vortioxetine   Click here for help

GtoPdb Ligand ID: 7351

Synonyms: Brintellix® | compound 5m [PMID: 21486038] | Lu AA21004 | Trintellix®
Approved drug PDB Ligand Immunopharmacology Ligand
vortioxetine is an approved drug (FDA and EMA (2013))
Compound class: Synthetic organic
Comment: Vortioxetine is an atypical (multimodal) antidepressant [1].
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View more information in the IUPHAR Pharmacology Education Project: vortioxetine

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 40.57
Molecular weight 298.15
XLogP 4.61
No. Lipinski's rules broken 0
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Canonical SMILES Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1
Isomeric SMILES Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1
InChI InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3
No information available.
Summary of Clinical Use Click here for help
Approved for the treatment of major depressive disorder (MDD). Clinical formulations contain vortioxetine hydrobromide (PubChem CID 56843850).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Vortioxetine is both a serotonin modulator and stimulator [1]. The Wikipedia page for the drug lists its potential pharmacological targets. The targets include serotonin 5-HT receptors, the serotonin transporter, SERT (SLC6A4) and norepinephrine transporter, NET (SLC6A2). Activity at β1-adrenoceptors may be associated with side effects of the drug [1].
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