Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Associated Proteins
- Functional Characteristics
- Ion Selectivity and Conductance
- Rank order lists
- Activators
- Channel Blockers
- Immunopharmacology Comments
- Immuno Cell Type Associations
- Tissue Distribution
- Functional Assays
- Physiological Functions
- Phenotypes, Alleles and Disease Models
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 836 | 4q27 | TRPC3 | transient receptor potential cation channel subfamily C member 3 | 38 |
| Mouse | 6 | 1 | 836 | 3 17.93 cM | Trpc3 | transient receptor potential cation channel, subfamily C, member 3 | 23 |
| Rat | 6 | 1 | 836 | 2q25 | Trpc3 | transient receptor potential cation channel, subfamily C, member 3 | 24 |
| Previous and Unofficial Names |
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| TRP3 [38] | short transient receptor potential channel 3 | transient receptor protein 3 | trp-related protein 3 | transient receptor potential cation channel | |
| Database Links |
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| Alphafold | Q13507 (Hs), Q9QZC1 (Mm), Q9JMI9 (Rn) |
| CATH/Gene3D | 1.25.40.20 |
| ChEMBL Target | CHEMBL2417348 (Hs), CHEMBL4739706 (Mm), CHEMBL4105916 (Rn) |
| Ensembl Gene | ENSG00000138741 (Hs), ENSMUSG00000027716 (Mm), ENSRNOG00000016070 (Rn) |
| Entrez Gene | 7222 (Hs), 22065 (Mm), 60395 (Rn) |
| Human Protein Atlas | ENSG00000138741 (Hs) |
| KEGG Gene | hsa:7222 (Hs), mmu:22065 (Mm), rno:60395 (Rn) |
| OMIM | 602345 (Hs) |
| Pharos | Q13507 (Hs) |
| RefSeq Nucleotide | NM_001130698 (Hs), NM_019510 (Mm), NM_021771 (Rn) |
| RefSeq Protein | NP_001124170 (Hs), NP_062383 (Mm), NP_068539 (Rn) |
| UniProtKB | Q13507 (Hs), Q9QZC1 (Mm), Q9JMI9 (Rn) |
| Wikipedia | TRPC3 (Hs) |
| Associated Proteins |
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| Functional Characteristics |
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| γ = 66 pS; conducts mono and di-valent cations non-selectively (PCa/PNa = 1.6); monovalent cation current suppressed by extracellular Ca2+; dual (inward and outward) rectification | |
| Ion Selectivity and Conductance |
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| Ion Selectivity and Conductance Comments | ||||||
| Non-selective cation channel. |
| Chemical activators (Human) |
| diacylglycerols |
Download all structure-activity data for this target as a CSV file 
| Activators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Channel Blockers | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| Expressed on B cells, T cells, neutrophils and monocytes/macrophages [25]. |
| Cell Type Associations | ||||||
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| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| Phenotypes, Alleles and Disease Models
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References
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3. Bandyopadhyay BC, Swaim WD, Liu X, Redman RS, Patterson RL, Ambudkar IS. (2005) Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. J Biol Chem, 280 (13): 12908-16. [PMID:15623527]
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