Top ▲

serine/threonine kinase 32C

Click here for help

Target id: 1539

Nomenclature: serine/threonine kinase 32C

Abbreviated Name: YANK3

Family: YANK family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 486 10q26.3 STK32C serine/threonine kinase 32C
Mouse - 488 7 F4 Stk32c serine/threonine kinase 32C
Rat - 488 1q41 Stk32c serine/threonine kinase 32C
Previous and Unofficial Names Click here for help
PKE | Pkek
Database Links Click here for help
Alphafold Q86UX6 (Hs), Q8QZV4 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5405 (Hs)
Ensembl Gene ENSG00000165752 (Hs), ENSMUSG00000015981 (Mm), ENSRNOG00000006962 (Rn)
Entrez Gene 282974 (Hs), 57740 (Mm), 365381 (Rn)
Human Protein Atlas ENSG00000165752 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:282974 (Hs), mmu:57740 (Mm), rno:365381 (Rn)
Pharos Q86UX6 (Hs)
RefSeq Nucleotide NM_173575 (Hs), NM_021302 (Mm), NM_001108922 (Rn)
RefSeq Protein NP_775846 (Hs), NP_001156012 (Mm), NP_067277 (Mm), NP_001102392 (Rn)
UniProtKB Q86UX6 (Hs), Q8QZV4 (Mm)
Wikipedia STK32C (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: YANK3
Ligand Sp. Type Action Value Parameter
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.3 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.5 pKd
erlotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
GSK690693 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
masitinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
A-674563 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition <5.5 pKd
gefitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

Show »

1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

YANK family: serine/threonine kinase 32C. Last modified on 18/08/2014. Accessed on 25/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1539.