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RIO kinase 3

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Target id: 2188

Nomenclature: RIO kinase 3

Abbreviated Name: RIOK3

Family: RIO3 subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 519 18q11.2 RIOK3 RIO kinase 3
Mouse - 519 18 6.15 cM Riok3 RIO kinase 3
Rat - 519 18 p13 Riok3 RIO kinase 3
Previous and Unofficial Names Click here for help
SUDD
Database Links Click here for help
Alphafold O14730 (Hs), Q9DBU3 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5659 (Hs)
Ensembl Gene ENSG00000101782 (Hs), ENSMUSG00000024404 (Mm), ENSRNOG00000023376 (Rn)
Entrez Gene 8780 (Hs), 66878 (Mm), 361293 (Rn)
Human Protein Atlas ENSG00000101782 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:8780 (Hs), mmu:66878 (Mm), rno:361293 (Rn)
OMIM 603579 (Hs)
Pharos O14730 (Hs)
RefSeq Nucleotide NM_003831 (Hs), NM_024182 (Mm), NM_001108423 (Rn)
RefSeq Protein NP_003822 (Hs), NP_077144 (Mm), NP_001101893 (Rn)
UniProtKB O14730 (Hs), Q9DBU3 (Mm)
Wikipedia RIOK3 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: RIOK3
Ligand Sp. Type Action Value Parameter
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.1 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 7.2 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.1 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.7 pKd
PHA-665752 Small molecule or natural product Hs Inhibitor Inhibition 6.4 pKd
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.4 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.2 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.2 pKd
A-674563 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

RIO3 subfamily: RIO kinase 3. Last modified on 18/08/2014. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2188.