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RIO kinase 1

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Target id: 2186

Nomenclature: RIO kinase 1

Abbreviated Name: RIOK1

Family: RIO1 subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 568 6p24.3 RIOK1 RIO kinase 1
Mouse - 567 13 A3.3 Riok1 RIO kinase 1
Rat - 566 17 p12 Riok1 RIO kinase 1
Previous and Unofficial Names Click here for help
AD034 | RRP10
Database Links Click here for help
Alphafold Q9BRS2 (Hs), Q922Q2 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5975 (Hs)
Ensembl Gene ENSG00000124784 (Hs), ENSMUSG00000021428 (Mm), ENSRNOG00000014049 (Rn)
Entrez Gene 83732 (Hs), 71340 (Mm), 291061 (Rn)
Human Protein Atlas ENSG00000124784 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:83732 (Hs), mmu:71340 (Mm), rno:291061 (Rn)
Pharos Q9BRS2 (Hs)
RefSeq Nucleotide NM_031480 (Hs), NM_024242 (Mm), NM_001100511 (Rn)
RefSeq Protein NP_113668 (Hs), NP_077204 (Mm), NP_001093981 (Rn)
UniProtKB Q9BRS2 (Hs), Q922Q2 (Mm)
Wikipedia RIOK1 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: RIOK1
Ligand Sp. Type Action Value Parameter
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.1 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 7.5 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 7.3 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.9 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.5 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.4 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 6.4 pKd
PHA-665752 Small molecule or natural product Hs Inhibitor Inhibition 6.3 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

RIO1 subfamily: RIO kinase 1. Last modified on 18/08/2014. Accessed on 30/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2186.