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B1 receptor

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Target id: 41

Nomenclature: B1 receptor

Family: Bradykinin receptors

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 353 14q32.2 BDKRB1 bradykinin receptor B1 16
Mouse 7 334 12 E Bdkrb1 bradykinin receptor, beta 1 69
Rat 7 337 6q32 Bdkrb1 bradykinin receptor B1 62
Previous and Unofficial Names Click here for help
B1BKR | BKR1 | B1R | kinin B1 receptor | bradykinin receptor | bradykinin receptor, B1
Database Links Click here for help
Specialist databases
GPCRdb bkrb1_human (Hs), bkrb1_mouse (Mm), bkrb1_rat (Rn)
Other databases
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands Click here for help
bradykinin {Sp: Human, Mouse, Rat}
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat}
[des-Arg10]kallidin {Sp: Human}
[Hyp3]bradykinin {Sp: Human}
kallidin {Sp: Human}
Lys-[Hyp3]-bradykinin {Sp: Human}
T-kinin {Sp: Human, Rat}
Comments: [Des-Arg10]kallidin is the most potent endogenous ligand in human
Potency order of endogenous ligands (Human)
[des-Arg10]kallidin (KNG1, P01042) > [des-Arg9]bradykinin (KNG1, P01042) = kallidin (KNG1, P01042) > bradykinin (KNG1, P01042)

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[des-Arg10]kallidin {Sp: Human} Peptide Ligand is endogenous in the given species Hs Full agonist 9.6 – 10.0 pKi 6,9,37,48
pKi 9.6 – 10.0 [6,9,37,48]
D-Lys0-[des-Arg10]kallidin Peptide Hs Full agonist 9.5 pKi 6
pKi 9.5 [6]
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Mm Full agonist 9.2 pKi 45
pKi 9.2 [45]
[des-Arg10]kallidin {Sp: Human} Peptide Click here for species-specific activity table Mm Full agonist 8.8 pKi 45
pKi 8.8 [45]
[des-Arg10]kallidin {Sp: Human} Peptide Rn Full agonist 8.7 – 8.9 pKi 48
pKi 8.7 – 8.9 [48]
kallidin {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Full agonist 7.0 – 8.9 pKi 6,9,48
pKi 7.0 – 8.9 [6,9,48]
[D-Lys1,des-Arg10]kallidin Peptide Hs Full agonist 7.4 – 7.6 pKi 6
pKi 7.4 – 7.6 [6]
[des-Arg11]T-kinin Peptide Rn Full agonist 7.2 – 7.5 pKi 48
pKi 7.2 – 7.5 [48]
[Sar,D-Phe8,des-Arg9]bradykinin Peptide Rn Full agonist 7.1 – 7.4 pKi 48
pKi 7.1 – 7.4 [48]
Lys-kallidin Peptide Hs Full agonist 6.7 – 6.9 pKi 6
pKi 6.7 – 6.9 [6]
bradykinin {Sp: Human, Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Mm Full agonist 6.7 pKi 45
pKi 6.7 [45]
kallidin {Sp: Human} Peptide Rn Full agonist 6.5 – 6.6 pKi 48
pKi 6.5 – 6.6 [48]
kallidin {Sp: Human} Peptide Click here for species-specific activity table Mm Full agonist 6.3 pKi 44-45
pKi 6.3 [44-45]
[des-Phe9,des-Arg10]kallidin Peptide Hs Full agonist 6.1 – 6.2 pKi 6
pKi 6.1 – 6.2 [6]
[des-Pro8,des-Phe9,des-Arg10]kallidin Peptide Hs Full agonist 5.8 – 5.9 pKi 6
pKi 5.8 – 5.9 [6]
[des-Arg11]T-kinin Peptide Hs Full agonist 5.7 – 5.9 pKi 48
pKi 5.7 – 5.9 [48]
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Full agonist 5.7 – 5.8 pKi 9,48
pKi 5.7 – 5.8 [9,48]
[Sar,D-Phe8,des-Arg9]bradykinin Peptide Hs Full agonist 5.7 pKi 5,48
pKi 5.7 (Ki 1.99x10-6 M) [5,48]
T-kinin {Sp: Human, Rat} Peptide Ligand is endogenous in the given species Hs Full agonist 5.2 pKi 48
pKi 5.2 [48]
bradykinin {Sp: Human, Mouse, Rat} Peptide Ligand is endogenous in the given species Rn Full agonist 5.1 – 5.3 pKi 48
pKi 5.1 – 5.3 [48]
T-kinin {Sp: Human, Rat} Peptide Ligand is endogenous in the given species Rn Full agonist 5.0 – 5.2 pKi 48
pKi 5.0 – 5.2 [48]
bradykinin {Sp: Human, Mouse, Rat} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Hs Full agonist 4.0 pKi 6
pKi 4.0 [6]
[Leu8,des-Arg9]bradykinin Peptide Mm Partial agonist 7.3 pEC50 55
pEC50 7.3 [55]
NG29 Peptide Hs Full agonist 9.5 pIC50 75
pIC50 9.5 (IC50 3.16x10-10 M) [75]
Met-Lys-bradykinin Peptide Click here for species-specific activity table Hs Full agonist 7.1 pIC50 58
pIC50 7.1 [58]
View species-specific agonist tables
Agonist Comments
The presence of arginine carboxypeptidases in functional systems frequently distorts the potency estimates for BK or Lys-BK on the B1 receptor, as these ligands are transformed into their respectice des-Arg9 metabolites [56].
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
B-9858 Peptide Hs Antagonist 9.2 pA2 72
pA2 9.2 [72]
R-954 Peptide Hs Antagonist 8.6 pA2 38
pA2 8.6 [38]
R-715 Peptide Hs Antagonist 8.5 pA2 36
pA2 8.5 [36]
B-9430 Peptide Click here for species-specific activity table Hs Antagonist 7.7 pA2 72
pA2 7.7 [72]
[des-Arg10]icatibant Peptide Mm Antagonist 7.2 pA2 72
pA2 7.2 [72]
[Leu9,des-Arg10]kallidin Peptide Mm Antagonist 7.0 pA2 1
pA2 7.0 [1]
R-715 Peptide Mm Antagonist 7.0 pA2 1
pA2 7.0 [1]
[Leu8,des-Arg9]bradykinin Peptide Mm Antagonist 6.9 pA2 1
pA2 6.9 [1]
B-9430 Peptide Click here for species-specific activity table Mm Antagonist 6.1 pA2 72
pA2 6.1 [72]
compound 11 [PMID: 12812482] Small molecule or natural product Hs Antagonist 10.5 pKi 78
pKi 10.5 [78]
NPC 18565 Peptide Click here for species-specific activity table Hs Antagonist 10.2 pKi 53
pKi 10.2 [53]
B-9958 Peptide Hs Antagonist 9.2 – 10.3 pKi 35,72
pKi 9.2 – 10.3 (Ki 6.3x10-10 – 5.1x10-11 M) [35,72]
B-9858 Peptide Hs Antagonist 8.7 – 10.4 pKi 48,53,55
pKi 8.7 – 10.4 [48,53,55]
B-10356 Peptide Hs Antagonist 8.8 – 10.2 pKi 35
pKi 8.8 – 10.2 [35]
[Leu9,des-Arg10]kallidin Peptide Hs Antagonist 9.1 – 9.3 pKi 6,9
pKi 9.1 – 9.3 [6,9]
R-715 Peptide Hs Antagonist 9.2 pKi 55
pKi 9.2 (Ki 6.3x10-10 M) [55]
compound 12 [PMID: 12723943] Small molecule or natural product Hs Antagonist 9.2 pKi 84
pKi 9.2 [84]
SSR240612 Small molecule or natural product Hs Antagonist 9.1 – 9.2 pKi 39
pKi 9.1 – 9.2 [39]
compound 12 [PMID: 12723943] Small molecule or natural product Rn Antagonist 9.0 pKi 84
pKi 9.0 [84]
B-9858 Peptide Rn Antagonist 8.4 – 8.7 pKi 48
pKi 8.4 – 8.7 [48]
[Leu8,des-Arg9]bradykinin Peptide Mm Antagonist 8.4 pKi 45
pKi 8.4 [45]
B-9858 Peptide Mm Antagonist 8.3 pKi 55
pKi 8.3 [55]
PS020990 Small molecule or natural product Hs Antagonist 8.2 pKi 47
pKi 8.2 [47]
[Leu9,des-Arg10]kallidin Peptide Mm Antagonist 8.1 pKi 45
pKi 8.1 [45]
NVP-SAA164 Small molecule or natural product Hs Antagonist 7.9 – 8.1 pKi 30,74
pKi 7.9 – 8.1 [30,74]
B-9430 Peptide Click here for species-specific activity table Hs Antagonist 7.9 pKi 55,77
pKi 7.9 [55,77]
[des-Arg10]icatibant Peptide Mm Antagonist 7.6 pKi 45
pKi 7.6 [45]
[Leu8,des-Arg9]bradykinin Peptide Rn Antagonist 7.4 – 7.7 pKi 48
pKi 7.4 – 7.7 [48]
[des-Arg10]icatibant Peptide Hs Antagonist 6.6 – 8.4 pKi 9,48
pKi 6.6 – 8.4 [9,48]
[des-Arg10]icatibant Peptide Rn Antagonist 7.4 – 7.6 pKi 48
pKi 7.4 – 7.6 [48]
R-715 Peptide Mm Antagonist 7.4 pKi 55
pKi 7.4 [55]
compound 11 [PMID: 12812482] Small molecule or natural product Rn Antagonist 7.2 pKi 78
pKi 7.2 [78]
JMV1431 Peptide Click here for species-specific activity table Hs Antagonist 7.1 pKi 2
pKi 7.1 [2]
NPC 17731 Peptide Click here for species-specific activity table Hs Antagonist 6.9 pKi 53
pKi 6.9 [53]
icatibant Peptide Approved drug Click here for species-specific activity table Immunopharmacology Ligand Hs Antagonist 6.4 – 7.0 pKi 9,48
pKi 6.4 – 7.0 [9,48]
B-9430 Peptide Click here for species-specific activity table Mm Antagonist 6.6 pKi 55
pKi 6.6 [55]
[Leu8,des-Arg9]bradykinin Peptide Hs Antagonist 5.8 – 7.2 pKi 3,6,9,48,58
pKi 5.8 – 7.2 [3,6,9,48,58]
icatibant Peptide Approved drug Click here for species-specific activity table Immunopharmacology Ligand Rn Antagonist 6.1 – 6.4 pKi 48
pKi 6.1 – 6.4 [48]
Ac-Lys-[MeAla6,Leu8,des-Arg9]bradykinin Peptide Hs Antagonist 6.2 pKi 55
pKi 6.2 [55]
[Leu9,des-Arg10]kallidin Peptide Hs Antagonist 8.9 pIC50 58
pIC50 8.9 [58]
chroman 28 Small molecule or natural product Hs Antagonist 8.5 pIC50 20
pIC50 8.5 [20]
chroman 28 Small molecule or natural product Rn Antagonist 8.3 – 8.5 pIC50 20
pIC50 8.3 – 8.5 [20]
View species-specific antagonist tables
Antagonist Comments
B-9958 is an aminopeptidase N substrate [35]. B-10356 is an aminopeptidase N inhibitor [35].
The classical antagonists, [Leu8,des-Arg9]bradykinin and [Leu9,des-Arg10]kallidin, act as partial agonists at the mouse B1 receptors [1,55]. Moreover, the B1 receptor antagonist [Leu8, des-Arg9]bradykinin behaves as partial agonist on the cloned dog B1 receptor [46] and caused a transient fall in blood pressure in anaesthetized dogs [61].
Immunopharmacology Comments
Bradykinin is a vasoactive, pain inducing and pro-inflammatory kinin released during acute inflammation, and its receptors, B1 and B2, are expressed on eosinophils, and neutrophils.
Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   eosinophil (CL:0000771)
neutrophil (CL:0000775)
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family
Gq/G11 family
Adenylyl cyclase inhibition
Phospholipase C stimulation
References:  6
Tissue Distribution Click here for help
Human brain glioblastoma.
Species:  Human
Technique:  Immunohistochemistry.
References:  63
Human brain endothelial cells during inflammatory response. Signalling via theB1 receptor can regulate blood-brain barrier permeability and chemokine production.
Species:  Human
Technique:  RT-PCR, Western blot.
References:  70
Human colon.
Species:  Human
Technique:  Pharmacological bioassay.
References:  19
Prostatic intraepithelial neoplasia and malignant lesions.
Species:  Human
Technique:  Immunohistochemistry.
References:  81
T lymphocytes.
Species:  Human
Technique:  RT-PCR, Western blot.
References:  71
Gastric mucosa.
Species:  Human
Technique:  Immunohistochemistry.
References:  12
Lung fibroblasts.
Species:  Human
Technique:  Immunohistochemistry.
References:  73
Macrophages and CD4+ T cells: B1 receptor is upregulated on these cells in the pancreas of type 1 diabetic rats. B1R blockade exerts anti-diabetic action by preventing the infiltration of these immune cells in the pancreas and by preserving the integrity of Langerhans islets β-cells.
Species:  Rat
Technique:  Macrophages, CD4+ T lymphocytes
References:  82
Dorsal root ganglion primary afferent terminations.
Species:  Rat
Technique:  Immunohistochemistry.
References:  31
Laminae 1 and 2 of the dorsal horn of the spinal cord, peripheral nerve terminals in the bladder, dorsal root ganglion.
Species:  Rat
Technique:  Immunohistochemistry.
References:  85
Thalamus and hypothalamus > cortical regions and hippocampus.
Species:  Rat
Technique:  Autoradiography and in situ hybridization.
References:  13
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of intracellular Ca2+ in human monocyte-derived dendritic cells endogenously expressing the B1 receptor.
Species:  Human
Tissue:  Monocyte-derived dendritic cells.
Response measured:  Increase in intracellular Ca2+.
References:  10
Measurement of intracellular Ca2+ in rat mesangial cells endogenously expressing the B1 receptor.
Species:  Rat
Tissue:  Mesangial cells.
Response measured:  Elevation of intracellular Ca2+.
References:  8
Measurement of phosphorylation of MAP kinase in rat vascular smooth muscle cells endogenously expressing the B1 receptor.
Species:  Rat
Tissue:  Vascular smooth muscle cells.
Response measured:  Phosphorylation of MAP kinase.
References:  17
Cigarette smoke-induced B1 receptor promotes NADPH oxidase activity in cultured human alveolar epithelial cells.
Species:  Human
Tissue:  Human alveolar epithelial A549 cells.
Response measured:  Increase of superoxide anion.
References:  80
Measurement of contractile responses in human umbilical veins endogenously expressing the B1R.
Species:  Human
Tissue:  Isolated umbilical veins.
Response measured:  Contraction.
References:  37,72
Physiological Functions Click here for help
Inhibition of arterial smooth muscle cell migration.
Species:  Human
Tissue:  Arterial smooth muscle.
References:  60
Activation of neutrophil recruitment.
Species:  Human
Tissue:  Neutrophils isolated from peripheral blood.
References:  26
Modulation of blood pressure.
Species:  Rat
Tissue:  In vivo.
References:  25
Modulation of hyperalgesia.
Species:  Rat
Tissue:  In vivo.
References:  31
Mediation of acute nociception.
Species:  Rat
Tissue:  In vivo.
References:  18
B1 blocking inhibits plasma extravasation in streptozotocin-induced diabetic rats.
Species:  Rat
Tissue:  In vivo.
References:  52
Modulation of vascular permeability of the skin and retina of type 1 diabetic rats.
Species:  Rat
Tissue:  In vivo.
References:  51
Modulation of antigen-induced pulmonary inflammation in mice.
Species:  Mouse
Tissue:  In vivo.
References:  28
B1 receptor blockade causes antinociception in induced hyperalgesia.
Species:  Rat
Tissue:  In vivo.
References:  66
Prevention of the insulitis and renal damage in a model of insulin-dependent diabetes.
Species:  Rat
Tissue:  In vivo.
References:  86
Control of inflammatory pain conditions.
Species:  Mouse
Tissue:  In vivo.
References:  30
Colocalisation and functional interaction between B1 receptor and inducible nitric oxide synthase (iNOS) in rat diabetic retina.
Species:  Rat
Tissue:  Retina
References:  65
Close interaction and reciprocal regulatory mechanism between B1R and TRPV1 on astrocytes and nociceptors in rat neuropathic pain.
Species:  Rat
Tissue: 
References:  15
B1R is co-localized with NADPH oxidase (NOX1 and NOX2) on endothelial and vascular smooth muscle cells and macrophages in rat diabetic blood vessels and B1R stimulation increases superoxide anion production.
Species:  Rat
Tissue:  Endothelial cells, vascular smooth muscle cells, macrophages.
References:  43
B1 receptor was found on astrocytes in a mouse brain tumour, and uncontrolled tumour growth occurs in B1 receptor knockout mice or SSR240612-treated mice, which was blunted by B2 receptor blockade or deletion.
Species:  Mouse
Tissue:  Tumour-derived astrocytes.
References:  63
B1 receptor antagonism abrogates amyloidosis, cerebrovascular and memory deficits in a mouse model of Alzheimer's disease.
Species:  Mouse
Tissue:  In vivo
References:  49
B1 receptor blockade is of therapeutic value in models of type 2 diabetes, obesity and insulin resistance (mouse and rat).
Species:  Mouse
Tissue:  In vivo
References:  22-24,27,79
B1R is expressed in platelets and plays a primary role in inflammation, organ damage, and lethal thrombosis in a rat model of septic shock in diabetes.
Species:  Rat
Tissue: 
References:  83
Upregulation of B1R in endothelial and glial cells in rat diabetic retina and a rat model of age-related macular degeneration. Therapeutic value of eye-drop application of a B1R antagonist in both ocular diseases.
Species:  Rat
Tissue: 
References:  40-42
Attenuation of cardiac remodeling.
Species:  Rat
Tissue:  In vivo.
References:  59
Activation of B1 receptors in the kindled rat hippocampus results in increase extracellular glutamate levels.
Species:  Rat
Tissue:  Kindled hippocampus.
References:  57
Physiological Consequences of Altering Gene Expression Click here for help
B1 receptor knockout mice display hypoalgesia and altered inflammatory responses when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  68
Diabetic hyperalgesia is absent in streptozotocin-induced type 1 diabetic B1 receptor knockout mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  32-34
B1 knockout mice display reduced pancreatic vascular permeability when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  4
B1 knockout mice display reduced nerve injury-induced neuropathic pain when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  29
Mice lacking both the B1 and B2 receptor are normotensive and protected from endotoxin- induced hypotension when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  14
B1 receptor knockout mice display worsened myocardial ischemia when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  50
B1 knockout mice display altered inflammatory responses following intestinal ischemia and reperfusion injury, when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  76
Mice lacking both the B1 and B2 receptor are normotensive and protected from endotoxin- induced hypotension when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells
References:  14
B1 knockout mice display lower fasting plasma glucose concentrations but exhibit higher glycemia after feeding when compared to wild-type mice. B1 knockout mice also present pancreas abnormalities, which lead to hypoinsulinemia and reduced insulin release after a glucose load.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  4
Xenobiotics Influencing Gene Expression Click here for help
B1 receptor expression is induced by cigarette-smoke in rat airways.
Species:  Rat
Tissue:  Lung slices.
Technique:  Western blot
References:  54
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0002498 abnormal acute inflammation PMID: 10859349 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0002135 abnormal kidney morphology PMID: 17452647 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0002734 abnormal mechanical nociception PMID: 10859349 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0004756 abnormal proximal convoluted tubule morphology PMID: 17452647 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0002733 abnormal thermal nociception PMID: 10859349 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0005566 decreased blood urea nitrogen level PMID: 17452647 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0001982 decreased chemically-elicited antinociception PMID: 10859349 
Bdkrb1tm2Bdr|Bdkrb2tm1Jfh Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MGI:88144  MP:0005333 decreased heart rate PMID: 16497152 
Bdkrb1tm2Bdr|Bdkrb2tm1Jfh Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MGI:88144  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 16497152 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0008734 decreased susceptibility to endotoxin shock PMID: 16497152 
Bdkrb1tm2Bdr|Bdkrb2tm1Jfh Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
involves: 129S7/SvEvBrd * C57BL/6
MGI:102845  MGI:88144  MP:0008734 decreased susceptibility to endotoxin shock PMID: 16497152 
Bdkrb1tm1Bdr Bdkrb1tm1Bdr/Bdkrb1tm1Bdr
involves: 129P2/OlaHsd
MGI:88144  MP:0003043 hypoalgesia PMID: 10859349 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0005565 increased blood urea nitrogen level PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0005553 increased circulating creatinine level PMID: 17452647 
Bdkrb2/Bdkrb1tm1Mki Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki
involves: C57BL/6J
MGI:88144  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 17452647 
Bdkrb1tm1Dgen Bdkrb1tm1Dgen/Bdkrb1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:88144  MP:0002169 no abnormal phenotype detected
Bdkrb1tm1(BDKRB1)Jfh Bdkrb1tm1(BDKRB1)Jfh/Bdkrb1tm1(BDKRB1)Jfh
involves: 129 * C57BL/6
MGI:88144  MP:0002169 no abnormal phenotype detected PMID: 16497152 
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Description:  The B1 receptor polymorphism -699 G/C has been associated with renal disease.
References:  7
Type:  Single nucleotide polymorphism
Species:  Human
Description:  The -699 G/C polymorphism has been found to be a predictor of cardiovascular risk in hypertension.
References:  21
General Comments
B1 and B2 receptors are overexpressed in the hippocampus of humans with temporal lobe epilepsy [67]. B1 receptor is overexpressed in the retina of humans affected with the wet form of age-related macular degeneration [64], and in the retina of diabetic patients [11].

References

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1. Allogho SN, Gobeil F, Pheng LH, Nguyen-Le XK, Neugebauer W, Regoli D. (1995) Kinin B1 and B2 receptors in the mouse. Can J Physiol Pharmacol, 73 (12): 1759-64. [PMID:8834490]

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