XMD8-92 [Ligand Id: 8057] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1673046
  • phosphoinositide kinase, FYVE-type zinc finger containing/1-phosphatidylinositol 3-phosphate 5-kinase in Human [ChEMBL: CHEMBL1938222] [GtoPdb: 2857] [UniProtKB: Q9Y2I7]
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  • 3-phosphoinositide dependent protein kinase 1/3-phosphoinositide-dependent protein kinase 1 in Human [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530]
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  • protein kinase AMP-activated catalytic subunit alpha 1/5`-AMP-activated protein kinase catalytic subunit alpha-1 in Human [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131]
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  • protein kinase AMP-activated catalytic subunit alpha 2/5`-AMP-activated protein kinase catalytic subunit alpha-2 in Human [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646]
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  • tyrosine kinase non receptor 2/Activated CDC42 kinase 1 in Human [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
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  • protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/AMPK alpha1/alpha2 in Human [ChEMBL: CHEMBL3038454] [GtoPdb: 1542, 1541] [UniProtKB: P54646, Q13131]
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  • bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
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  • bromodomain testis associated/Bromodomain testis-specific protein in Human [ChEMBL: CHEMBL1795185] [GtoPdb: 2729] [UniProtKB: Q58F21]
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  • calcium/calmodulin dependent protein kinase kinase 1/Calcium/calmodulin-dependent protein kinase kinase 1 in Human [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9]
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  • calcium/calmodulin dependent protein kinase ID/Calcium/calmodulin-dependent protein kinase type 1D in Human [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
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  • calcium/calmodulin-dependent protein kinase II delta subunit/Calcium/calmodulin-dependent protein kinase type II subunit delta in Human [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557]
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  • calcium/calmodulin-dependent protein kinase II gamma subunit/Calcium/calmodulin-dependent protein kinase type II subunit gamma in Human [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555]
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  • casein kinase 1 alpha 1/Casein kinase I isoform alpha in Human [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
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  • cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
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  • cyclin dependent kinase 10/Cyclin-dependent kinase 10 in Human [ChEMBL: CHEMBL1795191] [GtoPdb: 1962] [UniProtKB: Q15131]
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  • cyclin dependent kinase 11B/Cyclin-dependent kinase 11B in Human [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127]
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  • cyclin dependent kinase 12/Cyclin-dependent kinase 12 in Human [ChEMBL: CHEMBL3559692] [GtoPdb: 1965] [UniProtKB: Q9NYV4]
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  • cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004]
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  • cyclin dependent kinase 15/Cyclin-dependent kinase 15 in Human [ChEMBL: CHEMBL5856] [GtoPdb: 1968] [UniProtKB: Q96Q40]
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  • cyclin dependent kinase 16/Cyclin-dependent kinase 16 in Human [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536]
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
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  • cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613]
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  • cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
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  • protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase catalytic subunit in Human [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527]
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  • mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
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  • mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734]
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  • mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
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  • mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163]
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  • mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
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  • mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
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  • CDC like kinase 3/Dual specificity protein kinase CLK3 in Human [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
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  • eukaryotic translation initiation factor 2 alpha kinase 4/eIF-2-alpha kinase GCN2 in Human [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8]
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  • TP53 regulating kinase/EKC/KEOPS complex subunit TP53RK in Human [ChEMBL: CHEMBL1938223] [GtoPdb: 2248] [UniProtKB: Q96S44]
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  • EPH receptor A2/Ephrin type-A receptor 2 in Human [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
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  • EPH receptor B4/Ephrin type-B receptor 4 in Human [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760]
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  • epidermal growth factor receptor/Epidermal growth factor receptor in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • eukaryotic elongation factor 2 kinase/Eukaryotic elongation factor 2 kinase in Human [ChEMBL: CHEMBL5026] [GtoPdb: 2014] [UniProtKB: O00418]
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  • eukaryotic translation initiation factor 2 alpha kinase 3/Eukaryotic translation initiation factor 2-alpha kinase 3 in Human [ChEMBL: CHEMBL6030] [GtoPdb: 2017] [UniProtKB: Q9NZJ5]
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  • protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
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  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
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  • inhibitor of nuclear factor kappa B kinase subunit epsilon/TANK binding kinase 1/IKK epsilon/TBK1 in Human [ChEMBL: CHEMBL3038486] [GtoPdb: 2040, 2237] [UniProtKB: Q14164, Q9UHD2]
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  • component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa-B kinase subunit alpha in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
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  • inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa-B kinase subunit beta in Human [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
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  • Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
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  • integrin linked kinase/Integrin-linked protein kinase in Human [ChEMBL: CHEMBL5247] [GtoPdb: 2041] [UniProtKB: Q13418]
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  • eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
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  • interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
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  • interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
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  • leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
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  • macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912]
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  • microtubule affinity regulating kinase 3/MAP/microtubule affinity-regulating kinase 3 in Human [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
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  • Microtubule associated serine/threonine kinase 3/Microtubule-associated serine/threonine-protein kinase 3 in Human [ChEMBL: CHEMBL2417352] [GtoPdb: 1512] [UniProtKB: O60307]
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  • mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
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  • mitogen-activated protein kinase 14/Mitogen-activated protein kinase 14 in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • mitogen-activated protein kinase 3/Mitogen-activated protein kinase 3 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
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  • mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152]
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  • mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164]
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  • mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233]
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  • mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
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  • mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5]
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  • ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mitogen-activated protein kinase kinase kinase 20 in Human [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
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  • mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4]
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  • mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
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  • mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318]
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  • mitogen-activated protein kinase kinase kinase 8/Mitogen-activated protein kinase kinase kinase 8 in Human [ChEMBL: CHEMBL4899] [GtoPdb: 2083] [UniProtKB: P41279]
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  • mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
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  • mixed lineage kinase domain like pseudokinase/Mixed lineage kinase domain-like protein in Human [ChEMBL: CHEMBL1938217] [GtoPdb: 2106] [UniProtKB: Q8NB16]
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  • tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470]
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  • PAN2-PAN3 deadenylation complex subunit PAN3 in Human [ChEMBL: CHEMBL4105985] [UniProtKB: Q58A45]
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  • calcium/calmodulin dependent serine protein kinase/Peripheral plasma membrane protein CASK in Human [ChEMBL: CHEMBL1908381] [GtoPdb: 1959] [UniProtKB: O14936]
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  • phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
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  • phosphatidylinositol 4-kinase alpha/Phosphatidylinositol 4-kinase alpha in Human [ChEMBL: CHEMBL3667] [GtoPdb: 2148] [UniProtKB: P42356]
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  • phosphatidylinositol 4-kinase beta/Phosphatidylinositol 4-kinase beta in Human [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8]
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  • phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta in Human [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750]
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  • phosphatidylinositol-5-phosphate 4-kinase type 2 alpha/Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha in Human [ChEMBL: CHEMBL1795194] [GtoPdb: 2858] [UniProtKB: P48426]
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  • phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol 5-phosphate 4-kinase type-2 beta in Human [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356]
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  • phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma in Human [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8]
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  • phosphorylase kinase catalytic subunit gamma 2/Phosphorylase b kinase gamma catalytic chain, liver/testis isoform in Human [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735]
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  • protein kinase C iota/Protein kinase C iota type in Human [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
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  • protein kinase C theta/Protein kinase C theta type in Human [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
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  • protein kinase C zeta/Protein kinase C zeta type in Human [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
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  • AKT serine/threonine kinase 1/RAC-alpha serine/threonine-protein kinase in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
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  • ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha-1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
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  • ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha-2 in Human [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
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  • ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha-3 in Human [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
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  • ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha-5 in Human [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
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  • ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase beta-1 in Human [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
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  • ribosomal protein S6 kinase B2/Ribosomal protein S6 kinase beta-2 in Human [ChEMBL: CHEMBL3111] [GtoPdb: 1526] [UniProtKB: Q9UBS0]
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  • ATM serine/threonine kinase/Serine-protein kinase ATM in Human [ChEMBL: CHEMBL3797] [GtoPdb: 1934] [UniProtKB: Q13315]
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  • serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
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  • serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716]
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  • serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0]
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  • serine/threonine kinase 3/Serine/threonine-protein kinase 3 in Human [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
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  • Serine/threonine kinase 38/Serine/threonine-protein kinase 38 in Human [ChEMBL: CHEMBL1075155] [GtoPdb: 1517] [UniProtKB: Q15208]
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  • Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1]
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  • serine/threonine kinase 4/Serine/threonine-protein kinase 4 in Human [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
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  • A-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase A-Raf in Human [ChEMBL: CHEMBL1169596] [GtoPdb: 1933] [UniProtKB: P10398]
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  • ATR checkpoint kinase/Serine/threonine-protein kinase ATR in Human [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535]
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  • B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
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  • checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
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  • checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
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  • protein kinase D2/Serine/threonine-protein kinase D2 in Human [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
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  • protein kinase D3/Serine/threonine-protein kinase D3 in Human [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806]
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  • doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075]
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  • doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568]
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  • endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460]
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  • Microtubule associated serine/threonine kinase-like/Serine/threonine-protein kinase greatwall in Human [ChEMBL: CHEMBL4105826] [GtoPdb: 1514] [UniProtKB: Q96GX5]
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  • large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835]
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  • large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7]
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  • microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
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  • microtubule affinity regulating kinase 2/Serine/threonine-protein kinase MARK2 in Human [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7]
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  • CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2]
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  • mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
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  • protein kinase N2/Serine/threonine-protein kinase N2 in Human [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
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  • NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
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  • NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956]
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  • NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957]
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  • NIMA related kinase 7/Serine/threonine-protein kinase Nek7 in Human [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
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  • NIMA related kinase 8/Serine/threonine-protein kinase Nek8 in Human [ChEMBL: CHEMBL2417353] [GtoPdb: 2123] [UniProtKB: Q86SG6]
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  • NIMA related kinase 9/Serine/threonine-protein kinase Nek9 in Human [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19]
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  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
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  • polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
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  • pre-mRNA processing factor kinase PRP4K/Serine/threonine-protein kinase PRP4 homolog in Human [ChEMBL: CHEMBL1908382] [GtoPdb: 2177] [UniProtKB: Q13523]
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  • serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141]
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  • serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
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  • SMG1 nonsense mediated mRNA decay associated PI3K related kinase/Serine/threonine-protein kinase SMG1 in Human [ChEMBL: CHEMBL1795195] [GtoPdb: 2201] [UniProtKB: Q96Q15]
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  • TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54]
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  • TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8]
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  • tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8]
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  • tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8]
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  • unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
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  • unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2]
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  • WNK lysine deficient protein kinase 1/Serine/threonine-protein kinase WNK1 in Human [ChEMBL: CHEMBL1075173] [GtoPdb: 2280] [UniProtKB: Q9H4A3]
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  • STE20 like kinase/STE20-like serine/threonine-protein kinase in Human [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2]
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  • STE20 related adaptor beta/STE20-related kinase adapter protein beta in Human [ChEMBL: CHEMBL4105756] [GtoPdb: 2228] [UniProtKB: Q9C0K7]
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  • tripartite motif containing 28/Transcription intermediary factor 1-beta in Human [ChEMBL: CHEMBL3769297] [GtoPdb: 2253] [UniProtKB: Q13263]
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  • C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
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  • FER tyrosine kinase/Tyrosine-protein kinase Fer in Human [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591]
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  • FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fyn in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
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  • Janus kinase 1/Tyrosine-protein kinase JAK1 in Human [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
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  • AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
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  • WEE1 G2 checkpoint kinase/Wee1-like protein kinase in Human [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphoinositide kinase, FYVE-type zinc finger containing/1-phosphatidylinositol 3-phosphate 5-kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938222] [GtoPdb: 2857] [UniProtKB: Q9Y2I7]
ChEMBL Inhibition of PIP5K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
3-phosphoinositide dependent protein kinase 1/3-phosphoinositide-dependent protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530]
ChEMBL Inhibition of PDK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase AMP-activated catalytic subunit alpha 1/5`-AMP-activated protein kinase catalytic subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131]
ChEMBL Inhibition of AMPKalpha1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase AMP-activated catalytic subunit alpha 2/5`-AMP-activated protein kinase catalytic subunit alpha-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646]
ChEMBL Inhibition of AMPKalpha2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
tyrosine kinase non receptor 2/Activated CDC42 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
ChEMBL Selectivity interaction (Kinase panel (KiNativ method in HeLa cells)) EUB0000122b TNK2 B 4.74 pIC50 18000 nM IC50 Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Inhibition of ACK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.74 pIC50 18000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
Acylglycerol kinase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2417354] [UniProtKB: Q53H12]
ChEMBL Inhibition of AGK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/AMPK alpha1/alpha2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038454] [GtoPdb: 1542, 1541] [UniProtKB: P54646, Q13131]
ChEMBL Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
aurora kinase A/Aurora kinase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Inhibition of AURA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
ChEMBL Inhibition of BRD4 (unknown origin) B 5.8 pKd 1600 nM Kd Eur J Med Chem (2019) 178: 530-543 [PMID:31212132]
ChEMBL Binding affinity to recombinant human N-terminal hexaHis-tagged BRD4 expressed in Escherichia coli BL21 (DE3) cells by MST assay B 6.1 pKd 800 nM Kd J Med Chem (2021) 64: 15772-15786 [PMID:34710325]
ChEMBL Binding affinity to recombinant human N-terminal hexaHis-tagged BRD4 expressed in Escherichia coli BL21 (DE3) cells by ITC analysis B 6.13 pKd 735 nM Kd J Med Chem (2021) 64: 15772-15786 [PMID:34710325]
ChEMBL Binding affinity to recombinant human N-terminal hexaHis-tagged BRD4 expressed in Escherichia coli BL21 (DE3) cells by qPCR assay B 6.69 pKd 205 nM Kd J Med Chem (2021) 64: 15772-15786 [PMID:34710325]
bromodomain testis associated/Bromodomain testis-specific protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795185] [GtoPdb: 2729] [UniProtKB: Q58F21]
ChEMBL Binding affinity to recombinant human N-terminal hexaHis-tagged BRDT expressed in Escherichia coli BL21 (DE3) cells by ITC analysis B 5.38 pKd 4200 nM Kd J Med Chem (2021) 64: 15772-15786 [PMID:34710325]
ChEMBL Binding affinity to recombinant human N-terminal hexaHis-tagged BRDT expressed in Escherichia coli BL21 (DE3) cells by MST assay B 5.46 pKd 3500 nM Kd J Med Chem (2021) 64: 15772-15786 [PMID:34710325]
ChEMBL Binding affinity to recombinant human N-terminal hexaHis-tagged BRDT expressed in Escherichia coli BL21 (DE3) cells by qPCR assay B 6.17 pKd 675 nM Kd J Med Chem (2021) 64: 15772-15786 [PMID:34710325]
calcium/calmodulin dependent protein kinase kinase 1/Calcium/calmodulin-dependent protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9]
ChEMBL Inhibition of CAMKK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
calcium/calmodulin dependent protein kinase ID/Calcium/calmodulin-dependent protein kinase type 1D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
ChEMBL Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
calcium/calmodulin-dependent protein kinase II delta subunit/Calcium/calmodulin-dependent protein kinase type II subunit delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557]
ChEMBL Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
calcium/calmodulin-dependent protein kinase II gamma subunit/Calcium/calmodulin-dependent protein kinase type II subunit gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555]
ChEMBL Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
casein kinase 1 alpha 1/Casein kinase I isoform alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729]
ChEMBL Inhibition of CK1alpha in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL Inhibition of CDC2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 10/Cyclin-dependent kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795191] [GtoPdb: 1962] [UniProtKB: Q15131]
ChEMBL Inhibition of CDK10 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 11B/Cyclin-dependent kinase 11B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127]
ChEMBL Inhibition of PITSLRE in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 12/Cyclin-dependent kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559692] [GtoPdb: 1965] [UniProtKB: Q9NYV4]
ChEMBL Inhibition of CRK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004]
ChEMBL Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 15/Cyclin-dependent kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5856] [GtoPdb: 1968] [UniProtKB: Q96Q40]
ChEMBL Inhibition of PFTAIRE2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 16/Cyclin-dependent kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536]
ChEMBL Inhibition of PCTAIRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535]
ChEMBL Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613]
ChEMBL Inhibition of CDK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750]
ChEMBL Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527]
ChEMBL Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734]
ChEMBL Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
ChEMBL Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163]
ChEMBL Inhibition of MAP2K5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
ChEMBL Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
ChEMBL Inhibition of MAP2K7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
ChEMBL Inhibition of CLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
eukaryotic translation initiation factor 2 alpha kinase 4/eIF-2-alpha kinase GCN2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8]
ChEMBL Inhibition of GCN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
TP53 regulating kinase/EKC/KEOPS complex subunit TP53RK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938223] [GtoPdb: 2248] [UniProtKB: Q96S44]
ChEMBL Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
ChEMBL Inhibition of EphA2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760]
ChEMBL Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
epidermal growth factor receptor/Epidermal growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
eukaryotic elongation factor 2 kinase/Eukaryotic elongation factor 2 kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5026] [GtoPdb: 2014] [UniProtKB: O00418]
ChEMBL Inhibition of EEF2K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
eukaryotic translation initiation factor 2 alpha kinase 3/Eukaryotic translation initiation factor 2-alpha kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6030] [GtoPdb: 2017] [UniProtKB: Q9NZJ5]
ChEMBL Inhibition of PEK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
ChEMBL Selectivity interaction (Kinase panel (KiNativ method in HeLa cells)) EUB0000122b PTK2 B 4.41 pIC50 39000 nM IC50 Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Inhibition of FAK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.41 pIC50 39000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Inhibition of GSK3A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Inhibition of MET in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
inhibitor of nuclear factor kappa B kinase subunit epsilon/TANK binding kinase 1/IKK epsilon/TBK1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038486] [GtoPdb: 2040, 2237] [UniProtKB: Q14164, Q9UHD2]
ChEMBL Inhibition of IKKE/TBK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa-B kinase subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL Inhibition of IKKA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa-B kinase subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
ChEMBL Inhibition of IKKB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL Inhibition of IGF1R in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Inhibition of INSR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
integrin linked kinase/Integrin-linked protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5247] [GtoPdb: 2041] [UniProtKB: Q13418]
ChEMBL Inhibition of ILK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525]
ChEMBL Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
ChEMBL Inhibition of IRAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
ChEMBL Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007]
ChEMBL Inhibition of LRRK2 G2019S mutant (unknown origin) using LRRKtide as substrate incubated for 1 hrs in presence of ATP by Adapta TR-FRET assay B 7.23 pIC50 59 nM IC50 Eur J Med Chem (2013) 70: 758-767 [PMID:24239623]
ChEMBL Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substrate measured after 1 hr by Alexa fluor-647 ADP tracer-based ADAPTA assay B 7.34 pIC50 46 nM IC50 J Med Chem (2020) 63: 7817-7826 [PMID:32530623]
macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912]
ChEMBL Inhibition of RON in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
microtubule affinity regulating kinase 3/MAP/microtubule affinity-regulating kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448]
ChEMBL Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
Microtubule associated serine/threonine kinase 3/Microtubule-associated serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2417352] [GtoPdb: 1512] [UniProtKB: O60307]
ChEMBL Inhibition of MAST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of ERK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase 14/Mitogen-activated protein kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of P38a in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of P38a interaction site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase 3/Mitogen-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152]
ChEMBL Inhibition of ERK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164]
ChEMBL In vitro Erk5 : In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound. B 7.1 pKd 80 nM Kd US-9266890-B2. Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders (2016)
ChEMBL Affinity Biochemical interaction (ATP-binding displacement assay) EUB0000122b MAPK7 B 7.1 pKd 80 nM Kd Affinity Biochemical Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Selectivity interaction (Kinase panel (ATP-site competition binding assay)) EUB0000122b MAPK7 B 7.1 pKd 80 nM Kd Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Binding affinity to ERK5 (unknown origin) assessed as dissociation constant by ATP-competition binding assay B 7.1 pKd 80 nM Kd Cancer Cell (2010) 18: 258-267 [PMID:20832753]
GtoPdb - - 7.1 pKd 80 nM Kd Cancer Cell (2010) 18: 258-67 [PMID:20832753]
ChEMBL Inhibition of ERK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 5.82 pIC50 1500 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Affinity On-target Cellular interaction (KiNativ assay (HeLa cell lysate)) EUB0000122b MAPK7 B 5.82 pIC50 1500 nM IC50 Affinity On-target Cellular Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Inhibition of N-terminal 6His-tagged human ERK5 expressed in baculovirus infected Sf21 cells co-expressing HA-tagged human MEK5-DD using ARKKRRHPSGPPTA peptide as substrate incubated for 20 mins in presence of [gamma-32P]-ATP by radiochemical assay B 6.44 pIC50 364 nM IC50 Eur J Med Chem (2013) 70: 758-767 [PMID:24239623]
ChEMBL Inhibition of ERK5 in human HeLa cells incubated for 15 mins prior to ATP addition by KiNativ profiling method B 6.52 pIC50 300 nM IC50 Eur J Med Chem (2019) 178: 530-543 [PMID:31212132]
ChEMBL Inhibition of ERK5 (unknown origin) B 6.62 pIC50 240 nM IC50 J Med Chem (2023) 66: 4491-4502 [PMID:37002872]
ChEMBL Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis B 6.62 pIC50 240 nM IC50 ACS Med Chem Lett (2011) 2: 195-200 [PMID:21412406]
ChEMBL Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin-Ahx-PPGDYSTTPGGTLFSTTPGGTRI peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins in presence of ATP by TR-FRET assay B 6.7 pIC50 200 nM IC50 J Med Chem (2019) 62: 928-940 [PMID:30563338]
ChEMBL Inhibition of ERK5 (unknown origin) by ADP-Glo kinase assay B 7.28 pIC50 52.3 nM IC50 J Med Chem (2023) 66: 13568-13586 [PMID:37751283]
ChEMBL Affinity Phenotypic Cellular interaction (Reduction of BMK1-dependent transactivating activity of MEF2C) EUB0000122b MAPK7 B 5.3 pEC50 <5000 nM EC50 Affinity Phenotypic Cellular Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Inhibition of EGF-stimulated ERK5 autophosphorylation in human HeLa cells preincubated with compound for 1 hrs followed by EGF stimulation for 17 mins by SDS-PAGE analysis B 6.62 pEC50 240 nM EC50 Eur J Med Chem (2013) 70: 758-767 [PMID:24239623]
mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233]
ChEMBL Inhibition of MAP3K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584]
ChEMBL Inhibition of MLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5]
ChEMBL Inhibition of MAP3K2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mitogen-activated protein kinase kinase kinase 20 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2]
ChEMBL Inhibition of ZAK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4]
ChEMBL Inhibition of MAP3K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
ChEMBL Inhibition of MAP3K5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318]
ChEMBL Inhibition of TAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase kinase 8/Mitogen-activated protein kinase kinase kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4899] [GtoPdb: 2083] [UniProtKB: P41279]
ChEMBL Inhibition of COT in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
ChEMBL Inhibition of GCK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mixed lineage kinase domain like pseudokinase/Mixed lineage kinase domain-like protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938217] [GtoPdb: 2106] [UniProtKB: Q8NB16]
ChEMBL Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470]
GtoPdb - - 6.05 pKd 890 nM Kd Cancer Cell (2010) 18: 258-67 [PMID:20832753]
ChEMBL Selectivity interaction (Kinase panel (ATP-site competition binding assay)) EUB0000122b TNK1 B 6.05 pKd 890 nM Kd Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Binding affinity to TNK1 (unknown origin) assessed as dissociation constant by ATP-competition binding assay B 6.05 pKd 890 nM Kd Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Selectivity interaction (Kinase panel (KiNativ method in HeLa cells)) EUB0000122b TNK1 B 5 pIC50 10000 nM IC50 Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Inhibition of TNK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 5 pIC50 10000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
PAN2-PAN3 deadenylation complex subunit PAN3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105985] [UniProtKB: Q58A45]
ChEMBL Inhibition of PAN3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
calcium/calmodulin dependent serine protein kinase/Peripheral plasma membrane protein CASK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908381] [GtoPdb: 1959] [UniProtKB: O14936]
ChEMBL Inhibition of CASK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
ChEMBL Inhibition of PIK3C3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
phosphatidylinositol 4-kinase alpha/Phosphatidylinositol 4-kinase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3667] [GtoPdb: 2148] [UniProtKB: P42356]
ChEMBL Selectivity interaction (Kinase panel (KiNativ method in HeLa cells)) EUB0000122b PI4KA B 4.44 pIC50 36000 nM IC50 Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Inhibition of PIK4CA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.44 pIC50 36000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
phosphatidylinositol 4-kinase beta/Phosphatidylinositol 4-kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8]
ChEMBL Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.47 pIC50 34000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750]
ChEMBL Inhibition of PIK3C2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha/Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795194] [GtoPdb: 2858] [UniProtKB: P48426]
ChEMBL Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PIP5K2A LIP1 labeling site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PIP5K2A LIP1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol 5-phosphate 4-kinase type-2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356]
ChEMBL Inhibition of PIP5K2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8]
ChEMBL Inhibition of PIP5K2C in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
phosphorylase kinase catalytic subunit gamma 2/Phosphorylase b kinase gamma catalytic chain, liver/testis isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735]
ChEMBL Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase C iota/Protein kinase C iota type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
ChEMBL Inhibition of PKCiota in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase C theta/Protein kinase C theta type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
ChEMBL Inhibition of PKCtheta in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase C zeta/Protein kinase C zeta type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
ChEMBL Inhibition of PKCzeta in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
AKT serine/threonine kinase 1/RAC-alpha serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL Inhibition of AKT1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL Inhibition of RSK1 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of RSK1 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.51 pIC50 31000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of RSK1 domain 2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.54 pIC50 29000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of RSK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.59 pIC50 26000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
ChEMBL Selectivity interaction (Kinase panel (KiNativ method in HeLa cells)) EUB0000122b RPS6KA1 B 4.54 pIC50 29000 nM IC50 Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
ChEMBL Inhibition of RSK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of RSK2 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of RSK2 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.31 pIC50 49000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Selectivity interaction (Kinase panel (KiNativ method in HeLa cells)) EUB0000122b RPS6KA3 B 4.33 pIC50 47000 nM IC50 Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Inhibition of RSK2 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.33 pIC50 47000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha-5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
ChEMBL Inhibition of MSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MSK1 domain 1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MSK1 domain 1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
ChEMBL Inhibition of P70S6K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ribosomal protein S6 kinase B2/Ribosomal protein S6 kinase beta-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3111] [GtoPdb: 1526] [UniProtKB: Q9UBS0]
ChEMBL Inhibition of P70S6KB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ATM serine/threonine kinase/Serine-protein kinase ATM in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3797] [GtoPdb: 1934] [UniProtKB: Q13315]
ChEMBL Inhibition of ATM in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
ChEMBL Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716]
ChEMBL Inhibition of MPSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0]
ChEMBL Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
serine/threonine kinase 3/Serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188]
ChEMBL Inhibition of MST2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
Serine/threonine kinase 38/Serine/threonine-protein kinase 38 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075155] [GtoPdb: 1517] [UniProtKB: Q15208]
ChEMBL Inhibition of NDR1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1]
ChEMBL Inhibition of NDR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
serine/threonine kinase 4/Serine/threonine-protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
ChEMBL Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
A-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase A-Raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169596] [GtoPdb: 1933] [UniProtKB: P10398]
ChEMBL Inhibition of ARAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ATR checkpoint kinase/Serine/threonine-protein kinase ATR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535]
ChEMBL Inhibition of ATR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056]
ChEMBL Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL Inhibition of CHK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CHK1 inactive site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
ChEMBL Inhibition of CHK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
ChEMBL Inhibition of PKD2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase D3/Serine/threonine-protein kinase D3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806]
ChEMBL Inhibition of PKD3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075]
ChEMBL Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-COOH as substrate measured after 2 hrs by mobility shift assay B 6.15 pIC50 716 nM IC50 J Med Chem (2020) 63: 7817-7826 [PMID:32530623]
doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568]
GtoPdb - - 6.72 pKd 190 nM Kd Cancer Cell (2010) 18: 258-67 [PMID:20832753]
ChEMBL Selectivity interaction (Kinase panel (ATP-site competition binding assay)) EUB0000122b DCLK2 B 6.72 pKd 190 nM Kd Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Binding affinity to DCAMKL2 (unknown origin) assessed as dissociation constant by ATP-competition binding assay B 6.72 pKd 190 nM Kd Cancer Cell (2010) 18: 258-267 [PMID:20832753]
endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460]
ChEMBL Inhibition of IRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
Microtubule associated serine/threonine kinase-like/Serine/threonine-protein kinase greatwall in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105826] [GtoPdb: 1514] [UniProtKB: Q96GX5]
ChEMBL Inhibition of MASTL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835]
ChEMBL Inhibition of LATS1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7]
ChEMBL Inhibition of LATS2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
ChEMBL Inhibition of MARK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
microtubule affinity regulating kinase 2/Serine/threonine-protein kinase MARK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7]
ChEMBL Inhibition of MARK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2]
ChEMBL Inhibition of MRCKB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345]
ChEMBL Inhibition of FRAP in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
protein kinase N2/Serine/threonine-protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
ChEMBL Inhibition of PKN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6]
ChEMBL Inhibition of NEK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956]
ChEMBL Inhibition of NEK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957]
ChEMBL Inhibition of NEK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
NIMA related kinase 7/Serine/threonine-protein kinase Nek7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
ChEMBL Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
NIMA related kinase 8/Serine/threonine-protein kinase Nek8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2417353] [GtoPdb: 2123] [UniProtKB: Q86SG6]
ChEMBL Inhibition of NEK8 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
NIMA related kinase 9/Serine/threonine-protein kinase Nek9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19]
ChEMBL Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL Inhibition of PLK1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PLK1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of PLK1 splice variant in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444]
GtoPdb - - 6.22 pKd 600 nM Kd Cancer Cell (2010) 18: 258-67 [PMID:20832753]
ChEMBL Selectivity interaction (Kinase panel (ATP-site competition binding assay)) EUB0000122b PLK4 B 6.22 pKd 600 nM Kd Selectivity Literature for EUbOPEN Chemogenomics Library wave 3
ChEMBL Binding affinity to PLK4 (unknown origin) assessed as dissociation constant by ATP-competition binding assay B 6.22 pKd 600 nM Kd Cancer Cell (2010) 18: 258-267 [PMID:20832753]
pre-mRNA processing factor kinase PRP4K/Serine/threonine-protein kinase PRP4 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908382] [GtoPdb: 2177] [UniProtKB: Q13523]
ChEMBL Inhibition of PRP4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141]
ChEMBL Inhibition of SGK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
ChEMBL Inhibition of SGK3 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of SGK3 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of SGK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
SMG1 nonsense mediated mRNA decay associated PI3K related kinase/Serine/threonine-protein kinase SMG1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795195] [GtoPdb: 2201] [UniProtKB: Q96Q15]
ChEMBL Inhibition of SMG1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54]
ChEMBL Inhibition of TAO2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8]
ChEMBL Inhibition of TAO3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8]
ChEMBL Inhibition of TLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8]
ChEMBL Inhibition of TLK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
ChEMBL Inhibition of ULK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2]
ChEMBL Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
WNK lysine deficient protein kinase 1/Serine/threonine-protein kinase WNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075173] [GtoPdb: 2280] [UniProtKB: Q9H4A3]
ChEMBL Inhibition of Wnk1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
SRSF protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4]
ChEMBL Inhibition of SRPK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
STE20 like kinase/STE20-like serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2]
ChEMBL Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
STE20 related adaptor beta/STE20-related kinase adapter protein beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105756] [GtoPdb: 2228] [UniProtKB: Q9C0K7]
ChEMBL Inhibition of ALS2CR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
tripartite motif containing 28/Transcription intermediary factor 1-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769297] [GtoPdb: 2253] [UniProtKB: Q13263]
ChEMBL Inhibition of TIF1b in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
FER tyrosine kinase/Tyrosine-protein kinase Fer in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591]
ChEMBL Inhibition of FER in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL Inhibition of FYN in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458]
ChEMBL Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
ChEMBL Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Inhibition of LYN in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
ChEMBL Inhibition of AXL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]
WEE1 G2 checkpoint kinase/Wee1-like protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291]
ChEMBL Inhibition of Wee1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis B 4.3 pIC50 >50000 nM IC50 Cancer Cell (2010) 18: 258-267 [PMID:20832753]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]