Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	507	19p13.3	MATK	megakaryocyte-associated tyrosine kinase
Mouse	-	505	10 C1	Matk	megakaryocyte-associated tyrosine kinase
Rat	-	467	7q11	Matk	megakaryocyte-associated tyrosine kinase

Previous and Unofficial Names

CHK | HHYLTK | hydroxyaryl-protein kinase | HYLTK | Lsk | protein kinase BATK | protein kinase HYL | tyrosine kinase MATK

Database Links
Alphafold	P42679 (Hs), P41242 (Mm), P41243 (Rn)
BRENDA	2.7.10.2
CATH/Gene3D	3.30.505.10
ChEMBL Target	CHEMBL4175 (Hs)
Ensembl Gene	ENSG00000007264 (Hs), ENSMUSG00000004933 (Mm), ENSRNOG00000020431 (Rn)
Entrez Gene	4145 (Hs), 17179 (Mm), 60450 (Rn)
Human Protein Atlas	ENSG00000007264 (Hs)
KEGG Enzyme	2.7.10.2
KEGG Gene	hsa:4145 (Hs), mmu:17179 (Mm), rno:60450 (Rn)
OMIM	600038 (Hs)
Pharos	P42679 (Hs)
RefSeq Nucleotide	NM_002378 (Hs), NM_010768 (Mm), NM_021859 (Rn)
RefSeq Protein	NP_002369 (Hs), NP_034898 (Mm), NP_068631 (Rn)
UniProtKB	P42679 (Hs), P41242 (Mm), P41243 (Rn)
Wikipedia	MATK (Hs)

Selected 3D Structures
	Description:  Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution PDB Id:  3US4 Resolution:  1.5Å Species:  Human References:

Enzyme Reaction
EC Number: 2.7.10.2

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2-3
Key to terms and symbols		Click column headers to sort
Target used in screen: CTK
Ligand Sp. Type Action Value Parameter staurosporine Hs Inhibitor Inhibition 6.6 pKd lestaurtinib Hs Inhibitor Inhibition 6.0 pKd AST-487 Hs Inhibitor Inhibition 5.9 pKd fedratinib Hs Inhibitor Inhibition 5.8 pKd NVP-TAE684 Hs Inhibitor Inhibition 5.6 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd erlotinib Hs Inhibitor Inhibition <5.5 pKd linifanib Hs Inhibitor Inhibition <5.5 pKd GSK690693 Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/CTK(MATK)
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM tofacitinib Hs Inhibitor Inhibition 66.9 Chk2 inhibitor II Hs Inhibitor Inhibition 68.5 dovitinib Hs Inhibitor Inhibition 74.9 staurosporine Hs Inhibitor Inhibition 75.0 lapatinib Hs Inhibitor Inhibition 75.9 erlotinib Hs Inhibitor Inhibition 77.2 seliciclib Hs Inhibitor Inhibition 77.6 VX-702 Hs Inhibitor Inhibition 77.6 vatalanib Hs Inhibitor Inhibition 78.1 tozasertib Hs Inhibitor Inhibition 78.6
Displaying the top 10 most potent ligands  View all ligands in screen »