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SMG1 nonsense mediated mRNA decay associated PI3K related kinase

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Target id: 2201

Nomenclature: SMG1 nonsense mediated mRNA decay associated PI3K related kinase

Abbreviated Name: SMG1

Family: SMG1 subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 3661 16p12.3 SMG1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Mouse - 3658 7 F1 Smg1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Rat - 3567 1q35 Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase
Previous and Unofficial Names Click here for help
ATX | LIP | SMG1 phosphatidylinositol 3-kinase-related kinase | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) | SMG1 | SMG1 homolog
Database Links Click here for help
Alphafold Q96Q15 (Hs), Q8BKX6 (Mm)
BRENDA 2.7.11.1
CATH/Gene3D 1.10.1070.11, 1.25.10.10
ChEMBL Target CHEMBL1795195 (Hs)
Ensembl Gene ENSG00000157106 (Hs), ENSMUSG00000030655 (Mm), ENSRNOG00000047386 (Rn)
Entrez Gene 23049 (Hs), 233789 (Mm), 691397 (Rn)
Human Protein Atlas ENSG00000157106 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:23049 (Hs), mmu:233789 (Mm), rno:691397 (Rn)
OMIM 607032 (Hs)
Pharos Q96Q15 (Hs)
RefSeq Nucleotide NM_015092 (Hs), NM_001031814 (Mm), XM_002728791 (Rn)
RefSeq Protein NP_055907 (Hs), NP_001026984 (Mm), XP_002728837 (Rn)
UniProtKB Q96Q15 (Hs), Q8BKX6 (Mm)
Wikipedia SMG1 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 11j [PMID: 23021994] Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 10.0 pIC50 3
⤷ pIC50 10.0 (IC50 1.1x10-10 M) [3]
General Comments
Given SMG1's role in ensuring integrity of translated proteins [1-2,4-5], and the observation that some disease phenotypes result from aberrant translation of truncated, partially functional proteins, SMG1 has become as a interventional molecular target. Therapeutic inhibitors of SMG1 are being sought [3].

References

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1. Abraham RT. (2004) The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst.), 3 (8-9): 919-25. [PMID:15279777]

2. Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP. (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem, 276 (25): 22709-14. [PMID:11331269]

3. Gopalsamy A, Bennett EM, Shi M, Zhang WG, Bard J, Yu K. (2012) Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett, 22 (21): 6636-41. [PMID:23021994]

4. Pulak R, Anderson P. (1993) mRNA surveillance by the Caenorhabditis elegans smg genes. Genes Dev, 7 (10): 1885-97. [PMID:8104846]

5. Yamashita A, Kashima I, Ohno S. (2005) The role of SMG-1 in nonsense-mediated mRNA decay. Biochim Biophys Acta, 1754 (1-2): 305-15. [PMID:16289965]

How to cite this page

SMG1 subfamily: SMG1 nonsense mediated mRNA decay associated PI3K related kinase. Last modified on 27/03/2019. Accessed on 04/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2201.