Gd3+   Click here for help

GtoPdb Ligand ID: 2426

Synonyms: gadolinium ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPC5 Hs Activator - - - 1x10-4
⤷ Conc range: 1x10-4 M
TRPP2 Hs Channel blocker - - - 1x10-4 3
⤷ Conc range: 1x10-4 M [3]
Voltage: -50.0 mV
TRPC1 Hs Channel blocker Antagonist - - 2x10-5 10
⤷ Conc range: 2x10-5 M [10]
Voltage: -70.0 mV
TRPC3 Hs Channel blocker Antagonist 7.0 pEC50 - 5
⤷ pEC50 7.0 (EC50 1x10-7 M) [5]
Voltage: -60.0 mV
TRPA1 Mm Channel blocker Antagonist 7.0 pIC50 - 8
⤷ pIC50 7.0 [8]
Voltage: -80.0 mV
TRPC6 Mm Channel blocker Antagonist 5.7 pIC50 - 6
⤷ pIC50 5.7 (IC50 1.9x10-6 M) [6]
Voltage: -60.0 mV
Navi2.1 Hs Channel blocker - 5.6 pIC50 -
⤷ pIC50 5.6 (IC50 1.4x10-6 M)
TRPML3 Mm Channel blocker Antagonist 4.7 pIC50 - 9
⤷ pIC50 4.7 (IC50 2x10-5 M) [9]
Voltage: -80.0 mV
ASIC3 Hs Channel blocker - 4.4 pIC50 - 1
⤷ pIC50 4.4 (IC50 4x10-5 M) [1]
TRPM3 Hs Channel blocker Antagonist 4.0 pIC50 - 4,7
⤷ pIC50 4.0 [4,7]
TRPV4 Hs Channel blocker - - - -
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Maxi Cl- Hs Channel blocker (extracellular Gd3+) - - - -
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Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Cation rank order of potency at CaS receptor Gd3+ > Ca2+ > Mg2+ 2
Other channel blockers at TRPV5 Pb2+ = Cu2+ = Gd3+ > Cd2+ > Zn2+ > La3+ > Co2+ > Fe2