- Guide to PHARMACOLOGY
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-7 is produced primarily by stromal cells and exerts its effects via a receptor complex consisting of IL-7 receptor alpha (IL7R) and a common IL-2 receptor gamma subunit (IL2RG). IL-7 signaling is essential for the establishment and maintenance of normal immune system functions. IL-7 stimulates the proliferation, differentiation, trafficking and survival of a variety of T cell subsets, including naive, central memory (CM), effector memory (EM), terminally differentiated effector memory (TEMRA) and natural killer (NK) T cells.
1. Lin J, Zhu Z, Xiao H, Wakefield MR, Ding VA, Bai Q, Fang Y. (2017)
The role of IL-7 in Immunity and Cancer.
Anticancer Res, 37 (3): 963-967. [PMID:28314253]