IL-7   Click here for help

GtoPdb Ligand ID: 4999

Synonyms: interleukin-7
Immunopharmacology Ligand
Comment: IL-7 is produced primarily by stromal cells and exerts its effects via a receptor complex consisting of IL-7 receptor alpha (IL7R) and a common IL-2 receptor gamma subunit (IL2RG). IL-7 signaling is essential for the establishment and maintenance of normal immune system functions. IL-7 stimulates the proliferation, differentiation, trafficking and survival of a variety of T cell subsets, including naive, central memory (CM), effector memory (EM), terminally differentiated effector memory (TEMRA) and natural killer (NK) T cells.
Species: Human
Natural/Endogenous Targets
Interleukin-7 receptor
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-7 receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -