Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	568	6p24.3	RIOK1	RIO kinase 1
Mouse	-	567	13 A3.3	Riok1	RIO kinase 1
Rat	-	566	17 p12	Riok1	RIO kinase 1

Previous and Unofficial Names

AD034 | RRP10

Database Links
Alphafold	Q9BRS2 (Hs), Q922Q2 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL5975 (Hs)
Ensembl Gene	ENSG00000124784 (Hs), ENSMUSG00000021428 (Mm), ENSRNOG00000014049 (Rn)
Entrez Gene	83732 (Hs), 71340 (Mm), 291061 (Rn)
Human Protein Atlas	ENSG00000124784 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:83732 (Hs), mmu:71340 (Mm), rno:291061 (Rn)
Pharos	Q9BRS2 (Hs)
RefSeq Nucleotide	NM_031480 (Hs), NM_024242 (Mm), NM_001100511 (Rn)
RefSeq Protein	NP_113668 (Hs), NP_077204 (Mm), NP_001093981 (Rn)
UniProtKB	Q9BRS2 (Hs), Q922Q2 (Mm)
Wikipedia	RIOK1 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: RIOK1
Ligand Sp. Type Action Value Parameter lestaurtinib Hs Inhibitor Inhibition 8.1 pKd sunitinib Hs Inhibitor Inhibition 7.5 pKd KW-2449 Hs Inhibitor Inhibition 7.3 pKd fedratinib Hs Inhibitor Inhibition 7.0 pKd staurosporine Hs Inhibitor Inhibition 6.9 pKd tamatinib Hs Inhibitor Inhibition 6.5 pKd tozasertib Hs Inhibitor Inhibition 6.4 pKd dovitinib Hs Inhibitor Inhibition 6.4 pKd PHA-665752 Hs Inhibitor Inhibition 6.3 pKd SU-14813 Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »