Gd3+   Click here for help

GtoPdb Ligand ID: 2426

Synonyms: gadolinium ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Babinski K, Catarsi S, Biagini G, Séguéla P. (2000)
Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+.
J Biol Chem, 275 (37): 28519-25. [PMID:10842183]
2. Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J, Hebert SC. (1993)
Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.
Nature, 366 (6455): 575-80. [PMID:8255296]
3. Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y, Brown EM, Reeders ST, Hediger MA, Zhou J. (1999)
Polycystin-L is a calcium-regulated cation channel permeable to calcium ions.
Nature, 401 (6751): 383-6. [PMID:10517637]
4. Grimm C, Kraft R, Sauerbruch S, Schultz G, Harteneck C. (2003)
Molecular and functional characterization of the melastatin-related cation channel TRPM3.
J Biol Chem, 278 (24): 21493-501. [PMID:12672799]
5. Halaszovich CR, Zitt C, Jungling E, Luckhoff A. (2000)
Inhibition of TRP3 channels by lanthanides. Block from the cytosolic side of the plasma membrane.
J Biol Chem, 275 (48): 37423-8. [PMID:10970899]
6. Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y. (2001)
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.
Circ Res, 88 (3): 325-32. [PMID:11179201]
7. Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, Huang M, Lin JH, Feder JN, Janovitz EB et al.. (2003)
Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3).
J Biol Chem, 278 (23): 20890-7. [PMID:12672827]
8. Nagata K, Duggan A, Kumar G, García-Añoveros J. (2005)
Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing.
J Neurosci, 25 (16): 4052-61. [PMID:15843607]
9. Nagata K, Zheng L, Madathany T, Castiglioni AJ, Bartles JR, García-Añoveros J. (2008)
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.
Proc Natl Acad Sci USA, 105 (1): 353-8. [PMID:18162548]
10. Zitt C, Zobel A, Obukhov AG, Harteneck C, Kalkbrenner F, Lückhoff A, Schultz G. (1996)
Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion.
Neuron, 16 (6): 1189-96. [PMID:8663995]