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pre-mRNA processing factor kinase PRP4K

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Target id: 2177

Nomenclature: pre-mRNA processing factor kinase PRP4K

Abbreviated Name: PRP4

Family: PRP4 subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1007 6p25.2 PRP4K pre-mRNA processing factor kinase PRP4K
Mouse - 1007 13 A3.3 Prpf4b pre-mRNA processing factor 4B
Rat - 1007 17p12 Prpf4b pre-mRNA processing factor 4B
Previous and Unofficial Names Click here for help
PR4H | pre-mRNA processing factor 4B | PRP4 pre-mRNA processing factor 4 homolog B (yeast) | PRPF4B
Database Links Click here for help
Alphafold Q13523 (Hs), Q61136 (Mm), Q5RKH1 (Rn)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL1908382 (Hs)
Ensembl Gene ENSG00000112739 (Hs), ENSMUSG00000021413 (Mm), ENSRNOG00000016705 (Rn)
Entrez Gene 8899 (Hs), 19134 (Mm), 291078 (Rn)
Human Protein Atlas ENSG00000112739 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:8899 (Hs), mmu:19134 (Mm), rno:291078 (Rn)
OMIM 602338 (Hs)
Pharos Q13523 (Hs)
RefSeq Nucleotide NM_003913 (Hs), NM_013830 (Mm), NM_001011923 (Rn)
RefSeq Protein NP_003904 (Hs), NP_038858 (Mm), NP_001011923 (Rn)
UniProtKB Q13523 (Hs), Q61136 (Mm), Q5RKH1 (Rn)
Wikipedia PRP4K (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: PRP4
Ligand Sp. Type Action Value Parameter
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 7.3 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.7 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 6.6 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.4 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.4 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.3 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 6.3 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 5.9 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.8 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.6 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

PRP4 subfamily: pre-mRNA processing factor kinase PRP4K. Last modified on 25/03/2024. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2177.