Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	2027	12q24.23	CIT	citron rho-interacting serine/threonine kinase
Mouse	-	2055	5 F	Cit	citron
Rat	-	2055	12q16	Cit	citron rho-interacting serine/threonine kinase

Previous and Unofficial Names

citron-K kinase | postsynaptic density protein (citron) | Cit-k | citron-N | CRIK-SK | serine/threonine-protein kinase 21 | STK21 | citron (rho-interacting, serine/threonine kinase 21)

Database Links
Alphafold	O14578 (Hs), P49025 (Mm)
BRENDA	2.7.11.1
CATH/Gene3D	2.30.29.30
ChEMBL Target	CHEMBL5579 (Hs)
Ensembl Gene	ENSG00000122966 (Hs), ENSMUSG00000029516 (Mm), ENSRNOG00000001143 (Rn)
Entrez Gene	11113 (Hs), 12704 (Mm), 83620 (Rn)
Human Protein Atlas	ENSG00000122966 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:11113 (Hs), mmu:12704 (Mm), rno:83620 (Rn)
OMIM	605629 (Hs)
Pharos	O14578 (Hs)
RefSeq Nucleotide	NM_001206999 (Hs), NM_007708 (Mm), NM_001029911 (Rn)
RefSeq Protein	NP_009105 (Hs), NP_031734 (Mm), NP_001025082 (Rn)
UniProtKB	O14578 (Hs), P49025 (Mm)
Wikipedia	CIT (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: CIT
Ligand Sp. Type Action Value Parameter A-674563 Hs Inhibitor Inhibition 7.9 pKd AST-487 Hs Inhibitor Inhibition 7.3 pKd lestaurtinib Hs Inhibitor Inhibition 7.1 pKd CHIR-265 Hs Inhibitor Inhibition 7.1 pKd SU-14813 Hs Inhibitor Inhibition 7.0 pKd alvocidib Hs Inhibitor Inhibition 7.0 pKd fedratinib Hs Inhibitor Inhibition 6.8 pKd GSK690693 Hs Inhibitor Inhibition 6.7 pKd motesanib Hs Inhibitor Inhibition 6.5 pKd staurosporine Hs Inhibitor Inhibition 6.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »