JNJ-7706621 [Ligand Id: 5932] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL191003 (JNJ-7706621)
  • 3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530]
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  • activin A receptor type 1/Activin receptor type-1 in Human [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
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  • activin A receptor type 1B/Activin receptor type-1B in Human [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896]
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  • activin A receptor type 2A/Activin receptor type-2A in Human [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037]
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  • activin A receptor type 2B/Activin receptor type-2B in Human [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705]
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  • AP2 associated kinase 1/Adaptor-associated kinase in Human [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8]
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  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
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  • protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Human [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131]
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  • protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646]
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  • ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2]
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  • BMP2 inducible kinase/BMP-2-inducible protein kinase in Human [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1]
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  • bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
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  • bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873]
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  • BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
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  • BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
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  • calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
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  • calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
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  • calcium/calmodulin dependent protein kinase IG/CaM kinase I gamma in Human [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5]
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  • calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7]
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  • calcium/calmodulin-dependent protein kinase II beta subunit/CaM kinase II beta in Human [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554]
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  • calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557]
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  • calcium/calmodulin-dependent protein kinase II gamma subunit/CaM kinase II gamma in Human [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555]
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  • calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
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  • calcium/calmodulin dependent protein kinase kinase 1/CaM-kinase kinase alpha in Human [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9]
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  • calcium/calmodulin dependent protein kinase kinase 2/CaM-kinase kinase beta in Human [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4]
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  • protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
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  • protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694]
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  • casein kinase 1 delta/Casein kinase I delta in Human [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
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  • casein kinase 1 epsilon/Casein kinase I epsilon in Human [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674]
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  • casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
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  • casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368]
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  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
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  • casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
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  • casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784]
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  • casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752]
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  • casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4]
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  • cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1]
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  • cyclin dependent kinase 8/Cell division protein kinase 8 in Human [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336]
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  • Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
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  • Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
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  • coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60]
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  • citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578]
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  • mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
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  • mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
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  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
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  • cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526]
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
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  • cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613]
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  • cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
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  • death associated protein kinase 1/Death-associated protein kinase 1 in Human [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355]
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  • death associated protein kinase 2/Death-associated protein kinase 2 in Human [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
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  • death associated protein kinase 3/Death-associated protein kinase 3 in Human [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
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  • discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
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  • mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
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  • mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
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  • mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734]
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  • mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
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  • mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
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  • CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
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  • CDC like kinase 3/Dual specificity protein kinase CLK3 in Human [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
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  • CDC like kinase 4/Dual specificity protein kinase CLK4 in Human [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
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  • TTK protein kinase/Dual specificity protein kinase TTK in Human [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
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  • testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
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  • dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
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  • CDC like kinase 1/Dual specificty protein kinase CLK1 in Human [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
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  • EPH receptor A1/Ephrin type-A receptor 1 in Human [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709]
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  • EPH receptor A2/Ephrin type-A receptor 2 in Human [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
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  • EPH receptor A3/Ephrin type-A receptor 3 in Human [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320]
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  • EPH receptor A4/Ephrin type-A receptor 4 in Human [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764]
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  • EPH receptor A5/Ephrin type-A receptor 5 in Human [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756]
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  • EPH receptor A6/Ephrin type-A receptor 6 in Human [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33]
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  • EPH receptor A7/Ephrin type-A receptor 7 in Human [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375]
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  • EPH receptor A8/Ephrin type-A receptor 8 in Human [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322]
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  • EPH receptor B1/Ephrin type-B receptor 1 in Human [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
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  • EPH receptor B2/Ephrin type-B receptor 2 in Human [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
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  • EPH receptor B3/Ephrin type-B receptor 3 in Human [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753]
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  • EPH receptor B4/Ephrin type-B receptor 4 in Human [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
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  • eukaryotic translation initiation factor 2 alpha kinase 4/Eukaryotic translation initiation factor 2-alpha kinase 4 in Human [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8]
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  • fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
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  • fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
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  • fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
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  • fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
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  • protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
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  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
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  • inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
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  • Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
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  • Insulin receptor-related receptor/Insulin receptor-related protein in Human [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616]
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  • eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
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  • interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616]
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  • leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376]
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  • colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333]
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  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
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  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
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  • mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
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  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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  • MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • mitogen-activated protein kinase 11/MAP kinase p38 beta in Human [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
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  • mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778]
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  • MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
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  • microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7]
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  • microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34]
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  • maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
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  • mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08]
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  • mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152]
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  • mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659]
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  • mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164]
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  • mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779]
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  • mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
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  • mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4]
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  • mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
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  • mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
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  • mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918]
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  • mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8]
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  • mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819]
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  • mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4]
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  • ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
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  • muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
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  • myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6]
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  • Myosin light chain kinase, smooth muscle in Chicken [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
  • myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
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  • DM1 protein kinase/Myotonin-protein kinase in Human [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013]
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  • neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
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  • neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
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  • tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470]
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  • neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288]
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  • NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285]
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  • NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093]
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  • phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha in Human [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755]
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  • phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol-5-phosphate 4-kinase type-2 beta in Human [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356]
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  • phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase gamma subunit 1 in Human [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816]
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  • phosphorylase kinase catalytic subunit gamma 2/Phosphorylase kinase gamma subunit 2 in Human [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
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  • cyclin dependent kinase 11B/PITSLRE serine/threonine-protein kinase CDC2L1 in Human [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127]
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  • cyclin dependent kinase 11A/PITSLRE serine/threonine-protein kinase CDC2L2 in Human [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88]
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  • platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
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  • platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
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  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
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  • protein kinase C eta/Protein kinase C eta in Human [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
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  • protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
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  • protein kinase D3/Protein kinase C nu in Human [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806]
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  • protein kinase C theta/Protein kinase C theta in Human [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
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  • protein kinase N1/Protein kinase N1 in Human [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512]
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  • protein kinase N2/Protein kinase N2 in Human [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
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  • protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
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  • MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
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  • c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
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  • receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546]
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  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
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  • ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
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  • ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
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  • ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
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  • ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676]
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  • ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
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  • ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
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  • serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
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  • serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
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  • serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716]
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  • serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5]
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  • serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768]
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  • STE20 like kinase/Serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2]
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  • serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0]
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  • serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506]
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  • serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57]
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  • serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6]
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  • serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
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  • serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7]
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  • Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1]
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  • AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
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  • AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
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  • AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
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  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
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  • aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
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  • aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9]
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  • B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
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  • checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
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  • microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
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  • protein kinase D2/Serine/threonine-protein kinase D2 in Human [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
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  • doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075]
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  • doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568]
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  • doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098]
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  • cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976]
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  • large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835]
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  • large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7]
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  • microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
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  • CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
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  • CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2]
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  • CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37]
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  • serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
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  • serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
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  • serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289]
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  • NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
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  • NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
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  • NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8]
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  • NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
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  • NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
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  • NIMA related kinase 9/Serine/threonine-protein kinase NEK9 in Human [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19]
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  • nemo like kinase/Serine/threonine protein kinase NLK in Human [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
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  • p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
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  • p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177]
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  • p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
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  • p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013]
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  • p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
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  • p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK7 in Human [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286]
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  • cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536]
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  • cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537]
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  • cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002]
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  • cyclin dependent kinase 14/Serine/threonine-protein kinase PFTAIRE-1 in Human [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921]
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
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  • Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
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  • Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86]
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  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
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  • polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
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  • polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
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  • protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817]
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  • Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
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  • activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
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  • RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2]
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  • RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730]
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  • receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
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  • salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059]
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  • salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1]
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  • SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4]
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  • SRSF protein kinase 2/Serine/threonine-protein kinase SRPK2 in Human [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362]
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  • TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18]
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  • tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8]
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  • tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8]
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  • WEE1 G2 checkpoint kinase/Serine/threonine-protein kinase WEE1 in Human [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291]
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  • KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
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  • testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
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  • transforming growth factor beta receptor 1/TGF-beta receptor type I in Human [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
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  • transforming growth factor beta receptor 2/TGF-beta receptor type II in Human [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
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  • TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5]
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  • tubulin alpha 1a/Tubulin alpha-1 chain in Rat [ChEMBL: CHEMBL4139] [GtoPdb: 2638] [UniProtKB: P68370]
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  • protein kinase, membrane associated tyrosine/threonine 1/Tyrosine- and threonine-specific cdc2-inhibitory kinase in Human [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640]
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  • tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
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  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
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  • ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
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  • BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
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  • BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813]
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  • protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
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  • Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
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  • C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
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  • FER tyrosine kinase/Tyrosine-protein kinase FER in Human [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591]
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  • FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
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  • FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769]
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  • fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685]
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  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
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  • HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
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  • IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
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  • Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
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  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
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  • Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
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  • LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
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  • fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
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  • ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
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  • tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590]
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  • TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
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  • AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
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  • src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6]
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
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  • tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680]
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  • TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
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  • TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
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  • tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
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  • YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
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  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
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  • coenzyme Q8B/Uncharacterized aarF domain-containing protein kinase 4 in Human [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53]
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  • fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
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  • fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530]
ChEMBL Binding constant for full-length PDPK1 B 5.51 pKd 3100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771]
ChEMBL Binding constant for ACVR1 kinase domain B 5.23 pKd 5900 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896]
ChEMBL Binding constant for ACVR1B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
activin A receptor type 2A/Activin receptor type-2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037]
ChEMBL Binding constant for ACVR2A kinase domain B 5.54 pKd 2900 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
activin A receptor type 2B/Activin receptor type-2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705]
ChEMBL Binding constant for ACVR2B kinase domain B 5.23 pKd 5900 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
AP2 associated kinase 1/Adaptor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8]
ChEMBL Binding constant for AAK1 kinase domain B 6.7 pKd 200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Binding constant for ALK kinase domain B 5.15 pKd 7100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131]
ChEMBL Binding constant for AMPK-alpha1 kinase domain B 5.77 pKd 1700 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646]
ChEMBL Binding constant for AMPK-alpha2 kinase domain B 5.74 pKd 1800 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2]
ChEMBL Binding constant for ANKK1 kinase domain B 6.3 pKd 500 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
BMP2 inducible kinase/BMP-2-inducible protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1]
ChEMBL Binding constant for BIKE kinase domain B 6.74 pKd 180 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894]
ChEMBL Binding constant for BMPR1A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873]
ChEMBL Binding constant for BMPR2 kinase domain B 6.06 pKd 880 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
ChEMBL Binding constant for BRSK1 kinase domain B 5.19 pKd 6500 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3]
ChEMBL Binding constant for full-length BRSK2 B 5.57 pKd 2700 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
ChEMBL Binding constant for full-length CAMK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
ChEMBL Binding constant for CAMK1D kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin dependent protein kinase IG/CaM kinase I gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5]
ChEMBL Binding constant for CAMK1G kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7]
ChEMBL Binding constant for CAMK2A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin-dependent protein kinase II beta subunit/CaM kinase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554]
ChEMBL Binding constant for CAMK2B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557]
ChEMBL Binding constant for CAMK2D kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin-dependent protein kinase II gamma subunit/CaM kinase II gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555]
ChEMBL Binding constant for CAMK2G kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
ChEMBL Binding constant for CAMK4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin dependent protein kinase kinase 1/CaM-kinase kinase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9]
ChEMBL Binding constant for CAMKK1 kinase domain B 5.54 pKd 2900 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
calcium/calmodulin dependent protein kinase kinase 2/CaM-kinase kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4]
ChEMBL Binding constant for CAMKK2 kinase domain B 5.59 pKd 2600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
ChEMBL Binding constant for PKAC-alpha kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694]
ChEMBL Binding constant for full-length PKAC-beta B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
ChEMBL Binding constant for full-length CSNK1D B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674]
ChEMBL Binding constant for full-length CSNK1E B 5.44 pKd 3600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0]
ChEMBL Binding constant for CSNK1G1 kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368]
ChEMBL Binding constant for full-length CSNK1G2 B 6.13 pKd 740 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL Inhibition of Casein kinase-2 B 4 pIC50 >100000 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL Binding constant for full-length CSNK2A1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784]
ChEMBL Binding constant for full-length CSNK2A2 B 5.7 pKd 2000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752]
ChEMBL Binding constant for full-length CSNK1A1L B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4]
ChEMBL Binding constant for full-length CSNK1G3 B 5.1 pKd 7900 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1]
ChEMBL Binding constant for CDK11 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 8/Cell division protein kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336]
ChEMBL Binding constant for CDK8 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
ChEMBL Binding constant for PRKG1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
ChEMBL Binding constant for PRKG2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60]
ChEMBL Binding constant for ADCK3 kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578]
ChEMBL Binding constant for CIT kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL Binding constant for full-length JNK1 B 5.77 pKd 1700 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL Binding constant for full-length JNK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Binding constant for JNK3 kinase domain B 5.89 pKd 1300 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb CDK1 in association with cyclin B - 8.19 pIC50 6.4 nM IC50 J Med Chem (2005) 48: 4208-11 [PMID:15974571]
ChEMBL Inhibition of CDK1 B 8.22 pIC50 6 nM IC50 Bioorg Med Chem Lett (2006) 16: 3639-3641 [PMID:16682186]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7]
GtoPdb CDK1 in association with cyclin B - 8.19 pIC50 6.4 nM IC50 J Med Chem (2005) 48: 4208-11 [PMID:15974571]
ChEMBL Inhibition of Cyclin B-cyclin-dependent kinase 1 B 8.19 pIC50 6.4 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
ChEMBL Inhibition of Cyclin B-cyclin-dependent kinase 1 B 8.22 pIC50 6 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Binding constant for full-length CDK2 B 7.64 pKd 23 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Inhibition of CDK2 B 8.7 pIC50 2 nM IC50 Bioorg Med Chem Lett (2006) 16: 3639-3641 [PMID:16682186]
GtoPdb CDK2 in association with cyclin A - 8.7 pIC50 2 nM IC50 J Med Chem (2005) 48: 4208-11 [PMID:15974571]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396]
ChEMBL Inhibition of Cyclin-dependent kinase 2-cyclin A B 8.7 pIC50 2 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
GtoPdb CDK2 in association with cyclin A - 8.7 pIC50 2 nM IC50 J Med Chem (2005) 48: 4208-11 [PMID:15974571]
cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526]
ChEMBL Binding constant for full-length CDK3 B 6.74 pKd 180 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385]
ChEMBL Inhibition of Cyclin-dependent kinase 4-cyclin D1 B 6.96 pIC50 110 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
ChEMBL Binding constant for full-length CDK5 B 6.62 pKd 240 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Inhibition of CDK5 (unknown origin) B 7.9 pIC50 12.59 nM IC50 J Med Chem (2013) 56: 6991-7002 [PMID:23937569]
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613]
ChEMBL Binding constant for full-length CDK7 B 6.12 pKd 760 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
ChEMBL Binding constant for full-length CDK9 B 6.33 pKd 470 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
death associated protein kinase 1/Death-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355]
ChEMBL Binding constant for DAPK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
death associated protein kinase 2/Death-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
ChEMBL Binding constant for full-length DAPK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
ChEMBL Binding constant for DAPK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for full-length DLK B 5.28 pKd 5200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
ChEMBL Binding constant for DDR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL Binding constant for full-length MEK1 B 5.74 pKd 1800 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507]
ChEMBL Binding constant for full-length MEK2 B 5.25 pKd 5600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734]
ChEMBL Binding constant for full-length MEK3 B 5.82 pKd 1500 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
ChEMBL Binding constant for MEK4 kinase domain B 6.2 pKd 630 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
ChEMBL Binding constant for MEK6 kinase domain B 6 pKd 1000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL Binding constant for CLK2 kinase domain B 6.54 pKd 290 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
ChEMBL Binding constant for full-length CLK3 B 6.51 pKd 310 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
ChEMBL Binding constant for CLK4 kinase domain B 5.77 pKd 1700 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
ChEMBL Binding constant for TTK kinase domain B 6.72 pKd 190 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
ChEMBL Binding constant for TESK1 kinase domain B 5.51 pKd 3100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
ChEMBL Binding constant for full-length DYRK1B B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
ChEMBL Binding constant for full-length CLK1 B 6.18 pKd 660 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709]
ChEMBL Binding constant for EPHA1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
ChEMBL Binding constant for EPHA2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320]
ChEMBL Binding constant for EPHA3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764]
ChEMBL Binding constant for EPHA4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756]
ChEMBL Binding constant for EPHA5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor A6/Ephrin type-A receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33]
ChEMBL Binding constant for EPHA6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375]
ChEMBL Binding constant for EPHA7 kinase domain B 5.51 pKd 3100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322]
ChEMBL Binding constant for EPHA8 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
ChEMBL Binding constant for EPHB1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
ChEMBL Binding constant for EPHB2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753]
ChEMBL Binding constant for EPHB3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760]
ChEMBL Binding constant for EPHB4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Binding constant for EGFR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(E746-A750del) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(G719C) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(G719S) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L747-E749del, A750P) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L747-S752del, P753S) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L747-T751del,Sins) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L858R) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(L861Q) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for EGFR(S752-I759del) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Inhibition of Epidermal growth factor receptor B 4 pIC50 >100000 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345]
ChEMBL Binding constant for DDR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
eukaryotic translation initiation factor 2 alpha kinase 4/Eukaryotic translation initiation factor 2-alpha kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8]
ChEMBL Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain B 5.41 pKd 3900 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL Binding constant for FGFR1 kinase domain B 6.09 pKd 810 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
ChEMBL Binding constant for FGFR2 kinase domain B 6.17 pKd 680 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Inhibition of Fibroblast growth factor receptor 2 B 6.66 pIC50 220 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
ChEMBL Binding constant for FGFR3(G697C) kinase domain B 6.16 pKd 690 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FGFR3 kinase domain B 6.29 pKd 510 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
ChEMBL Binding constant for FGFR4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
ChEMBL Binding constant for PTK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Binding constant for full-length GSK3A B 6.8 pKd 160 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Binding constant for full-length GSK3B B 6.02 pKd 950 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Binding constant for MET kinase domain B 6.19 pKd 650 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
ChEMBL Binding constant for full-length IKK-epsilon B 5.08 pKd 8300 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL Binding constant for IGF1R kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Binding constant for INSR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Inhibition of Insulin kinase-beta activity B 4 pIC50 >100000 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
Insulin receptor-related receptor/Insulin receptor-related protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616]
ChEMBL Binding constant for INSRR kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
ChEMBL Binding constant for PRKR kinase domain B 5.2 pKd 6300 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616]
ChEMBL Binding constant for IRAK3 kinase domain B 5.47 pKd 3400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376]
ChEMBL Binding constant for LTK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
ChEMBL Binding constant for full-length LIMK1 B 6.21 pKd 620 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
ChEMBL Binding constant for full-length LIMK2 B 6 pKd 1000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333]
ChEMBL Binding constant for CSF1R kinase domain B 5.38 pKd 4200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL Binding constant for MAPKAPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
ChEMBL Binding constant for MAPKAPK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL Binding constant for full-length ERK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Binding constant for full-length ERK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
ChEMBL Binding constant for full-length MKNK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Binding constant for full-length p38-alpha B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
ChEMBL Binding constant for full-length p38-beta B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778]
ChEMBL Binding constant for full-length p38-gamma B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
ChEMBL Binding constant for MKNK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7]
ChEMBL Binding constant for MARK2 kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34]
ChEMBL Binding constant for MARK4 kinase domain B 6.18 pKd 660 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680]
ChEMBL Binding constant for full-length MELK B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08]
ChEMBL Binding constant for ERK8 kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152]
ChEMBL Binding constant for ERK4 kinase domain B 5.8 pKd 1600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659]
ChEMBL Binding constant for ERK3 kinase domain B 6.32 pKd 480 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164]
ChEMBL Binding constant for ERK5 kinase domain B 6.28 pKd 520 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779]
ChEMBL Binding constant for MLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
ChEMBL Binding constant for MLK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4]
ChEMBL Binding constant for MAP3K4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
ChEMBL Binding constant for MAP3K5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
ChEMBL Binding constant for MLK1 kinase domain B 5.44 pKd 3600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918]
ChEMBL Binding constant for MAP4K1 kinase domain B 6.92 pKd 120 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8]
ChEMBL Binding constant for MAP4K3 kinase domain B 6.09 pKd 820 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819]
ChEMBL Binding constant for MAP4K4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4]
ChEMBL Binding constant for MAP4K5 kinase domain B 5.68 pKd 2100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
ChEMBL Binding constant for ZAK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
ChEMBL Binding constant for MUSK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
myosin IIIA/Myosin IIIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5546] [GtoPdb: 2112] [UniProtKB: Q8NEV4]
ChEMBL Binding constant for MYO3A kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
myosin IIIB/Myosin-IIIB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5654] [GtoPdb: 2113] [UniProtKB: Q8WXR4]
ChEMBL Binding constant for MYO3B kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
myosin light chain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2777] [GtoPdb: 1553] [UniProtKB: Q9H1R3]
ChEMBL Binding constant for MYLK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6]
ChEMBL Binding constant for SgK085 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799]
ChEMBL Binding constant for MLCK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746]
ChEMBL Binding constant for MYLK kinase domain B 5.68 pKd 2100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
DM1 protein kinase/Myotonin-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013]
ChEMBL Binding constant for DMPK kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
ChEMBL Binding constant for TRKA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
ChEMBL Binding constant for TRKB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470]
ChEMBL Binding constant for full-length TNK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288]
ChEMBL Binding constant for TRKC kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285]
ChEMBL Binding constant for ARK5 kinase domain B 6.74 pKd 180 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093]
ChEMBL Binding constant for SNARK kinase domain B 7.59 pKd 26 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755]
ChEMBL Binding constant for full-length PIP5K1A B 5.04 pKd 9200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol-5-phosphate 4-kinase type-2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356]
ChEMBL Binding constant for full-length PIP5K2B B 5.89 pKd 1300 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase gamma subunit 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816]
ChEMBL Binding constant for full-length PHKG1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
phosphorylase kinase catalytic subunit gamma 2/Phosphorylase kinase gamma subunit 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735]
ChEMBL Binding constant for PHKG2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL Binding constant for PIK3CA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for PIK3CA(E545K) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 11B/PITSLRE serine/threonine-protein kinase CDC2L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127]
ChEMBL Binding constant for CDC2L1 kinase domain B 6.82 pKd 150 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 11A/PITSLRE serine/threonine-protein kinase CDC2L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88]
ChEMBL Binding constant for CDC2L2 kinase domain B 6.96 pKd 110 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL Binding constant for PDGFRA kinase domain B 5.4 pKd 4000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL Binding constant for PDGFRB kinase domain B 6.04 pKd 910 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Inhibition of Protein kinase C- beta 2 B 4 pIC50 >100000 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Binding constant for PRKCD kinase domain B 5.35 pKd 4500 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Binding constant for PRKCE kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
ChEMBL Binding constant for PRKCH kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL Binding constant for PRKD1 kinase domain B 5.08 pKd 8400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase D3/Protein kinase C nu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806]
ChEMBL Binding constant for PRKD3 kinase domain B 5.38 pKd 4200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
ChEMBL Binding constant for PRKCQ kinase domain B 5.36 pKd 4400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase N1/Protein kinase N1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512]
ChEMBL Binding constant for PKN1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
ChEMBL Binding constant for PKN2 kinase domain B 5.72 pKd 1900 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
ChEMBL Binding constant for full-length PTK2B B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
ChEMBL Binding constant for MERTK kinase domain B 5.55 pKd 2800 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
ChEMBL Binding constant for ROS1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546]
ChEMBL Binding constant for RIPK1 kinase domain B 5.74 pKd 1800 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL Binding constant for ERBB2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL Binding constant for RPS6KA1(Kin.Dom.2 - C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA1(Kin.Dom.1 - N-terminal) kinase domain B 5.4 pKd 4000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
ChEMBL Binding constant for RPS6KA2(Kin.Dom.2 - C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA2(Kin.Dom.1 - N-terminal) kinase domain B 6.39 pKd 410 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
ChEMBL Binding constant for RPS6KA3(Kin.Dom.1 - N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676]
ChEMBL Binding constant for RPS6KA4(Kin.Dom.2 - N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA4(Kin.Dom.1 - C-terminal) kinase domain B 5.52 pKd 3000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
ChEMBL Binding constant for RPS6KA5(Kin.Dom.1 - C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA5(Kin.Dom.2 - N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
ChEMBL Binding constant for RPS6KA6(Kin.Dom.1 - C-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
ChEMBL Binding constant for LOK kinase domain B 6.96 pKd 110 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
ChEMBL Binding constant for full-length LKB1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716]
ChEMBL Binding constant for STK16 kinase domain B 6.85 pKd 140 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5]
ChEMBL Binding constant for DRAK1 kinase domain B 5.25 pKd 5600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768]
ChEMBL Binding constant for full-length DRAK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
STE20 like kinase/Serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2]
ChEMBL Binding constant for SLK kinase domain B 7.32 pKd 48 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0]
ChEMBL Binding constant for MST3 kinase domain B 6.74 pKd 180 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506]
ChEMBL Binding constant for YSK1 kinase domain B 6.44 pKd 360 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57]
ChEMBL Binding constant for full-length YANK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6]
ChEMBL Binding constant for YANK3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
ChEMBL Binding constant for full-length STK33 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7]
ChEMBL Binding constant for STK36 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1]
ChEMBL Binding constant for NDR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL Binding constant for AKT1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
ChEMBL Binding constant for AKT2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
ChEMBL Binding constant for AKT3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Binding constant for AURKA kinase domain B 6.6 pKd 250 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Single-Cycle Kinetic parameter establishment of 8 compounds to gain n=3 B 7.01 pKd 96.67 nM Kd K4DD drug target binding kinetics data
ChEMBL Single-Cycle Kinetic parameter establishment of 8 compounds to gain n=3 B 7.19 pKd 65.21 nM Kd K4DD drug target binding kinetics data
ChEMBL Single-Cycle Kinetic parameter establishment of 8 compounds to gain n=3 B 7.29 pKd 50.94 nM Kd K4DD drug target binding kinetics data
ChEMBL Multi-Cycle Kinetic parameter establishment of 8 compounds to gain n=3Completed over 3 identical immbolized CM5 chips B 7.48 pKd 33.2 nM Kd K4DD drug target binding kinetics data
ChEMBL Multi-Cycle Kinetic parameter establishment of 8 compounds to gain n=3 Completed over 3 identical immbolized CM5 chips B 7.52 pKd 30.13 nM Kd K4DD drug target binding kinetics data
GtoPdb - - 7.74 pIC50 18 nM IC50 J Med Chem (2018) 61: 9105-9120 [PMID:30234987]
ChEMBL Inhibition of NH2-terminal GST-tagged recombinant human Aurora A kinase (118-403 residues) expressed in baculovirus B 7.96 pIC50 11 nM IC50 Eur J Med Chem (2017) 140: 1-19 [PMID:28918096]
aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4]
ChEMBL Binding constant for AURKB kinase domain B 6.8 pKd 160 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
GtoPdb - - 7.89 pIC50 13 nM IC50 J Med Chem (2018) 61: 9105-9120 [PMID:30234987]
ChEMBL Inhibition of NH2-terminal GST-tagged recombinant full length human Aurora B kinase expressed in baculovirus B 8.4 pIC50 4 nM IC50 Eur J Med Chem (2017) 140: 1-19 [PMID:28918096]
aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9]
ChEMBL Binding constant for full-length AURKC B 7.07 pKd 86 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
ChEMBL Binding constant for BRAF kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for BRAF(V600E) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL Binding constant for CHEK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
ChEMBL Binding constant for full-length MARK3 B 6.22 pKd 600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
ChEMBL Binding constant for PRKD2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075]
ChEMBL Binding constant for DCAMKL1 kinase domain B 5.6 pKd 2500 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568]
ChEMBL Binding constant for DCAMKL2 kinase domain B 5.35 pKd 4500 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098]
ChEMBL Binding constant for DCAMKL3 kinase domain B 5.19 pKd 6500 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976]
ChEMBL Binding constant for GAK kinase domain B 5.62 pKd 2400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835]
ChEMBL Binding constant for LATS1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7]
ChEMBL Binding constant for LATS2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
ChEMBL Binding constant for MARK1 kinase domain B 6.21 pKd 620 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
ChEMBL Binding constant for MRCKA kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2]
ChEMBL Binding constant for MRCKB kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37]
ChEMBL Binding constant for DMPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
ChEMBL Binding constant for full-length MST1 B 6.89 pKd 130 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
ChEMBL Binding constant for MST2 kinase domain B 7.21 pKd 61 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289]
ChEMBL Binding constant for full-length MST4 B 6.68 pKd 210 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
ChEMBL Binding constant for NEK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL Binding constant for NEK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8]
ChEMBL Binding constant for NEK5 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98]
ChEMBL Binding constant for NEK6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
ChEMBL Binding constant for full-length NEK7 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
NIMA related kinase 9/Serine/threonine-protein kinase NEK9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19]
ChEMBL Binding constant for NEK9 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
ChEMBL Binding constant for full-length NLK B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
ChEMBL Binding constant for PAK1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177]
ChEMBL Binding constant for PAK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
ChEMBL Binding constant for full-length PAK3 B 5.68 pKd 2100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013]
ChEMBL Binding constant for PAK4 kinase domain B 5.64 pKd 2300 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
ChEMBL Binding constant for PAK6 kinase domain B 5.85 pKd 1400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286]
ChEMBL Binding constant for PAK7/PAK5 kinase domain B 6.08 pKd 830 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536]
ChEMBL Binding constant for PCTK1 kinase domain B 7.64 pKd 23 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537]
ChEMBL Binding constant for full-length PCTK2 B 6.54 pKd 290 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002]
ChEMBL Binding constant for full-length PCTK3 B 5.68 pKd 2100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
cyclin dependent kinase 14/Serine/threonine-protein kinase PFTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921]
ChEMBL Binding constant for full-length PFTK1 B 5.44 pKd 3600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Binding constant for PIM1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
ChEMBL Binding constant for PIM2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86]
ChEMBL Binding constant for PIM3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL Binding constant for PLK1 kinase domain B 5.3 pKd 5000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
ChEMBL Binding constant for PLK3 kinase domain B 5.15 pKd 7100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
ChEMBL Binding constant for PLK4 kinase domain B 6.92 pKd 120 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817]
ChEMBL Binding constant for full-length PRKX B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
ChEMBL Binding constant for RAF1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023]
ChEMBL Binding constant for ACVRL1 kinase domain B 5.54 pKd 2900 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2]
ChEMBL Binding constant for full-length RIOK1 B 5.96 pKd 1100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730]
ChEMBL Binding constant for full-length RIOK3 B 5.92 pKd 1200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
ChEMBL Binding constant for RIPK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059]
ChEMBL Binding constant for SNF1LK kinase domain B 5.66 pKd 2200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1]
ChEMBL Binding constant for full-length SNF1LK2 B 5.8 pKd 1600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4]
ChEMBL Binding constant for full-length SRPK1 B 5.55 pKd 2800 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
SRSF protein kinase 2/Serine/threonine-protein kinase SRPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362]
ChEMBL Binding constant for full-length SRPK2 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18]
ChEMBL Binding constant for full-length TNNI3K B 5.85 pKd 1400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8]
ChEMBL Binding constant for TLK1 kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8]
ChEMBL Binding constant for TLK2 kinase domain B 6.12 pKd 750 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
WEE1 G2 checkpoint kinase/Serine/threonine-protein kinase WEE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291]
ChEMBL Binding constant for WEE1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
ChEMBL Binding constant for KIT(V559D,V654A) kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for KIT(D816V) kinase domain B 5.6 pKd 2500 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to human KIT D816V mutant incubated for 1 hr by kinase binding assay B 5.6 pKd 2500 nM Kd Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632]
ChEMBL Binding constant for KIT kinase domain B 5.74 pKd 1800 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to human KIT incubated for 1 hr by kinase binding assay B 5.74 pKd 1800 nM Kd Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632]
ChEMBL Binding constant for KIT(V559D) kinase domain B 5.85 pKd 1400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for KIT(V559D,T670I) kinase domain B 6.23 pKd 590 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
ChEMBL Binding constant for full-length TSSK1 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897]
ChEMBL Binding constant for TGFBR1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173]
ChEMBL Binding constant for TGFBR2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5]
ChEMBL Binding constant for TNIK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
tubulin alpha 1a/Tubulin alpha-1 chain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4139] [GtoPdb: 2638] [UniProtKB: P68370]
ChEMBL Binding constant for ERBB4 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein kinase, membrane associated tyrosine/threonine 1/Tyrosine- and threonine-specific cdc2-inhibitory kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640]
ChEMBL Binding constant for PKMYT1 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
ChEMBL Binding constant for TNK2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Binding constant for ABL1(E255K) kinase domain B 5.66 pKd 2200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(H396P) kinase domain B 5.8 pKd 1600 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(Y253F) kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1 kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(Q252H) kinase domain B 5.92 pKd 1200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(M351T) kinase domain B 6.09 pKd 820 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for ABL1(T315I) kinase domain B 7.17 pKd 68 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
ChEMBL Binding constant for ABL2 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
ChEMBL Binding constant for BLK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813]
ChEMBL Binding constant for full-length BMX B 5.33 pKd 4700 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
ChEMBL Binding constant for PTK6 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187]
ChEMBL Binding constant for full-length BTK B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL Binding constant for full-length CSK B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
FER tyrosine kinase/Tyrosine-protein kinase FER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591]
ChEMBL Binding constant for FER kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
ChEMBL Binding constant for FES kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769]
ChEMBL Binding constant for FGR kinase domain B 5.7 pKd 2000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685]
ChEMBL Binding constant for FRK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL Binding constant for FYN kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
ChEMBL Binding constant for HCK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
ChEMBL Binding constant for ITK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
ChEMBL Binding constant for JAK1(Kin.Dom.1/JH2 - pseudokinase) kinase domain B 7.68 pKd 21 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to JAK1 B 7.68 pKd 21 nM Kd Bioorg Med Chem Lett (2010) 20: 7454-7457 [PMID:21106455]
ChEMBL Binding affinity to JAK1 JH2 domain (unknown origin) B 7.68 pKd 21 nM Kd ACS Med Chem Lett (2017) 8: 618-621 [PMID:28626521]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Binding affinity to wild type JAK2 JH2 domain (unknown origin) by competitive fluorescence polarization assay B 6.1 pKd 800 nM Kd ACS Med Chem Lett (2017) 8: 614-617 [PMID:28626520]
ChEMBL Binding affinity to human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain V617F mutant (536 to 812 residues) expressed in baculovirus infected sf9 insect cells measured for 1 hr in presence of fluorescein conjugate tracer by competitive fluorescence polarization assay B 6.22 pKd 600 nM Kd J Med Chem (2020) 63: 5324-5340 [PMID:32329617]
ChEMBL Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expressed in baculovirus infected sf9 insect cells by microscale thermophoresis assay B 6.31 pKd 490 nM Kd J Med Chem (2020) 63: 5324-5340 [PMID:32329617]
GtoPdb Affinity for JAK2 JH2 by competitive fluorescence polarization (FP) assay - 6.34 pKd 456 nM Kd J Med Chem (2022) 65: 8380-8400 [PMID:35653642]
GtoPdb Binding affinity for JAK2 JH2 pseudokinase domain - 6.34 pKd 460 nM Kd ACS Med Chem Lett (2017) 8: 618-621 [PMID:28626521]
ChEMBL Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expressed in baculovirus infected sf9 insect cells measured for 1 hr in presence of fluorescein conjugate tracer by competitive fluorescence polarization assay B 6.34 pKd 456 nM Kd J Med Chem (2020) 63: 5324-5340 [PMID:32329617]
ChEMBL Binding constant for JAK2(Kin.Dom.2/JH1 - catalytic) kinase domain B 6.66 pKd 220 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to human JAK2 (kinase domain 2/JH1 catalytic domain) by competitive binding assay B 6.66 pKd 220 nM Kd J Med Chem (2020) 63: 5324-5340 [PMID:32329617]
ChEMBL Binding affinity to JAK2 JH1 domain (unknown origin) B 6.66 pKd 220 nM Kd ACS Med Chem Lett (2017) 8: 618-621 [PMID:28626521]
ChEMBL Binding affinity to JAK2 B 6.66 pKd 220 nM Kd Bioorg Med Chem Lett (2010) 20: 7454-7457 [PMID:21106455]
ChEMBL Binding affinity to human C-terminal His8-tagged JAK2 pseudokinase (513 to 827 residues) expressed in baculovirus infected Hi-5 cells by intrinsic tryptophan fluorescence assay B 7.03 pKd 94 nM Kd J Med Chem (2020) 63: 5324-5340 [PMID:32329617]
ChEMBL Binding affinity to N-terminal TEV-cleavable hexa-histidine tagged human JAK2 JH1 domain (840 to 1132 residues) expressed in baculovirus-infected Sf9 cells by ITC assay B 7.51 pKd 31 nM Kd ACS Med Chem Lett (2017) 8: 618-621 [PMID:28626521]
ChEMBL Inhibition of full length human C-terminal FLAG-tagged JAK2 V617F mutant (1 to 1132 residues) autophosphorylation expressed in HEK293T cells incubated in buffer with compound for 1 hr followed by treatment with enzyme and [gamma32P]-ATP for 15 mins by immunoprecipitation assay based autoradiography B 4.96 pIC50 11050 nM IC50 J Med Chem (2020) 63: 5324-5340 [PMID:32329617]
ChEMBL Inhibition of wild type full length human JAK2 (1 to 1132 residues) autophosphorylation expressed in HEK293T cells incubated in buffer with compound for 1 hr followed by treatment with enzyme and [gamma32P]-ATP for 15 mins by immunoprecipitation assay based autoradiography B 5.53 pIC50 2960 nM IC50 J Med Chem (2020) 63: 5324-5340 [PMID:32329617]
GtoPdb Binding to the JH2 pseudo kinase domain of JAK2 was determined using isothermal titration calorimetry (ITC). - 6.97 pIC50 106 nM IC50 ACS Med Chem Lett (2017) 8: 618-621 [PMID:28626521]
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domain B 6.74 pKd 180 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to JAK3 B 6.74 pKd 180 nM Kd Bioorg Med Chem Lett (2010) 20: 7454-7457 [PMID:21106455]
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239]
ChEMBL Binding constant for LCK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Binding constant for LYN kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL Binding constant for FLT3(ITD) kinase domain B 5.85 pKd 1400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT3(N841I) kinase domain B 5.85 pKd 1400 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT3 kinase domain B 6.07 pKd 850 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT3(D835H) kinase domain B 6.08 pKd 840 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for FLT3(D835Y) kinase domain B 6.23 pKd 590 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
ChEMBL Binding constant for RET(M918T) kinase domain B 5.38 pKd 4200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding constant for RET kinase domain B 6 pKd 1000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590]
ChEMBL Binding constant for TIE1 kinase domain B 6.59 pKd 260 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
ChEMBL Binding constant for TYRO3 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
ChEMBL Binding constant for AXL kinase domain B 5.66 pKd 2200 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Binding constant for SRC kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6]
ChEMBL Binding constant for SRMS kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Binding constant for SYK kinase domain B 5.89 pKd 1300 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680]
ChEMBL Binding constant for TEC kinase domain B 6 pKd 1000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763]
ChEMBL Binding constant for TIE2 kinase domain B 6.02 pKd 950 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681]
ChEMBL Binding constant for TXK kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597]
ChEMBL Binding constant for TYK2(Kin.Dom.2/JH1 - catalytic) kinase domain B 7.49 pKd 32 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Binding affinity to TYK2 B 7.49 pKd 32 nM Kd Bioorg Med Chem Lett (2010) 20: 7454-7457 [PMID:21106455]
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
ChEMBL Binding constant for YES kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL Binding constant for ZAP70 kinase domain B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
coenzyme Q8B/Uncharacterized aarF domain-containing protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53]
ChEMBL Binding constant for full-length ADCK4 B 5 pKd >10000 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL Binding constant for FLT1 kinase domain B 5.68 pKd 2100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Binding constant for VEGFR2 kinase domain B 5.43 pKd 3700 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]
ChEMBL Inhibition of Vascular endothelial growth factor receptor 2 B 6.89 pIC50 130 nM IC50 J Med Chem (2005) 48: 4208-4211 [PMID:15974571]
fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916]
ChEMBL Binding constant for FLT4 kinase domain B 5.96 pKd 1100 nM Kd Nat Biotechnol (2008) 26: 127-132 [PMID:18183025]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]