S44]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TNIK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TNIK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TRPM6/Transient receptor potential cation channel subfamily M member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628470] [GtoPdb: 498] [UniProtKB: Q9BX84]
ChEMBL Binding constant for TRPM6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tubulin alpha 1a/Tubulin alpha-1 chain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4139] [GtoPdb: 2638] [UniProtKB: P68370]
ChEMBL Binding constant for ERBB4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase, membrane associated tyrosine/threonine 1/Tyrosine- and threonine-specific cdc2-inhibitory kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PKMYT1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PKMYT1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
ChEMBL Binding constant for TNK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TNK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 5.97 pKd 1062 nM Kd Science (2017) 358: null-null [PMID:29191878]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ABL1(E255K) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(H396P) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(M351T) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(Q252H) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(T315I) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(Y253F) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(E255K)-phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(F317I)-non phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(F317I)-phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(F317L)-non phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(F317L)-phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(Y253F)-phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1-non phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1-phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(M351T)-phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(Q252H)-non phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(Q252H)-phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(T315I)-non phosphorylated kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(H396P)-phosphorylated kinase domain B 5.17 pKd 6700 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(H396P)-non phosphorylated kinase domain B 5.35 pKd 4500 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for ABL1(T315I)-phosphorylated kinase domain B 5.66 pKd 2200 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for ABL2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
ChEMBL Binding constant for BLK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BLK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813]
ChEMBL Binding constant for full-length BMX B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BMX kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for PTK6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BRK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length BTK B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BTK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay B 7 pIC50 >100 nM IC50 Bioorg Med Chem (2020) 28: 115236-115236 [PMID:31843459]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for full-length CSK B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for CSK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of CSK B 5 pIC50 >10000 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
megakaryocyte-associated tyrosine kinase/Tyrosine-protein kinase CTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4175] [GtoPdb: 2101] [UniProtKB: P42679]
ChEMBL Binding constant for CTK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
FER tyrosine kinase/Tyrosine-protein kinase FER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for FER kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FER kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for FES kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FES kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769]
ChEMBL Binding constant for FGR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FGR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for FRK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FRK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for FYN kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FYN kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for HCK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for HCK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
ChEMBL Binding constant for ITK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ITK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for JAK1(Kin.Dom.1/JH2 - pseudokinase) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to JAK1 B 5 pKd >10000 nM Kd Bioorg Med Chem Lett (2010) 20: 7454-7457 [PMID:21106455]
ChEMBL Binding constant for JAK1(JH2domain-pseudokinase) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of JAK1 B 8.77 pKd 1.7 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for JAK1(JH1domain-catalytic) kinase domain B 8.8 pKd 1.6 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of JAK1 B 9.15 pKi 0.7 nM Ki J Med Chem (2012) 55: 5901-5921 [PMID:22591402]
ChEMBL Inhibition of human GST-fused JAK1 catalytic domain expressed in baculovirus-infected Sf9 cells using polyglutamic acid-tyrosine as substrate after 30 mins by ELISA B 9.15 pKi 0.7 nM Ki J Med Chem (2013) 56: 4521-4536 [PMID:23668484]
ChEMBL Inhibition of recombinant JAK1 (unknown origin) using Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins in presence of ATP B 9.15 pKi 0.7 nM Ki J Med Chem (2013) 56: 4764-4785 [PMID:23659214]
ChEMBL Inhibition of JAK1 (unknown origin) assessed as inhibition constant B 9.15 pKi 0.7 nM Ki J Med Chem (2021) 64: 1283-1345 [PMID:33481605]
ChEMBL Inhibition of human recombinant GST-tagged JAK1 using 5-FAM-KKSRGDYMTMQIG as substrate by peptide mobility shift assay B 9.17 pKi 0.68 nM Ki J Med Chem (2012) 55: 5901-5921 [PMID:22591402]
ChEMBL Inhibition of recombinant human JAK1 (854 to 1154 residues) expressed in insect cells using Y1-B as substrate incubated for 30 mins by microfluidic mobility shift assay B 9.19 pKi 0.64 nM Ki Bioorg Med Chem Lett (2019) 29: 1522-1531 [PMID:30981576]
ChEMBL Inhibition of JAK1 in IL6-stimulated human ME180 cells expressing stably integrated beta-lactamase reporter gene under control of sis-inducible element by fluorescence assay B 6.91 pIC50 124 nM IC50 J Med Chem (2017) 60: 9676-9690 [PMID:29156136]
ChEMBL Inhibition of JAK1 B 6.95 pIC50 112 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
ChEMBL Inhibition of JAK1 (unknown origin) B 6.95 pIC50 112 nM IC50 Eur J Med Chem (2023) 256: 115434-115434 [PMID:37148849]
ChEMBL Inhibition of JAK1 B 6.95 pIC50 112 nM IC50 J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISA B 6.96 pIC50 110 nM IC50 J Med Chem (2010) 53: 8468-8484 [PMID:21105711]
ChEMBL Inhibition of JAK1 in human PBMC cells assessed as inhibition of IL-6-induced MCP1 secretion B 7.02 pIC50 95 nM IC50 Bioorg Med Chem Lett (2016) 26: 1803-1808 [PMID:26927423]
ChEMBL Inhibition of JAK1 in human STAT6-bla-RA1 cells assessed as reduction in IL4-induced STAT6-signalling pre-incubated for 1 hrs before human recombinant IL4 addition and further incubated for 4 hrs fluorescence based assay B 7.06 pIC50 87 nM IC50 J Med Chem (2020) 63: 7008-7032 [PMID:32462873]
ChEMBL Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1 B 7.13 pIC50 74 nM IC50 J Med Chem (2014) 57: 9323-9342 [PMID:25369270]
ChEMBL Inhibition of recombinant JAK1 (unknown origin) using ULight-conjugated JAK-1(Tyr^1023) peptide as substrate measured after 90 mins by microplate reader B 7.48 pIC50 33 nM IC50 J Med Chem (2022) 65: 893-921 [PMID:33539089]
ChEMBL Inhibition of TEL-fused JAK1 expressed in Ba/F3 cells assessed as inhibition of STAT5 phosphorylation after 60 mins by AlphaScreen assay B 7.59 pIC50 26 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of JAK1 JH1 domain (unknown origin) using FITC-Ahx-KKSRGDYMTMQIG-NH2 peptide as substrate incubated for 60 mins in the presence of ATP by caliper microfluidic mobility shift technology B 7.77 pIC50 17 nM IC50 J Med Chem (2023) 66: 2161-2168 [PMID:36657024]
GtoPdb In a biochemical enzyme assay. - 7.82 pIC50 15 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK1 (unknown origin) B 7.82 pIC50 15.1 nM IC50 J Med Chem (2022) 65: 11949-11969 [PMID:36053746]
ChEMBL Inhibition of JAK1 (unknown origin) B 7.82 pIC50 15.1 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of human JAK1 using fluorescence labeled peptide as substrate and using 1 mM ATP by microfluidic based mobility shift assay B 7.82 pIC50 15 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK1 (unknown origin) B 7.82 pIC50 15 nM IC50 Bioorg Med Chem (2016) 24: 2660-2672 [PMID:27137359]
ChEMBL Inhibition of recombinant human JAK1 using 5'FAM-KKSRGDYMTMQID as substrate in presence of 1 mM ATP by mobility shift assay B 7.82 pIC50 15 nM IC50 J Med Chem (2018) 61: 1130-1152 [PMID:29298069]
ChEMBL Inhibition of JAK1 (unknown origin) B 7.82 pIC50 15 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged JAK1 (850 to 1154 residues) expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay B 8.08 pIC50 8.3 nM IC50 Bioorg Med Chem (2020) 28: 115236-115236 [PMID:31843459]
ChEMBL Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP B 8.21 pIC50 6.1 nM IC50 J Med Chem (2011) 54: 284-288 [PMID:21155605]
ChEMBL Inhibition of JAK1 by solution phase kinase assay B 8.39 pIC50 4.1 nM IC50 J Med Chem (2010) 53: 8468-8484 [PMID:21105711]
ChEMBL Inhibition of JAK1 (unknown origin) B 8.42 pIC50 3.8 nM IC50 Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299]
ChEMBL Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method B 8.43 pIC50 3.7 nM IC50 Bioorg Med Chem (2015) 23: 4846-4859 [PMID:26059596]
ChEMBL Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA B 8.43 pIC50 3.7 nM IC50 Bioorg Med Chem (2017) 25: 5311-5326 [PMID:28789911]
ChEMBL Inhibition of JAK1 (unknown origin) B 8.48 pIC50 3.3 nM IC50 Bioorg Med Chem (2014) 22: 1156-1162 [PMID:24398382]
ChEMBL Inhibition of recombinant GST-fused JAK1 kinase domain (852 to 1142) (unknown origin) using 5-FAM-KKSRGDYMTMQIG as substrate assessed as inhibition of substrate phosphorylation by peptide mobility shift assay B 8.49 pIC50 3.2 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting method B 8.49 pIC50 3.2 nM IC50 Bioorg Med Chem (2016) 24: 5036-5046 [PMID:27555284]
ChEMBL Inhibition of JAK1 (unknown origin) B 8.49 pIC50 3.2 nM IC50 J Med Chem (2023) 66: 5753-5773 [PMID:37057760]
ChEMBL Inhibition of recombinant GST-tagged human JAK1 (852 to 1142 residues) using IRS-1 as substrate in presence of 40 uM ATP by mobility shift assay B 8.51 pIC50 3.1 nM IC50 Bioorg Med Chem (2018) 26: 1495-1510 [PMID:29452839]
ChEMBL Inhibition of N-terminal GST-tagged human JAK1 catalytic domain (850 to 1154 residues) incubated for 40 mins in presence of TK substrate-biotin by TR-FRET assay B 8.51 pIC50 3.1 nM IC50 J Med Chem (2020) 63: 7008-7032 [PMID:32462873]
ChEMBL Inhibition of human recombinant N-terminal GST-tagged JAK1 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FRET assay B 8.52 pIC50 3 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of JAK1 (unknown origin) using Kinase/Tyr 6 peptide as substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader analysis B 8.52 pIC50 3 nM IC50 J Med Chem (2022) 65: 11949-11969 [PMID:36053746]
ChEMBL Inhibition of N-terminal GST-fused human JAK1 (850 to 1154 residues) expressed in baculovirus expression system using TK-substrate-biotin as substrate incubated for 60 mins in presence of ATP by fluorescence method B 8.54 pIC50 2.9 nM IC50 J Med Chem (2020) 63: 7163-7185 [PMID:32511913]
ChEMBL Inhibition of GST-tagged recombinant human JAK1 (866 to 1154 residues) expressed in baculovirus infection system by FRET assay B 8.66 pIC50 2.2 nM IC50 J Med Chem (2022) 65: 10674-10690 [PMID:35860875]
ChEMBL Inhibition of JAK1 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 1 hr in presence of [gamma-33P]ATP by scintillation counting analysis B 8.7 pIC50 2 nM IC50 Bioorg Med Chem Lett (2014) 24: 4969-4975 [PMID:25262541]
ChEMBL Inhibition of JAK1 (unknown origin) using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition measured after 1 hr by Topcount analysis B 8.7 pIC50 2 nM IC50 Bioorg Med Chem Lett (2013) 23: 2522-2526 [PMID:23541670]
ChEMBL Inhibition of recombinant human JAK1 (866-end residues) in presence of ATP B 8.7 pIC50 2 nM IC50 Bioorg Med Chem (2018) 26: 1495-1510 [PMID:29452839]
ChEMBL Inhibition of JAK1 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 mins by HTRF assay B 8.77 pIC50 1.7 nM IC50 Bioorg Med Chem (2019) 27: 2592-2597 [PMID:30926315]
ChEMBL Inhibition of recombinant human GST-tagged JAK1 catalytic domain (866 to 1154 residues) expressed in baculovirus expression system using TK-substrate-biotin preincubated for 5 mins followed by substrate addition measured after 30 mins by HTRF assay B 8.8 pIC50 1.6 nM IC50 Bioorg Med Chem (2018) 26: 4774-4786 [PMID:30139575]
ChEMBL Inhibition of JAK1 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by filtration assay B 8.8 pIC50 1.6 nM IC50 Bioorg Med Chem Lett (2013) 23: 2793-2800 [PMID:23540648]
ChEMBL Inhibition of JAK1 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 1 hr by scintillation counting analysis in presence of [gamma-33P]ATP B 8.8 pIC50 1.6 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
ChEMBL Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measured after 30 mins by Lanthascreen TR-FRET assay B 8.81 pIC50 1.55 nM IC50 J Med Chem (2021) 64: 958-979 [PMID:33428419]
ChEMBL Inhibition of JAK1 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding method B 8.85 pIC50 1.42 nM IC50 J Med Chem (2018) 61: 10440-10462 [PMID:30460842]
ChEMBL Inhibition of JAK1 (unknown origin) B 8.85 pIC50 1.4 nM IC50 Bioorg Med Chem Lett (2022) 74: 128905-128905 [PMID:35870730]
ChEMBL Inhibition of human JAK1 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subsequently measured after 1 hr by HTRF assay B 8.85 pIC50 1.4 nM IC50 Bioorg Med Chem (2019) 27: 1646-1657 [PMID:30853331]
ChEMBL Inhibition of GST-tagged recombinant human JAK1 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrate preincubated for 30 mins followed by ATP addition measured after 120 mins by HTRF assay B 8.89 pIC50 1.3 nM IC50 J Med Chem (2017) 60: 9676-9690 [PMID:29156136]
ChEMBL Inhibition of JAK1 (unknown origin) B 8.89 pIC50 1.3 nM IC50 Bioorg Med Chem Lett (2016) 26: 1803-1808 [PMID:26927423]
ChEMBL Inhibition of JAK1-JH1/JH2 domain (574 to 1154 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured after 90 mins by MS analysis B 8.89 pIC50 1.3 nM IC50 J Med Chem (2020) 63: 2915-2929 [PMID:32134643]
ChEMBL Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assay B 8.9 pIC50 1.26 nM IC50 J Med Chem (2023) 66: 16342-16363 [PMID:38031930]
ChEMBL Inhibition of human recombinant JAK1 B 9.1 pIC50 0.8 nM IC50 J Med Chem (2014) 57: 9323-9342 [PMID:25369270]
ChEMBL Inhibition of human JAK1 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric method B 9.3 pIC50 0.5 nM IC50 J Med Chem (2018) 61: 5350-5366 [PMID:29852068]
ChEMBL Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL2-induced STAT3 phosphorylation B 7.28 pEC50 53 nM EC50 J Med Chem (2012) 55: 5901-5921 [PMID:22591402]
ChEMBL Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins prior to IL6-induction measured after 30 to 45 mins B 7.28 pEC50 53 nM EC50 J Med Chem (2012) 55: 6176-6193 [PMID:22698084]
ChEMBL Inhibition of JAK1 (unknown origin) assessed as inhibition of STAT3 phosphorylation by cell-based assay B 7.28 pEC50 53 nM EC50 J Med Chem (2013) 56: 4521-4536 [PMID:23668484]
ChEMBL Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins B 7.28 pEC50 53 nM EC50 J Med Chem (2013) 56: 4764-4785 [PMID:23659214]
ChEMBL Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins in presence of whole blood B 7.37 pEC50 43 nM EC50 J Med Chem (2013) 56: 4764-4785 [PMID:23659214]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Binding constant for JAK2(Kin.Dom.2/JH1 - catalytic) kinase domain B 8.3 pKd 5 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to JAK2 B 8.3 pKd 5 nM Kd Bioorg Med Chem Lett (2010) 20: 7454-7457 [PMID:21106455]
ChEMBL Inhibition of JAK2 B 8.74 pKd 1.8 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for JAK2(JH1domain-catalytic) kinase domain B 9.24 pKd 0.58 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of JAK2 (unknown origin) B 9 pKi 1 nM Ki J Med Chem (2021) 64: 1283-1345 [PMID:33481605]
ChEMBL Inhibition of human recombinant JAK2 kinase domain using FITC-KGGEEEEYFELVKK as substrate by peptide mobility shift assay B 9 pKi 0.99 nM Ki J Med Chem (2012) 55: 5901-5921 [PMID:22591402]
ChEMBL Inhibition of JAK2 B 9.15 pKi 0.7 nM Ki J Med Chem (2012) 55: 5901-5921 [PMID:22591402]
ChEMBL Inhibition of human GST-fused JAK2 catalytic domain expressed in baculovirus-infected Sf9 cells using polyglutamic acid-tyrosine as substrate after 30 mins by ELISA B 9.15 pKi 0.7 nM Ki J Med Chem (2013) 56: 4521-4536 [PMID:23668484]
ChEMBL Inhibition of recombinant JAK2 (unknown origin) using Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins in presence of ATP B 9.15 pKi 0.7 nM Ki J Med Chem (2013) 56: 4764-4785 [PMID:23659214]
ChEMBL Inhibition of JAK2 V617F mutant in human HEL cells assessed as reduction in cell proliferation B 5.33 pIC50 4724 nM IC50 Bioorg Med Chem (2019) 27: 2592-2597 [PMID:30926315]
ChEMBL Inhibition of JAK2 V617F mutant in human HEL cells after 1 hr B 5.33 pIC50 4724 nM IC50 Bioorg Med Chem (2017) 25: 75-83 [PMID:27771180]
ChEMBL Inhibition of JAK2 homodimer in human monocytes assessed as inhibition of GM-CSF-induced STAT-5 phosphorylation preincubated for 60 mins followed by GM-CSF addition measured after 8 to 20 mins by FACS analysis B 5.86 pIC50 1377 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of JAK2 in human TF1 cells assessed as reduction in IL2-induced STAT6 phosphorylation at Tyr694/699 residues B 5.95 pIC50 1110 nM IC50 J Med Chem (2018) 61: 9030-9058 [PMID:29870256]
ChEMBL Inhibition of JAK2 in human whole blood assessed as inhibition of GM-CSF-induced pSTAT5 B 6.13 pIC50 740 nM IC50 J Med Chem (2014) 57: 9323-9342 [PMID:25369270]
ChEMBL Inhibition of JAK2 in human whole blood assessed as inhibition of TPO-stimulated STAT5 phosphorylation preincubated for 30 mins prior to TPO challenge measured after 15 mins by intracellular phosflow staining B 6.17 pIC50 682 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of JAK2 homodimer signaling pathway in human spiked CD34 +ve cells of whole blood assessed as reduction in EPO induced STAT5 phosphorylation preincubated for 45 mins followed by EPO addition and measured measured after 15 mins by FACS assay B 6.48 pIC50 328 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK2 homodimer in human CD34+ cells spiked into human whole blood assessed as inhibition of EPO-induced STAT-5 phosphorylation preincubated for 45 mins followed by EPO addition measured after 15 mins by FACS analysis B 6.52 pIC50 302 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of JAK2 in human TF-1 cells assessed as reduction in GM-CSF-induced cell proliferation B 6.56 pIC50 275.1 nM IC50 Bioorg Med Chem (2019) 27: 2592-2597 [PMID:30926315]
ChEMBL Inhibition of JAK2 in human TF1 cells assessed as suppression of cell growth B 6.56 pIC50 275.1 nM IC50 Bioorg Med Chem (2017) 25: 75-83 [PMID:27771180]
ChEMBL Inhibition of TEL-fused JAK2 expressed in Ba/F3 cells assessed as inhibition of STAT5 phosphorylation after 60 mins by AlphaScreen assay B 6.58 pIC50 265 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of JAK2 in human PBMC expressing CD14 assessed as inhibition of GM-CSF-induced STAT5a phosphorylation B 6.72 pIC50 190 nM IC50 Bioorg Med Chem Lett (2013) 23: 2522-2526 [PMID:23541670]
ChEMBL Inhibition of JAK2 in human monocytes expressing CD14 assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation B 6.74 pIC50 184 nM IC50 Bioorg Med Chem Lett (2013) 23: 2793-2800 [PMID:23540648]
ChEMBL Inhibition of JAK2 in human PBMC expressing CD14 assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis B 6.74 pIC50 184 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
ChEMBL Inhibition of JAK2 in human PBMC assessed as inhibition of TPO-stimulated STAT5 phosphorylation preincubated for 30 mins prior to TPO challenge measured after 15 mins by intracellular phosflow staining B 6.81 pIC50 155 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of JAK2 in human STAT5-irf1-bla TF1 cells assessed as reduction in EPO-induced STAT5-signalling pre-incubated for 1 hrs before EPO addition and further incubated for 4 hrs fluorescence based assay B 6.92 pIC50 120 nM IC50 J Med Chem (2020) 63: 7008-7032 [PMID:32462873]
ChEMBL Inhibition of JAK2 in GMCSF-stimulated human TF1 cells assessed as suppression of STAT5 phosphorylation preincubated for 2 hrs followed by GMCSF stimulation for 50 mins by FACS reader analysis B 7.02 pIC50 95 nM IC50 Bioorg Med Chem Lett (2016) 26: 2936-2941 [PMID:27130359]
GtoPdb In a biochemical enzyme assay. - 7.11 pIC50 77 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of JAK2 (unknown origin) B 7.11 pIC50 77.4 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of JAK2 (unknown origin) B 7.11 pIC50 77 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
ChEMBL Inhibition of human JAK2 using fluorescence labeled peptide as substrate and using 1 mM ATP by microfluidic based mobility shift assay B 7.11 pIC50 77 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK2 (unknown origin) B 7.11 pIC50 77 nM IC50 Bioorg Med Chem (2016) 24: 2660-2672 [PMID:27137359]
ChEMBL Inhibition of JAK2 in human CD34+ cells assessed as inhibition of EPO-mediated cell proliferation B 7.15 pIC50 71 nM IC50 Bioorg Med Chem Lett (2016) 26: 1803-1808 [PMID:26927423]
ChEMBL Inhibition of recombinant JAK2 (unknown origin) in presence of 0.1 mM ATP by alpha-screen assay B 7.36 pIC50 44 nM IC50 J Med Chem (2018) 61: 9030-9058 [PMID:29870256]
ChEMBL Inhibition of JAK2/JAK2 in human PBMC assessed as reduction in GM-CSF-induced STAT5 phosphorylation pre-incubated for 30 mins before GM-CSF stimulation for 30 mins AlphaLISAassay B 7.42 pIC50 38 nM IC50 J Med Chem (2020) 63: 2915-2929 [PMID:32134643]
ChEMBL Inhibition of GST-tagged JAK2 kinase B 7.48 pIC50 33 nM IC50 Bioorg Med Chem Lett (2009) 19: 5887-5892 [PMID:19762238]
ChEMBL Inhibition of JAK2 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presence of ATP by caliper microfluidic mobility shift technology B 7.59 pIC50 26 nM IC50 J Med Chem (2023) 66: 2161-2168 [PMID:36657024]
ChEMBL Inhibition of GST tagged recombinant human JAK2 expressed in baculovirus infection system by FRET assay B 7.59 pIC50 26 nM IC50 J Med Chem (2022) 65: 10674-10690 [PMID:35860875]
ChEMBL Inhibition of JAK2 B 7.7 pIC50 20 nM IC50 J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Inhibition of JAK2 (unknown origin) B 7.7 pIC50 20 nM IC50 Eur J Med Chem (2023) 256: 115434-115434 [PMID:37148849]
ChEMBL Inhibition of JAK 2 (unknown origin) B 7.7 pIC50 20 nM IC50 J Med Chem (2022) 65: 893-921 [PMID:33539089]
ChEMBL Inhibition of JAK2 B 7.7 pIC50 20 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
ChEMBL Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay B 7.84 pIC50 14.3 nM IC50 Bioorg Med Chem (2020) 28: 115236-115236 [PMID:31843459]
ChEMBL Inhibition of GST-tagged Jak2 expressed in insect cells using 20 uM ATP B 7.92 pIC50 12 nM IC50 J Med Chem (2011) 54: 284-288 [PMID:21155605]
ChEMBL Inhibition of JAK2 B 7.96 pIC50 11 nM IC50 Bioorg Med Chem Lett (2006) 16: 5633-5638 [PMID:16934457]
ChEMBL Inhibition of JAK2 by kinase-Glo luminescent assay B 7.96 pIC50 11 nM IC50 Bioorg Med Chem Lett (2007) 17: 1250-1253 [PMID:17189692]
ChEMBL Inhibition of JAK2 (unknown origin) B 7.97 pIC50 10.7 nM IC50 Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299]
ChEMBL Inhibition of recombinant JAK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assay B 8.02 pIC50 9.63 nM IC50 J Med Chem (2023) 66: 16342-16363 [PMID:38031930]
ChEMBL Inhibition of JAK2 (unknown origin) using Kinase/Tyr 6 peptide as substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader analysis B 8.13 pIC50 7.4 nM IC50 J Med Chem (2022) 65: 11949-11969 [PMID:36053746]
ChEMBL Inhibition of JAK2-JH1/JH2 domain (532 to 1132 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured after 90 mins by MS analysis B 8.3 pIC50 5 nM IC50 J Med Chem (2020) 63: 2915-2929 [PMID:32134643]
ChEMBL Inhibition of recombinant JAK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measured after 30 mins by Lanthascreen TR-FRET assay B 8.3 pIC50 4.98 nM IC50 J Med Chem (2021) 64: 958-979 [PMID:33428419]
ChEMBL Inhibition of recombinant human GST-tagged JAK2 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated for 5 mins followed by substrate addition measured after 30 mins by HTRF assay B 8.37 pIC50 4.3 nM IC50 Bioorg Med Chem (2018) 26: 4774-4786 [PMID:30139575]
ChEMBL Inhibition of recombinant human GST-tagged JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system using TK-biotin as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by HTRF assay B 8.37 pIC50 4.3 nM IC50 Bioorg Med Chem (2019) 27: 1562-1576 [PMID:30846405]
ChEMBL Inhibition of JAK2 (unknown origin) B 8.39 pIC50 4.1 nM IC50 J Med Chem (2023) 66: 5753-5773 [PMID:37057760]
ChEMBL Inhibition of recombinant JAK2 kinase domain (unknown origin) using FITC-KGGEEEEYFELVKK as substrate assessed as inhibition of substrate phosphorylation by peptide mobility shift assay B 8.39 pIC50 4.1 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP by TR-FRET assay B 8.39 pIC50 4.1 nM IC50 Bioorg Med Chem (2016) 24: 5036-5046 [PMID:27555284]
ChEMBL Inhibition of JAK2 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by filtration assay B 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2013) 23: 2793-2800 [PMID:23540648]
ChEMBL Inhibition of human recombinant N-terminal GST-tagged JAK2 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FRET assay B 8.4 pIC50 4 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of recombinant human GST-tagged JAK2 expressed in baculovirus expression system using Z'-LYTE Try6 peptide as substrate incubated for 1 hr by Z'-LYTE assay B 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2016) 26: 2936-2941 [PMID:27130359]
ChEMBL Inhibition of JAK2 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP B 8.4 pIC50 4 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
ChEMBL Inhibition of JAK2 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 1 hr in presence of [gamma-33P]ATP by scintillation counting analysis B 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2014) 24: 4969-4975 [PMID:25262541]
ChEMBL Inhibition of JAK2 (unknown origin) expressed in SF21 cells using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition measured after 30 mins by Topcount analysis B 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2013) 23: 2522-2526 [PMID:23541670]
ChEMBL Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA B 8.51 pIC50 3.1 nM IC50 Bioorg Med Chem (2017) 25: 5311-5326 [PMID:28789911]
ChEMBL Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method B 8.51 pIC50 3.1 nM IC50 Bioorg Med Chem (2015) 23: 4846-4859 [PMID:26059596]
ChEMBL Inhibition of human JAK2 by radiometric assay B 8.54 pIC50 2.9 nM IC50 J Med Chem (2021) 64: 2228-2241 [PMID:33570945]
ChEMBL Inhibition of GST-tagged recombinant human JAK2 expressed in baculovirus using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition after 30 mins by HTRF assay B 8.55 pIC50 2.8 nM IC50 Bioorg Med Chem (2017) 25: 75-83 [PMID:27771180]
ChEMBL Inhibition of N-terminal His-tagged human JAK2 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assay B 8.57 pIC50 2.7 nM IC50 J Med Chem (2020) 63: 7008-7032 [PMID:32462873]
ChEMBL Inhibition of JAK2 (unknown origin) B 8.57 pIC50 2.7 nM IC50 Bioorg Med Chem Lett (2022) 74: 128905-128905 [PMID:35870730]
ChEMBL Inhibition of JAK2 (unknown origin) B 8.6 pIC50 2.5 nM IC50 Bioorg Med Chem (2014) 22: 1156-1162 [PMID:24398382]
ChEMBL Inhibition of JAK2 by solution phase kinase assay B 8.8 pIC50 1.6 nM IC50 J Med Chem (2010) 53: 8468-8484 [PMID:21105711]
ChEMBL Inhibition of JAK2 (unknown origin) B 8.85 pIC50 1.4 nM IC50 Bioorg Med Chem Lett (2016) 26: 1803-1808 [PMID:26927423]
ChEMBL Inhibition of N-terminal GST-fused human JAK2 (880 to end residues) expressed in baculovirus infected Sf21 cells using TK-substrate-biotin as substrate incubated for 60 mins in presence of ATP by fluorescence method B 8.92 pIC50 1.2 nM IC50 J Med Chem (2020) 63: 7163-7185 [PMID:32511913]
ChEMBL Inhibition of JAK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding method B 8.96 pIC50 1.09 nM IC50 J Med Chem (2018) 61: 10440-10462 [PMID:30460842]
ChEMBL Inhibition of JAK2 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 mins by HTRF assay B 9 pIC50 1 nM IC50 Bioorg Med Chem (2019) 27: 2592-2597 [PMID:30926315]
ChEMBL Inhibition of human recombinant JAK2 B 9.22 pIC50 0.6 nM IC50 J Med Chem (2014) 57: 9323-9342 [PMID:25369270]
ChEMBL Inhibition of human JAK2 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subsequently measured after 1 hr by HTRF assay B 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem (2019) 27: 1646-1657 [PMID:30853331]
ChEMBL Inhibition of JAK2 in human PBMC expressing CD14 assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis B 6.74 pEC50 184 nM EC50 Bioorg Med Chem Lett (2014) 24: 4969-4975 [PMID:25262541]
ChEMBL Inhibition of JAK2 in human TF1 cells assessed as inhibition of EPO-induced STAT5 phosphorylation incubated for 20 mins prior to EPO-induction measured after 30 to 45 mins B 7.03 pEC50 93 nM EC50 J Med Chem (2012) 55: 6176-6193 [PMID:22698084]
ChEMBL Inhibition of JAK2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assay B 7.03 pEC50 93 nM EC50 J Med Chem (2013) 56: 4521-4536 [PMID:23668484]
ChEMBL Inhibition of JAK2 in human TF1 cells assessed as inhibition of EPO-induced STAT5 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins B 7.03 pEC50 93 nM EC50 J Med Chem (2013) 56: 4764-4785 [PMID:23659214]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649049] [GtoPdb: 2048] [UniProtKB: Q62120]
ChEMBL Inhibition of JAK2 in C57BL/6 mouse whole blood assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric analysis B 5.69 pIC50 2040 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075225] [GtoPdb: 2048] [UniProtKB: Q62689]
ChEMBL Inhibition of JAK2 in Lewis rat T cells assessed as reduction in ConA/CD3/CD28-induced cell proliferation measured after 72 hrs by alamar blue staining based fluorescence assay B 5.28 pIC50 5300 nM IC50 Bioorg Med Chem (2019) 27: 1562-1576 [PMID:30846405]
ChEMBL Inhibition of JAK2 in Lewis rat T cells assessed as reduction in IL-2-induced cell proliferation measured after 72 hrs by alamar blue staining based fluorescence assay B 5.74 pIC50 1840 nM IC50 Bioorg Med Chem (2019) 27: 1562-1576 [PMID:30846405]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domain B 8.66 pKd 2.2 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to JAK3 B 8.66 pKd 2.2 nM Kd Bioorg Med Chem Lett (2010) 20: 7454-7457 [PMID:21106455]
ChEMBL Inhibition of JAK3 B 9.15 pKd 0.7 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for JAK3(JH1domain-catalytic) kinase domain B 9.8 pKd 0.16 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of JAK3 B 9 pKi 1 nM Ki Chem Biol (2005) 12: 621-637 [PMID:15975507]
ChEMBL Inhibition of JAK3 B 9.4 pKi 0.4 nM Ki J Med Chem (2012) 55: 5901-5921 [PMID:22591402]
ChEMBL Inhibition of human GST-fused JAK3 catalytic domain expressed in baculovirus-infected Sf9 cells using polyglutamic acid-tyrosine as substrate after 30 mins by ELISA B 9.4 pKi 0.4 nM Ki J Med Chem (2013) 56: 4521-4536 [PMID:23668484]
ChEMBL Inhibition of JAK3 (unknown origin) using Leu-Pro-Leu-Asp-Lys-Asp-Tyr-Tyr-Val-Val-Arg as substrate after 30 mins in presence of ATP B 9.4 pKi 0.4 nM Ki J Med Chem (2013) 56: 4764-4785 [PMID:23659214]
ChEMBL Inhibition of human recombinant JAK3 kinase domain using FITC-KGGEEEEYFELVKK as substrate by peptide mobility shift assay B 9.62 pKi 0.24 nM Ki J Med Chem (2012) 55: 5901-5921 [PMID:22591402]
ChEMBL Inhibition of JAK3 (unknown origin) B 9.7 pKi 0.2 nM Ki J Med Chem (2021) 64: 1283-1345 [PMID:33481605]
ChEMBL Inhibition of recombinant human JAK3 using FITC-KGGEEEEYFELVKK as substrate in presence of 1 mM ATP by mobility shift assay B 5.1 pIC50 >=8000 nM IC50 J Med Chem (2018) 61: 1130-1152 [PMID:29298069]
ChEMBL Inhibition of JAK3 in human SZ4 cells assessed as reduction in IL2-stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL2 stimulation and measured after 15 mins by MSD assay B 5.92 pIC50 1210 nM IC50 J Med Chem (2018) 61: 10440-10462 [PMID:30460842]
ChEMBL Inhibition of JAK3 in human HT-2 cells assessed as reduction in IL-2-induced cell proliferation B 6.81 pIC50 156 nM IC50 Bioorg Med Chem (2019) 27: 2592-2597 [PMID:30926315]
ChEMBL Inhibition of JAK3 (unknown origin) using Kinase/Tyr 6 peptide as substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader analysis B 7.03 pIC50 93.5 nM IC50 J Med Chem (2022) 65: 11949-11969 [PMID:36053746]
ChEMBL Inhibition of recombinant JAK3 (unknown origin) measured after 90 mins by microplate reader B 7.12 pIC50 76 nM IC50 J Med Chem (2022) 65: 893-921 [PMID:33539089]
ChEMBL Inhibition of JAK3 (unknown origin) B 7.26 pIC50 55 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of JAK3 (unknown origin) B 7.26 pIC50 55 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
ChEMBL Inhibition of human JAK3 using fluorescence labeled peptide as substrate and using 1 mM ATP by microfluidic based mobility shift assay B 7.26 pIC50 55 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of JAK3 (unknown origin) B 7.26 pIC50 55 nM IC50 Bioorg Med Chem (2016) 24: 2660-2672 [PMID:27137359]
GtoPdb In a biochemical enzyme assay. - 7.26 pIC50 55 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of TEL-fused JAK3 expressed in Ba/F3 cells assessed as inhibition of STAT5 phosphorylation after 60 mins by AlphaScreen assay B 7.27 pIC50 54 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 1 mM ATP by HTRF assay B 7.3 pIC50 50 nM IC50 J Med Chem (2019) 62: 1054-1066 [PMID:30615446]
ChEMBL Inhibition of JAK3 (unknown origin) B 7.47 pIC50 34 nM IC50 J Med Chem (2023) 66: 5753-5773 [PMID:37057760]
ChEMBL Inhibition of Jak3-mediated IL15-induced Stat5 phosphorylation in human MO7 cells by cell-based assay B 7.62 pIC50 24 nM IC50 J Med Chem (2011) 54: 284-288 [PMID:21155605]
ChEMBL Inhibition of JAK3 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presence of ATP by caliper microfluidic mobility shift technology B 7.68 pIC50 21 nM IC50 J Med Chem (2023) 66: 2161-2168 [PMID:36657024]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged JAK3 (781 to end residues) expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ADP-Glo kinase assay B 7.7 pIC50 20.1 nM IC50 Bioorg Med Chem Lett (2023) 92: 129389-129389 [PMID:37379957]
ChEMBL Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay B 7.85 pIC50 14.1 nM IC50 Bioorg Med Chem (2020) 28: 115236-115236 [PMID:31843459]
ChEMBL Inhibition of JAK3 by kinase-Glo luminescent assay B 7.89 pIC50 13 nM IC50 Bioorg Med Chem Lett (2007) 17: 1250-1253 [PMID:17189692]
ChEMBL Inhibition of JAK3 B 7.89 pIC50 13 nM IC50 Bioorg Med Chem Lett (2006) 16: 5633-5638 [PMID:16934457]
ChEMBL Covalent inhibition of recombinant recombinant human GST-tagged JAK3(781 to 1124 residues) expressed in baculovirus expression system incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assay B 7.96 pIC50 11 nM IC50 Bioorg Med Chem Lett (2022) 64: 128680-128680 [PMID:35306167]
ChEMBL Inhibition of JAK3 (unknown origin) B 7.96 pIC50 10.9 nM IC50 Bioorg Med Chem (2014) 22: 1156-1162 [PMID:24398382]
ChEMBL Inhibition of JAK3-JH1/JH2 domain (512 to 1124 residues) (unknown origin) pre-incubated before NH2-KGGEEEEYFELVKK-CO2 substrate addition and measured after 45 mins by MS analysis B 8.07 pIC50 8.5 nM IC50 J Med Chem (2020) 63: 2915-2929 [PMID:32134643]
ChEMBL Inhibition of GST-tagged Jak3 expressed in insect cells using 18 uM ATP B 8.1 pIC50 8 nM IC50 J Med Chem (2011) 54: 284-288 [PMID:21155605]
ChEMBL Inhibition of GST tagged recombinant human JAK3 expressed in baculovirus infection system by FRET assay B 8.17 pIC50 6.7 nM IC50 J Med Chem (2022) 65: 10674-10690 [PMID:35860875]
GtoPdb - - 8.22 pIC50 6 nM IC50 Future Med Chem (2016) 8: 1537-51 [PMID:27572962]
ChEMBL Inhibition of GST-tagged JAK3 kinase B 8.3 pIC50 5 nM IC50 Bioorg Med Chem Lett (2009) 19: 5887-5892 [PMID:19762238]
ChEMBL Inhibition of recombinant human GST-tagged JAK3 expressed in baculovirus expression system using Z'-LYTE Try6 peptide as substrate incubated for 1 hr by Z'-LYTE assay B 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2016) 26: 2936-2941 [PMID:27130359]
ChEMBL Inhibition of recombinant human JAK3 (781 to 1124 residues) expressed in baculovirus expression system assessed as reduction in polypeptide substrate phosphorylation in presence of ATP by ELISA B 8.46 pIC50 3.5 nM IC50 J Med Chem (2018) 61: 5350-5366 [PMID:29852068]
ChEMBL Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA B 8.48 pIC50 3.3 nM IC50 J Med Chem (2010) 53: 8468-8484 [PMID:21105711]
ChEMBL Inhibition of JAK3 by solution phase kinase assay B 8.49 pIC50 3.2 nM IC50 J Med Chem (2010) 53: 8468-8484 [PMID:21105711]
ChEMBL Inhibition of JAK3 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP B 8.66 pIC50 2.2 nM IC50 J Med Chem (2013) 56: 345-356 [PMID:23214979]
ChEMBL Inhibition of JAK3 (unknown origin) using [33gammaP]ATP and Biotin-KAIETDKEYYTVKD as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by filtration assay B 8.66 pIC50 2.2 nM IC50 Bioorg Med Chem Lett (2013) 23: 2793-2800 [PMID:23540648]
ChEMBL Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated for 5 mins followed by substrate addition measured after 30 mins by HTRF assay B 8.68 pIC50 2.1 nM IC50 Bioorg Med Chem (2018) 26: 4774-4786 [PMID:30139575]
ChEMBL Inhibition of JAK3 (unknown origin) using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition measured after 30 mins by Topcount analysis B 8.7 pIC50 2 nM IC50 Bioorg Med Chem Lett (2013) 23: 2522-2526 [PMID:23541670]
ChEMBL Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assay B 8.77 pIC50 1.7 nM IC50 J Med Chem (2019) 62: 1054-1066 [PMID:30615446]
ChEMBL Inhibition of JAK3 (unknown origin) measured after 1 hr in presence of ATP by TR-FRET assay B 8.8 pIC50 1.6 nM IC50 Bioorg Med Chem (2016) 24: 5036-5046 [PMID:27555284]
ChEMBL Inhibition of recombinant JAK3 kinase domain (unknown origin) using FITC-KGGEEEEYFELVKK as substrate assessed as inhibition of substrate phosphorylation by peptide mobility shift assay B 8.8 pIC50 1.6 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of N-terminal His-tagged human JAK3 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assay B 8.82 pIC50 1.5 nM IC50 J Med Chem (2020) 63: 7008-7032 [PMID:32462873]
ChEMBL Inhibition of JAK3 (unknown origin) B 8.85 pIC50 1.4 nM IC50 Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299]
ChEMBL Inhibition of GST-tagged recombinant human cytoplasmic JAK3 expressed in baculovirus using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition after 30 mins by HTRF assay B 8.92 pIC50 1.2 nM IC50 Bioorg Med Chem (2017) 25: 75-83 [PMID:27771180]
ChEMBL Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mins in presence of ATP by fluorescence method B 8.96 pIC50 1.1 nM IC50 J Med Chem (2020) 63: 7163-7185 [PMID:32511913]
ChEMBL Inhibition of JAK3 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 mins by HTRF assay B 8.96 pIC50 1.1 nM IC50 Bioorg Med Chem (2019) 27: 2592-2597 [PMID:30926315]
GtoPdb - - 9 pIC50 1 nM IC50 J Med Chem (2010) 53: 8468-84 [PMID:21105711];
Science (2003) 302: 875-8 [PMID:14593182]
ChEMBL Inhibition of JAK3 B 9 pIC50 1 nM IC50 J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Inhibition of JAK3 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured after 1 hr in presence of [gamma-33P]ATP by scintillation counting analysis B 9 pIC50 1 nM IC50 Bioorg Med Chem Lett (2014) 24: 4969-4975 [PMID:25262541]
ChEMBL Inhibition of JAK3 (unknown origin) B 9 pIC50 1 nM IC50 J Med Chem (2018) 61: 9811-9840 [PMID:29969256]
ChEMBL Inhibition of JAK 3 (unknown origin) B 9 pIC50 1 nM IC50 J Med Chem (2022) 65: 893-921 [PMID:33539089]
ChEMBL Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA B 9 pIC50 1 nM IC50 J Med Chem (2010) 53: 8468-8484 [PMID:21105711]
ChEMBL Inhibition of JAK3 (unknown origin) B 9 pIC50 1 nM IC50 Eur J Med Chem (2023) 256: 115434-115434 [PMID:37148849]
ChEMBL Inhibition of recombinant JAK3 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assay B 9 pIC50 0.99 nM IC50 J Med Chem (2023) 66: 16342-16363 [PMID:38031930]
ChEMBL Inhibition of recombinant JAK3 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measured after 30 mins by Lanthascreen TR-FRET assay B 9.01 pIC50 0.98 nM IC50 J Med Chem (2021) 64: 958-979 [PMID:33428419]
ChEMBL Inhibition of recombinant human GST-tagged JAK3 cytoplasmic domain (781 to 1124 residues) expressed in baculovirus expression system using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and measured after 30 mins by HTRF assay B 9.05 pIC50 0.9 nM IC50 Eur J Med Chem (2020) 191: 112148-112148 [PMID:32097841]
ChEMBL Inhibition of JAK3 (unknown origin) B 9.1 pIC50 0.8 nM IC50 Bioorg Med Chem Lett (2022) 74: 128905-128905 [PMID:35870730]
ChEMBL Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate and ATP incubated for 1 hr by ELISA method B 9.1 pIC50 0.8 nM IC50 Bioorg Med Chem (2015) 23: 4846-4859 [PMID:26059596]
ChEMBL Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA B 9.1 pIC50 0.8 nM IC50 Bioorg Med Chem (2017) 25: 5311-5326 [PMID:28789911]
ChEMBL Inhibition of human JAK3 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subsequently measured after 1 hr by HTRF assay B 9.15 pIC50 0.7 nM IC50 Bioorg Med Chem (2019) 27: 1646-1657 [PMID:30853331]
ChEMBL Inhibition of human recombinant N-terminal GST-tagged JAK3 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FRET assay B 9.22 pIC50 0.6 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of JAK3 (unknown origin) B 9.46 pIC50 0.35 nM IC50 Bioorg Med Chem Lett (2016) 26: 1803-1808 [PMID:26927423]
ChEMBL Inhibition of GST-tagged recombinant human JAK3 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrate preincubated for 30 mins followed by ATP addition measured after 120 mins by HTRF assay B 9.47 pIC50 0.34 nM IC50 J Med Chem (2017) 60: 9676-9690 [PMID:29156136]
ChEMBL Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of 10 uM [gamma33P]ATP by radiometric method B 9.54 pIC50 0.29 nM IC50 J Med Chem (2018) 61: 5350-5366 [PMID:29852068]
ChEMBL Inhibition of JAK3 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding method B 9.62 pIC50 0.24 nM IC50 J Med Chem (2018) 61: 10440-10462 [PMID:30460842]
ChEMBL Inhibition of JAK3 (unknown origin) B 8.3 pEC50 <5 nM EC50 J Med Chem (2022) 65: 955-982 [PMID:34081439]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5250] [GtoPdb: 2049] [UniProtKB: Q62137]
ChEMBL Inhibition of JAK3 in mouse T cells assessed as reduction in IL2-stimulated cell proliferation measured after 72 hrs by MTS assay B 5.82 pIC50 1500 nM IC50 Eur J Med Chem (2020) 191: 112148-112148 [PMID:32097841]
ChEMBL Inhibition of JAK3 in mouse T cells assessed as reduction in anti-CD3/-CD28-stimulated cell proliferation measured after 72 hrs by MTS assay B 5.86 pIC50 1380 nM IC50 Eur J Med Chem (2020) 191: 112148-112148 [PMID:32097841]
ChEMBL Inhibition of JAK3 in mouse HT2 cells assessed as suppression of cell growth B 6.81 pIC50 156 nM IC50 Bioorg Med Chem (2017) 25: 75-83 [PMID:27771180]
ChEMBL Inhibition of Jak3-mediated IL2-induced Stat5 phosphorylation in mouse CTLL cells by cell-based assay B 7.32 pIC50 48 nM IC50 J Med Chem (2011) 54: 284-288 [PMID:21155605]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295857] [GtoPdb: 2049] [UniProtKB: Q63272]
ChEMBL Inhibition of JAK3 in rat splenocytic T cells assessed as reduction in IL-2-induced cell proliferation after 72 hrs by MTS assay B 5.92 pIC50 1200 nM IC50 Bioorg Med Chem (2018) 26: 4774-4786 [PMID:30139575]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for LCK kinase domain B 5.74 pKd 1800 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for LCK kinase domain B 6.34 pKd 460 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of Lck B 5.41 pIC50 3870 nM IC50 J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Inhibition of Lck B 5.41 pIC50 3870 nM IC50 Science (2003) 302: 875-878 [PMID:14593182]
ChEMBL Inhibition of N-terminal His6-tagged recombinant full-length human Lck using TK-substrate-biotin as substrate incubated for 60 mins in presence of ATP by fluorescence method B 6.47 pIC50 340 nM IC50 J Med Chem (2020) 63: 7163-7185 [PMID:32511913]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for LYN kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for LYN kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for FLT3(N841I) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT3(D835H) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT3(D835Y) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for FLT3(ITD) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT3(D835Y) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for FLT3(ITD) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for FLT3(K663Q) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for FLT3(N841I) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for FLT3(R834Q) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for FLT3(D835H) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for RET(M918T) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RET kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for RET kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RET(V804L) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for RET(V804M) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for RET(M918T) kinase domain B 5.48 pKd 3300 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590]
ChEMBL Binding constant for TIE1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TIE1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
ChEMBL Binding constant for TYRO3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TYRO3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
ChEMBL Binding constant for AXL kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for AXL kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for SRC kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for SRC kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6]
ChEMBL Binding constant for SRMS kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for SRMS kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for SYK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for SYK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TEC kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TEC kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
ChEMBL Binding constant for TIE2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TIE2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
ChEMBL Binding constant for TXK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for TXK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for TYK2(JH2domain-pseudokinase) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Binding constant for TYK2(Kin.Dom.2/JH1 - catalytic) kinase domain B 6.21 pKd 620 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to TYK2 B 6.21 pKd 620 nM Kd Bioorg Med Chem Lett (2010) 20: 7454-7457 [PMID:21106455]
ChEMBL Binding affinity to TYK2 B 6.6 pKd 250 nM Kd J Med Chem (2008) 51: 8012-8018 [PMID:19053756]
ChEMBL Binding constant for TYK2(JH1domain-catalytic) kinase domain B 8.32 pKd 4.8 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
ChEMBL Inhibition of TYK2 B 8.11 pKi 7.8 nM Ki J Med Chem (2012) 55: 5901-5921 [PMID:22591402]
ChEMBL Inhibition of TYK2 (unknown origin) B 8.11 pKi 7.8 nM Ki J Med Chem (2013) 56: 4521-4536 [PMID:23668484]
ChEMBL Inhibition of recombinant TYK2 (unknown origin) using Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins in presence of ATP B 8.14 pKi 7.3 nM Ki J Med Chem (2013) 56: 4764-4785 [PMID:23659214]
ChEMBL Inhibition of TYK2 (unknown origin) B 8.36 pKi 4.4 nM Ki J Med Chem (2021) 64: 1283-1345 [PMID:33481605]
ChEMBL Inhibition of human recombinant GST-tagged TYK2 using 5-FAM-KKSRGDYMTMQIG as substrate by peptide mobility shift assay B 8.36 pKi 4.39 nM Ki J Med Chem (2012) 55: 5901-5921 [PMID:22591402]
ChEMBL Inhibition of TEL-fused TYK2 expressed in Ba/F3 cells assessed as inhibition of STAT5 phosphorylation after 60 mins by AlphaScreen assay B 5.92 pIC50 1200 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
GtoPdb In a biochemical enzyme assay. - 6.31 pIC50 489 nM IC50 J Med Chem (2014) 57: 5023-38 [PMID:24417533]
ChEMBL Inhibition of TYK2 (unknown origin) B 6.31 pIC50 489 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of human TYK2 using fluorescence labeled peptide as substrate and using 1 mM ATP level by microfluidic based mobility shift assay B 6.31 pIC50 489 nM IC50 J Med Chem (2018) 61: 8597-8612 [PMID:30113844]
ChEMBL Inhibition of TYK2 (unknown origin) B 6.31 pIC50 489 nM IC50 Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986]
ChEMBL Inhibition of Tyk2 (unknown origin) B 6.59 pIC50 260 nM IC50 Bioorg Med Chem (2019) 27: 2592-2597 [PMID:30926315]
ChEMBL Inhibition of recombinant human N-terminal GST-tagged TYK2 (871 to 1187 residues) expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay B 6.63 pIC50 235 nM IC50 Bioorg Med Chem (2020) 28: 115236-115236 [PMID:31843459]
ChEMBL Inhibition of TYK2 (unknown origin) by caliper technology B 6.68 pIC50 208 nM IC50 J Med Chem (2023) 66: 2161-2168 [PMID:36657024]
ChEMBL Inhibition of GST-tagged Tyk2 expressed in insect cells using 35 uM ATP B 6.75 pIC50 176 nM IC50 J Med Chem (2011) 54: 284-288 [PMID:21155605]
ChEMBL Inhibition of human TYK2 by FRET assay B 6.95 pIC50 112 nM IC50 J Med Chem (2022) 65: 10674-10690 [PMID:35860875]
ChEMBL Inhibition of N-terminal GST-tagged human TYK2 catalytic domain (871 to 1187 residues) incubated for 40 mins in presence of TK substrate-biotin by TR-FRET assay B 7.14 pIC50 72 nM IC50 J Med Chem (2020) 63: 7008-7032 [PMID:32462873]
ChEMBL Inhibition of human recombinant N-terminal GST-tagged TYK2 expressed in Sf9 cells using Biotin-LC-EQEDEPEGDYFEWLE as substrate after 90 mins by TR-FRET assay B 7.28 pIC50 52 nM IC50 J Med Chem (2011) 54: 8440-8450 [PMID:22087750]
ChEMBL Inhibition of N-terminal GST-fused human TyK2 (871 to end residues) expressed in baculovirus expression system using TK-substrate-biotin as substrate incubated for 60 mins in presence of ATP by fluorescence method B 7.38 pIC50 42 nM IC50 J Med Chem (2020) 63: 7163-7185 [PMID:32511913]
ChEMBL Inhibition of recombinant human GST-tagged TYK2 catalytic domain expressed in baculovirus expression system using TK-substrate-biotin preincubated for 5 mins followed by substrate addition measured after 30 mins by HTRF assay B 7.45 pIC50 35.5 nM IC50 Bioorg Med Chem (2018) 26: 4774-4786 [PMID:30139575]
ChEMBL Inhibition of recombinant GST-fused TYK2 kinase domain (870 to 1187) (unknown origin) harboring C1187S modification using 5-FAM-KKSRGDYMTMQIG as substrate assessed as inhibition of substrate phosphorylation by peptide mobility shift assay B 7.47 pIC50 34 nM IC50 J Med Chem (2014) 57: 5023-5038 [PMID:24417533]
ChEMBL Inhibition of Tyk2 by solution phase kinase assay B 7.47 pIC50 34 nM IC50 J Med Chem (2010) 53: 8468-8484 [PMID:21105711]
ChEMBL Inhibition of human TYK2 using TK-substrate-biotin preincubated for 5 mins followed by substrate addition and further incubated for 30 mins and subsequently measured after 1 hr by HTRF assay B 7.49 pIC50 32.3 nM IC50 Bioorg Med Chem (2019) 27: 1646-1657 [PMID:30853331]
ChEMBL Inhibition of TYK2 (unknown origin) B 7.62 pIC50 24 nM IC50 Bioorg Med Chem Lett (2014) 24: 1116-1121 [PMID:24461299]
ChEMBL Inhibition of TYK2 (unknown origin) B 7.89 pIC50 12.8 nM IC50 Bioorg Med Chem Lett (2016) 26: 1803-1808 [PMID:26927423]
ChEMBL Inhibition of recombinant TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assay B 7.91 pIC50 12.4 nM IC50 J Med Chem (2023) 66: 16342-16363 [PMID:38031930]
ChEMBL Inhibition of N-terminal GST-tagged recombinant human TYK2 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrate preincubated for 30 mins followed by ATP addition measured after 120 mins by HTRF assay B 7.92 pIC50 12 nM IC50 J Med Chem (2017) 60: 9676-9690 [PMID:29156136]
ChEMBL Inhibition of TYK2 (unknown origin) preincubated for 20 mins followed by [33P]-ATP addition measured after 2 hrs by filter-binding method B 7.98 pIC50 10.38 nM IC50 J Med Chem (2018) 61: 10440-10462 [PMID:30460842]
ChEMBL Inhibition of recombinant TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr followed by anti-pSTAT1 antibody addition and measured after 30 mins by Lanthascreen TR-FRET assay B 8 pIC50 10.1 nM IC50 J Med Chem (2021) 64: 958-979 [PMID:33428419]
ChEMBL Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of 10 uM [gamma33P]ATP by radiometric method B 8.05 pIC50 9 nM IC50 J Med Chem (2018) 61: 5350-5366 [PMID:29852068]
ChEMBL Inhibition of Tyk2 (unknown origin) B 8.44 pIC50 3.6 nM IC50 Bioorg Med Chem (2014) 22: 1156-1162 [PMID:24398382]
ChEMBL Inhibition of TYK2 (unknown origin) B 9.4 pIC50 0.4 nM IC50 J Med Chem (2023) 66: 5753-5773 [PMID:37057760]
ChEMBL Inhibition of TYK2 in human NK92 cells assessed as inhibition of IL12-induced STAT4 phosphorylation incubated for 20 mins followed by IL12 challenge for 45 mins B 6.15 pEC50 710 nM EC50 J Med Chem (2013) 56: 4764-4785 [PMID:23659214]
ChEMBL Inhibition of TYK2 (unknown origin) assessed as inhibition of STAT4 phosphorylation by cell-based assay B 6.2 pEC50 625 nM EC50 J Med Chem (2013) 56: 4521-4536 [PMID:23668484]
ChEMBL Inhibition of TYK2 (unknown origin) B 8.3 pEC50 <5 nM EC50 J Med Chem (2022) 65: 955-982 [PMID:34081439]
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
ChEMBL Binding constant for YES kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for YES kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL Binding constant for ZAP70 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ZAP70 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Tyrosyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3179] [UniProtKB: P54577]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
U5 small nuclear ribonucleoprotein 200 kDa helicase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105972] [UniProtKB: O75643]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
aarF domain containing kinase 1/Uncharacterized aarF domain-containing protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105885] [GtoPdb: 1925] [UniProtKB: Q86TW2]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
coenzyme Q8B/Uncharacterized aarF domain-containing protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53]
ChEMBL Binding constant for full-length ADCK4 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ADCK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
aarF domain containing kinase 5/Uncharacterized aarF domain-containing protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105886] [GtoPdb: 1929] [UniProtKB: Q3MIX3]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
Uncharacterized protein FLJ45252 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105933] [UniProtKB: Q6ZSR9]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL Binding constant for FLT1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Binding constant for VEGFR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for VEGFR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
ChEMBL Binding constant for FLT4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105892] [UniProtKB: P49748]
ChEMBL Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. B 4.52 pKd >30000 nM Kd Science (2017) 358: null-null [PMID:29191878]
WEE2 oocyte meiosis inhibiting kinase/Wee1-like protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5095] [GtoPdb: 2279] [UniProtKB: P0C1S8]
ChEMBL Binding constant for WEE2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]