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Y1 receptor

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Target id: 305

Nomenclature: Y1 receptor

Family: Neuropeptide Y receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 384 4q32.2 NPY1R neuropeptide Y receptor Y1 26-27,39
Mouse 7 382 8 33.15 cM Npy1r neuropeptide Y receptor Y1 17,44,67
Rat 7 382 16p14 Npy1r neuropeptide Y receptor Y1 16,37,55
Previous and Unofficial Names Click here for help
NPY-Y1 receptor [55] | FC5 | neuropeptide Y receptor type 1 | Y1-R
Database Links Click here for help
Specialist databases
GPCRdb npy1r_human (Hs), npy1r_mouse (Mm), npy1r_rat (Rn)
Other databases
Alphafold P25929 (Hs), Q04573 (Mm), P21555 (Rn)
ChEMBL Target CHEMBL4777 (Hs), CHEMBL4739851 (Mm), CHEMBL2587 (Rn)
Ensembl Gene ENSG00000164128 (Hs), ENSMUSG00000036437 (Mm), ENSRNOG00000014149 (Rn)
Entrez Gene 4886 (Hs), 18166 (Mm), 29358 (Rn)
Human Protein Atlas ENSG00000164128 (Hs)
KEGG Gene hsa:4886 (Hs), mmu:18166 (Mm), rno:29358 (Rn)
OMIM 162641 (Hs)
Pharos P25929 (Hs)
RefSeq Nucleotide NM_000909 (Hs), NM_010934 (Mm), NM_001113357 (Rn)
RefSeq Protein NP_000900 (Hs), NP_035064 (Mm), NP_001106828 (Rn)
UniProtKB P25929 (Hs), Q04573 (Mm), P21555 (Rn)
Wikipedia NPY1R (Hs)
Natural/Endogenous Ligands Click here for help
neuropeptide Y {Sp: Human, Mouse, Rat}
pancreatic polypeptide {Sp: Human} , pancreatic polypeptide {Sp: Mouse} , pancreatic polypeptide {Sp: Rat}
peptide YY {Sp: Human} , peptide YY {Sp: Mouse, Rat, Pig}
Comments: Neuropeptide Y is the principal endogenous agonist
Potency order of endogenous ligands (Human)
neuropeptide Y = peptide YY >> pancreatic polypeptide

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]PYY (pig) Peptide Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Full agonist 9.1 – 10.2 pKd 39,60
⤷ pKd 10.2 [60]
pKd 9.1 [39]
[125I]NPY (human, mouse, rat) Peptide Ligand is labelled Ligand is radioactive Rn Full agonist 9.2 pKd 37
⤷ pKd 9.2 [37]
[3H]NPY (human, mouse, rat) Peptide Ligand is labelled Ligand is radioactive Mm Full agonist 8.8 pKd 67
⤷ pKd 8.8 [67]
[Leu31,Pro34]NPY Peptide Click here for species-specific activity table Rn Full agonist 10.6 pKi 20
⤷ pKi 10.6 [20]
neuropeptide Y {Sp: Human, Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Rn Full agonist 10.5 pKi 20
⤷ pKi 10.5 [20]
peptide YY {Sp: Mouse, Rat, Pig} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Rn Full agonist 10.2 pKi 20
⤷ pKi 10.2 [20]
[Leu31,Pro34]PYY (human) Peptide Click here for species-specific activity table Rn Full agonist 10.2 pKi 20
⤷ pKi 10.2 [20]
NPY {Sp: Pig} Peptide Click here for species-specific activity table Rn Full agonist 10.0 pKi 20
⤷ pKi 10.0 [20]
NPY {Sp: Pig} Peptide Click here for species-specific activity table Hs Full agonist 9.7 pKi 60
⤷ pKi 9.7 [60]
NPY-(2-36) Peptide Click here for species-specific activity table Rn Full agonist 9.2 pKi 20
⤷ pKi 9.2 [20]
pancreatic polypeptide {Sp: Bovine} Peptide Click here for species-specific activity table Rn Full agonist 7.9 pKi 20
⤷ pKi 7.9 [20]
pancreatic polypeptide {Sp: Human} Peptide Click here for species-specific activity table Rn Full agonist 7.9 pKi 20
⤷ pKi 7.9 [20]
NPY-(13-36) (pig) Peptide Click here for species-specific activity table Rn Full agonist 7.8 pKi 20
⤷ pKi 7.8 [20]
NPY-(3-36) (pig) Peptide Click here for species-specific activity table Rn Full agonist 7.7 pKi 20
⤷ pKi 7.7 [20]
PYY-(13-36) (mouse, rat, pig) Peptide Click here for species-specific activity table Rn Full agonist 7.5 pKi 20
⤷ pKi 7.5 [20]
PYY-(3-36) {Sp: Human} Peptide Click here for species-specific activity table Rn Full agonist 7.4 pKi 20
⤷ pKi 7.4 [20]
pancreatic polypeptide {Sp: Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Rn Full agonist 7.0 pKi 20
⤷ pKi 7.0 [20]
[Leu31,Pro34]NPY Peptide Click here for species-specific activity table Hs Agonist 7.1 pEC50 12
⤷ pEC50 7.1 (EC50 7.87x10-8 M) [12]
neuropeptide Y {Sp: Human, Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Rn Full agonist 8.6 – 8.8 pIC50 37
⤷ pIC50 8.6 – 8.8 [37]
[Leu31,Pro34]NPY (pig) Peptide Click here for species-specific activity table Rn Full agonist 8.4 pIC50 15
⤷ pIC50 8.4 [15]
[Leu31,Pro34]NPY Peptide Click here for species-specific activity table Rn Full agonist 8.0 – 8.6 pIC50 37
⤷ pIC50 8.0 – 8.6 [37]
peptide YY {Sp: Human} Peptide Click here for species-specific activity table Rn Full agonist 7.6 – 8.5 pIC50 15,37
⤷ pIC50 7.6 – 8.5 [15,37]
[Leu31,Pro34]PYY (pig) Peptide Click here for species-specific activity table Rn Full agonist 7.4 pIC50 15
⤷ pIC50 7.4 [15]
NPY-(2-36) (pig) Peptide Rn Full agonist 6.3 pIC50 15
⤷ pIC50 6.3 [15]
[Ala31,Aib32]NPY (pig) Peptide Click here for species-specific activity table Hs Full agonist 6.0 pIC50 7
⤷ pIC50 6.0 [7]
neuropeptide Y {Sp: Human, Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Agonist - -
⤷
peptide YY {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Agonist - -
⤷
View species-specific agonist tables
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]GR231118 Peptide Click here for species-specific activity table Ligand is labelled Ligand is radioactive Rn Antagonist 10.0 pKd 15
⤷ pKd 10.0 [15]
GR231118 Peptide Click here for species-specific activity table Rn Antagonist 10.9 pKi 20
⤷ pKi 10.9 [20]
BIBP3226 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.1 – 9.3 pKi 14,71
⤷ pKi 8.1 – 9.3 (Ki 7.6x10-9 – 4.7x10-10 M) [14,71]
SR120819A Small molecule or natural product Hs Antagonist 8.4 pKi 60
⤷ pKi 8.4 [60]
BIBP3226 Small molecule or natural product Rn Antagonist 7.9 – 8.5 pKi 14,20,28
⤷ pKi 7.9 – 8.5 [14,20,28]
BIBO3304 Small molecule or natural product Rn Antagonist 9.7 pIC50 15
⤷ pIC50 9.7 [15]
BIBO3304 Small molecule or natural product Hs Antagonist 9.5 pIC50 70
⤷ pIC50 9.5 (IC50 3.8x10-10 M) [70]
GR231118 Peptide Click here for species-specific activity table Rn Antagonist 9.5 pIC50 15
⤷ pIC50 9.5 [15]
View species-specific antagonist tables
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family Adenylyl cyclase inhibition
References:  27,37,47,67
Tissue Distribution Click here for help
Colon, kidney, adrenal gland, heart, placenta.
Species:  Human
Technique:  in situ hybridisation.
References:  68
Heart.
Species:  Human
Technique:  Immunohistochemistry.
References:  31
Pial vessels, intracortical microvessels, capillaries.
Species:  Human
Technique:  RT-PCR.
References:  1
CNS: cortex, hippocampus, striatum, hypothalamus, amygdala.
Species:  Human
Technique:  in situ hybridisation.
References:  6
Colon (nonepithelial tissue).
Species:  Rat
Technique:  RT-PCR.
References:  22
Catecholaminergic neurons of the medulla oblongata.
Species:  Rat
Technique:  immunocytochemistry.
References:  72
Aorta, tail artery, hypothalamus, femoral artery, pulmonary artery, renal artery.
Species:  Rat
Technique:  RT-PCR.
References:  4
Ventrolateral portion of the suprachiasmatic nucleus.
Species:  Rat
Technique:  in situ hybridisation.
References:  40
Brain: cortex, hippocampus, thalamus, specific nuclei of the hypothalamus (such as supraoptic and arcuate), amygdala and brainstem nuclei.
Species:  Rat
Technique:  in situ hybridisation.
References:  52
Small arteries and arterioles: in the thyroid and parathyroid glands, spleen, gastrointestinal tract, salivary glands, pancreas, trachea, bladder, reproductive system.
Species:  Rat
Technique:  Immunohistochemistry.
References:  46
Antrum, small intestine, proximal colon.
Species:  Rat
Technique:  RT-PCR.
References:  18
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of cAMP levels in COS-1 cells transfected with the human Y1 receptor.
Species:  Human
Tissue:  COS-1 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  39
Measurement of cAMP levels in HEK 293 cells transfected with the rat Y1 receptor.
Species:  Rat
Tissue:  HEK 293 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  37
Measurement of Ca2+ levels in COS-1 cells transfected with the human Y1 receptor.
Species:  Human
Tissue:  COS-1 cells.
Response measured:  Ca2+ influx.
References:  39
Measurement of Ca2+ levels in HEK 293 cells transfected with the rat Y1 receptor.
Species:  Rat
Tissue:  HEK 293 cells.
Response measured:  Ca2+ influx.
References:  37
Measurement of Ca2+ levels in CHO cells transfected with the human Y1 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Increase in intracellular Ca2+.
References:  27
Measurement of cAMP levels in the mouse adrenocortical Y-1 cell line endogenously expressing the Y1 receptor.
Species:  Mouse
Tissue:  Adrenocortical Y-1 cell line.
Response measured:  Inhibition of cAMP accumulation.
References:  67
Physiological Functions Click here for help
Modulation of food intake.
Species:  Rat
Tissue:  In vivo.
References:  32
Inhibition of noradrenaline release.
Species:  Rat
Tissue:  Hypothalamus and medulla.
References:  25
Hyperinsulinemia independent of food ingestion.
Species:  Rat
Tissue:  In vivo.
References:  19
Stimulation of ethanol consumption.
Species:  Mouse
Tissue:  In vivo.
References:  61
Increase in blood pressure.
Species:  Rat
Tissue:  In vivo.
References:  2,9,23
Increase in heart rate.
Species:  Rat
Tissue:  In vivo.
References:  73
Antinociception.
Species:  Rat
Tissue:  In vivo.
References:  41,45,63,65-66,74
Modulation of anxiety-related behaviour.
Species:  Rat
Tissue:  In vivo.
References:  36,62
Stimulation of LH release.
Species:  Rat
Tissue:  In vivo.
References:  30
Stimulation of aldosterone secretion.
Species:  Rat
Tissue:  Adrenal capsular tissue.
References:  57
Inhibition of electrogenic ion transport.
Species:  Human
Tissue:  Isolated descending colon.
References:  13
Inhibition of electrogenic ion transport.
Species:  Mouse
Tissue:  Colonic mucosal preparaions.
References:  11
Physiological Consequences of Altering Gene Expression Click here for help
Y1 receptor knockout mice exhibit diet-induced obesity.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  58
Y1 receptor knockout mice exhibit obesity and hyperinsulinemia.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  5,38
Y1 receptor knockout mice exhibit an altered susceptibility to chemically-induced seizures.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  42
The feeding behaviour of Y1 receptor knockout mice is unaltered following antagonist administration, unlike in wild-type mice where feeding is suppressed.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  32
Y1 receptor knockout mice exhibit an increase in catecholamine synthesis and secretion from the adrenal medulla.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  8
Y1 receptor knockout mice do not exhibit potentiation of pentobarbital-induced sedation, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  49-50
Y1 receptor knockout mice exhibit an increase in ethanol consumption.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  64
In response to fasting, Y1 receptor knockout mice do not exhibit an impairment of reproductive function (measured as pituitary LH content and weight of seminal vesicles), as seen in fasted wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  56
Y1 receptor knockout mice exhibit impaired sensing of poor metabolic conditions by the gonadotrope axis.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  21
Y1 receptor knockout mice exhibit an increased territorial aggressive behaviour.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  35
Y1 receptor knockout mice exhibit a lack of blood pressure response to NPY, reduced fast-induced refeeding and an increase in body fat.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  54
Y1 receptor knockout mice exhibit a reduced somatomotor reactivity, reduced basal heart rate, increased heart rate activation during social challenge, an increase in the number of α2-adrenoceptors in the dorsal motor nucleus of the vagus and the locus coeruleus and a larger volume fraction of myocardial fibrosis.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  10
The dentate gyrus of Y1 receptor knockout mice exhibit reduced cell proliferation and fewer immature doublecortin-positive neurons.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  29
Y1 receptor knockout mice exhibit stress exposure and circadian rhythm-dependent changes in motor activity, exploration, and anxiety.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  34
T cells from Y1 receptor knockout mice exhibit hyperresponsive. Y1 receptor knockout mice are resistant to Th1 cell-mediated inflammatory responses, show reduced levels of the Th1 cell-promoting cytokine Il-12 and reduced IFN-γ production.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  69
Y1 receptor knockout mice exhibit mechanical pain hypersensitivity. Following peripheral nerve injury they exhibit an increase in synthesis, transport and release of CGRP and substance P in the dorsal horn.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  59
Y1 receptor knockout mice exhibit half as many dividing olfactory neuronal precursor cells and fewer olfactory neurons compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  24
Y1 receptor knockout mice exhibit hyperalgesia.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  51
Y1 receptor knockout mice exhibit reduced NPY-induced food intake, compared to wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  33
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0004185 abnormal adipocyte glucose uptake PMID: 11287097 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0002452 abnormal antigen presenting cell physiology PMID: 16330815 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0001544 abnormal cardiovascular system physiology PMID: 15652259 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0005450 abnormal energy expenditure PMID: 9623984 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0002078 abnormal glucose homeostasis PMID: 11287097 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0005437 abnormal glycogen level PMID: 11287097 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0001819 abnormal immune cell physiology PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0002722 abnormal immune system organ morphology PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0001790 abnormal immune system physiology PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0002490 abnormal immunoglobulin level PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0001845 abnormal inflammatory response PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008828 abnormal lymph node cell ratio PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0002451 abnormal macrophage physiology PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0009937 abnormal neuron differentiation PMID: 12859678 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: C57BL/6		 MGI:104963  MP:0006092 abnormal olfactory neuron morphology PMID: 18305161 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: C57BL/6		 MGI:104963  MP:0004275 abnormal postnatal subventricular zone morphology PMID: 18305161 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: C57BL/6		 MGI:104963  MP:0004279 abnormal rostral migratory stream morphology PMID: 18305161 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0000689 abnormal spleen morphology PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008826 abnormal splenic cell ratio PMID: 16330815 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0001007 abnormal sympathetic system morphology PMID: 15652259 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0001828 abnormal T cell activation PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0006387 abnormal T cell number PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0005465 abnormal T-helper 1 physiology PMID: 16330815 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0000250 abnormal vasoconstriction PMID: 9623984 
Npy1rtm1Pern|Npy2rtm1Pern Npy1rtm1Pern/Npy1rtm1Pern,Npy2rtm1Pern/Npy2rtm1Pern
involves: 129/Sv		 MGI:104963  MGI:108418  MP:0002862 altered righting response PMID: 11579129 
Npy1rtm1Pern Npy1rtm1Pern/Npy1rtm1Pern
Not Specified		 MGI:104963  MP:0002862 altered righting response PMID: 11579129 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0005608 cardiac interstitial fibrosis PMID: 15652259 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0005017 decreased B cell number PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008079 decreased CD8-positive T cell number PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008618 decreased circulating interleukin-12 level PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008554 decreased circulating tumor necrosis factor level PMID: 16330815 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0003910 decreased eating behavior PMID: 9623984 
Npy1rtm1Aka Npy1rtm1Aka/Npy1rtm1Aka
involves: C57BL/6 * CBA		 MGI:104963  MP:0003910 decreased eating behavior PMID: 10698177 
Npy1rtm1Mnak Npy1rtm1Mnak/Npy1rtm1Mnak
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0004890 decreased energy expenditure PMID: 9861026 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0001417 decreased exploration in new environment PMID: 15652259 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0005333 decreased heart rate PMID: 15652259 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008496 decreased IgG2a level PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008567 decreased interferon-gamma secretion PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008182 decreased marginal zone B cell number PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008211 decreased mature B cell number PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: C57BL/6		 MGI:104963  MP:0004981 decreased neuronal precursor cell number PMID: 18305161 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0005290 decreased oxygen consumption PMID: 9623984 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality PMID: 16650144 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0005616 decreased susceptibility to type IV hypersensitivity reaction PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008190 decreased transitional stage B cell number PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0001399 hyperactivity PMID: 15314215 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0001559 hyperglycemia PMID: 11287097 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0001402 hypoactivity PMID: 9623984 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0009755 impaired behavioral response to alcohol PMID: 11826154 
Npy1rtm1Mnak Npy1rtm1Mnak/Npy1rtm1Mnak
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0005293 impaired glucose tolerance PMID: 9861026 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0001353 increased aggression towards mice PMID: 15314215 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0003545 increased alcohol consumption PMID: 11826154 
Npy1rtm1Mnak Npy1rtm1Mnak/Npy1rtm1Mnak
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0001260 increased body weight PMID: 9861026 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008074 increased CD4-positive T cell number PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008078 increased CD8-positive T cell number PMID: 16330815 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0001745 increased circulating corticosterone level PMID: 14525913 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0001554 increased circulating free fatty acid level PMID: 9623984 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0002079 increased circulating insulin level PMID: 9623984 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0002079 increased circulating insulin level PMID: 11287097  14525913 
Npy1rtm1Mnak Npy1rtm1Mnak/Npy1rtm1Mnak
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0002079 increased circulating insulin level PMID: 9861026 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0005669 increased circulating leptin level PMID: 9623984 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0005669 increased circulating leptin level PMID: 14525913 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0009288 increased epididymal fat pad weight PMID: 11287097 
Npy1rtm1Mnak Npy1rtm1Mnak/Npy1rtm1Mnak
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0009285 increased gonadal fat pad weight PMID: 9861026 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0002495 increased IgA level PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008501 increased IgG2b level PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0002494 increased IgM level PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0002461 increased immunoglobulin level PMID: 16330815 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0001934 increased litter size PMID: 15314215 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0005458 increased percent body fat PMID: 11287097 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0009304 increased retroperitoneal fat pad weight PMID: 14525913 
Npy1rtm1Mnak Npy1rtm1Mnak/Npy1rtm1Mnak
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0009304 increased retroperitoneal fat pad weight PMID: 9861026 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0008082 increased single-positive T cell number PMID: 16330815 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0010024 increased total body fat amount PMID: 9623984 
Npy1rtm1Wpg Npy1rtm1Wpg/Npy1rtm1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0002169 no abnormal phenotype detected PMID: 12859678 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
involves: 129P2/OlaHsd * C57BL/6		 MGI:104963  MP:0001261 obese PMID: 9623984 
Npy1rtm1Tped Npy1rtm1Tped/Npy1rtm1Tped
B6.129P2-Npy1r		 MGI:104963  MP:0001261 obese PMID: 14525913 
Npy1rtm1Aka Npy1rtm1Aka/Npy1rtm1Aka
involves: C57BL/6 * CBA		 MGI:104963  MP:0001261 obese PMID: 10698177 
Npy1rtm1.1Wpg Npy1rtm1.1Wpg/Npy1rtm1.1Wpg
involves: 129X1/SvJ * C57BL/6		 MGI:104963  MP:0000692 small spleen PMID: 16330815 
Biologically Significant Variants Click here for help
Type:  Splice variants
Species:  Mouse
Description:  Two splice variants exist for the murine Y1 receptor, one of which has a shortened TM7 and lacks the C-terminus. This variant binds NPY but couples less effectively to signal transduction
References:  48
Type:  Splice variants
Species:  Human
Description:  Three splice variants of the human Y1 receptor have been identified which yield multiple promoters with tissue-specific expression patterns.
References:  3
General Comments
For a review on NPY receptor knockout mice see [43].
For a review specifically on Y1 receptor knockouts see [53].

References

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