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coenzyme Q8A

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Target id: 1927

Nomenclature: coenzyme Q8A

Abbreviated Name: ADCK3

Family: ABC1-B subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 647 1q42.13 COQ8A coenzyme Q8A
Mouse 1 645 1 H4 Coq8a coenzyme Q8A
Rat 1 649 13q26 Coq8a coenzyme Q8A
Previous and Unofficial Names Click here for help
CABC1 | chaperone activity of bc1 complex-like, mitochondrial | chaperone, ABC1 activity of bc1 complex homolog | SCAR9 | ADCK3
Database Links Click here for help
Alphafold Q8NI60 (Hs), Q60936 (Mm), Q5BJQ0 (Rn)
BRENDA 2.7.11.-
ChEMBL Target CHEMBL5550 (Hs)
Ensembl Gene ENSG00000163050 (Hs), ENSMUSG00000026489 (Mm), ENSRNOG00000043201 (Rn)
Entrez Gene 56997 (Hs), 67426 (Mm), 360887 (Rn)
Human Protein Atlas ENSG00000163050 (Hs)
KEGG Enzyme 2.7.11.-
KEGG Gene hsa:56997 (Hs), mmu:67426 (Mm), rno:360887 (Rn)
OMIM 606980 (Hs)
Orphanet ORPHA140053 (Hs)
Pharos Q8NI60 (Hs)
RefSeq Nucleotide NM_020247 (Hs), NM_001163290 (Mm), NM_001013185 (Rn)
RefSeq Protein NP_064632 (Hs), NP_001156762 (Mm), NP_001013203 (Rn)
UniProtKB Q8NI60 (Hs), Q60936 (Mm), Q5BJQ0 (Rn)
Wikipedia COQ8A (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.-
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: ADCK3
Ligand Sp. Type Action Value Parameter
TG-100-115 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
dasatinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.7 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.0 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.0 pKd
canertinib Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 5.8 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.8 pKd
erlotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 5.7 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Coenzyme Q10 deficiency, primary, 4
Synonyms: Autosomal recessive ataxia due to ubiquinone deficiency [Orphanet: ORPHA139485]
Coenzyme Q10 deficiency disease [Disease Ontology: DOID:0050730]
Disease Ontology: DOID:0050730
OMIM: 612016
Orphanet: ORPHA139485

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

ABC1-B subfamily: coenzyme Q8A. Last modified on 18/08/2014. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1927.