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phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

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Target id: 2163

Nomenclature: phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Abbreviated Name: PIP4K2C

Family: Phosphatidylinositol phosphate kinases, Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 421 12q13.3 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Mouse - 421 10 D3 Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Rat - 420 7q22 Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Previous and Unofficial Names Click here for help
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | PIP4KII-gamma | PIP5K2C | phosphatidylinositol-5-phosphate 4-kinase, type II, gamma | phosphatidylinositol-5-phosphate 4-kinase
Database Links Click here for help
Alphafold Q8TBX8 (Hs), Q91XU3 (Mm), O88370 (Rn)
BRENDA 2.7.1.149
CATH/Gene3D 3.30.800.10, 3.30.810.10
ChEMBL Target CHEMBL1770034 (Hs)
Ensembl Gene ENSG00000166908 (Hs), ENSMUSG00000025417 (Mm), ENSRNOG00000005138 (Rn)
Entrez Gene 79837 (Hs), 117150 (Mm), 140607 (Rn)
Human Protein Atlas ENSG00000166908 (Hs)
KEGG Enzyme 2.7.1.149
KEGG Gene hsa:79837 (Hs), mmu:117150 (Mm), rno:140607 (Rn)
Pharos Q8TBX8 (Hs)
RefSeq Nucleotide NM_001146258 (Hs), NM_054097 (Mm), NM_080480 (Rn)
RefSeq Protein NP_001139730 (Hs), NP_473438 (Mm), NP_536728 (Rn)
UniProtKB Q8TBX8 (Hs), Q91XU3 (Mm), O88370 (Rn)
Wikipedia PIP4K2C (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
PDB Id:  2GK9
Resolution:  2.8Å
Species:  Human
References: 
Enzyme Reaction Click here for help
EC Number: 2.7.1.149
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
LRK-4189 Small molecule or natural product Hs Binding - - 2
⤷ Degrader: DC50< 500 nM [2]
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3
Key to terms and symbols Click column headers to sort
Target used in screen: PIP5K2C
Ligand Sp. Type Action Value Parameter
foretinib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.6 pKd
BI-2536 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.9 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.6 pKd
pazopanib Small molecule or natural product Approved drug Hs Inhibitor Inhibition 6.6 pKd
imatinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.4 pKd
TG-100-115 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
PI-103 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.2 pKd
PP-242 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.1 pKd
alvocidib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Good A, Brown K, Goodman KB, Ye G, O'Shea M. (2024) Inhibitors and degraders of pip4k protein. Patent number: WO2024233846A1. Assignee: Larkspur Biosciences, Inc.. Priority date: 09/05/2024. Publication date: 14/11/2024.

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Phosphatidylinositol phosphate kinases: phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. Last modified on 08/09/2025. Accessed on 25/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2163.