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Microtubule associated serine/threonine kinase 3

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Target id: 1512

Nomenclature: Microtubule associated serine/threonine kinase 3

Abbreviated Name: MAST3

Family: MAST family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1309 19p13.11 MAST3 microtubule associated serine/threonine kinase 3
Mouse - 1321 8 B3.3 Mast3 microtubule associated serine/threonine kinase 3
Rat - 1305 16p14 Mast3 microtubule associated serine/threonine kinase 3
Database Links Click here for help
Alphafold O60307 (Hs), Q3U214 (Mm)
BRENDA 2.7.11.1
CATH/Gene3D 1.20.1480.20
ChEMBL Target CHEMBL2417352 (Hs)
Ensembl Gene ENSG00000099308 (Hs), ENSMUSG00000031833 (Mm), ENSRNOG00000022753 (Rn)
Entrez Gene 23031 (Hs), 546071 (Mm), 688540 (Rn)
Human Protein Atlas ENSG00000099308 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:23031 (Hs), mmu:546071 (Mm), rno:688540 (Rn)
OMIM 612258 (Hs)
Pharos O60307 (Hs)
RefSeq Nucleotide NM_015016 (Hs), NM_199308 (Mm), NM_001134796 (Rn)
RefSeq Protein NP_055831 (Hs), NP_955012 (Mm), NP_001128268 (Rn)
UniProtKB O60307 (Hs), Q3U214 (Mm)
Wikipedia MAST3 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  The crystal structure of the PDZ domain of human Microtubule Associated Serine/Threonine Kinase 3 (MAST3)
PDB Id:  3KHF
Resolution:  1.2Å
Species:  Human
References: 
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 35 [PMID: 23916259] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.6 pIC50 1
⤷ pIC50 6.6 (IC50 2.4x10-7 M) [1]

References

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1. Li B, Cociorva OM, Nomanbhoy T, Weissig H, Li Q, Nakamura K, Liyanage M, Zhang MC, Shih AY, Aban A et al.. (2013) Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors. Bioorg Med Chem Lett, 23 (18): 5217-22. [PMID:23916259]

How to cite this page

MAST family: Microtubule associated serine/threonine kinase 3. Last modified on 23/09/2015. Accessed on 26/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=1512.