- Guide to PHARMACOLOGY
Synonyms: (+)-staurosporine | antibiotic 230 | antibiotic AM-2282
Compound class: Natural product or derivative
Comment: Staurosporine is a non-specific, ATP-competitive inhibitor of protein kinase C (PKC) isolated from a Streptomyces strain . It inhibits all PKC enzyme isoforms [2,12], but has a more potent inhibitory effect on PKCs associated with the cell membrane compared to cytosolic PKCs.
Staurosporine analogues such as midostaurin and 7-hydroxystaurosporine are being investigated as therapeutics.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Natural product or derivative|
|(+)-staurosporine | antibiotic 230 | antibiotic AM-2282|
|CAS Registry No.||62996-74-1|
|GtoPdb PubChem SID||135652717|
|RCSB PDB Ligand||STU|
|Search Google for chemical match using the InChIKey||HKSZLNNOFSGOKW-FYTWVXJKSA-N|
|Search Google for chemicals with the same backbone||HKSZLNNOFSGOKW|
|Search UniChem for chemical match using the InChIKey||HKSZLNNOFSGOKW-FYTWVXJKSA-N|
|Search UniChem for chemicals with the same backbone||HKSZLNNOFSGOKW|
81547 (in complex with death associated protein kinase 1)
81546 (in complex with mitogen-activated protein kinase kinase 6)
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Cat. No. 1285