Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	1297	1q23.1	INSRR	insulin receptor related receptor
Mouse	1	1300	3 38.7 cM	Insrr	insulin receptor-related receptor
Rat	1	1300	2q34	Insrr	insulin receptor-related receptor

Previous and Unofficial Names

IR-related receptor | Sirr

Database Links
Alphafold	P14616 (Hs), Q9WTL4 (Mm), Q64716 (Rn)
BRENDA	2.7.10.1
CATH/Gene3D	2.60.40.10, 3.80.20.20
ChEMBL Target	CHEMBL5483 (Hs)
Ensembl Gene	ENSG00000027644 (Hs), ENSMUSG00000005640 (Mm), ENSRNOG00000057702 (Rn)
Entrez Gene	3645 (Hs), 23920 (Mm), 60663 (Rn)
Human Protein Atlas	ENSG00000027644 (Hs)
KEGG Enzyme	2.7.10.1
KEGG Gene	hsa:3645 (Hs), mmu:23920 (Mm), rno:60663 (Rn)
OMIM	147671 (Hs)
Pharos	P14616 (Hs)
RefSeq Nucleotide	NM_014215 (Hs), NM_011832 (Mm), NM_022212 (Rn)
RefSeq Protein	NP_055030 (Hs), NP_035962 (Mm), NP_071548 (Rn)
UniProtKB	P14616 (Hs), Q9WTL4 (Mm), Q64716 (Rn)
Wikipedia	INSRR (Hs)

Enzyme Reaction
EC Number: 2.7.10.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference linsitinib Hs Inhibition 7.1 pIC50 4 ⤷ pIC50 7.1 (IC50 7.5x10-8 M) [4]

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,5
Key to terms and symbols		Click column headers to sort
Target used in screen: INSRR
Ligand Sp. Type Action Value Parameter NVP-TAE684 Hs Inhibitor Inhibition 8.2 pKd GSK-1838705A Hs Inhibitor Inhibition 8.1 pKd foretinib Hs Inhibitor Inhibition 7.3 pKd staurosporine Hs Inhibitor Inhibition 7.1 pKd tozasertib Hs Inhibitor Inhibition 6.5 pKd KW-2449 Hs Inhibitor Inhibition 6.4 pKd sunitinib Hs Inhibitor Inhibition 6.4 pKd crizotinib Hs Inhibitor Inhibition 6.2 pKd JNJ-28312141 Hs Inhibitor Inhibition 5.9 pKd AST-487 Hs Inhibitor Inhibition 5.8 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,3
Key to terms and symbols		Click column headers to sort
Target used in screen: IRR/IRR(INSRR)
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM staurosporine Hs Inhibitor Inhibition 1.7 1.5 1.0 indirubin derivative E804 Hs Inhibitor Inhibition 2.8 2.0 2.0 SU11652 Hs Inhibitor Inhibition 4.3 13.0 0.0 SB 218078 Hs Inhibitor Inhibition 7.2 74.0 63.0 K-252a Hs Inhibitor Inhibition 14.4 6.0 1.0 isogranulatimide Hs Inhibitor Inhibition 20.7 5.0 3.0 GSK-3 inhibitor XIII Hs Inhibitor Inhibition 20.7 8.0 1.0 sunitinib Hs Inhibitor Inhibition 21.7 indirubin-3'-monoxime Hs Inhibitor Inhibition 35.7 2.0 1.0 bosutinib Hs Inhibitor Inhibition 36.9
Displaying the top 10 most potent ligands  View all ligands in screen »