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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 4 | 453 | 5q34 | GABRA6 | gamma-aminobutyric acid type A receptor subunit alpha6 | 3,5 |
Mouse | 4 | 453 | 11 25.03 cM | Gabra6 | gamma-aminobutyric acid type A receptor subunit alpha 6 | 8 |
Rat | 4 | 453 | 10q21 | Gabra6 | gamma-aminobutyric acid type A receptor subunit alpha6 | 26 |
Database Links ![]() |
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Alphafold | Q16445 (Hs), P16305 (Mm), P30191 (Rn) |
CATH/Gene3D | 2.70.170.10 |
ChEMBL Target | CHEMBL2579 (Hs), CHEMBL2094133 (Mm), CHEMBL293 (Rn) |
DrugBank Target | Q16445 (Hs), Q16445 (Hs) |
Ensembl Gene | ENSG00000145863 (Hs), ENSMUSG00000020428 (Mm), ENSRNOG00000003569 (Rn) |
Entrez Gene | 2559 (Hs), 14399 (Mm), 29708 (Rn) |
Human Protein Atlas | ENSG00000145863 (Hs) |
KEGG Gene | hsa:2559 (Hs), mmu:14399 (Mm), rno:29708 (Rn) |
OMIM | 137143 (Hs) |
Pharos | Q16445 (Hs) |
RefSeq Nucleotide | NM_000811 (Hs), NM_001099641 (Mm), NM_021841 (Rn) |
RefSeq Protein | NP_000802 (Hs), NP_001093111 (Mm), NP_068613 (Rn) |
UniProtKB | Q16445 (Hs), P16305 (Mm), P30191 (Rn) |
Wikipedia | GABRA6 (Hs) |
Natural/Endogenous Ligands ![]() |
GABA |
5α-pregnan-3α-ol-20-one |
tetrahydrodeoxycorticosterone |
Zn2+ |
Download all structure-activity data for this target as a CSV file
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Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Allosteric Modulators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Tissue Distribution ![]() |
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Physiological Consequences of Altering Gene Expression ![]() |
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Biologically Significant Variants ![]() |
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7. Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Mäkelä R, Mellor JR, Pollard S, Bahn S, Stephenson FA, Randall AD, Sieghart W, Somogyi P, Smith AJ, Wisden W. (1997) Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci, 17 (4): 1350-62. [PMID:9006978]
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9. Korpi ER, Kleingoor C, Kettenmann H, Seeburg PH. (1993) Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor. Nature, 361 (6410): 356-9. [PMID:7678923]
10. Korpi ER, Koikkalainen P, Vekovischeva OY, Mäkelä R, Kleinz R, Uusi-Oukari M, Wisden W. (1999) Cerebellar granule-cell-specific GABAA receptors attenuate benzodiazepine-induced ataxia: evidence from alpha 6-subunit-deficient mice. Eur J Neurosci, 11 (1): 233-40. [PMID:9987027]
11. Laurie DJ, Seeburg PH, Wisden W. (1992) The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci, 12 (3): 1063-76. [PMID:1312132]
12. Lüddens H, Pritchett DB, Köhler M, Killisch I, Keinänen K, Monyer H, Sprengel R, Seeburg PH. (1990) Cerebellar GABAA receptor selective for a behavioural alcohol antagonist. Nature, 346 (6285): 648-51. [PMID:2166916]
13. Maison SF, Rosahl TW, Homanics GE, Liberman MC. (2006) Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. J Neurosci, 26 (40): 10315-26. [PMID:17021187]
14. Mäkelä R, Uusi-Oukari M, Homanics GE, Quinlan JJ, Firestone LL, Wisden W, Korpi ER. (1997) Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines. Mol Pharmacol, 52 (3): 380-8. [PMID:9281599]
15. Nusser Z, Ahmad Z, Tretter V, Fuchs K, Wisden W, Sieghart W, Somogyi P. (1999) Alterations in the expression of GABAA receptor subunits in cerebellar granule cells after the disruption of the alpha6 subunit gene. Eur J Neurosci, 11 (5): 1685-97. [PMID:10215922]
16. Nusser Z, Sieghart W, Somogyi P. (1998) Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci, 18 (5): 1693-703. [PMID:9464994]
17. Nusser Z, Sieghart W, Stephenson FA, Somogyi P. (1996) The alpha 6 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells. J Neurosci, 16 (1): 103-14. [PMID:8613776]
18. Persohn E, Malherbe P, Richards JG. (1992) Comparative molecular neuroanatomy of cloned GABAA receptor subunits in the rat CNS. J Comp Neurol, 326 (2): 193-216. [PMID:1336019]
19. Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. (2000) GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience, 101 (4): 815-50. [PMID:11113332]
20. Ramerstorfer J, Furtmüller R, Vogel E, Huck S, Sieghart W. (2010) The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes. Eur J Pharmacol, 636 (1-3): 18-27. [PMID:20303942]
21. Saba L, Porcella A, Sanna A, Congeddu E, Marziliano N, Mongeau R, Grayson D, Pani L. (2005) Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats. Brain Res Mol Brain Res, 137 (1-2): 252-7. [PMID:15950783]
22. Sharma R, Nakamura M, Neupane C, Jeon BH, Shin H, Melnick SM, Glenn KJ, Jang IS, Park JB. (2020) Positive allosteric modulation of GABAA receptors by a novel antiepileptic drug cenobamate. Eur J Pharmacol, 879: 173117. [PMID:32325146]
23. Sieghart W, Chiou LC, Ernst M, Fabjan J, M Savic; M, Lee MT. (2022) α 6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials. Pharmacol Rev, 74 (1): 238-270. [PMID:35017178]
24. Sieghart W, Savić MM. (2018) International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans. Pharmacol Rev, 70 (4): 836-878. [PMID:30275042]
25. Varecka L, Wu CH, Rotter A, Frostholm A. (1994) GABAA/benzodiazepine receptor alpha 6 subunit mRNA in granule cells of the cerebellar cortex and cochlear nuclei: expression in developing and mutant mice. J Comp Neurol, 339 (3): 341-52. [PMID:8132866]
26. Wieland HA, Lüddens H, Seeburg PH. (1992) A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J Biol Chem, 267 (3): 1426-9. [PMID:1346133]
27. Wisden W, Laurie DJ, Monyer H, Seeburg PH. (1992) The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci, 12 (3): 1040-62. [PMID:1312131]