- Guide to PHARMACOLOGY
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-7 is produced primarily by stromal cells and exerts its effects via a receptor complex consisting of IL-7 receptor alpha (IL7R) and a common IL-2 receptor gamma subunit (IL2RG). IL-7 signaling is essential for the establishment and maintenance of normal immune system functions. IL-7 stimulates the proliferation, differentiation, trafficking and survival of a variety of T cell subsets, including naive, central memory (CM), effector memory (EM), terminally differentiated effector memory (TEMRA) and natural killer (NK) T cells.
|IL-7 participates in human T cell development and homeostatic proliferation, generation of CD4+ and CD8+ memory T cells and regulation of V(D)J recombination at the TCR gamma, TCR beta, and immunoglobulin heavy chain loci . IL-7 produced by stromal cells of the fetal liver, bone marrow, spleen and thymus functions during B cell development. IL-7 is essential for mouse B cell development.
NeoImmuneTech are developing a stabilised IL-7 Fc fusion protein as a long-acting T cell amplifier, for immunooncology-enabling potential. Called efineptakin alfa (Hyleukin-7TM, research code NT-I7), this agent is engineered to induce a persistent and long-lasting anti-tumour T cell response.