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The IUPHAR Guide to MALARIA PHARMACOLOGY ligand list

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Ligand name ID Synonyms
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ACT-451840 Antimalarial Ligand 10022 ACT451840, Actelion-451840
AIM-1290 Antimalarial Ligand 11823
albitiazolium Antimalarial Ligand 10407 SAR97276, SAR97276A, T3
altiratinib PDB Ligand Antimalarial Ligand 9174 DCC-270, DCC-2701, DP-5164
amodiaquine Approved drug PDB Ligand Antimalarial Ligand 10018 Alphaquine®, Amdaquine®, Amoquin®, Camoquin®, Flavoquine®
AN13762 Antimalarial Ligand 10085 AN762
AN3661 Antimalarial Ligand 10084
analog 18 [PMID: 28696697] Antimalarial Ligand 11567
AQ-13 Antimalarial Ligand 10391 Ro 47-0543
artefenomel Antimalarial Ligand 9971 OZ439
arteflene Antimalarial Ligand 10397 Ro 42-1611
artemether Approved drug PDB Ligand Antimalarial Ligand 9955 β-artemether, beta-artemether
artemotil Antimalarial Ligand 9958 β-arteether
artesunate Approved drug PDB Ligand Antimalarial Ligand 9956
atovaquone Approved drug PDB Ligand Antimalarial Ligand 9695 566C80, Mepron®, Wellvone®
azithromycin Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6510
 
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BCH070 Antimalarial Ligand 10614
bortezomib Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6391 peptide boronate, PS-341, Velcade®
BRD3444 Antimalarial Ligand 9648
BRD7929 PDB Ligand Antimalarial Ligand 11723
BRD9185 Antimalarial Ligand 11469 compound 27 [PMID: 28435533]
brilacidin Antimalarial Ligand 13807 MMV1634402, PMX30063
bulaquine Antimalarial Ligand 10414 CDRI-80/53, elubaquine
 
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CDRI-97/78 Antimalarial Ligand 10399
chloroquine Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 5535 Aralen®, chloraquine, Malaquin®
CHMFL-PI4K-127 Antimalarial Ligand 11285
cipargamin Antimalarial Ligand 9721 KAE609, NITD609
clindamycin Approved drug PDB Ligand Antimalarial Ligand 10607
compound 14a [WO2021155612A1] Antimalarial Ligand 11958
compound 1a [WO2021204952A1] Antimalarial Ligand 11928
compound 11c [PMID: 30613327] PDB Ligand Antimalarial Ligand 11263
compound 34c [PMID: 24641010] PDB Ligand Antimalarial Ligand 9647
compound 49c [PMID: 29074775] Antimalarial Ligand 10418
compound 2h [PMID: 30664827] Antimalarial Ligand 10604
compound 3j [PMID: 33975947] Antimalarial Ligand 11553
compound 1 [PMID: 33929818] Antimalarial Ligand 11709
compound 24 [PMID: 32959656] Antimalarial Ligand 11319
compound 27 [PMID: 32945666] Antimalarial Ligand 11294
compound 28 [PMID: 31188540] Antimalarial Ligand 10617
compound 2 [PMID: 33085774] Antimalarial Ligand 11322
compound 3 [PMID: 32258933] Antimalarial Ligand 11214
compound 55 [PMID: 29889526] Antimalarial Ligand 10016
compound 5 [PMID: 30894487] PDB Ligand Antimalarial Ligand 10398
compound 1u [PMID: 30245402] Antimalarial Ligand 10258
compound VII [WO2021149692A1] Antimalarial Ligand 11926
compound 4 [WO2022008639A1] Antimalarial Ligand 11933
cycloguanil PDB Ligand Antimalarial Ligand 10027
 
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dapsone Approved drug Antimalarial Ligand 10934 Aczone®, NSC-6091
DDD85646 PDB Ligand Antimalarial Ligand 11455 compound 1a [PMID: 24451586], IMP-366
doxycycline Approved drug PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 6464 BMY-28689, Monodox®, Vibramycin®
DSM265 PDB Ligand Antimalarial Ligand 9644
DSM421 PDB Ligand Antimalarial Ligand 10020
DSM502 Antimalarial Ligand 11219
DSM705 PDB Ligand Antimalarial Ligand 11554 compound 79
 
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E209 Antimalarial Ligand 10465
ELQ-300 Antimalarial Ligand 10021 ELQ300
 
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ferroquine Antimalarial Ligand 9972 SSR97193
FNDR-20123 Antimalarial Ligand 11797
forodesine PDB Ligand Antimalarial Ligand 8272 BCX-1777, BCX1777, Fodosine® (proposed trade name), immucillin H, immucillin-H
 
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ganaplacide Antimalarial Ligand 9946 GNF156, KAF156
GSK030 Antimalarial Ligand 10611 GSK3212030A
GSK369796 Antimalarial Ligand 10411 N-tert-Butyl isoquine
GSK484 Antimalarial Ligand 13705 GSK-484, MMV-1793192, MMV1793192
 
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halofantrine Approved drug Antimalarial Ligand 10019 Halfan®, WR-171669
halofuginone PDB Ligand Antimalarial Ligand 10153
HTI-1 Antimalarial Ligand 11255 compound 1c
hydroxychloroquine Approved drug Immunopharmacology Ligand Antimalarial Ligand 7198 Dolquine®, Plaquenil®
 
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IMP-1002 PDB Ligand Antimalarial Ligand 11850
indolmycin PDB Ligand Antimalarial Ligand 11021 PA 155 A, PA-155-A, PA-155A, TAK-083
INE963 Antimalarial Ligand 11929 MMV1582617, NVP-INE963
IWY357 Antimalarial Ligand 13524 IWY-357
 
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JPC-3210 Antimalarial Ligand 10395 MMV646, MMV892646
JX21108 Antimalarial Ligand 11808
JX35 Antimalarial Ligand 11945
 
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KDU691 Antimalarial Ligand 11863
KH7 Antimalarial Ligand 10216 KH 7, KH-7
 
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L-45 PDB Ligand Antimalarial Ligand 11703 L-Moses
lumefantrine Approved drug Antimalarial Ligand 9969 benflumetol
Lys01 PDB Ligand Antimalarial Ligand 10320 compound 3a [PMID: 30344903]
 
M Back to top
M5717 Antimalarial Ligand 9737 DDD107498, DDD498, MMV121
mefloquine Approved drug PDB Ligand Antimalarial Ligand 4252 GNF-Pf-5544, Lariam®, Ro-21-5998-001, WR-142490
mepacrine PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 10172 Atabrine®, quinacrine
methnaridine Antimalarial Ligand 11318
MK-4815 PDB Ligand Antimalarial Ligand 10410 MK4815
ML10 PDB Ligand Antimalarial Ligand 10225
ML324 Immunopharmacology Ligand Antimalarial Ligand 9584 ML-324, MMV1580488
MMV008138 Antimalarial Ligand 10229 GNF-Pf-4188, TCMDC-125815
MMV009108 PDB Ligand Antimalarial Ligand 11463 GNF-Pf-3616
MMV019313 PDB Ligand Antimalarial Ligand 11456 TCMDC-123889
MMV024101 Antimalarial Ligand 10017 compound 8 [PMID: 29889526]
MMV030084 Antimalarial Ligand 11201 TCMDC-140369
MMV048 Antimalarial Ligand 9726 MMV390048
MMV1803022 Antimalarial Ligand 11824
MMV367 Antimalarial Ligand 13673 GSK3772701, GSK701, MMV1582367
MMV688533 Antimalarial Ligand 11704 MMV533, SAR121, SAR441121
MMV689258 Antimalarial Ligand 11466
MMV693183 Antimalarial Ligand 11796 MMV183
MMV897698 Antimalarial Ligand 11825 compound 6 [PMID: 32678591], OSM-S-369
mupirocin Approved drug PDB Ligand Antimalarial Ligand 10916 Bactroban®, BRL-4910A, BRL-4910F, Centany®, pseudomonic acid
 
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naphthoquine Antimalarial Ligand 10396
NCATS-SM3710 Antimalarial Ligand 11822
NPC1161B Antimalarial Ligand 10393 NPC-1161B
 
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OSM-S-38 Antimalarial Ligand 9708
 
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P218 PDB Ligand Antimalarial Ligand 9740 MMV000147
PA21A092 Antimalarial Ligand 10415 PA92
panobinostat Approved drug PDB Ligand Antimalarial Ligand 7489 Farydak®, LBH-589, LBH589
piperaquine Approved drug Antimalarial Ligand 10025
primaquine Approved drug PDB Ligand Antimalarial Ligand 9952
proguanil Approved drug PDB Ligand Antimalarial Ligand 9676 Bigumal®, chloroguanide, Paludrine®
pyrimethamine Approved drug PDB Ligand Antimalarial Ligand 4800 Daraprim®, GNF-Pf-5586, TCMDC-125860
pyronaridine Antimalarial Ligand 10086 7351, Malaridine®
 
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quisinostat PDB Ligand Antimalarial Ligand 7503 JNJ-26481585
 
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sapanisertib PDB Ligand Antimalarial Ligand 7933 INK 128, INK-128, INK128, MLN0128, TAK-228
SC83288 Antimalarial Ligand 10175
SGC-CBP30 PDB Ligand Immunopharmacology Ligand Antimalarial Ligand 7529
(+)-SJ733 Antimalarial Ligand 9723 (+)-SJ000557733, (+)-SJ557733
SQ-109 Antimalarial Ligand 7997 MMV687273, SQ 109, SQ109
sulfadoxine Approved drug Antimalarial Ligand 10173 sulphadoxine
sulfalene Antimalarial Ligand 10174 Kelfizine®, sulfamethopyrazine, sulfamethoxypyrazine, sulfametopyrazine
sutidiazine Antimalarial Ligand 10024 AZ13721412, MMV253, MMV674253, ZY19489
 
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tafenoquine Approved drug Antimalarial Ligand 9722 Arakoda®, etaquine, Krintafel®, WR238605
TCMDC-125163 Antimalarial Ligand 10339
TCMDC-135051 PDB Ligand Antimalarial Ligand 11109
tebuquine Antimalarial Ligand 10392 WR 228,258
 
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UCT943 Antimalarial Ligand 10093
 
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WEHI-842 PDB Ligand Antimalarial Ligand 10616
WLL-vs Antimalarial Ligand 11321
WM382 PDB Ligand Antimalarial Ligand 11162