quizartinib   Click here for help

GtoPdb Ligand ID: 5658

Synonyms: AC 010220 | AC 220 | AC220 | Vanflyta®
Approved drug PDB Ligand
quizartinib is an approved drug (Japan (2019), FDA (2023))
Compound class: Synthetic organic
Comment: Quizartinib (AC220) is an inhibitor of class III receptor tyrosine kinases (FLT3, CSF1 receptor, KIT, PDGF receptors). It was developed to treat oncogenic FLT3 activation in acute myeloid leukemia. It is compound 7 in [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

quizartinib is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 134.4
Molecular weight 560.22
XLogP 4.14
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C(Nc1noc(c1)C(C)(C)C)Nc1ccc(cc1)c1cn2c(n1)sc1c2ccc(c1)OCCN1CCOCC1
Isomeric SMILES O=C(Nc1noc(c1)C(C)(C)C)Nc1ccc(cc1)c1cn2c(n1)sc1c2ccc(c1)OCCN1CCOCC1
InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChI Key CVWXJKQAOSCOAB-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (Japan (2019), FDA (2023))
IUPAC Name Click here for help
3-(5-tert-butyl-1,2-oxazol-3-yl)-1-(4-{10-[2-(morpholin-4-yl)ethoxy]-7-thia-2,5-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),3,5,8,10-pentaen-4-yl}phenyl)urea
International Nonproprietary Names Click here for help
INN number INN
9356 quizartinib
Synonyms Click here for help
AC 010220 | AC 220 | AC220 | Vanflyta®
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9674318
Reactome Reaction Reactome logo R-HSA-9702510, R-HSA-9695831, R-HSA-9702618
Other databases
CAS Registry No. 950769-58-1
ChEMBL Ligand CHEMBL576982
DrugCentral Ligand 5341
GtoPdb PubChem SID 178102286
PubChem CID 24889392
RCSB PDB Ligand P30
Search Google for chemical match using the InChIKey CVWXJKQAOSCOAB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone CVWXJKQAOSCOAB
Search PubMed clinical trials quizartinib
Search PubMed titles quizartinib
Search PubMed titles/abstracts quizartinib
UniChem Compound Search for chemical match using the InChIKey CVWXJKQAOSCOAB-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey CVWXJKQAOSCOAB-UHFFFAOYSA-N
Wikipedia Quizartinib

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Tocris
Quizartinib (links to external site)
Cat. No. 6788